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Article Information
Received 17 Nov 2015
Received in revised form 12 Jan 2016
Accepted 15 Jan 2016
Abstract
Diabetes mellitus is a global metabolic epidemic affecting essential biochemical activities in
Keywords:
Diabetes mellitus
Phytoconstituents,
Blood glucose,
Insulin.
almost every age group. Diabetes mellitus is a group of metabolic diseases characterized by high
Corresponding Author:
E-mail: pushpaprasad81@gmail.com
Mob.: 09907105687
lowering property. Some of these have proved remarkable for cure of diabetes and its
blood glucose level. When the body failed to produce sufficient insulin or is not able to insulin
effectively or both leading to diabetes. Presently herbal drugs are widely used for the treatment of
diabetes in worldwide. India has a long list of native medicinal plants with confirmed blood sugar
complications. In this paper an attempt has been made to give an overview of certain Indian
plants with their phytoconstituents and mechanism of action which have been studied for their
antidiabetic activity.
1 Introduction
Diabetes is characterized in people having high blood glucose called
high blood sugar or hyperglycemia. It is one of the common
metabolic disorders, according to current survey on diabetes about
2.8% of the population suffers from diabetes throughout the world
and it may cross 5.4% by the year 2025. In India, the prevalence rate
1-3
Many Indian plants have been investigated for their beneficial use in
excessive muscle loss in the ancient world. Blood glucose levels are
lowers the blood glucose level. When the blood glucose elevates,
4,5
level.
9-21
which are used for medicinal purposes around the world. Among
these 2500 species are in India, out of which 150 species are used
dysfunctions, etc.
antiageing,
antiarthritic,
sedative,
antidepressant,
22,23
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Environmental insult
Genetic predisposition
Autoimmune attack
cells destruction
Type 1 Diabetes
Environmental insult
Abdominal obesity
Insulin resistance
Hyperglycaemia
Type II diabetes
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
The use of herbal drugs in the correct way provides effective and
safe treatment for many diseases. The efficiency of the herbal drugs
is typically subjective to the patient. The strength of the herbal drugs
varies based on the genetic distinction, growing conditions, timing
and method of harvesting, revelation of the herbs to air, light and
dampness, and type of conservation of the herbs. These raw material
are further processed and prepare methods of preparation may differ
4 Competing interest
Author claims no competing interests.
5 Authors contributions
PS, KS and PP carried out literature review and draft the manuscript.
SC, RKS and AR participated in collection of data. All authors read
and approved the final manuscript.
6 References
24-29
1.
2(2): 97-103.
diseases
like
accompanied
diabetes
with
mellitus.
several
Diabetes
other
diseases
mellitus
is
2.
healthy
infecting
alone
13,14
very good source of drug and many of the currently available drugs
have been derived directly or indirectly form them. India is the largest
Indian
15
world .
antidiabetic
potential
among
namely
Combretum
4.
Diabetes
Research
and
Clinical
Parinari
excelsa,
Ricinus
communis,
Sarcopoterium
population.
5.
herbal plants source and their active principles are given in the table
different
type
of
biological
activity,
among
these
alkaloids,
6.
7.
8.
Shin HJ, Kim JH, Yi JH, Han SW, Kim HJ. Polyuria with
This review discussed selective herbal plants and showed that they
activity due to presence of tannin, saponins, alkaloid, glycoside,
and
Criteria,
potential according to the different part used and mode of action are
3 Conclusions
Diagnostic
Classification,
16.
presented in tables 1
MI.
The current review is focus on use of herbal drug for the treatment of
Harris
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
10.
23.
Research
J.
Pharmacognosy
24.
25.
26.
27.
28.
29.
Guidelines
for
the
Gossell M, Simon OR, West ME. The past and the present
report
technical
WHO
22.
124.
21.
5(2): 783-787.
20.
19.
Clinical
18.
medicine.
17.
alternative
16.
or
207(2): 160-169.
15.
opinion
14.
and
20-23.
35.
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
36.
37.
48.
49.
39.
40.
41.
42.
43.
mangroves,
III.
Free
amino
acids,
total
50.
51.
40(3): 163-173.
52.
Shyaula
SL,
Phytochemicals,
Traditional
Uses
and
53.
54.
(diallyl
disulphide-oxide)
on
alloxan
diabetes
I,
56.
40(3): 163-173.
57.
high
367371.
cysteine
47.
46.
45.
44.
sulfoxide
from
Allium
cepa
Linn
in
58.
59.
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
60.
71.
72.
407-413.
73.
64.
65.
N.
experimental
observations.
Hormone
74.
alloxan-induced
75.
of
19(4): 322-25.
76.
77.
alloxan-induced
diabetic
rats.
79.
81.
Possible
mechanism
of
lowering
agents
of
plant
origin.
J.
RR.
on
streptozotocin-induced
Chattopadhyay
blood
report
andrographolide
Preliminary
of
SK.
2935.
effect
Maitra
363.
G,
70.
Journal
69.
rats.
68.
diabetic
67.
66.
Parman
876878.
82.
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
medicinal
plants
in
alloxan
diabetic
rats.
J.
93.
83.
1(6): 468-471.
94.
spectabilis.
In-vivo
studies
in
murine
of
Action.
Iranian
Journal
96.
97.
and
pharmacological
ingredient.
International
journal
of
98.
Agadjanov
MI,
acid
cycle
in
alloxan-
diabetic
rats
Almeida
RN,
Filho
J,
Naik
SR.
Chemistry
and
14(2): 216-221.
100.
101.
102.
beet,
Hypoglycemic
oleanolic
Alloxan
To
study
Induced
Caesaplinia
Diabetic
Rats.
acid
workers.
co
14(2): 216-221.
Biswas,
bonducellaMethanol
995-997.
92.
GS,
91.
Vartanyan
3650.
90.
KG,
Karageuzyan
417-422.
their
Hypotensive,
activity.
SA.
glucosefatty
Hussain
M,
Ahmad
of
R,
Saleem
86.
Chang SL, Chang CL, Chiang YM, Hsieh RH, Tzeng CR,
Wu TK, Sytwu HK, Shyur LF, Yang WC. Polyacetylenic
103.
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
104.
116.
105.
106.
117.
and
Islam
MS,
Choi
H,
Green
tea.
anti-
diabetic
118.
119.
120.
122.
Islam
MS,
Choi
H.
Green
tea,
anti-diabetic
or
Adaobi
CE,
Peter
AA,
Charles
CO,
Chinwe
BO.
22.
1032-1033.
124.
114.
of
29(1): 45-53.
113.
journal
327-36.
112.
rats.
diabetic
111.
alloxan-induced
110.
from
polyphenols
109.
of
237.
127(2): 457-462.
activities
antibacterial
or
29(1): 45-53.
108.
107.
127.
128.
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
129.
130.
linked
2011;49(1):125-131
141.
142.
147.
149.
triacetate
isolated
from
Ginkgo
biloba
litturale
126(2): 339-344.
blume
in
alloxan
induced
diabetic
rats.
150.
97(3): 497-501.
140.
139.
138.
137.
Toxicol.
136.
Chem
Kitamura H
135.
Food
134.
diabetes.
133.
132.
type
131.
to
151.
Navarrete
A,
Mata
R.
Antihyperglycemic
effect
of
152.
Ojewole
JA.
Antinociceptive.
Anti-inflammatory
and
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
153.
154.
137189.
167.
168.
170.
2001;47(4): 340344.
171.
159.
172.
145151.
174.
J,
Karunanayake
EH.
Journal
of
175.
161.
Welihinda
Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM,
Passwater R. Antidiabetic activity of a standardized extract
158.
156.
176.
1240.
Welihinda
J,
Karunanayake
HE.
Journal
of
50.
Basch
WE,
Gabardi
S,
Ulbricht
C.
Bitter
Melon
diabetes
mellitus.
Metabolism.1998;
179.
47(6): 663-668.
476482.
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
mice Journal of Ethnopharmacology. 2001; 76(3): 233
192.
238.
181.
193.
Antiinflammatory,
analgesic
195.
196.
3(10):
198.
2(3):
199.
109-121.
Knoss W, Reuter B, Zapp J. Biosynthesis of the Labdane
1137-1140.
449-454.
Hypoglycemic
effect
of
ethanolic
extract
of
200.
relation
with
antioxidant
potential.
Thymoquinone
on
201.
Sciatic
Nerves
rats.
in
in
33(1): 87-96.
state
38(2): 3945.
hyperglycemic
Herb
Musa
191.
3639-3650.
190.
189.
188.
its
50.
187.
and
186.
eugenol
185.
on
and
184.
note
Ojewole
with
183.
Linn
182.
202.
279-28.
UK J Pharm & Biosci, 2016: 4(1); 92
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
203.
JR.
Hypoglycemic
activity
of
216.
217.
219.
214.
220.
triterpenoids
with
alloxaninduced
diabetic
rats.
Journal
of
221.
417.
222.
the
drugs.
Journal
of
223.
treatment
of
diabetes
in
Israel.
224.
medicinal-plants
PK,
Mehta
S,
Watal
G.
Hypolipidaemic
of
Rai
Journal
Applied
&
225.
in
Northern
Israel.
Journal
of
Internationales
820-824.
226.
de
Pharmacody-
name
et
de
Z,
39853992
R.
Sampson
S,
Rosenzweig
T.
Sarcopoterium
17.
215.
mangle
450-2.
213.
Rhizophora
herbal
212.
LA.
211.
Williams
210.
and
209.
369378.
905-909.
208.
218.
207.
206.
Pterocarpus
227.
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
228.
229.
230.
240.
241.
98(1): 171175.
242.
properties
of
Tinospora
cordifolia
stem
indian
herbal
medicines
used
for
244.
245.
3(1): 18-29.
Ali L. Characterization of the hypoglycemic effects of
246.
61(4): 358-360.
Metzker H, Holscher U. Efficacy of a combined sabal-
247.
237.
236.
235.
Abdl- zaher Ao, Salim SY, Assaf MH, Abdel- Hady RH.
Teucrium polium antidiabetic activity and toxicity of
234.
233.
232.
231.
248.
Osadebe PO, Odoh EU, Uzor PF. The search for new
hypoglycemic agent from plants. African journal of
pharmacy and pharmacology. 2011; 8: 292-303.
239.
acetate:Isopropanol
(1:1)
fraction
of
Vernonia
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Table 1: Medicinal plants reported antidiabetic activity along with active constituents and mechanism of action
Medicinal
plants
Family
Parts used
Active constituents
Mechanism of action
Structure of chemical
(MOA)
constituent
Ref
Ome
Acacia Arabica
Rubiaceae
Seeds
Flavonoid
Insulin secretagogue
activity
HO
10,30,31,32,3
3,34
Ome
meO
OH
Ambrettolide,
Abelmoschus
moschatus
Whole plant,
Malvaceae
Aerial part of
plant
essential oils,
myricetin (3,5,7trihydroxy
phenyl)chromen-4-
HO
OH
O
HO
OH
glucose
35,248
OH
OH
one.
Achinochloa spp.
Poaceae
Seeds
Changes in hexokinase
activity
CH2OH
C
H
H
C
H
OH C
H
C
OH
H
C
OH
OH
Increase the
H
O
Aconitum
carmichaelic
Ranuculaceae
Roots
Diterpenoid, alkaloids
permeability of the
H3C
37,38
H
H
HO
OH
HO
carmichaeli
Ranuculaceae
Roots
Glycan A,B,C,D
CH3
Aconitum
O
OH
HO
Stimulation of in vitro
OH
OH
O
HO
O
O
insulin secretion
36
HO
HO
NHAc
HO NHAc
39,40,41
NH
HO
HO
O
HO
Glycosides,
Adansonnia
digitata
R1
O
Bombacaeae
Stem bark
42
semigossypal
Abroma
augustum
CH3
Abromine, its
Malvaceae
Roots
R2
alkaloids,
hydrochloride and
CH3
H3C
CH3
phytosterol
CH3
H3C
42
H
HO
CH3
Abies pindrow
Pinaceae
Root,Leaf
D-pinitol (3-o-mehtylchiroinositol)
Insulin secretogouge
activity
HO
6
OH
43
3
H2 CO
OH
CH3
(justice
aadhtoda)
CH2
Pegain-type alkaloid
Adhtoda vasica
Acanthaceae
leaves
42
N
OH
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Allium
cepa(Onion)
Liliaceae
Bulbs(oil),
5-methy cysteine
Lowering blood
sulfoxide (SMCE),
glucose level,
CH3
Diphenylamine,
Regulation of the
stems, tops
Onion,
Sulphide
O
44,45,46,47
H2C
enzyme
hexokinase/glucokinas
H2N
COOH
CH
Allyl propyl
Disulphide,allicin,5Allium sativum
Alliaceae
Bulbs, cloves
allyl
cysteine(SACE),Allici
Antihyperglycemic and
antinociceptive effect
48,49,50,51,5
CH2
H2C
2,53,54
n(diallyl thiosulfinate)
HO
Liliaceae
leaves
Pentosidesbarbaloin,i
Maintain glucose
sobarbaloin,aloin,Lop
homeostasis,
henol(phytosterols),24
Stimulates insulin
-methyene-
cycloartanol
OH
OH
55,56,57,58,5
HO
-cells
9,60
O
OH
HO
OH
CH3
Aloe
Barbadensis
Liliaceae
leaves
ArboranA,ArboarnB,
Aloesin
Stimulating synthesis
OH
H3C
and/or release of
61,62,63,64
HO
insulin
OH
HO
HO
CH3
H3C
Althaea
officinalis
Malvaceae
Leaves, whole
plants
Mucilage
CH3
COOH
42
COOH
H3C
N
H
O
OH
H3C O
Ajuga spp.
Labiatae
Diterpenoid,ajugalact
one
CH3
H3C
O
36,248
CH3
H
HO
OH
Stimulating effect on
Allium spp.
Liliaceae
H2C
Allicin, allylpropyl
glucose,
cloves
Utilaization and
antioxidant enzyme
OH
NH2
HO
36
OH
Isoquercitrin,
Althaea spp.
Malvaceae
42
HO
O
OH
O
HO
OH
OH
HO
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Amaranthus
spinosus
Amaranthaceae
Stem
HO
CH3
NH
Cl
42
CH3
Cl
HO
Anacardium
occident tale
Anacardiaceae
Cashew leaves
Phenolic compound
&tannins
OH
Reduces diabetic
HO
induce functional
36
OH
O
OH
Sesguiterpenes,
Arctium lappa
Compositae
Burdock roots
36
CH3 OH
tropane alkaloids
CH3
CH3
CH3
OH
Andrographis
paniculata
Acanthaceae
Root
Flovones, glucosides
Increase glucose
lactones
metabolism
65,66,67,68
CH3 OH
CH3
CH3
CH3
HOH2C
O
Anemarrhena
asphodeloids
CH3
OH
Annoaceace
Rhizomes
Anemarans A,B,C,D.
HO
HOOH
OH
42
HO
Atractylode
japonica
CH3
OH
Compositae
Rhizomes
Atractans A,B,&C
H3C
HO
42
O
HO
Indole, Isoguinoline
Argyreia cuneata
Convolvulaceae
Rivea leaves
pyrrolidine, tropane
36
N
H
alkaloide
Annona
squamosa
Atriplex halimus
Annonaceae
Chenopodiaceae
Fruits
Liriodenine,
moupinamide
Salt bush
Alkaloids,
leaves
oils
Hypoglycaemic and
antihyperglycemic
NH
69,70,71,72,2
activities of ethanolic
48
R1
O
R2
36
N
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Areca catechu
Arecaceae
Seed
HO
73
N
CH3
HO
Increased plasma
insulin lavel
Artemisia pallens
Aseraceae
Leaves &
flowers
Hypoglycemic,
Germacranolide
increases peripheral
74
glucose utilization or
inhibits glucose
reabsorption
O
O
Azadirachta
indica
Glycogenolytic effect
Meliaceae
Leaves &seeds
due to epinephrine
CO
2ME O
H3C
O
O OH
O
me
H3C
9,80,81,82,83
OH
me
Aco
CO
2Me
,84
OH
75,76,77,78,7
Bamusa
arundinacea
Gramineae
Dimethoxybenzoquino
ne, allantoin
H
N
N
H
NH
O
NH2
36
Alkaloids,tannins
Barleria lupulina
Acanthaceae
Aerial part
Diterpinoids,cyanogen
etic compound,
CH3
H3C
saponin
Berberidaceae
Bhighia sapida
jatrorrhizine
Sapindaceae
Sapindaceae
Akee apple
seeds
42
H
3C
O
H
NH2
Hypogylcin A& C
O
H2C
Scrophulariaceae
Hypogylcin A& B
CH2
HO
Aerial parts,
Hersaponin,
leaf
bacoside A
H3C
Zygophyllaceae
Mespcarp of
Pure saponin,
fruit
steroidal saponins
CH3
H3C
COOH
CH2OH
H3C
CH3
H3C
COOH
CH3
RO
H3C
85,86
CH3
H3C
aegyptiaca
36
H2N
RO
H3C
Balanites
42
OH
H3C
Bacooa monnieri
42
H3C
columbamine
D)
Bhighia sapida
OH
Berberine, palmitine
Berberis
aristata(DARHAL
H3C
CH2OH
87
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
H3C
Bauhinia
candicans
Fabaceae
Leaf
Trigonelline,kaempfer
Reduce plasma
ol dirhamnoside
glucose level
88,248
OH
O
Ome
Bauhinia
purpurea
Fabaceae
Leaf
Flavonoid containing
fraction
HO
10,89
Ome
meO
OH
H3C
Bauhinia
Caesalpiniaceae &
variegate
Fabaceae
Bark, leaves
Flavonoids
,Roseoside
HO
H3C
CH3
H3C
90
OH
OH
OH HO
Beta vulgaris
Amaranthaceae
Root
Phenolics
,betacyanins
H C H
OH
H3C
-cells
CH
H
OH
HCH
H
H3C
Berberis vulgaris
Berberideceae
Root bark
Saponins
H3C
CH3
H3C
COOH
H3C
CH2OH
OG
H3C
Asteraceae
Whole plant,
leaf
cytopiloyne
93
CH3
RO
Bidens pilosa
91,92
HC H
CH3
94
OH
Bombax ceiba
Bombacaceae
Fruit, heart
C-flavonol, glycoside
wood, leaf
shaimimin
HO
OH
HO
HO
OH
OH
95
OH
HO
HO
HO
H3C
H3C
H3C
Boswellia serrata
Burseraceae
Gum resin
Oleo-gum, resin
H3C
CH3
89
CH3
CH3
HO
H H
O
OH
CH3
Bougainvillea
Rubiaceae &
spectabilis
nyctaginaceae
pinitol (3-o-methyl
chiroinositol)
Increase glucose
uptake
HO
6
OH
36,89
3
H2 CO
OH
CH3
OH
Bryonia alba
Cucurbitaceae
Root
Trihydroxyoctadecadi-
Metabolic changes
enoic acids
induced in diabetic
O
OH
HO
OH
OH
OH
HO
OH
OH
OH
96,97
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
H3C
COOH
Mucilage
Brassica oleracla
Brassicaceae
Cabbage
oils
COOH
36,248
H3C
CH3
N
H
Myricetin (3,4,7Bumelia
sartorum
Saptoceae
Root bark
HO
OH
trihydroxy-2(3,4,5-
trihydroxy phenyl)
level
HO
OH
98
OH
chromen -4-one
OH
OH
Caesalpinia
bonducella
Rubiaceae
Seed
Tannins, alkaloids
OH
Blocking of glucose
99,100,101
HO
absorption
OH
O
OH
Caeseria
esculanta
Caesalpinoideceae
Root
Tannins
OH
Reduction in blood
42
HO
glucose
OH
O
CH3
Cannabis indica
Cannabinaceae
Whole plant,
leaves
Cannabinoids
cannabinol
OH OH
42
H
H3C
CH3
H3C
Alkaloids-stachydrine
Capparis
sepiaria
Capparaceae
Leaves
glucocapparin
flavinoide, sterols,
1
2
CH3
19 9
Leguminosae
Roots
Sennoside mixture
20
16
14
42,248
15
Lowering blood
OH
HO
OH
COOH
glucose
HO
Auriculata
18 17
13
10
terpenes
Cassia
CH3
12
11
102,103,248
OH
HO
O
O
OH
OH
OH
HO
HO
OH
HO
C.fistula
Leguminosae
Seeds
Sennoside mixture
COOH
42
OH
HO
O
O
OH
OH
HO
C2 H 5
Catharanthus
roseus
Flower, leaves,
Apocynaceae
Alkaloid
catharanthine,lochneri
stem, root
ne,vindoline etc.
Increase metabolism of
glucose
104,105
N
H
O
O
OH
Clematis
Montana
OH
Ranucculin glycoside
Ranuculaceae
Fruits
& isoquinoline
alkaloids
HO
42
O
HO
OH
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Cluytia
richardiana
H3C
Euphorbiaceae
Whole plant
Saudin (diterpenoid)
CH3
42
H3C
Ceiba pentandra
Malvaceae
Roots ,leaves
Saponins,tannins
H3C
CH3
H3C
COOH
36
CH3
RO
H3C
CH2OH
R1
Centratherum
anthelminticum
Asteraceae
Seed
Alkaloids
R2
36
N
R1
Clerodendron
phlomoides
Verbenaceae
Whole plant
Valeporiates
36
H3C
CH3
R2
Theaceae
Leaves
H3C
damage,
N
C
hypoglycemic activity
Capparis
deciduas
Cinnamomum
zeylanicum
Capparidaceae
Lauraceae
Fruit
Bark
Spermidine,
Isocodono carpine
Cinnamaldehyde,
eugenol
CH3
C
CH
106,107
CH3
H
Hypoglycaemic,
H2N
hypolipideamic
NH2
108
CHO
109,110,111,
112,113
OH
Combretum
micronthum
Combretaceae
Leaves
Polyphenols
HO
OH
114,115,116,
117,118
OH
OH
OH
OH
Camellia
sinensis
Theaceae
Leaf
Epigallocatechin 3-
Increases insulin
gallate
secretion
HO
OH
O
OH
119,120
OH
OH
O
OH
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
NH
H2N
NH
Cajanus cajan
Fabaceae
Leaves, seed,
Arginine, ascorbic
Lowering plasma
fruit
acid
glucose level
121,122
OH
O
H2N
Ellagic acid
OH
Caesalpinia
ferrea
(EA),2 (2,3,6Caesalpinaceae
Fruit
trihydroxy-4carboxy
OH
pheny)
89
O
HO
OH
Caesalpinia
digyna
OH
Fabaceae
Root
Bergenin
OH
OH
H3C
89
CH3
HO
O
H3C
Caesalpinia
bonducella
Caesalpiniaceae
Seed
Caesalpin F
OH
OH
89
Caesalpinia
Bonduc
Caesalpiniaceae
Seed, kernel
Caesalpinianone
Me O
Cucurbitacins
Coccinia spp.
Cucurbitaceae
Coccinia
root/Tvy gourd
(triterpenoid),
89
HO
Stimulation of glycogen
synthatase activity
Me
O
H
HO
Me
H
HO
Me
OH
Me
36
Me
-elaterin
Me
Me
OH
Coptis chinensis
Ranunculaceae
Whole plant
Ranunculin glycoside,
isoquinolin alkaloid
HO
36
O
HO
O
OH
CH3
12
Corchorous
olitoris
11
Tiliaceae
Jute leave
cardiac glycoside
Cucurbitaceae
Cucumber fruit
(terpenoids),
16
14
OH
36
15
5
4
Me O
Cucurbitacins
Cucumis sativus
10
3
HO
17
13
CH3
HO
Me
HO
Me
-elaterin
Me
H
HO
Me
OH
36
Me
O
Me
Me
CH3
Cuminus
cyminus
Ambelifereae
Cumin seed
-Pinene, -terpinol
H3C
123
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
domestica
Zingiberaceae
Leaf
roxb
H3C
O
eugenol, -sitesterol
valeton
Cuscuta reflexa
pinene,camphene,
OH
HO
Curcumin, -
Curcumo
Flavonoid,dulcitol,
Convolvuraceae
Stem
bergenin, loumerins
124
CH3
O O
Ome
HO
10,124
Ome
meO
glycoside, lactone
OH
CH2
H3C
Cryptostegia
grandiflora
Asclepialaceae
Arial part
Triterpene alkaloids
CH3
CH3
CH3
42
CH3
HO
CH3
CH3
Cuminum nigrum
Umbeliferae
Flower, seeds
Volatile oil
125,126
(zira siyah)
HO
CH
OH
2
H
HOHH
Cyamposis
tetragonolobus
H
H
Leguminasae
Fruit seeds
Gaur gum
HO O
H2C
O
H
dactylon
OHHO
H
Mucilage, arabinose,
Roaceae
Whole plant
CH3
H
HOH
2C
H3C
Cynodon
OHHO
O
H3C
127
COOH
COOH
derivetives
42
COOH
N
H
Carotenes,
Daucus carota
linn.
C
H
3
carotenoids,
Apiaceae
Root
glycoside, flavonoids,
128
C
H
3
H
3C
suger quarternary
base
Dendrophthoe
memecylifolia
Loranthaceae
Whole plant
Glycoprotien,
Polypeptide lignans
H
3C
H
3C
C
H
H
3 C
3
H
3C H
3C
RO
RO
RO R O
C
H
3
H
CC
C NC C N C 3
H
2NC C N C
H
H
H
H
H HH
36
Me O
HO
Diflocyclos
palmatus
Cucurbitaceae
Fruit
Cucurbitacins
(terpenoids) -elaterin
Me
HO
Me
Me
H
HO
Me
OH
36
Me
O
Me
Me
CH3
H3C
Dioscorrea spp.
Dioscoreaceae
Tubers
Diosgenin
CH3
CH3
H
H
H
H
36
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
R1
Dipteracanthus
prostrates
Acanthaceae
Whole plant
Alkaloid, terpenoid,
diterpenoid, saponin
R2
36
N
H3C
COOH
Discorea batelus
Discoraeceae
Tubers
Mucilage alkaloids
COOH
42
COOH
N
H
H
H3C
Dioscorea
Demetorum
Mucilage, saponin,
Discoraeceae
Tuber
alkaloids discoretine,
dihydrodiscorine
COOH
To posses
COOH
hypoglycemic effect
H3C
129,42,89
COOH
N
H
H3C
OH
D.japonica
Echinops
echinatus
Discoreaceae
Discorane A,B,C,D,E
89
Isobutylamide,
Asteraceae
Roots
steroidal
COOH
HN
CH3
H
H
H
glycoalkaloids
36
H
H
H3C
Eleuthrococus
senticosus
Araliaceae
Siberian
Saponins,
ginseng
eleutharans
H3C
CH3
H3C
COOH
36
CH3
RO
H3C
CH2OH
OH
Ephedra
dislachya
Ephedraceae
Ephedrin, ephedrans
arial stem
A,B,C,D,E
CH3
130,131,132
CH3
Increase insulin
Eucalyptus
globules
Leaves
Calytosides
133
(BRIN-BD 11)
CH3
Eriobotrya
japonica
Rosaceae
Leaves
H3C
H
CH3
O
H3C
H
O
CH3
H3C
H3C
Euphorbia
prostrate
Euphorbiaceae
Whole plant
Triterpenoids,
eupohol, euphorbol
H3C
CH3
CH3
officenalis garth
Euphorbiaceae
Fruit
polyphenol, ellagic
CH3
CO 2H
HO
42
CH3
H3C
CH3
CH2
CH3
Embelica
36
CH3
134
HO
OH
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
tannins
O
O
Elephentopus
scarber
Asteraceae
Whole plant
Trienoloids
glucose level
CH3
OH
CH3
135
OH
H3C
O
HO
OO
OH
HO
Eugenia uniflora
Myrtaceae
Leaf
OH OH
H H
CH3
N
Uniflorin A, uniflorin B
Regulation of the
(+)-(3a,4a,5b)-L, 2-
enzyme
methylpiperidine-
hexokinase/glucokinas
3,4,5-Triol
O
O
OH
OH
Erigenon
breviscapus
Campositae
Plant extract
Scutellarin
HO
HO
O
HO
89
89
OH
Corosolic acid,
3-epicorosolic acid,
CH3
methyl ester,
Eriobotrya
japonica
H3C
2--hydroxy-3Rosaceae
Leaf
3oxours-12-en-28-oic
CH3
HO
OH
CH3 CH3
acid,
89
CH3
HO
H3C
CH3
ester,
ursolic acid
Enicotema
littorale
Gentianaceae
Whole plant
Swertiamerin, ophelic
acid, tannins,alkaloids
CH3
Decrease glucosylated
hb & glucose 6
HO
HO
OH
OH
136
phosphates
OH
Polyphenols,
Embelica
officinalis
Euphorbiaceae
Flavonoids,
Kaempferol,ellagic
OH
HO
10,137,138
OH
OH
acid,gallic acid
OH
Eleusin coracana
Poaceae
Seed coat
Polyphenols
HO
OH
89
OH
OH
Terpenoids,
Eichhornia
crassipes
Pontederiaceae
Shoot rhizome
glycoside,
flavonoids,tannis,
alkaloids
CH3
OH
N
H3C
89
CH3
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Exostema
mexicanum
4-phenylcoumarins
Rubaceae
Stem bark
glycoside, chlorogenic
OH
89
acid,ursolic acid
HO
4-phenylcoumerins
Exotema
caribecum
Rubiaceae
Stem bark
glycosides,
chlorogenic acid,
OH
ursolic acid
89
HO
Coumestane like
eudelolactone,
Eulipta alba
Asteraceae
Whole plant,
leaf
tesmethylecedelol
acetone,
furanocoumarins
oleanane, taraxastane
CH3
Regulation of the
CH3
enzyme
CH3
hexokinase/glucokinas
e
CH3
CH3
139
CH3
H
CH3
H3C
glycosides
Bengalinoside,Phytost
CH3
Ficus
eroine flavonoids,
bengelensis
glycosides, glycosidal
Inhibit insulin
fraction,
degradative process
(Anjir jangli,
Moraceae
H3C
H
140,141,142,
CH3
CH3 H
Leucopelphinidin &
katumani)
CH3
CH3
143
H
HO
leucopepargonin
CH3
H3C
CH3
CH3
F. glomerata
Mortaceae
Bark
Sitaosteryl glucoside
H3C
CH3
42
HOH2C
O
HO
HO
OH
CH3
H3C
Ficus spp.
Moraceae
Leaves
CH3
OH
CH3 CH3
HO
36
CH3
HO
H3C
CH3
Volatile oil,
Foeniculum
valgare mill.
Apiaceae
Fruit oil
fenchone,anethole,lim
onene, anisaldehyde,
H3C
CH3
124
CH3
estragole
Fumeria
palviflora
Papaveraceae
Whole plant
Sanguinarine,
alkaloids
H3C
N
H
42
O
O
CH3
H3C
Ficus erligiosa
Moraceae
Bark
-sitosteryl-dglucoside
CH3
CH3
CH3
H3C
89
HOH2C
O
HO
HO
OH
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
OH
Ficus racemosa
Moraceae
Stem bark
-sitosterol
Cl
CH3
NH
89
CH3
Cl
CH3
Fraxinus
excelsior
Oleaceae
Seed, plant
extract
Iridoids-secoiridoids
glucosides,
excelsides A and B
H 3C
144
OH
Galega officinalis
Leguminosae
Gouts rue
seeds, leave
Berberin,alkaloids
CH3OH
42,36
CH3OH
Glycyrhhizine,flavonoi
Glycyrrhiza
glabra
Om
ds,liquirithin,
Leguminosae
Roots
isoliquirithin,rhamnoliq
uirithin,2-
HO
36,124
Ome
meO
OH
methylsoflavones
Glycine max
(soya oil)
Fatty acid-linoleic,
Leguminosae
Seeds
oleic, palmitic,
H
3C
145
O
H
Gymnema
sylvestre
Asclepiadoceae
Leaf, roots,
whole plant
triacetate, gymnemic
acid,glycosamine
glycan & protein
CH3
H3C
HOHOOC
O
O
HO
bound polysaccharide
CH3
OH
OH
CH3 CH3
level
CH3
O
OH
CH3
146,147,148
HO
H3C
H3C CH
OH
2
Gynandropsis
gynantra
Capparidaceae
Roots
N,n-diethyltolumide
CH3
73
CH3
CH3
Ginkgo-flavone
Ginkgo biloba
Ginkgoaceae
Leaf
OH
glycoside,fraction
Inhibit -amyloid
quercetin, kaempferol,
deposition
HO
149
OH
isorhamnetin
OH
H 3C
Glycyrhhiza
uralensis
CH3
Fabaceae
Root
Glycyrhhizin
O
HO
H 3C
CH3
CH 3
89
H
CH 3
HO
HOOC
O
O
HO
Alkanoids and
Gentiana olivieri
CH 3
H
COOH
O
HO HOOC
Gentianaceae
Plant extract
biflavonoid extract of
seeds
HO
R1
R2
89
level
N
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
OH
Hamada
salicornica
Hamamelidaceae
Whole plant
Hamamelitanin,
hamamelose
HO
OH
OH
42
OH
CH3
Humulus lupulus
Cannabinaceae
Sterobiles
CH3
OH
OH
CH3
H3C
O
42
OH
HO
CH3
CH3
Haldinia
cardifolia
Hippophae
rhamnoide
Rubaceae
Elaeagnaceae
Thorn plant
Indole,
oxindole,quinoline,
36
N
H
purine alkaloids
Indole alkaloide ,
cyclitols
36
N
H
H3C
Hordueme
valgare
Gramineae
Barley sprouts
Volatile oil,alkaloids,
saponin, terpenoids
H3C
H3C
COOH
36
CH3OH
36
CH3
RO
H3C
CH3
CH2OH
Hydrostis
Canadensis
Berberidaceae
Goldenseal
Hydrastine, berberin
root
CH3OH
Hygrophila
auriculata
Acanthaceae
Berleria plant
root, seed
CH3
H3C
Semidrying oil
36
O
CH3
H3C
Ome
Hovenia dulcis
Rhamnaceae
Entire plant
Flavonoids
HO
10,89
Ome
meO
OH
Ome
Holostemma
adakodien
Asclepiadaceae
Root
Flavonoids
HO
10,89
Ome
meO
OH
Hintonia
standleyana
Rubiaceae
Leaf
Phenylcoumarins
150
Hintonia laciflora
Rubiaceae
Leaf, root
Neoflavonoid,
coutareagenin
89
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Harpagophytum
procumbens
Isovenillic acid-3
Pedalliaceae
Root
hydroxy-4-methoxy-
OH
benzoic acid
CH3
89
OH
Acetyllbetulinic acid,
Hydnocarpus
wightiana
Achariaceae
Seed hulls
OH
acid
89
HO
HO
Hypoxis
hemerocallidea
OH
Hypoxidaceae
Root tuber
Hypoxoside
C C CH CH
OH
151,152
H H
HOH2C
Inula heleniam
Campositae
Elecampnae
root
HO
Inulin
HO O
H
HOH2C
H HO
H
HO
Inula rocemosa
Asteraceae
Root
Volatile oil
Ipomoea batatus
Convolvulaceae
Root, leaf
AN acidic glycoprotein
O
OH H
36
CH2
OH
153
154
Reduced insulin
resistance & blood
glucose level
O
Juniperus
communis
Increase peripheral
Cupressaceae
Dried berries
Isocrupressic acid
CH3
H
HO
CH2
CH3
89
H3C
OH
4-hydroxy -tetralone-
Juglans regia
Juglandaceae
Root, leaves,
unripe fruit
4-0--D-E6-0(3,4,5,trihydroxybenzo
155
Kalopanax pictus
Araliaceae
Stem bark
Kalopanax, saponin A
H3C
CH3
H3C
COOH
36
CH3
RO
CH2OH
H3C
O
O
Kalanchoe
pinnata
Crossulaceae
Leaf
Bryophilin A
HO
CH3
H
O
OH
36
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Lantanoside,
Lantana camara
Verbenacae
Leaves
lantanone
CH3
CH3
H3C
H3 C
OH
156
O
OH
H3 C
O
OH
HO
O
O
HO
OH
O
OH
CH3
Alkaloids,nephthaquin
olone,
Lagerstroemic
speciosa (jarul)
Bark, root,
Lythraceae
lausone,gallotanins-
penta-o-galloyl-
ripe fruits
glucopyranose (pgg)
O
OH
157
OH
Lathyrus spp
Papilionoceae
Whole plant
Berberin, kaempferol,
quercetin
HO
36
OH
OH
Launaea
nudicaulis
Composite
Roots
Glycoside
42
OH
H
HO
CH3
CH3
Lepidium
ruderale
Crucifarae
Arial part
Lepidine
42
CH3
O
OH
Leucena
leucocephala
Leguminosae
Seed
Mimosine
42
CH2
H2N
CH
HOOC
Masoprocal
Larrea tridentate
Zygophyllaceae
Leaf
nordihydroguaiaretic
HO
CH3
HO
throrhizon
H3C
Whole plant
coumarin
OH
OH
Lithospermumery
89
CH3
acid
lithosperman A,B,C
N
C
CH3
C
C
N
CH
36
CH3
Lupines albus
Leguminosae
Lupin seed
H
3C
36
O
H
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
CH3
H2C
H
Lupus albus
Papilionaceae
Stem, flower
Lupelol
42
CH3
H
HO
CH3
CH3
CH3
H
CH3
H3C
OH
OH
Lythrum salicaria
Lythraceae
Stem, flower
Alkaloide, tannins
42
OH
OH
CH3
OH
Lyceum
barbarum
Solanaceae
Box, thorn,
Withanolides, indole,
leaves
isoquinoline alkaloids
CH3
virginicus
Liriope spicata
Momordica
charantia linn.
Labiatae
Liliaceae
Cucurbitaceae &
Bugleueced
Terpenoid,pyridine,
plant
pyrolidine alkaloids
Root
glucose level
polypeptide,plant
meliaceae
stigmasterol
fruit,
158,159
Charantin, sterol
Beta-sitosterol,
Leave, root,
CH3
OH
Lycopus
CH3
H3C
36
OH
CH3
Cl
CH3
12
11
1
2
level
18 17
19 9
165,166,167,
20
168,169,170,
16
14
171,172,173,
15
5
4
160,161,162,
163,164
13
CH3
10
triterpene glycosides
CH3
NH
Cl
174,175,176,
177
Morus alba
Moraceae
Mucuna pruriens
Leguminosae
Murraya koienigii
Musa
paradisiacal
Rutaceae
Leave, root
bark
Seed
Leaves, fruit
juice
Morana
l-dopa(1-by)
Quarcetin,
murrayacine,carbazol
e bis-indole alkaloide
Increase glucose
uptake
O
HO
OH
Flower
acid, anthocynin
Increase glycogenesis,
decrease
180
glycogenolysis &
N
H
gluconeogenesis
terpenoides,sterols
linn.
Ancardiaceae
CH3
12
11
1
2
3
Cynogenetic
glycoside
intestinal reduction of
polyphenols, vita+c
the absorption of
mangiferin, beta
glucose as well as
CH3
19 9
18 17
16
14
181
15
OH
HO
20
HO
13
10
Mangifera indica
179
NH2
HO
Fructossan, phendic
Musaceae
178
OH
OH
182,183,184
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
sitosterol quercetin,
pancreatic and
extrapancreatic
machanism
O
H3C
Melia azadirecta
Meliaceae
Pericarp of
Nimbin,nimbidin,nimbi
nin,azadirectinin
O
O
CH3
CH3
O
H3C
H
CH3
H
185,248
O
H3C
Marrubium
valgare
Lamiaceae
Leaf,root
Marrubin,marrubiaol
CH3
CH3
186,187,188
CH3
Momordica spp.
Cucurbitaceae
Buglue seed
Terpenoide, pyridine,
plant
pyrolidine alkaloids
level
36
H3C
CH3
O
O
Marus spp.
Maraceae
Mulberry
Pyridine alkaloids,
leaves
cardenoloides
CH3
36
OH
RO
OH
Mucuna spp.
Leguminosae
Seed/fruit
OH
OH
O
OH
36
OH
HO
OH
Phenolic acid ,
Musa sapientum
Musaceae
CH3
12
Banana flower
sterols,
root
anthocynine,indole
& glycosylated Hb
11
1
2
CH3
Nigella sativa
Ranunculaceae
Thymoquinone
189
15
5
4
20
16
14
10
alkaloids ,terpenoids
CH3
19 9
18 17
13
CH3
190,191
H3C
O
R1
Nymphaea
nouchali
Nymphaceae
Roots
Alkaloids,starch
Increase plasma
R2
42
glucose level
N
R1
O
Nymphaea lotus
Nymphacea
Lotus root
Alkaloids ,tannins
R2
36
N
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Volatile oil,
CH3
terpenoide,eugenol,
Ocimum
sanctum linn.
Lamiaceae
Leaf
thymol,estragole,
level
192,193,194
H3C
pyridine,pyrolidine
CH3
alkaloids
Sugar alcohol,
Olea europoea
Oleaceae
Leaves
Oenothera
biennis
Opuntia spp.
Opuntia
sterptacanthus
Potentiation of glucose,
HOH2C
O
H HH
HO
HO
uptake of glucose
OH
primrose
Gammo-linolenic acid
H
3C
36
O
H
leaves
Cactaceae
Prickly pear
stem & fruits
198
OH
Evening
Onagraceae
195,196,197,
Isoquinoline alkaloide
cyanogenetic
36
glycoside
Isoquinoline
Cactaceae
Sap
alkaloids,cynogenetic
HO
OH
HO
Root, external
Gramineae
Oryza sativa
seed coat,
seed
Glycan-oryzanans
A,B,C,D
42
glycoside
O
OH
HO
OH
OH
O
HO
O
O
HO
HO
NHAc
HO NHAc
42
NH
HO
HO
O
HO
CH3
Otholobium
pubescens
H2C
Bakuchiol-4[-3Fabaceae
Plant extract
ethenyl-3,7-dimethyl-
CH3
199
CH3
1,6-octadienyl)phenol]
OH
H3C
CH3
O
HO
O
HO
HO
Opuntia dilenii
Cactaceae
Fruit
Polysachharides
HO
O
HO
HO
89
HO
O
HO
HO
HO
O
HO
HO
H3C
O
CH3
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
H3C
CH3
HO
HO
HO
Ophiopogon
japonicas
Asparagaceae
Roots
Polysachharides
HO
O
HO
HO
89
HO
HO
HO
HO
HO
HO
Panax spp.
Araliaceae
Ginseng root
oleanolic acid
level
CH3
OH
CH3
CH3
Peganum
harmala
Rutaceae
Seed
Peganine alkaloids
36
HO
H3C
CH3
CH3
H3C
Panaxanes,ginseng &
H3C
CH3
36
N
OH
OH
Kinotennic acid,
Phaseolus
valgaris
Leguminosae
Pod, seed,
whole plant
kinored &
(-)epicathechin
Hypoglycaemic,hypolipi
demic,inhibit alpha
H
O
HO
OH
antioxidant
OH
Aucubin,
Plantago spp.
Plantaginaceae
globularinoleanolic
OH
HO
acid, luteolin
Polygonatum
multflorum
Liliaceae
Solomons seal
root
alkaloids
36
OH
amylase activity,
OH
36
N
MOA not available
36
N
H
Ome
Primula
denticulate
Primulaceae
Flowers
Flavonoids,saponins
HO
10,36
Ome
meO
OH
Kinotanic acid,
kino red &
Pterocarpus
morsupium
Leguminosae
Stem bark,
(-)epicatechin,
gum resin,
pyrocatechin,
bark,
heartwood,
wood
pterocarpol,
Ome
10,200,201,2
HO
02,203,204,2
Ome
meO
OH
05
pterostilben,
pterostilbine,
flavonoids
Bitter,
R
R
Phylanthus
amarus
Phylanthaceae
Leaf, whole
plant
lignans-phylanthin,
hypophylanthine,
bioflavonoids
R
3
BR
20
21
R A
206
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Panax quinque
folius
Ginsenoside,
Arliaceae
Root
protopanaxadiol
CH3
HO
OH
CH3
CH3
CH3
73
CH3
Gle2Gle-O
H3C
CH3
OH
OH
Parinari excels
Chrysobalanaceae
Bark
Myricetin,quircetin
HO
OH
73
OH
OH
OH
HO
Prunus
amygdalus
Rosaceae
Seed
Amygdalin
HO
HO
HO
73,248
O
OH
HO
C
N
CH3
HO
OH
OH
HO
Punica granatum
Lythraceae
Fruits
Punicolagin,punicalin
OH
207
HO
CH2
OH
OH
HO
O
Panax ginseng
Araliaceae
Roots
Panaxans A,B,C,D
HO
HO
H3C
CH3
H
CH3
level
R
H3C
CH3
CH3
OH
208,209,210
CH3
H
CH3
H3C
Ome
Phylanthus
fraternus
Euphorbiaceae
Leaves
Flavonoids
HO
10,42
Ome
meO
OH
Pongamia pinnta
Psoralea
corylifolia linn.
Leguminoceae
Bark
Oil
Seed
resin,bakuchiol
42
O
O
(monoterpene phenol)
(amrood
H3C
Myrtaceae
Juice
Triterpenoid,saponin
H3C
CH3
H3C
COOH
H3C
CH2OH
H3C
Poterium
ancisrodies
Rosaceae
Leaves
Triterpenoids,termenti
la acid
211,212
CH3
RO
,guavava)
124
Psidium guajava
H3C
CH3
CH2
CH3
CH3
42
CH3
CH3
O
H3C
H
CH3
OH
HO
Pruns persica
Rosaceae
Leaves
Amygdalin
HO
HO
HO
42,248
O
OH
HO
C
N
CH3
Quercus
lancaefolia
Fagaceae
Stem bark
N
H3C
36
CH3
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
OH
OH
Quercus
infectoria
Fagaceae
Leaf
Quercetin
HO
89
OH
OH
Vanadium
Quercus rubra
Fagaceae
Seed
manganese,
magnesium,copper,
O
+
Cr
3+
89
chromium
N
O
OH
OH
Quercus alba
Fagaceae
Bark
Quercetin
HO
89
OH
OH
CH3
Fagaceae &
Stem bark,
serpentine
Apocynaceae
root, leaves
terpenoids,
42,36
total alkaloids,ajmalin
H3C
CH3
O
OH
Rhus typhina
Anacardiaceae
Staghorn
Phenolic compound
stomach
and tannin
OH
36
HO
OH
O
Anthraquinone,
Ricinus comunis
Euphorbiaceae
Caster been
root
R1
O
triterpenoids,
216
OH
HO
apiculata
Rhizophoraceae
Root
213,214,215,
alkaloids,ricinoic acid
Rhizophora
R2
Inositol,pinito
H
HO
HH H H
217,218,219
OH
OH HO
Volatile oil,
Santalum album
linn.
Santalaceae
Heartwood
bark
santalol,-santalol,-
OH
Solanum nigrum
linn.
124
CH3
Cl
santalol,-sinosterol
CH3
NH
Cl
Polyphenolic
Solanaceae
Leaf
compounds,flavonoid,
Ome
HO
220,10
Ome
meO
steroids
OH
OH
Salacia oblonga
wall
Celastraceae
Root bark
Salcinol
Inhibits -glucosidase
OH
HO
S
activity
HO
so3o
OH
221
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
OH
Sarcopoterum
spinosum
Rosaceae
Root
Catechin &
epicatechin
OH
222,223,224,
HO
225,226
OH
OH
Sachharum
officinarum
Gramineae
Sachharin
NH
Si
2-
Decreased
Scoparia dulcis
Scrophulariaceae
Sweet broom
plant
glycosylated Hb &
inc.total Hb, insulin
227,228
O
CH3
Anthraquinone,
virosa
Euphorbiaceae
Fluggea seeds
triterpenoids,
aucuparia
Spinaceae
oleracea
R1
O
36
N
HO
HO
Rosaceae
Whole plant
Sarbitol, D glucitol
HO
R R
Spinach leaves
Volatile oil
OH
36
OH
OH
Chenopodiaceae
R2
alkaloids
Sarbus
CH3
secretagogue activity
Securinega
36
36
R1
O
Stephenia glabra
Menispermaceae
Tuber
Alkaloids,terpenoids
R2
36
N
HO
OH
HO
OH
O
Stevia
rebaudiana
O
HO
Compasitea
Whole plant
Stevioside
HO
OH
CH2
CH3
229
OH
HO
H3C
O
OH
HO
OH
Syzygium spp.
Myrtaceae
Fruit
Phenol,essential
Decrease blood
oil,tennin,alkaloids
glucose level
OH
36
HO
OH
O
Lignum,sesamin,
Sesamum
indicum
H3C
H C H
OH
Pedaliaceae
Seeds
Phenolic derivetives,
H3C
Semecarpus
anacardium
Fruit, nut
H C
CH3
89
CH3
Ome
OH
H3C
Flavonoids,
Anacardiaceae
HC H
sesamol,sesmolin
OH
HO
89,10
Ome
meO
OH
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
OH
OH
Scrophularia
ningpoensis
Scrophylaraceae
Root
Harpogoside
OH
CH3
OH
89
H3C
OH
HO
OH
Scrophularia
desrti
Scrophylaraceae
Arial part of
plant
OH
Scropolioside-D,
CH3
OH
89
H3C
harpagoside-B
OH
OH
HO
ome
meo
Schisandra
chinensis
meo
Schisandraceae
Fruit
Schizandrin B
89
me
O
me
Mangiferin,salacinol,k
Salacia oblonga
Cetastraceae
Root
otalanol,kotalagenin
16--acetate
HO
HO HO
Inhibition of alpha
OH
glucosidase activity
HO
HO
officinarum
221
OH O
OH
OH
HO
Sachharum
OH
Glycans A,B,C,D,E,F,
O
OH
HO
OH
OH
Poaceae
Stalk
HO
O
O
HO
protein sachharin
O
NHAc
HO
HO NHAc
89
NH
HO
HO
O
HO
CH3
O
Smallanthus
sonchifolius
Asteraceae
Leaves
Sochifolin,uvedolin
enhydrin,flunctanin
O
O
CH3
O
CH3
H3C
230
CH2
H3C
H3C
H3C
Sulertia punicea
Gentianaceae
Whole plant
..
73
CH2
Tecoma stans
Bignoniaceae
Tronadora
leaves
CH2
Monoterpenes
alkaloids,techomine
36
techostanin
H3C
CH3
OH
Taraxacum
officinalis
Sisquiterpenoids,
Asteraceaed
Dendiolon root
lactone,insulin
CH3
OH
36
CH3
CH3
CH3
H3C
Thalictrum
foliolosum
Ranunculaceae
Meadow reu
Saponin &
plant
triterpenoids
H3C
CH3
H3C
COOH
CH3
RO
H3C
CH2OH
36
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
Isoquinoline
Tinospora
cordifolia
Menispermaceae
Gulancha plant
alkaloids,tinosporin,
Decreased blood
root
berberin,tinosporinon
231,232,233
e,tinosporic acid
H3C
Trichosanthes
dioica
Cucurbitaceae
Whole plant
Trichosanthin &
saponins
H3C
CH3
H3C
COOH
CH2OH
H3C
H3C
Trigonella
foenum graecum
Papilionaceae
Fenugreek
Decreased blood
4-hydroxy isoluecine
glucose concentration
36
CH3
RO
H3C
CH3
H3C
COOH
234,235
CH3
RO
CH2OH
H3C
Ome
Triticum sativum
Gramineae
Wheat leaves
Alkaloids,terpenoids,s
aponin,flavonoids
HO
36,10
Ome
meO
OH
Urginia
indica/drimia
Liliaceae
Tuber ,leaves
Allicin, allin
indica
H2C
CH2
36
H3C
Urtica dioica
Urticaceae
Stinging nettle
plant
Phenolic compounds,
lignans
H C H
Increase insulin
OH
H3C
secretion
OH
OH
H C
HC H
CH3
236
CH3
H3C
H3C
H C H
Vaccinium
myrtillus
Ericaceae
Bilberry leaves
Phenolic
compound,ligans
OH
H3C
OH
OH
H C
HC H
anthelmintica
Asteraceae
Seed
Epoxy acid,vernolic
acid
Catharanthine,
Vinca rosea
Apocynaceae
Whole plant,
leaves, roots
locherine, vindoline,
luerosine, vindolinine
CH3
36
CH3
H3C
Vernonia
237,238,239,
H
3C
C2H5
-cell rejuvenation,
regeneration &
242
N
H
stimulation
240,241
O
H3C
OH
Vernonia
amygdaline
Asteraceae
Leaves
Vernonioside B and
myricetin
OH
HO
OH
243
OH
OH
Somniferine,
O
withanine,
Withania
somnifera dunal
Solanaceae
O
NH
level
acid,withaferin A,
UK J Pharm & Biosci, 2016: 4(1); 119
244
Sen et al. Phytochemistry and Mechaniasm of Action of Plants having Antidiabetic Activity
cholin steroidal
lactone
Hypoglycaemic
diterpen-kaurenoic
Wedelia
paludosa
Compositeae
Stem, root
acid,
CH2
CH3
(ent-16-kauren-19-oic
89
O
OH
acid)
HOOC
Xanthium
strumarium
Asteroceae
Increase glucose
(cat)
utilization
Seed, fruit
CH3
O
Carboxyatractyloside
CH3
HOOC
OH
HOOC
89
COOH
COOH
HOOC
CH2
H3C HC
CH3
-tocopherol,
Plant, seed,
Zea mays
Gramineae
quercetin, flavonoids,
terpenoids,
Ome
HO
89,10
Ome
meO
OH
glucorono-xylo
oligosachharides
[6]-gingerols,
Zingiber
officinale
Juice of ginger,
Zingiberaceae
tannins,polyphenolic
compound,
(eg.coumarins)
Ome
decrease fasting
HO
glucose level
meO
245,246,10
Ome
OH
Flavonoids,
triterpenoids
H3C
Zizyphus
spinachristy
Rhamnaceae
Leaves
Saponin glycoside-
Reduction in blood
christinin-A
glucose level
H3C
H3C
COOH
CH2OH
Triterpene acid,
Zygophylum
gaetulum
Zygophyllaceae
Arial part,
leaves
defferent sugar
residue at c3 & c8 of
the -glycone
247
CH3
RO
H3C
Bistesmoside with
CH3
CH2
H3C
Glucose- lowering
CH3
effect
CH3
CH2OH
CH3
HO
CH3
CH3
89