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Submitted by
CEM USMANGL
BETL MALAK
Yeditepe University
Istanbul
TABLE OF CONTENTS
1.
INTRODUCTION..................................................................................................
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2.
BIOMATERIALS...................................................................................................
3
2.1 Metallic Biomaterials
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2.2 Ceramic Biomaterials
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2.3 Polymer Biomaterials
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2.4 Composite Biomaterials
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3.
4.
5.
REFERENCES.....................................................................................................
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1. INTRODUCTION
Biomaterials can be divided into four major classes of materials: polymers, metals,
ceramics (including carbons, glass ceramics, and glasses), and natural materials as
known as composite materials (including those from both plants and animals).
Sometimes two different classes of materials are combined together into a composite
material, such as silica-reinforced silicone rubber or carbon fiber- or hydroxyapatite
particle-reinforced poly (lactic acid). Such composites are a fifth class of biomaterials.
The use of biomaterials did not become practical until the advent of an aseptic
surgical technique developed by Dr.J.Lister in the 1860s. Earlier surgical procedures,
whether they involved biomaterials or not, were generally unsuccessful as a result of
infection. The wide diversity and sophistication of materials currently used in
medicine and biotechnology is testimony to the significant scientific and technological
advances that have occurred over the past 50 years. From World War II to the early
1960s, relatively few pioneering surgeons were taking commercially available
polymers and metals, fabricating implants and components of medical devices from
them, and applying them clinically. There was little government regulation of this
activity, and yet these earliest implants and devices had a remarkable success.
However, there were also some dramatic failures. This led the surgeons to enlist the
aid of physical, biological, and materials scientists and engineers, and the earliest
interdisciplinary bioengineering collaborations were born. These teams of
physicians and scientists and engineers not only recognized the need to control the
composition, purity, and physical properties of the materials they were using, but they
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also recognized the need for new materials with new and special properties. This
stimulated the development of many new materials in the 1970s. New materials were
designed de novo specifically for medical use, such as biodegradable polymers and
bioactive ceramics. Some were derived from existing materials fabricated with new
technologies, such as polyester fibers that were knit or woven in the form of tubes for
use as vascular grafts, or cellulose acetate plastic that was processed as bundles of
hollow fibers for use in artificial kidney dialyzers. Some materials were borrowed
from unexpected sources such as pyrolytic carbons or titanium alloys that had been
developed for use in air and space technology.
And other materials were modified to provide special biological properties, such as
immobilization of heparin for anti-coagulant surfaces. More recently biomaterials
scientists and engineers have developed a growing interest in natural tissues and
polymers in combination with living cells. This is particularly evident in the field of
tissue engineering, which focuses on the repair or regeneration of natural tissues and
organs. This interest has stimulated the isolation, purification, and application of
many different natural materials.
2. BIOMATERIALS
Biomaterial is used to make devices to replace a part or a function of the body in a
safe, reliable, economic, and physiologically acceptable manner. Over the years,
various definitions of the term biomaterials have been purposed. For example, a
biomaterial can be simply defined as a synthetic material used to replace part of a
living system or a function in intimate contact with living tissue. The Clemson
University Advisory Board for Biomaterials has formally defined a biomaterial to be a
systemically and pharmacologically inert substance designed for implantation within
the or incorporation with living systems The National Institutes of Health Consensus
Development Conference defined a biomaterials as any substance (other than a
drug) or combination of substances, synthetic or natural in origin, which can be used
for any period of time, as a whole or as a part of a system which treats, augments, or
replaces any tissue, organ, or function of the body [1]. Black defined biomaterials as
a nonviable material used in a medical device, intended to interact with biological
systems[2]
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The common denominator in all the definitions that have been proposed for
biomaterials is the undisputed recognition that biomaterials are distinct from other
classes of materials because of the special biocompatibility criteria they must meet.
Examples
Artificial hip joint, kidney dialysis machine
Sutures, bone plates, and screws
Cardiac pacemaker, intraocular lens
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Aid to diagnosis
Aid to treatment
Correct functional abnormality
predict the tensile strength of the material(ceramic). This is also the reason ceramics
have low tensile strength compared to compressive strength. If a ceramic is awless,
it is very strong even when subjected to tension. Flawless glassbers have twice the
tensile strengths of high strength steel[5].
Composite materials are solids which contain two or more distinct constituent
materials or phases on a scale larger than the atomic. The term composite is usually
reserved for those materials in which the distinct phases are separated on a scale
larger than the atomic, and in which properties such as the elastic modulus are
signicantly altered in comparison with those of a homogeneous material. Accordingly,
reinforced plastics such as berglass as well as natural materials such as bone are
viewed as composite materials, but alloys such as brass are not. A foam is a
composite in which one phase is empty space. Natural biological materials tend to be
composites. Natural composites include bone, wood, dentin, cartilage, and skin.
Natural foams include lung, cancellous bone, and wood. Natural composites often
exhibit hierarchical structures in which particulate, porous, and brous structural
features are seen on different micro-scales [9]. Composite materials offer a variety of
advantages in comparison with homogeneous materials. These include the ability for
the scientist orengineer to exercise considerable control over material properties.
There is the potential for stiff, strong, lightweight materials as well as for highly resilient
and compliant materials. In biomaterials, it is important that each constituent of the
composite be biocompatible. Moreover, the interface between constituents should not
be degraded by the body environment. Some applications of composites in biomaterial
applications are dental lling composites, reinforced methyl methacrylate bone cement
and ultra-high-molecular-weight polyethylene, and orthopedic implants with porous
surfaces.
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Application
Types of materials
Skeletal system
Joint replacements
(hip, knee)
Bone cement
Bony defect repair
Artificial tendon and
ligament
Poly(methyl methacrylate)
Hydroxylapatite
Teflon, Dacron
Cardiovascular system
Blood vessel prosthesis
Heart valve
Catheter
Organs
Artificial heart
Skin repair template
Heartlung machine
Artificial kidney
(hemodialyzer)
Senses
Polyurethane
Siliconecollagen composite
Silicone rubber
Cellulose, polyacrylonitrile
Cochlear replacement
Contact lens
Intraocular lens
Platinum electrodes
Silicone-acrylate, hydrogel
Poly(methyl methacrylate), silicone
rubber, hydrogel
Biomaterials describes both living tissue and materials used for implantation.An
implant should possess some important properties in order to long-term usage in the
body without rejection. Therefore , the selection of an appropriate material to place in
the human body is one of the most difficult tasks.
The selection of these biomaterials depend on their mechanical and non- mechanical
characteristics.
Inadequate strength can cause to fracture the implant. This fact causes pain to
patient.
Large differences in modulus between implant materials and the surrounding
bone can contribute to a generation of stress shielding effect, that may weaken
the bond and deteriorate the implant/bone interface and loosening.
The implants release undesirable metal ions (corrosion products) either can
accumulate in tissues, near the implant or they may be transported to other
parts of the body. this phenomena reduce the life of implant device and leads to
an alergic reactions.
The low wear resistance results in implant loosening and lead to the destruction
of the healthy bone which supports the actual implant.
Biocompatibility is the ability to exist in contact with tissues of the human body
without causing an unacceptable degree of harm to the body. Body reaction
and adverse effects in the organic system.
Osseointegration is the process of formation of new bone and bone healing.
The incapability of an implant surface to join with the adjacent bone and other tissues
results in formation of a fibrous tissue around the implant and promote loosening of the
prostheses. Thus, materials with a proper surface are extremely essential for the
implant to integrate well with the surrounding bone.
316 L Stainless steels used primarily because of their better corrosion
resistance than other metals due to their high Cr content.
In spite of this, the wear resistance of 316 L stainless steel is relatively poor. As
a result of low wear resistance, corrosion occurs. Undesirable metal ions either can
accumulate in tissues, near the implant or they may be transported to other parts of the
body and leads to an allergic reactions appears in a patients.
Large differences between modulus and resistance results in implant loosening
and lead to the destruction of the healthy bone which supports the actual implant.
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Moreover, the the modulus of stainless steel is much higher than that of bone.
This phenomena can contribute to a generation of stress shielding effect, that may
weaken the bond and deteriorate the implant/bone interface and loosening.Thus,
stainless steels are suitable fr use only in temporary implant devices such as fracture
plates,screws, and hip nails.
Co-Ni-Cr-Mo alloy has been used for many decades in dentistry, making
artificial joints, the stems of prosthesis of heavily loaded joints such as the knee and
hip.
These materials have superior mechanical properties such as high resistance to
fatigue and cracking caused by corrosion with a good wear resistance. Also they are
not brittle because they have a minimum elongation.
Titanium alloys also have high strength, good resistance to corrosion ,complete
inertness to body environment, enhanced biocompatibility, moderate elastic modulus
suitable choice for implantation. Ti and its alloy also have this ability to become tightly
integrated into bone. This high capacity to join with bone and other tissues
considerably improves the long-term behavior of the implanted devices, decreasing the
risks of loosening and failure.
Ceramics generally have ionic bonds or ionic with some covalent bonds.
In prosthetic hip and knee bearings, ceramic surfaces offer a major benefit of
drastically reduced wear rates and excellent long-term biocompatibility, which can
increase the longevity of prosthetic hip and knee joints.
However, ceramics are brittle and the risk of catastrophic bearing failure in
biological applications. Improvements in material quality, manufacturing methods, and
implant design have resulted in a drastic reduction of the incidence of such failures, so
that modern ceramic bearings are safe and reliable if used with components of proven
design and durability.
Polymers are organic materials that form large chains made up of many
repeating units. Polymers are extensively used in joint replacement components. The
main advantages of polymeric biomaterials compared to metal and ceramics are ease
of manufacturability to produce variousshapes(latex,film,sheet,fibers), ease of
secondary processability,reasonable cost and availability with desired mechanical and
physical properties.
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5. REFERENCES
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