Kre-Alkalyn

RESEARCH BOOKLET

JEFF GOLINI

1832

1847

Creatine is discovered by French scientist

Michel Eugne Chevreul. (Pictured on the cover)

It is first observed that creatine accumulates in

muscles as a consequence of physical activity.

PATENTS AWARDED:
United States #6,399,661
New Zealand #519,305
late
1800s

The Germans introduce the first synthetic creatine.

PATENTS PENDING:
Australia
Austria

1912

Researchers found that ingesting creatine can

dramatically boost the creatine content of muscle.

Belgium
Bulgaria
Canada
Cyprus

1927

1928

Fiske and Subbarow discovered creatine

phosphate, and determined that creatine is a
key player in the metabolism of skeletal muscle.
Creatine is found to be unstable in liquids and acids.

Czech Republic
Denmark
Estonia
Finland
France
Germany
Greece

1992
1993

It was reported that British athletes used creatine

supplementation at the Barcelona Olympics.
Creatine is introduced to the U.S. market.

Hungary
Ireland
Italy
Luxembourg
Monaco
Netherlands

2002

Jeff Golini is awarded U.S. Patent #6,399,661 for his

invention Kre-Alkalyn...The worlds first and only
100% stable form of creatine.

Poland
Portugal
Romania
Slovak Republic
Slovenia
Spain
Sweden
Switzerland

2376 Main Street

Billings, MT 59105
go to: www.getkre-alkalyn.com

Turkey
United Kingdom

I suppose it's possible that some small

company or entrepreneur has discovered
a stabilization process that eluded one
of the top laboratories in the world that
works with creatine, but I highly doubt it.
-Industry Expert
Doubt no more...

Kre-Alkalyn
Revolutionary Sports Nutrient Break-Through
Patented and Patents Pending in numerous countries around the world
EXECUTIVE SUMMARY

Kre-Alkalyn is a huge leap forward in sports nutrition technology. It has major implications for explosive sports, and is making
old technology creatine obsolete.
Liquid Convenience Sports Drinks Are Now Possible.
More Pronounced Explosive Power And Energy!
More Strength (5%+ greater than conventional creatine)!
Better Power To Weight Ratio! (No water retention problems)
Improved Nimbleness!
Improved Speed!
Faster Muscle Gains Possible If Desired
(If used in conjunction with heavy weight training and a diet high in protein)

No Water Retention and no other side effects like conventional creatine.

In addition Kre-Alkalyn has a number of other significant
benefits that are still subject to patent applications around the
world and hence cannot yet be revealed. In other words, Kre-

Alkalyn is simply a whole lot better than we can even say

right now!

Table of Contents

Page

1.

Executive Summary

2.

Index

3.

Important Points For Manufacturers/Formulators

4.

Creatine Monhydrate: Background / History

5.

Kre-Alkalyn

6.

Creatinine

7.

Frequently Asked Questions

9.

Profiles Of Various Creatine Products On The Market

10.

Conversion Time Results - Creatine to Creatinine

9-11

Test results of various products on the market

11.

12-15

16-19

Analytical Diagnostic & Pharmaceutical Validation Tool

Using Near Infared Analysis - Technical Description

12.

5-7

The Metabolic Acid Buffer

23-31

www.kre-alkalyn.net
1845 Main St.
Billings, MT 59105 USA
www.allamericanpharmaceutical.com

Copyright 2004. IVD. All Rights Reserved.

20-22

IMPORTANT POINTS FOR MANUFACTURERS /

FORMULATORS TO NOTE
Explosive Sports

Women

Kre-Alkalyn is the ideal product for explosive

Women absolutely LOVE Kre-Alkalyn!

They get a lot stronger when using it, they see results faster and they dont get the bloated look of
conventional creatine! There is a whole new market application here. Many women have avoided
using conventional creatine in the past because
they hated looking bloated. This is no longer a problem.

sports athletes. It gives superior strength increases

and power over conventional creatine (5%+). It can
be used just on the days athletes are training or
competing - making it, if desired, more economical
to use. Because Kre-Alkalyn does not cause
water retention is another important reason why it is
more ideal for explosive sports athletes. It yields far
better power to weight ratio because you get superior strength improvements and no water retention
(no extra weight to carry). It also means the athlete
will be a lot nimbler - able to dodge, duck, sprint and
jump better. Using higher doses DO lead to improved
strength increases yet again. However note particularly when used with a carbohydrate/insulin spiking
formula and every day in succession, it may cause
water retention. We have noticed this when using
high doses of 57.5g with an athlete weighing 80kg.
Taking Kre-Alkalyn with simple carbohydrates to
increase the uptake through the insulin spike effect,
yields a more pronounced effect than taking KreAlkalyn in isolation (for obvious
reasons).
Sports Drinks
This is the holy grail of sports nutrition - to put creatine into a convenient sports drink and keep it
stable. With Kre-Alkalyn this is now made possible. A convenient sports drink will leads to big sales
increases. If a consumer can easily access the drink
from the 1000s of convenience stores in each country, this will lead to much higher impulse sales. Because Kre-Alkalyn requires NO LOADING this
means it is even more ideal for this type of product
as it gives instant results within just 1 hour of taking
it! We recommend a combination of simple and complex carbohydrates for a better, longer energy boosting effect.

Team Kre-Alkalyn will Help

Our scientists will help you formulate any type of
product using Kre-Alkalyn. From sport nutritiongeneral nutrition, from funcional food-gums.

Real Gains
Another point to make, but this is an education
issue, because Kre-Alkalyn does not cause
water retention, all of the gains made while using
it are real gains! With conventional creatine,
once you stop you loose the water retention and
hence loose a lot of the weight gained.

Creatine Monohydrate
History / Background: Creatine was discovered in the late 1800s. It
wasnt till the 1970s that Creatines true benefits were discovered by
athletes who used it in the Olympics, to help maximise their explosive
energy. Over the years it has become one of the biggest selling sports
supplements in history.
The goal of every athlete is to maximize energy levels. One of the bodies primary short burst energy sources is adenosine triphosphate (ATP).
The body uses creatine in its process of naturally replenishing ATP. When
you exercise or tense a muscle, force is produced. That force is translated into a muscle contraction. In order for the muscle to function properly, it requires energy. The energy it uses comes from several different
sources, but the primary source comes from the nutrients that you obtain from your diet. These nutrients are then broken down & absorbed;
they will then continue on in the system for usage. One of the compounds that is formed, after several complicated processes and reactions, is adenosine triphosphate (ATP). When muscle energy is needed,
this ATP is broken down one step further into a chemical called adenosine diphosphate (ADP). With this process of ATP being broken down
into ADP, energy is released and used by the contracting muscles. Without this in sufficient amounts, your muscle would not be able to work or
perform properly. The body naturally produces creatine (about 2 grams
per day).
Muscle can only store so much ATP, typically only giving about 5-10
seconds of muscle exertion before those storage receptors are depleted.
This results in muscle failure along with bio energetic depletion or ATP
depletion. When this happens, your body tries to restore its immediate
source of ATP by borrowing a high energy phosphate from a chemical
called creatine phosphate (CP). Muscle cells store the chemical CP in
the same way it stores ATP. If high intensity exercise goes beyond 10
seconds, your body will continue to try and restore its ATP levels by a
process called glycolysis. This process is complicated and is a slow
method of restoring ATP levels, especially for the anaerobic athletes
who require instant energy to maintain and sustain high-powered muscle
contractions. By orally supplementing with creatine, you can enhance
your bodys storage levels of CP. As the muscle runs out of ATP it can
recharge itself by borrowing this CP phosphate molecule. Research has
shown that by supplementing with 5 grams of creatine, 4-6 times a day,
for 2 or more days, the human body showed a significant increase in
total creatine concentration.
5

Athletes discovered orally supplementing creatine boosted the bodys

stores and extended the length of explosive bursts and strength levels.
Creatine monohydrate has proven itself a very effective nutritional supplement for many athletes. You cannot supplement with just ATP or CP,
due to the fact that these chemicals are destroyed in the gut. Therefore,
creatine supplementation is the best route to go. The main advantage
of taking creatine is the fact that cellular concentrations after administration is stable and is not prone to being lost.
The most commonly used oral creatine supplement is creatine monohydrate. The most commonly used amounts has varied from 20 to 30
grams daily. It has been taken in powder, capsule, tablet & liquid form.
With current creatine products, we have been instructed that creatine
should be taken in water, with fruit juice, an acidic effervescent, and/or
acidic fruit flavored drink mixes. The amount of fluid that has been suggested for it to be taken with varies from 300 milliliters, to mixing to
taste. Other forms of creatine have also been used, such as creatine
citrate, creatine phosphate & creatine pyruvate. The method of intake
that has been recommended is the same as creatine monohydrate.
Many so-called improvements have hit the market place over the last 5
years, each claiming to be the best. Some advertisements have even
started to inform us that impurities found in other companys products,
contain higher amounts of creatinine (a poison and toxic by-product)
than theirs. Yet the same side effects reported with creatine use in
general, were also reported with these so-called pure creatine
monohydrates.
As comforting as all these ads may seem, it is a far cry from the whole
truth. Creatine Monohydrate is known for its stability, once manufactured, only if kept in a powder form and stored in a cool, dry place. All of
their testing was done in a dry powder form and under strict lab conditions. Of course, this was conventional creatines only stable form.
What has not been known till recent, is that most of the creatine being
injested had already converted over to creatinine. Once activated with
water, juice or any other fluid, most of it converts over to creatinine.
Athletes have been consuming as much as 20-30 grams of creatine to
maximise the effect, but less than 1-2 grams was actually still creatine
by the time they had swallowed it. The rest of it had already converted
over to creatinine, which caused a number of side effects in some people
including:- stomach cramps, indemia, being bloated, excess
6

water retention, dehydration, cottonmouth, headaches, liver problems, lack

of energy, creatinine poisoning and impaired renal function. The bodys
natural defense to a toxin is to try and dilute the toxin with water and flush
it from the body.
Recent reports in the news media by a group of French scientists, claimed
that using large amounts of creatine monohydrate, over an extended period of time, might cause cancer. They went on to state that this is due to
the large amounts of creatinine found in the blood stream.
I wonder, Where might the creatinine have come from?

Kre-Alkalyn
(US Patent number 6,399,661. Numerous International Patents Pending)
A new ground breaking development in the Dietary Supplement and Sports
Nutrition Industry is the use of NIR technology (Bran+Luebbe Infraprover
II) for routine purity and stability tests. It provides accurate evaluation of
ingredient quality through all stages of the manufacturing process without
compromising the sample. The technology was being used by the team
who developed Kre-Alkalyn , to test a variety of products available on the
market. These same products were then tested after activation with fluid.
What was discovered was that immediately after adding water or liquid to
creatine, a significant proportion of it rapidly converted over to creatinine.
Most of the creatine serums and liquids had virtually no creatine left. The
effervescent and fruit drinks were the worst, due to the low pH levels. Only
a percentage of what is being consumed is still creatine, which the body
can use. Worse, some of it has converted to the toxin creatinine.
Our researchers developed and extensively tested a successful novel
method of keeping Creatine stable after adding water or any liquid, which
is now referred to as Kre-Alkalyn. Not only is Kre-Alkalyn stable in a
powder form, but also is completely stable after water or liquid activation.
This means it is safe (since it does not convert to creatinine), and you
need much less since the creatine conversion loss problem has now been
eliminated. This allows you not only to consume creatine without concern
about creatinine levels in the body; you only need a fraction of what you
have been using previously, to get the full potent effect. Because Kre-

Alkalyn

is a creatine source, which never converts, it can now be added

to, and kept in liquid form, for extended periods of time.
7

Creatinine
Facts:

1). A waste product in the blood that results from the normal breakdown
of muscle.
(Medline)
2). A component of urine and the final product of creatine catabolism;
formed by the nonenzymatic dephosphorylative cyclization of
phosyphocreatine to form the internal anhydride of creatine.
(PDR Medical
Dictionary)
3). Creatinine(CRN) is a by-product of the creatine production. The
ingested creatinine is waste for the body and is excreted by the
kidney.
(Degus Germany)
4). Creatinine is excreted by the kidneys. (Greys, Anatomy & Physiology)
5). Normal Creatinine clearance levels in healthy humans:
Men
.97 to 1.37 mg/dl (97-137 ml/min)
Women .88 to 1.28 mg/dl (88-128 ml/min)
(St. Vincent Healthcare, Department of Pathology, Billings, MT)
(American Kidney Foundation)
6). Creatinine clearance levels above
1.37 mg/dl (for men) and
1.28 mg/dl (for women)
is dangerous to healthy kidneys.
(St. Vincent Healthcare, Department of Pathology, Billings, MT)
(American Kidney Foundation)
7). Increased creatinine levels produces additional stress on the kidneys.
Continued stress may damage kidneys long term.
8). Damaged kidneys are non reversible.

FREQUENTLY
ASKED
QUESTIONS

Kre-Alkalyn
New Advanced Form
Patented and Patents Pending Internationally including the USA and Europe.
The ONLY form of creatine completely stable and 100% bio-available after adding to
liquid, water or juice. It can now be made into a liquid convenient sports drink!
10% 30% Strength Increases (5%+ greater than conventional creatine)
Pronounced Performance Enhancement short burst sports and weight training
More Effective gram for gram
No Side Effects
No Loading Phase Necessary
Helps Promote Lean Muscle Gains
(if used with appropriate weight training and a healthy balanced diet rich in protein)

Many people are reporting big improvements in strength after taking Kre-Alkalyn
in doses as little as only 1.5g for only 1-4 days! Kre-Alkalyn is the new Super
Stable and 100% Bio-Active Creatine.

10

FREQUENTLY ASKED QUESTIONS

Conversion problem
Q If I understand this correctly the new data
says that a significant proportion of the creatine
monohydrate I have been taking converts to
the toxin creatinine within minutes when added
to any liquid be it juice or water etc. So I could
be in effect taking a lot of creatinine (a toxin)
and very little of actual creatine monohydrate.
How is this so? I have been using creatine for
years and got a good effect from it. Please
explain.
A. The best way to explain it is, your body
makes around 2 grams per day. When you
supplement 5000mg of creatine you probably
only get the benefit from part of the actual dose
you took. The additional milligrams on top of
your 2 grams your body naturally produces,
would give an increase in the pool of creatine
available. That is why good results were still
being experienced. You just have to start
looking at it differently. Most of the creatine may
be lost when added to liquid, and more is
converted when passing through your acidic
stomach. Note: some companies were pointing
to the virtual lack of creatinine in their powder,
as proof of purity of their powder over other
sources. In most cases this was true but only
while it was still in its powder form.
Q This new form of creatine monohydrate -

Kre-Alkalyn says it never converts to the

toxin creatinine. How does that work?
A. Our researchers discovered that while
creatine monohydrate is nice and stable and
pure in its powder form, as soon as you add it
to a liquid, it is no longer stable and rapidly
converts to the by-product toxin creatinine.
What they discovered was, the speed of
conversion was directly proportional to the pH
of the liquid it was being added to. Merely
having it added to a strong alkaline drink did
not solve the problem due to the digestion
issue, of it having to pass through the highly
acidic stomach. They discovered if they
buffered it with an alkaline greater than pH12
then it remained completely stable in any liquid
for long periods of time (now opening the way

11

to completely stable Kre-Alkalyn drinks

and serums). It also ensured the new buffered
creatine would pass intact through the
stomach and at full strength into the blood
stream.
Q. So what does this all mean?
A. Simply a better, more effective form of
creatine. You can opt to use less what you
used to, no loading, get a better effect and
with none of the side effects from taking
conventional creatine, nor the possible longterm risks of continued use over a period of

years. Kre-Alkalyn is superior - full stop!

As good as
conventional creatine
monohydrate was, this new form is a big leap
forward again. Its like comparing a 1950s
sports car to a modern F1 car.
Q. Why arent other brands marketing it yet?

A. Kre-Alkalyn is brand new. Innovative

and progressive supplement companies will
recognise this products full potential and will
be quick to bring it to the market. Other
companies unfortunately are slow adopters
or have a follow the pack mentality. They
typically are two to three years behind
research breakthoughs but sometimes even
20-30 years behind. Competitive athletes will
want to use the best nutrition technology
available. Dont be a sheep, find out how good
it is yourself.

Q. Kre-Alkalyn is Buffered Creatine

Monohydrate - what is it buffered with?
A. We call it buffered creatine. The buffering
takes place in the synthesis process, allowing
us to retain a safe, high pH.
Q. A strong alkaline will burn human tissue in
the same way as a strong acid will it not?
A. This is food grade technology same
analogy as a 3.0 pH acid will burn the skin,
yet you can drink a soda pop (pH 3) that has
used phosphoric or citric acid).
Q. Once it hits the stomach will it no longer
be stable because of the strong acids
present?

A. Kre-Alkalyn is also designed to buffer

the stomach, raising the pH long enough for
absorption.

Laboratory Spectrum
Analysis Profiles
Various Creatine
Products Available On The Market

12

13

14

15

Laboratory Test Results

Conversion Rate
(measured in 15 second intervals)

Creatine to Creatinine
of various products on the market
once added to water or a liquid

16

17

18

19

ANALYTICAL DIAGNOSTIC
AND PHARMACEUTICAL
VALIDATION TOOL

USING
NEAR INFRARED ANALYSIS
Technical Description

20

Bran+Luebbe InfraProver II
The Bran+Luebbe InfraProver is a polarization interferometer Fourier
transform NIR instrument based on principles of HPCS (High Performance
Crystal Spectroscopy). The system uses a moving crystal wedge to obtain
FT Interferograms for the materials being tested, resulting in a substantial
reduction in sensitivity to vibration compared to traditional lab grating and
FT instruments.
The design of the instrument allows presentation of a wide variety of
sample forms to the system via software control without changing the
hardware. Two options are available for solids. A 2-meter fiber optic probe
enables probing of containers in the reflectance mode. Materials can be
scanned directly in the containers or through plastic packaging material.
Alternatively, the Solid Presentation Accessory (SPA) permits
spectroscopic interrogation through the base of a vial when the vial is
placed on the optical window of the SPA. Tablets or capsules can also be
analyzed with this accessory. Liquids were scanned in the transmission
cell, a built-in cuvette chamber located in the center of the InfraProver.
Long term stability of the instrument is achieved via internal laser
referencing for all wavelengths ensuring wavelength accuracy and
reproducibility.
Near Infrared technology scans the product in its entirety. Mathematical
algorithms then separate the chemical or physical properties of interest
from the rest of the matrix. Samples are therefore analyzed as -is with
no sample preparation

21

The InfraProver was specifically developed for the pharmaceutical industry

so it is designed to meet GLP, GMP, GSP principles, and FDA &
Pharmacopeia guidelines. Many pharmaceutical companies have validated
the instrument for their applications.
Assay methods have been developed. Purity can be determined, giving
the information if raw materials have been spiked or doped. In some cases,
NIR has shown that similar materials were substituted or co-mingled with
incoming raw materials.
Method development can be turned around to adapt the technology to new
products or new formulations.
Library Identification Method
Identification is performed using a Library model. Several batches of each
raw material are placed in glass vials, which are placed on the optical window
of the Sample Presentation Accessory (SPA). The InfraProver scans the
raw materials through the glass vial. Mathematical modeling is used to
determine acceptable radii and residual for each material in factor space.
When an unknown sample is scanned, the Mahalanobis distance radii and
spectral residual are evaluated in relation to those used to develop the
library model. If the radii and residual are within the established criteria for
a material, the InfraProver will confirm that the identity is ok. If the radii and
residual are not within the established criteria, the InfraProver will inform
the user that the identity is not ok, will print out a list of nearest materials to
the one scanned.
www.kre-alkalyn.net
U.S.A. 406-245-5793
22

Kre-AlkalynR
US Patent# 6,399,661
Part II
The Metabolic Acid BufferTM
by Jeff Golini
BioCeuticals Research & Development Analytical Laboratory
a division of All American Pharmaceutical & Natural Foods Corporation

_________________________________________________________________________________________________________________________________

The United States Patent office issued Patent #6,399,661 to Kre-AlkalynR on June
4, 2002 as the only patented buffered creatine in the World.
Kre-AlkalynRs preferred function is to increase creatine and creatine phosphate stores in the human system. The reason for this is as follows:
When you exercise or tense a muscle, force is produced resulting in muscle
contraction. In order for the muscle to function properly, it requires energy. This energy
comes from several different sources, but primary from the nutrients obtained from
your diet which are broken down & absorbed. One of the compounds that is formed
after several complicated processes and reactions, is adenosine triphosphate (ATP). When
muscle energy is needed this ATP is broken down one step further into a chemical called
adenosine diphosphate (ADP). When this process of ATP being broken down into ADP
occurs, energy is released and used by the contracting muscles. Without this in sufficient amounts, your muscle would not be able to work or perform properly. The goal of
athletes is to maximize the efficiency of their energy systems, which in turn boosts their
athletic performance.
Muscle can only store so much ATP, typically giving about 5-10 seconds of
muscle exertion before those storage receptors are depleted. This results in muscle failure along with bioenergetic depletion or ATP depletion. When this happens, your body
tries to restore its immediate source of ATP by borrowing a high energy phosphate from
a chemical called creatine phosphate (CP). Muscle cells store the chemical CP in the
same way it stores ATP. If high intensity exercise goes beyond 10 seconds, your body
will continue to try and restore its ATP levels by a process called glycolysis. This process is complicated and is a slow method of restoring ATP levels, especially for anaerobic athletes who require instant energy to maintain and sustain high powered muscle
contractions.
By orally supplementing with Kre-AlkalynR, you can enhance your bodys storage levels of CP. As the muscle runs out of ATP it can recharge itself by borrowing this
CP phosphate molecule. Research has shown that by supplementing with 1.5 grams of
Kre-AlkalynR daily for 2 or more days, that the human body will show a dramatic increase in CP concentration.
You can not supplement with just ATP or CP, due to the fact that these chemi23

cals are destroyed in the Gut. Therefore supplementing with Kre-AlkalynR is the only
way to increase these storage levels. Remember, the main advantages of taking KreAlkalynR is the fact that cellular concentrations after administration are stable and are
not prone to being lost or converted to creatinine after activation.
As published in our first research book, the main problem with all other existing creatine supplementation is their inability to deliver a concentrated and stable amount
of creatine to the system. Our research proved that these prior creatine arts actually have
the human body ingesting creatinine , a poisonous and toxic by product. Due to the
conversion rate of creatine to creatinine in all other creatine products, many negative
and dangerous side effects have been documented. These side effects are caused by the
bodys defense to the toxic compound creatinine. Creatinine is flushed in the kidneys,
which is our bodies internal defense mechanism to save itself from this ingested poison
by diluting this toxin with water.
Listed below are a few of the more common complaints & aliments of creatinine poising from creatine.:
*Stomach cramps
*Indemia
*Bloating
*Excess water retention
*Dehydration
*Cotton Mouth
*Headaches
*Liver problems
*Kidney problems
*Lack of energy
*Impaired renal function
Kre-AlkalynR Physiology: Among the people who question the validity of a buffered
or alkaline creatine, the biggest question is, What happens to your buffered creatine
once it reaches the stomach, which is highly acidic? We have heard this question not
only asked by consumers, but also educated medical doctors. Some have tried to state
(out of ignorance) that you can not drink an alkaline creatine with a pH higher than
neutral but they argue it is O.K. to drink a creatine acid mix with a pH lower than neutral.
The point being, it is safe to drink a pH 12 if done correctly as it is safe to drink a pH 4,
from a diet soda.
Basic human anatomy taught us that in order to digest food and kill bacteria
and viruses, the good Lord created our stomach to maintain a pH value of around 3.
When we eat food and drink water, the pH value inside the stomach goes up, depending
on the over all pH of what is ingested. Upon ingestion of a substance, our stomach
internal feedback mechanism detects this consumption and signals the interior walls to
secrete more hydrochloric acid. This signaling process is on going until the stomachs
acidic level is achieved. Again, ignorance says that a buffered creatine will convert to
creatinine in the stomach just like any other creatine product.
24

However, by going back to our high school anatomy and physiology books,
well re-discover how the stomach wall produces hydrochloric acid. As we read on we
will find that your stomach does not contain a hydriodic acid reservoir, just awaiting the
ingestion of food, but that the walls produce this acid instantly on a as-needed basis.
Incidently, if there were a such a reservoir or pouch, this acid would burn right through
the stomach wall!
The components in the cells of the stomach wall that produce hydrochloric
acid (HCl) are carbon dioxide (CO2), water (H2O), and sodium chloride (NaCl) or potassium chloride (Kcl).
Or as we scientist like to write:
NaCl + H2O + CO2 = HCl + NaHCO3, or KCl + H2O + CO2 = HCl + KHCO3
As we continue to read our anatomy books, well also discover that the byproduct
of making hydrochloric acid is sodium bicarbonate (NaHCO3) or potassium bicarbonate
(KHCO3). As our buffered creatine is mixed with these bicarbonates they pass through
the intestines and into the blood stream, all the while continuing to neutralize excess
acids in the blood (Lactic Acid). By only looking at the pH value of the stomach alone,
it seems that Kre-AlkalynR patented buffered system would never reach the bloodstream.
But research shows that upon the ingestion of Kre-AlkalynR there is a net gain of alkalinity in the body. When the stomach pH value rises higher than 4, the stomach knows what
to do to lower it, but if the pH value goes below 4, for any reason, the stomach doesnt
know what to do. Hence you take a antacid, such as TUMS (GlaxoSmithlkine), to
neutralize the acid in your stomach This will relieve acidic stomach gas pain. When you
ingest low pH creatine fizzes and drinks very little hydrochloric acid is produced by the
stomach wall. This results in small amounts of alkaline buffer being produced and introduced into the blood stream, resulting in a low blood pH..
The next series of terms are important, as their meanings helps to understand
the full scope and mechanics behind the world renown invention of US Patent# 6,399,661,
Kre-AlkalynR, The Metabolic Acid BufferTM.
pH: A well know Danish biochemist named Soren Sorensen, invented the pH system in
1909. A solutions pH is defined as the negative logarithm, to the base 10, of its hydrogen-ion concentration. This concentration is expressed in moles of hydrogen ions per
liter of solution.
The letters pH are a universal number used by all scientists to indicate the concentration of hydrogen ions in a solution. The p stands for potenz (the potential to
be) and the H stands for Hydrogen, therefore pH stands for potential hydrogen.
Metabolic Acids: This term refers to all the bodys acids except carbon dioxide. Metabolic acids are not respirable; they have to be neutralized, metabolized, or excreted via
25

the kidneys.
Acidosis: Acidosis is a condition in which the bodys fluids tend to have a higher acid
content than normal. The body has a variety of ways to compensate for mild acidosis,
but prolong acid ingestion will result in weakness, headache, heavy or rapid breathing.
Severe acidosis can lead to acidemia, which is a build-up of acids in the blood, resulting
in a coma or death.
Metabolic Acidosis: Metabolic acidosis arises from Kidney failure due to decreased pH
levels and creatinine poisoning. Metabolic Acidosis is a clinical disturbance characterized by an increase in total body acid. Most creatine supplements are delivered in a low
pH or acidic solution. These low pH creatines, combined with low pH sodas, drinks,
foods & deserts has shown to cause this dangerous clinical disturbance that hinders
athletic performance.
Lactic Acid: Lactic acid is the most famous Metabolic Acid that hinders athletic performance and is the term used most commonly to describe the intense pain felt during
exhaustive exercise. Lactic acid is a nasty compound produced by almost all tissues in
the human body. This acid is formed by glycolysis, which is a chemical process in
which glucose is broken down to pyruvic acid. This process (glycolysis) causes the
release of carbon dioxide, water and energy (ATP). When there is an excess of pyruvic
acid, lactic acid is then formed. Our bodies response to a normal build up of lactic acid
is to transport the buildup from the cramped muscle via the blood stream to the liver
where it is converted back to pyruvic acid, then to carbon dioxide, water & ATP.
Contracting muscle obtain this ATP from glucose stored in the blood stream
and from glycogen that is stored in the muscles. At first, pyruvic acid and small amounts
of ATP are generated. The pyruvic acid, mixed with oxygen is converted to carbon
dioxide, water and ATP. As muscle continue to contract with exercise, the circulatory
system can not keep up with the supply of oxygen. In this condition (which could occur
in seconds for some), most of the pyruvic acid produced in the breakdown of glucose is
converted to lactic acid. As this acid is produced in the muscles, it immediately leaks out
into the blood stream and is carried through out the body, causing a impairment to the
bodys normal function resulting in muscle fatigue. As more oxygen becomes available,
the lactic acid is converted back to pyruvic acid, then into carbon dioxide, water and
ATP. But unfortunately by this time, most humans will have quit exercising to allow the
body to re-oxygenate.
As stated, lactic acid is a by-product produced by muscle tissue in order to
obtain energy by metabolizing glucose in the absence of oxygen. Lactic acid in large
amounts is formed during strenuous exercise, which leads to muscle cramps, fatigue and
failure. Lactic acid fatigue is commonly called the burn or hitting the wall. Scientists,
26

athletes and the rest of the human population all agree on one thing; Lactic acid is not
our friend, but our foe when it comes to normal muscle function.

Low pH creatine supplements: Besides the fact that most of the creatine products on
the market are mixed with acids (to make them taste good while being nice and fizzy)
and the research that lead to US Patent # 6,399,661 proves these low pH creatines once
mixed with water or juice are instantaneously converted to creatinine, there is another
scientific and biological reason not to ingest these acidic mixes. By lowering the human
systems pH, these products cause the body to slip into acidosis leading to fatigue, lactic
acid build up and decreases in energy. So the question is, Doesnt this defeat the
whole reason why you are taking a creatine product? Basic metabolic research was
set aside by these creatine manufactures in attempt to justify why their product taste
better or mixed better then the next. By making the body more acidic, you are decreasing strength, endurance and over all athletic performance. Yes, that also means a decrease in reps during weight training.
The Metabolic Acid BufferTM
Kre-AlkalynR is the only creatine that buffers lactic acid. Accumulation of
metabolic acids (H+) is recognized as a rate limiting factor in anaerobic exercise. KreAlkalynRs buffering effect assists in sparing the bodys endogenous bicarbonate stores,
prolonging muscular performance and delaying the onset of fatigue.
Lactic acid is a powerful enemy to muscle growth. Muscles work within very
narrow chemical limits, which is called your Power Zone. When you squeeze out that
last rep, or you painfully make it through the last play before half time, lactic acid levels
build up and the chemistry in your muscle drops below the Power Zone. Not only do
you feel the familiar lactic acid burn, but your muscles stop pushing weight and your
legs feel like jelly. We have all been there no matter what activity we do, even a simple
walk. No matter how much your brain wants to keep lifting, you cant. The power is
gone and the pain is too great. After you rest for awhile, your bodys internal lactic acid
fighters do their job and you do the next sets.
Bob Fritz, a famous American researcher states, Lactic acid is the monster that
lives inside us all and only comes out when you lift hard or run fast. Kre-AlkalynR kicks
lactic acids butt. When lactic acid begins to build up, Kre-AlkalynR helps neutralize it.
Like the Calvary to the rescue, Kre-AlkalynR rushes to the muscle group thats lifting
and disarms lactic acid.
Like the famous antacid, called TUMS (GlaxoSmithlkine), which neutralizes
acid in your stomach, Kre-AlkalynR neutralizes lactic acid in your muscles. The advantage of antacids is that they start neutralizing stomach as soon as they reach the stomach

27

Kre-AlkalynRs patented buffer system immediately neutralizes the acid in the

stomach, protecting the buffered creatine from creatinine conversion. The acidity is
reduced and Kre-AlkalynR is ready for absorption. After entering the duodenum, bicarbonate ions are secreted to further alkalinize the Kre-AlkalynR for absorption into the
blood stream. What a powerful combination!
Acid-Base Physiology:
Basic acid-base physiology shows us the body has an internal buffering system
that protects us from normal acid production. The quantity of respiratory acids produced per day by non active humans is easily calculated. The average person produces
200 milliliters of carbon dioxide (respiratory acid) per minute, which equates to 288
liters per day. Since each gram molecule of gas occupies 22.4 liters, approximately 12
moles of CO2 (carbon dioxide) is produced daily. This is a very large quantity of acid,
but our body effectively matches this elimination through the lungs.
By contrast to CO2 production by non active humans, very little metabolic acid
is produced. We have measured only about 0.1 moles (100 mEq) of acid per day. This
normal metabolic acid production is matched by the kidneys, which is able to process far
less then the quantities of the lungs.
The power of the lungs to excrete large quantities of CO2 enables them to compensate rapidly for athletic performance. Unless the respiratory system is diseased or
damaged, the lungs can stimulate a rapid response even to severe acidosis from CO2, and
bring about equilibration within a few hours. Contrary to the lungs, the kidneys smaller
capacity to metabolize acid buildup is quite slow, sometimes taking a day or two for
equilibrium to occur.
Research taken from the Swan & Pitts Experiments, gave us a good starting
point of experimenting on human subjects to determine what our bodys internal buffering system can handle. In the Swan & Pitts Experiments, dogs received an infusion of
14 mmols H+ per liter of body water. This caused a drop in pH from 7.44 ([H+]=36
nmoles/l) to a pH of 7.14 ([H+]=72 nmoles/l). That was a rise in [H+] of 36 nmoles/l.
Besides drinking creatinine (from the conversion of creatine to creatinine at a low pH),
just think about the results of drinking an acidic creatine supplement every day at a pH
of 3.5 to 4.5? What does this have to do with absorption? You guessed it, not a thing.

Laboratory Studies:
1). NIR Analysis of stomach:
* 1.5 grams of creatine monohydrate mixed with water and added to
stomacher at pH 3, raised stomach pH level to 3.5, with remainder
of creatine being converted to creatinine.
*1.5 grams of effervescent creatine mixed with water and added to
28

stomacher at pH 3, raised stomach pH level to 3.9, with remainder

of creatine being converted to creatinine.
*1.5 grams of creatine fruit flavored powder mixed with water and
added to stomacher at pH 3, raised stomach pH level to pH 3.4, with
remainder of creatine being converted to creatinine.
*1.5 grams of Kre-AlkalynR mixed with water and added to stomacher
at pH 3,
buffered stomach pH level to 9, keeping buffer creatine
stable with ample time for absorption, with no conversion to creatinine.

.
2). Arterial blood gas:
*A low HCO3 level detected on a SMA (Sequential multiple analyzer)
was the first clue to metabolic acidosis.
*A further and more accurate test can then be performed by a ABG
(arterial blood gas) analyzer, which its measurements are based on
the Henderson-Hasselbalch equation.
The Henderson-Hasselbalch Equation mathematically describes the relationship between blood pH and components
of the H2CO3 buffering system.
pH = 6.1 + log (HCO3/H2CO3)
We use the following equation to calculate H2CO3
H2CO3 = PCO2 x 0.03
3). Serum chemistry:
*This type of test was used to detect elevated Creatinine levels in uremic acidosis, resulting from increase ingestion of creatinine and kidney failure to excrete this toxin.
4). Complete blood count:
*Checking WBC (white blood cells) and finding elevations in the total count, also
shows a serious consideration septicemia, which
causes lactic acidosis.
29

5). Urinalysis:
*A low pH was a quick detection method for acidemia.
Conclusion:
Scientific Facts: Kre-AlkalynR is the Worlds ONLY creatine supplement that
buffers lactic acid and enables a high concentration of cellular creatine to be
absorbed.
Common Facts: Kre-AlkalynR is the only form of creatine that Kicks Lactic
Acids, BUTT!
References:
1). US Patent #6,399,661
2). Wendy Lou Jones, MS, BA, More Bio Fuel, 2001
3). Integrated Bimolecular Corporation
Tucson, AZ
4). Karen L Stavile, MD, Associate Director at State University of New York Health
Science Center at Brooklyn, Metabolic Acidosis, Research 2001.
5). Stephen W Borron, MD, MS, Associate Clinical Professor, George Washington University Hospital, Lactic Acidosis, Research, 2001
6). BioCeuticals Research & Development Laboratory, 2001. Creatine-vs-Kre-AlkalynR
upon ingestion, Jeff Golini, Executive Scientist & Charles Burchell, Associate Director
of Chemistry..
7). Adrogue HJ, Madias NE: Changes in plasma potassium concentration during acute
acid-base disturbances. Am J Med 1981; 71(3): 456-67.
8). Adrogue HJ, Madias NE: Management of life-threatening acid-base disorders.
30

New England Journal of Medicine 1998; 338:26-34: 107-11.

9). Emmett M, Narins RG: Clinical use of the anion gap. Medicine (Baltimore) 1977
January; 56(1): 38-54.
10). Fulop M: Serum potassium in lactic acidosis and keto acidosis. New England Journal of Medicine 1979; 300(19):: 1087-1089.
11). Richardson RM, Halperin ML: The urine pH: Am J Kidney Dis 1987; 10(2): 140-3.
12). Muller-Plathe O: A nomogram for the interpretation of acid-base data. J Clin Chem
1987; 25(11): 795-798.
13). Fulop M: A guide for predicting arterial CO2 tension in metabolic acidosis. Am J
Nephrol 1997; 17(5): 421-424.
14). Kwong SC, Brubacher J: Phenformin and lactic acidosis: a case report and review.
J Emerg Med 1998 Nov-Dec; 16(6): 881-886.
15). Mitchell JH, Wildenthal K, Johnson Jr RL: The effects of acid-base disturbances on
cardiovascular and pulmonary function. Kidney Int 1972; 1(5): 375-389.
16). BioCeuticals Research & Development Laboratory, 2000. Various Creatine vs KreAlkalynR studies upon ingestion.
17). Kellum JA: Metabolic acidosis in the critically ill: lessons from physical chemistry.
Kidney Int. Supp, 1998; 66: S81-86.
18). Mitchell JH, Wildenthal K, & Johnson Jr RL: The effects of acid-base disturbances
on cardiovascular and pulmonary function. Kidney Int. 1981: 20: 799-809.
19). Greys Anatomy & Physiology, 1979.

31

BioCeuticals Research & Development Laboratory

3039 Grand Avenue, Suite B
Billings, MT 59102
www.BSRDL.com
______________________________________________________________________________
Date:
December 1th, 2001
Study:
Creatine-vs-Kre-AlkalynR US Patent 6,39,661 (Buffered
Creatine) upon ingestion
Purpose of Study:

To measure the stability upon ingestion of Creatine-vs-KreAlkalyn

Procedures:

18 Name brand products were purchased off the shelf from Retail
Stores in Billings, Montana. Six Creatine Monohydrate products,
Six Effervescent Creatine mixes, Six Creatine in Fruit
flavor/Dextrose, mixes were randomly chosen.
Six Lots of Kre-Alkalyn were chosen

Step 1:

All creatine products were tested for:

Total Creatine levels
Total Creatinine levels
Total Dicyanimide levels
Total Dihydrotriazine
pH
All lots of Kre-Alkalyn were tested for:
Total Creatine levels
Total Creatinine levels
Total Creatinine levels
Total Dicyanimide levels
Total Dihydrotriazine
pH

These test were done on an AS IS or DRY BASIS.

Testing Method:
FTNIR Analysis by:
Identification performed by FTNIR, against in-house external library standards obtained
from Sigma & produced by HPLC. / Quantification by FTNIR against external library
standards obtained from Sigma & produced by HPLC
Testing Equipment:
Bran & Luebbe InfraProver IIFTNIR
HPLC Analysis by:
Analysis performed by HPLC using Intersil ODS-2 5um (250x4.6mm) and 25 min.
gradient elution with 0.1% phosphoric acid buffer in H20 and 0.1% phosphoric acid in
acetonitrile. External reference standards obtained from Sigma-Aldrich.

32

Step 2:
All 24 products were activated with water according to the label.
Step 3:
All 24 products were placed in a stomacher at pH 3 for 15 minutes to simulate digestion.
Step 4:
After 15 minutes of digestion simulation in stomacher, all 24 products were tested for:
Total Creatine levels
Total Creatinine levels
Total Creatinine levels
pH
Results:
Product

Amount Used:
Elemental Creatine

pH of Stomacher
after addition of
product

Total conversion to
Creatinine at 15
minutes of digestion

Creatine 1

1.5 grams

3.5

100%

Creatine 2

1.5 grams

3.5

100%

Creatine 3

1.5 grams

3.5

100%

Creatine 4

1.5 grams

3.5

100%

Creatine 5

1.5 grams

3.5

100%

Creatine 6

1.5 grams

3.5

100%

Creatine
Effervescent 1

1.5 grams

3.9

100%

Creatine
Effervescent 2

1.5 grams

3.8

100%

Creatine
Effervescent 3

1.5 grams

3.8

100%

Creatine
Effervescent 4

1.5 grams

3.8

100%

Creatine
Effervescent 5

1.5 grams

3.9

100%

Creatine
Effervescent 6

1.5 grams

3.9

100%

Creatine Fruit
Drink mix 1

1.5 grams

3.4

100%

Creatine Fruit
Drink mix 2

1.5 grams

3.4

100%

33

Creatine Fruit
Drink mix 3

1.5 grams

3.3

100%

Creatine Fruit
Drink mix 4

1.5 grams

3.5

100%

Creatine Fruit
Drink mix 5

1.5 grams

3.4

100%

Creatine Fruit
Drink mix 6

1.5 grams

3.4

100%

Kre-Alkalyn
Lot#3311101

1.5 grams

9.0

0%

Kre-Alkalyn
Lot#3311102

1.5 grams

9.0

0%

Kre-Alkalyn
Lot#3311103

1.5 grams

9.0

0%

Kre-Alkalyn
Lot#3311201

1.5 grams

9.0

0%

Kre-Alkalyn
Lot#3311102

1.5 grams

9.0

0%

Kre-Alkalyn
Lot#3311103

1.5 grams

9.0

0%

1). NIR Analysis of stomach:

*1.5 grams of creatine monohydrate mixed with water and added to stomacher at
pH 3, raised stomach pH level to 3.5, with remainder of creatine being
converted to creatinine.
*1.5 grams of effervescent creatine mixed with water and added to stomacher at
pH 3, raised stomach pH level to 3.9, with remainder of creatine being
converted to creatinine.
*1.5 grams of creatine fruit flavored powder mixed with water and added to
stomacher at pH 3, raised stomach pH level to pH 3.4, with remainder of
creatine being converted to creatinine.
*1.5 grams of Kre-AlkalynR mixed with water and added to stomacher at pH 3,
buffered stomach pH level to 9, keeping buffer creatine stable with ample time
for absorption, with no conversion to creatinine.
Conclusions:
Eighteen Name brand creatine products were activated and digested. All eighteen
converted 100% creatinine. Since there was no creatine left in these products, no creatine would
be absorbed into the blood stream, only creatinine.
Six Kre-Alkalyn lots were activated and digested with 0% conversion to creatinine. All
creatine remained intact and would be absorbed into the blood stream.
Test performed by Charles Burchell, PHD.

34

How Dangerous is Creatinine?

by Jeff Golini
BioCeuticals Research & Development Analytical Laboratory
a division of All American Pharmaceutical & Natural Foods Corporation
www.getkre-alkalyn.com

Conversion rate of Creatine to Creatinine in market place products

Product

Instant Conversion Once Activated

Product

Instant
Conversion
Once
Activated

Creatine in
water

15
seconds

30
seconds

Yes

10%

20%

Yes

50%

Yes

1
minute

Total Time For Conversion

Total
Conversion

2
minutes

3
minutes

30%

40%

50%

8.4
minutes

90%

100%

!00%

100%

43 seconds

50%

90%

100%

!00%

100%

43 seconds

Yes

50%

90%

100%

!00%

100%

43 seconds

Yes

10%

20%

30%

40%

50%

8.4
minutes

Yes

50%

90%

100%

!00%

100%

43 seconds

Yes

30%

40%

50%

70%

77%

2.8
minutes

No

0%

0%

0%

0%

0%

Never

PH 7
Creatine in fruit
juice
PH 3
Creatine Fruit
Flavored drink
mixes
PH 3
Creatine in
effer-vescent
mixes
PH 3
Creatine in
protein mixes
PH 7
Creatine in
sports drinks
PH 3
Liquid Creatine
& serums
PH 4
Kre-AlkalynTM
PH 12

35

I. Metabolic Toxicity of Excess Creatinine

In the presence of normal kidney function (and the absence of artificial ingestion), the
level of serum creatinine generated is closely monitored via a series of physiological regulators.
The normal amounts of the toxic waste creatinine are kept very low.
But, when creatinine is ingested from the conversion of creatine to creatinine
(instantaneous conversion when activated with a fluid or ingested), concomitant metabolic
abnormalities can be observed in-vitro, and in-vivo in animals and in humans. This ingestion of
pure creatinine is toxic to humans and animals.
Lis and Bijan (1970) observed a sedating or stupefying property of creatinine when it was
injected into mice. Giovanetti (et al., 1969) demonstrated that injecting dogs with creatinine
could chronically intoxicate them. In addition to their observations of the animals aberrant
behavior, creatinine was also responsible for a significant decrease in the animals erythrocyte
survival time. The addition of creatinine to normal human blood initiated a significant increase
in spontaneous hemolysis. This same red cell lysing pattern was observed in normal human
volunteers whom had ingested creatinine. Golini and Golini (2004) also observed a sedating
effect when creatinine was given orally to mice. Mice were unable to run on wheels and showed
the same stupefying property reported by Lis and Bijan (1970).
Balestris research in 1970 gave us further evidence of this potential membraneassociated molecular blockade by showing that creatinine was able to effectively inhibit glucose
utilization by erythrocytes.
II. Mutagenicity and Carcinogenicity of Creatinine
It has been postulated that exposure to dietary creatinine may play a very significant part
in the initiation of cancer (most probably bowel and bladder cancer) in man. (Doll and Peto,
1981; Felton, et al., 1994). Creatinines ability to cause chromosomal damage and mutations in
cultured cells has been confirmed, as has their carcinogenicity in mice and rats (Aeschbacher,
1991) and in one instance, in monkeys (Adamson, et al., Felton et al. 1994)
III. Creatinine: Friend or Foe?
Fact:
1) Creatinine- A waste product in the blood that results from the normal breakdown of
muscle. (Medline)
2) Creatinine- A component of urine and the final product of creatine catabolism;
formed by the nonenzymatic dephosphorylative cyclization of phosyphocreatine to
form the internal anhydride of creatine. (PDR Medical Dictionary)
3) Creatinine- Creatinine (CRN) is a by-product of the creatine production. The
ingested creatinine is waste for the body and is excreted by the kidney. (Degussa,
Germany)
4) Creatinine is excreted by the kidneys. (Greys Anatomy & Physiology)
5) Normal Creatinine Clearance levels in healthy humans:
Men .97 to 1.37 mg/dl (97-137 ml/min)
Women .88 to 1.28 mg/dl (88-128 ml/min)
(St. Vincent Healthcare, Department of Pathology, Billings, MT & American
Kidney Foundation)
6) Creatinine clearance levels above 1.37 mg/dl (for men) and 1.28 mg/ml (for women)
is dangerous to healthy kidneys. (St. Vincent Healthcare, Department of Pathology,
Billings, MT & American Kidney Foundation)
36

7) Increased creatinine levels will damage kidneys

8) Damaged Kidneys are nonreversible.
Conclusion: Do you want to be ingesting gram levels of creatinine?
Answer: NO
I think by now it is very obvious that creatinine that is ingested from the conversion of
creatine-creatinine is toxic, dangerous and even life threatening.
Creatinine is thought to be the major cause (possible the sole cause) of renal failure.
Studies (such as Rooney, et al., 2002) using animals and humans have reported renal damage
from the ingesting of creatinine. By taking creatine (that has converted to creatinine) these
healthy human volunteers were shown to have induced abnormalities in pancreatic insulin
secretion and changes in glucose homeostasis, resulting in renal failure.
Edmunds (et al., 2001) studies, using a rat model of cystic kidney disease, reported that
when regular creatine monohydrate supplementation was given, larger and faster cyst growth and
exacerbation of disease progression was observed. This was due to the conversion of creatine to
creatinine.
Various types of glomerulonephritis, diabetic glomerulosclerosis, and glomerular
amyloidosis in humans, a significant correlation exists between the severity of fibrosis of the
renal cortical interstitium and tubular atrophy resulting from chronic interstitial inflammation
and serum creatinine concentrations (Bohle et al., 1986)
Today, more than 20 million people in the United States have some form of renal disease,
and more than 350,000, the US alone, require regular dialysis in order to stay alive. Renal
failure with the exception of toxic drug over dose or injury related acute failure) is a stepwise
deterioration process that is cumulative. This means is shows up gradually, and only after a
substantial percentage of the organ has suffered damage. This stepwise progression stems from
more than one primary insult to a specific facet of the organs filtration system. Creatinine
poising, un-stable creatine, & residual manufacturing contaminants in creatine play a big part in
this failure. (Benzi 2001: and 2000)
So, contrary to what some Doctors and PhDs think, creatinine is dangerous!

37

BioCeuticals Research & Development Analytical Laboratory

2003 Main Street
Billings, MT 59105
(406) 245-573 ext 201
(406) 252-1811 Fax
www.brdal.com
_____________________________________________________________________________

Contents
Page
I. INTRODUCTION
Purpose of Case Study
Reason for Study
Definitions

(1)
(1)
(1)

II. THE TESTING

Study

(2)

III. THE RESULTS

Results

(3)

VI. SUMMARY
Conclusion

(4)

38

BioCeuticals Research & Development Analytical Laboratory

2003 Main Street
Billings, MT 59105
(406) 245-573 ext 201
(406) 252-1811 Fax
www.brdal.com
_____________________________________________________________________________
Date: May 5, 2002
The purpose of this study is to show that Kre-AlkalynR (US Patent #6,399,661) increases
endurance in human beings.
Kre-AlkalynR is manufactured by All American Pharmaceutical & Natural Foods Corporation &
comes in powder, liquid, capsules, softgels and tablets. Capsules were used for this study do to
the convenience for administration and exact doses being administered.
The reason for the study is to prove weather Kre-AlkalynR increases endurance in athletes.
Kre-AlkalynR (US Patent #6,399,661) is buffered creatine, that is completely stable.

39

The Testing
Due to the complexity and many functions of the chemical, a direct case study approach
was taken. Since the product is Patented, there was no need to prove what was already known
and was not important to do a double blind test. Instead, we wanted to find out how effective
Kre-AlkalynR was for increasing endurance with out any changes to diet, workout programs or
activity levels.
Test Group 1
Group 1 was composed of professional male football players who are currently involved
in a heavy workout schedule (pre-season), with all being season veterans to this beginning part of
the season. Their position were wide receivers and defense of backs The body weight for this
group at the beginning of camp was as follows:
Subject A:
185 lbs
Subject B:
187 lbs
Subject C:
190 lbs
Subject D:
195 lbs
Group 1 started and finished with Two 750 mg capsules of Kre-AlkalynR, which were
administered in the A.M. This went on 7 days a week for 6 weeks. Body fat, body weight,
strength, endurance & stamina were measured before starting Kre-AlkalynR. Any aches and
pains were also noted.
Test Group 2
Group 2 was composed of professional male football players who are currently involved
in a heavy workout schedule (pre-season), with all being season veterans to this beginning part of
the season. Their positions were running back and linebacker. The body weight for this group at
the beginning of camp was as follows:
Subject E:
225 lbs
Subject F:
227 lbs
Subject G:
235 lbs
Subject H:
237 lbs
Group 2 started and finished with Two 750 mg capsules of Kre-AlkalynR, which were
administered in the A.M. This went on 7 days a week for 6 weeks. Body fat, body weight,
strength, endurance & stamina were measured before starting Kre-AlkalynR. Any aches and
pains were also noted.
Test Group 3
Group 3 was composed of professional male football players who are currently involved in a
heavy workout schedule (pre-season), with all being season veterans to this beginning part of the
season. Their positions were offence of line and defense of line. The body weight for this group
at the beginning of camp was as follows:
Subject E:
315 lbs
Subject F:
330 lbs
Subject G:
340 lbs
Subject H:
380 lbs
Group 3 started with Two 750 mg capsules of Kre-AlkalynR , for the first week,
increasing to four 750 mg capsules at week 2 and remaining on that amount. Capsules were
administered in the A.M. This went on 7 days a week for 6 weeks. Body fat, body weight,
strength, endurance & stamina were measured before starting Kre-AlkalynR. Any aches and
pains were also noted.

40

The Results
After a full 6 weeks of testing, the following were the results reported:
Test Group 1
Over all energy levels seemed to have increased, with a total body fat % being lowered by 1 %.
All reported increased endurance levels through out the two a day (times 3 hour) practices.
Recuperation between practices increased along with strength levels. Group 1 out performed,
out endured and out played other athletes of the same position through out the 6 week period.
Test Group 2
Over all energy levels seemed to have increased, with a total body fat % being lowered by 2 %.
All reported increased endurance levels through out the two a day (times 3 hour) practices.
Recuperation between practices increased along with strength levels. Group 1 out performed,
out endured and out played other athletes of the same position through out the 6 week period.
Test Group 3
Over all energy levels seemed to have increased, with a total body fat % being lowered by 3.5 %.
All reported increased endurance levels through out the two a day (times 3 hour) practices.
Recuperation between practices increased along with strength levels. Group 1 out performed,
out endured and out played other athletes of the same position through out the 6 week period.
All three groups reported less aches and pains then they other athletes on the team. Each subject
reported feeling better, had more energy, more endurance, more stamina that ever in the past.

41

Conclusion:
From the testing and research done with the product Kre-Alkalyn, we so conclude that this
product is very effective for increasing endurance and stamina, while eliminating fatigue due to
lactic acid build up.
These 12 subjects are professional athletes who were into pre-season training and are very in
tuned with their bodies. All athletes are continuing on the program along with the rest of the
team for later evaluation as the season progresses.
In finial summary conclusion, this laboratory has found Kre-Alkalyn to be a very safe and
effective was to increase endurance. It also is this laboratories conclusion that Kre-Alkalyn
could be effective for weight loss and joint pain.

42

BioCeuticals Research & Development Analytical Laboratory

3039 Grand Avenue
Suite B
Billings, MT 59102
www.BSRDL.com
_____________________________________________________________________________
Date:
February 10th, 2003
Study:

Study administering Kre-AlkalynR US Patent 6,399,661 - vs- Placebo to

12 endurance athletes in the off season phase

Purpose of Study:

To see if Kre-Alkalyn increases Energy, Endurance & Stamina in athletes.

Procedures:

6 subjects were administered 1.5 grams of Kre-AkalynR in the A.M. and 6

subjects were administered 1.5 grams of a placebo in the A.M. for 8
weeks. No changes were made to diet or off season training.
Endurance & Stamina levels were tested at the beginning of the study and
every 2 weeks for 8 weeks.
The testing equipment used was Life Fitness computerized bicycles.
These systems are able to monitor heat beat and revolutions per minute.

Results:

The pretest showed that both the placebo group and the Kre-AlkalynR
group were all at about the same Endurance & Stamina levels. They were
barely able to work up and maintain a level 5, at 100 rpms for 20 minutes.

Placebo Group:

Not much progress was made from Week 1 to Week 8. At the end of
week 8, placebo group could work up and maintain a level 6, at 100 rpms
for 20 minutes.
Stamina was still at 20 minutes while endurance was increased slightly to
level 6.

Kre-AlkalynR Group: Results were fantastic. At the end of Week 8, Kre-AlkalynR group was
able to work up to and maintain a level 15 at 100 rpms for 40 minutes.
Stamina increases from 20 minutes to 40 minutes. A 100% increase.
Endurance increased from level 5 to level 15 a 200% increase.
Conclusion:

Kre-AlkalynR dramatically increases endurance and stamina in endurance

athletes. Stamina increases of 100% and Endurance increases of 200%.

43

BioCeuticals Research & Development Analytical Laboratory

3039 Grand Avenue
Suite B
Billings, MT 59102
www.BSRDL.com
_____________________________________________________________________________
Date:
January 10, 2004
Study:

Case Study administering Kre-AlkalynR US Patent 6,399,661 to 4 Healthy

active adults

Purpose of Study:

To measure body pH, Energy Levels, Endurance Levels, & Physical Well
being in test subjects.

Procedures:

Two subjects were administered 750 mg daily and two subjects were
administered 1500 mg daily for 30 days. Kre-Alkalyn administration was
taken first thing in the A.M. upon awaking.
pH, Energy, Endurance & Physical levels were measured 3 times daily.
The first in the A.M. before Kre-Alkalyn administration, the second mid
day, and the 3rd in the evening. The following chart was used for
measurements.

Scale:1-5 number system

Energy

Endurance

Physical

1-Very energetic

1-Very

1- Feel Great

2- Fairly

2-Good

2-Good

3-So So

3-So So

3-So So

4-A bit sluggish

4-Not so good

4-Not so good

5-No energy

5-Bad

5-Bad

pH was measured by urinalysis.

The subjects were asked to not change their diet or workout schedules. All 4 subjects were male
from ages 25-44.
Definitions:
ENERGY
1. A: dynamic quality (narrative energy) B: the capacity of acting or being active
(intellectual energy) C: a usually positive spiritual force (the energy flowing
through all people)
2. Vigorous exertion of power: EFFORT (investing time and energy)
3. A fundamental entity of nature that is transferred between parts of a system in the
production of physical change within the system and usually regarded as the
capacity for doing work
4. Usable power (as heat or electricity); the resources for producing such power

44

ENDURANCE
1. Permanence, duration
2. The ability to withstand hardship or adversity, especially the ability to sustain a
prolonged stressful effort or activity (a marathon runners endurance)
3. The act or an instance of enduring or suffering
4. Capacity to endure pain or hardship, fortitude, stamina
PHYSICAL
1. An emotional state or action
2. The overall quality of ones awareness and well-being
3. Strength and power

Results:
Subject 1:

Subject 2:

Subject 3:

Energy
Before study:
During study:

3.00 (So-So)
1.17 (Average)

Very Energetic

Endurance
Before study:
During study:

3.00 (So-So)
1.56 (Average)

Very

Physical
Before study:
During study:

2.00 (Good)
1.33 (Average)

Feel Great

Energy
Before study:
During study:

3.00 (So-So)
1.26 (Average)

Very Energetic

Endurance
Before study:
During study:

3.00 (So-So)
1.30 (Average)

Very

Physical
Before study:
During study:

3.00 (Good)
1.33 (Average)

Feel Great

Energy
Before study:
During study:

4.00 (A bit sluggish)

1.64 (Average)
Very Energetic

Endurance
Before study:
During study:

4.00 (Not so good)

1.57 (Average)

Very

Physical
Before study:
During study:

4.00 (Not so good)

1.76 (Average)

Feel Great

45

Subject 4:

Energy
Before study:
During study:

5.00 (No energy)

3.76 (Average)

So-So

Endurance
Before study:
During study:

5.00 (Bad)
3.03 (Average)

So-So

Physical
Before study:
During study:

4.00 (Not so good)

3.06 (Average)

So-So

Subject 1:

Energy:
Endurance:
Physical:

156.4%
92.3%
50.3%

Subject 2:

Energy:
Endurance:
Physical:

138.9%
130.7%
125.5%

Subject 3:

Energy:
Endurance:
Physical:

143.9%
154.7%
127.2%

Subject 4:

Energy:
Endurance:
Physical:

32.9%
65.1%
30.7%

% Increases:

Average for study % Increases:

Energy:
Endurance:
Physical:

118.0%
110.7%
83.4%

Conclusion:
Kre-Alkalyn increased Energy levels by 118%, Endurance & Stamina by 110.7% and
Physical well-being 83.4%.

46

BioCeuticals Research & Development Analytical Laboratory

3039 Grand Avenue
Suite B
Billings, MT 59102
www.BSRDL.com
______________________________________________________________________________
Date:
March 8th, 2003
Study:

Rat Study with Kre-AlkalynR US Patent 6,399,661 (Buffered

Creatine)

Purpose of Study:

To measure Energy Levels & Muscle Gain in rats, with test and
control animals

Procedures:
White male albino rats where used for this study. A control group was used along with a
test group. Upon arrival to the lab both groups entered Phase I, stabilization.
Stabilization started with changing their diet to a more conventional food source. Good
Protein and Carb levels, low fat. Each rat was weighed at the start and each Monday for
six weeks. Rats were randomly selected for test group and control group.
Rats were observed for energy levels daily. Energy levels were measured by amount of
chewing, maze work & cage activity that occurred.
Rats were placed in a large 10-gallon glass cages that aloud movement and building of
nests. Chew items were also put in the cages to help measure night activity.
Kre-Alkalyn Administration: Based on human studies, 1.5 grams per 100 kg of body
weight was used. This worked out to 15 mcg/gram of rat starting weight.
The Start:
Both rats weighed in at 250 grams. Activity and Energy levels were extremely low.
Neither rats would work a maze. During stabilization, both control rat and test rat sleep
during the day, with very low night activity.
Results:
Animal
Control
Week 1
Week 2
Week 3
Week 4
Week 5
Week 6

Weight in
grams
250.00
259.20
285.80
317.80
344.80
359.80
382.80

Test

250.00

Week 1
Week 2
Week 3
Week 4
Week 5
Week 6

262.80
280.80
309.80
358.56
381.00
407.80

Week
Gain
Starting
Weight
9.20
26.60
32.00
27.80
15.00
23.00

Total
Gain

9.20
35.80
67.80
95.60
110.60
133.60

Starting
Weight
12.80
18.00
29.60
48.76
22.44
26.80

12.80
30.80
60.40
109.16
131.60
158.40

47

% Gained

Total

3.68
14.32
27.12
37.92
43.92
53.12

Total

Total

5.12
12.24
23.92
43.42
52.40
63.12

Total

Control Rat Weight Gain: Although the control rat gained 133.6 grams, he was very round
and soft.
Test Rat Weight Gain:

Kre-AlkalynR rat gained 158.4 grams or 63.12 % increase in lean

muscle in 6 weeks. He gained 10% more than control rat. KreAlkalynR rat was solid with no roundness or flabbiness like the
control rat.

Control Rat Energy:

Control rat was not active at all during the day. He slept in his
nest. The nest was a mess and un-organized. Chew toys were not
touched. Rat did not even come out for feeding. The only
evidence of night activity was food eaten. Control rat had no
energy or motivation to work a maze.

Test Rat Energy

Control rat was out of his nest each morning and most of the time
during the day. His next was clean and very organized. Control
rat went through 3 chew toys during the 6 week testing, along with
chewing at the top of the cage which was only accessible when
water bottle was climbed, which he did often during the day. Test
rat was extremely motivated and energized to work a maze. His
energy levels were extremely high for a rat.

Conclusion:

Not only did the test rat gain 63.12% lean muscle, but his energy
levels was increased 100% over the control rat and 100% from the
stabilization week.
Kre-AlkalynR (Buffered Creatine) increased lean muscle mass by
63.12% after 6 weeks, and energy levels increased by 100%.

48

Kre-Alkalyn
RESEARCH BOOKLET

JEFF GOLINI

1832

1847

Creatine is discovered by French scientist

Michel Eugne Chevreul. (Pictured on the cover)

It is first observed that creatine accumulates in

muscles as a consequence of physical activity.

PATENTS AWARDED:
United States #6,399,661
New Zealand #519,305
late
1800s

The Germans introduce the first synthetic creatine.

PATENTS PENDING:
Australia
Austria

1912

Researchers found that ingesting creatine can

dramatically boost the creatine content of muscle.

Belgium
Bulgaria
Canada
Cyprus

1927

1928

Fiske and Subbarow discovered creatine

phosphate, and determined that creatine is a
key player in the metabolism of skeletal muscle.
Creatine is found to be unstable in liquids and acids.

Czech Republic
Denmark
Estonia
Finland
France
Germany
Greece

1992
1993

It was reported that British athletes used creatine

supplementation at the Barcelona Olympics.
Creatine is introduced to the U.S. market.

Hungary
Ireland
Italy
Luxembourg
Monaco
Netherlands

2002

Jeff Golini is awarded U.S. Patent #6,399,661 for his

invention Kre-Alkalyn...The worlds first and only
100% stable form of creatine.

Poland
Portugal
Romania
Slovak Republic
Slovenia
Spain
Sweden
Switzerland

2376 Main Street

Billings, MT 59105
go to: www.getkre-alkalyn.com

Turkey
United Kingdom

I suppose it's possible that some small

company or entrepreneur has discovered
a stabilization process that eluded one
of the top laboratories in the world that
works with creatine, but I highly doubt it.
-Industry Expert
Doubt no more...