DAVID GOUKASSIAN, MD, PHD

West Newton, Massachusetts 02465

617-480-3890 david.goukassian@tufts.edu

PROFESSIONAL HIGHLIGHT
Highly skilled Research Physician/Scientist and Principal Investigator with more than 15 years of
biomedical/translational research experience. Demonstrated research expertise in cancer and cardiovascular disease
prevention, biomarker-based diagnostics and therapy development and testing. Extensive experience in Space
Radiation Biology research identifying long-term cardiovascular disease risks due to space radiation for NASA
Astronauts. Proven and published experience in stem cell and progenitor cell biology including testing and pre-clinical
validation of a universal therapy to improve stem cell and gene therapy outcomes in diseased and damaged tissue.
Solid record of medical research at reputable academic institutions including Boston University and Tufts University, and
also at a none-profit institution. Skilled at developing research funding, preparing grant proposals and providing
academic research oversight and mentoring graduate students, post-doctoral research scientists, clinical fellows and
medical residents as a Principal Investigator.

PROFESIONAL SKILLS
Biomedical Research Cancer Biology Cancer Therapeutics Transnational Medicine
Pre-Clinical Validation Clinical Research Patient Derived Xenograft Cancer Models Cardiovascular Research
Stem Cell Therapeutics Drug Discovery Immunology Pharmacogenomics Pre-Clinical Research
Budget Proposals Intellectual Portfolio Management Program Development Negotiations Proposal Writing
Strategic Planning Team Leadership / Motivation Grant Writing NASA NIH Training / Development
Public Speaking Fostering Collaborations Progress Reporting Scientific Presentations
Manuscript Writing Project Management Communication

PERSONAL TRAITS

Very strong believer in leadership by example and by inspiring team members to challenge themselves to do their
best.
Multi-talented; vast expertise and experience in basic, translational and clinical research.
Innovative, entrepreneurial; strategic, outside-the-box thinker; highly motivated, energetic, analytical, persistent.
Excellent writing and presentation skills; multilingual and multicultural.
Led and mentored Junior Faculty, Ph.D. candidates, Medical Residents, Clinical Fellows, M.Sc., B.A., undergrads.
Established and led multi-disciplinary and multi-institutional research teams and consortiums, including strategic
planning, opportunity development and management of activities on scientific and business operation levels.
Writing wining proposals for government grants (NIH and NASA), foundations and associations (American Heart
Association, American Federation of Aging Research, American Cancer Society, etc.), BigPharma (Merck and Co,
Industrial Farmaceutica Cantabria, Shiseido Corp., etc.).

SUMMARY OF EXPERTISE

Therapeutic angiogenesis and tissue regeneration including development of TNF-alpha ligand-receptors

interaction-based therapies to improve post-ischemic repair, regeneration and neovascularization processes.
Development of novel anticancer therapeutics including anti-cancer therapies based on inhibition of TNF-alpha
ligand-receptors interactions.
Translational research using transgenic and organ-specific models of human cancer and cardiovascular diseases.
Stem and progenitor cell biology (hematopoietic stem and progenitor cells, satellite cells) development of
universal platform therapeutics to improve stem cell and gene therapy outcomes in diseased/damaged tissues.
Space Radiobiology - molecular mechanisms of space radiation-induced long-term cardiovascular degenerative
risks, development of mouse models for evaluation of space radiation-induced Excess Relative Risks-ERR,
development of predictive biomarkers for estimation of ERR, development of countermeasures for NASAs future
long-duration space missions to Moon, near Earth asteroids and Mars.

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BOSTON UNIVERSITY SCHOOL OF MEDICINE Boston, Massachusetts 12/2010 2016

Associate Professor of Medicine, Whittaker Cardiovascular Institute - Directed cardiovascular and anti-cancer
drug-development research. Established multi-institutional and multidisciplinary collaborations with academic and
industry research scientists and investigators. Provided instruction and support to undergraduate and graduate students,
medical residents, clinical fellows and junior faculties. Assisted students in preparing and executing research studies,
preparing scientific presentations and writing manuscripts.
Achievements:
Served as principal research investigator managing doctoral and post-doctoral research scientists performing
medical research and preparing manuscripts. Resolved first author credit disputes and offered course in
Responsible Research Conduct for all research scientists to prevent future authorship disagreements.
Served as Faculty Supervisor of Research Laboratory maintaining service contracts for all major equipment.
Negotiated long-term contract with professional service company covering the majority of equipment saving
$120,000 annually the first year and $600,000 over the next six contract years.
Performed research focused on developing a small DNA oligonucleotide-based therapy to reduce sun exposure and
increases in skin mutagenesis and cancer development. Published research results in high profile medical journals
including PNAS USA, Lancet, and FASEB. Results received national and international media attention including the
Nature Publishing Group, Lancet Oncology, ASCO American Society of Clinical Oncology, The Scientist Journal,
WedMD Health, Medline Plus Technology News, Boston Herald, the Boston Globe, Daily Telegraph London, BBC
World News UK, Reuters, WolffSystem Germany, Der Spiegel Germany, Pressetext Schweiz Austria.
The paper Goukassian et al. Proc Natl Acad Sci USA was cited by Faculty of 1000 a consortium of faculty member
of 1000 research universities worldwide that evaluate research papers on monthly basis according to papers
originality, hypothesis, novelty and applicability in clinical setting.

TUFTS UNIVERSITY SCHOOL OF MEDICINE Boston, Massachusetts 3/2008 2016

Associate Professor of Medicine, Division of Cardiovascular Research, Department of Medicine, St. Elizabeths
Medical Center of Boston - Performed high-value cardiovascular drug-development research projects. Taught and
mentored 15 graduate students for their Master of Science research thesis manuscripts.
Achievements:
Developed research project to improve stem and progenitor cell-therapy effectiveness and outcomes. Created and
tested pre-clinical models of cardiovascular disease utilizing a new therapy employing modulation of TNF signaling
to improve recovery in damaged tissue through inhibition of apoptosis, inhibition of inflammation, and promotion of
angiogenesis and regeneration by increasing survival of the resident differentiated cells and adult stem cells.
Created tissue environment for recruitment, incorporation and function of endogenous and exogenous stem cells
providing damaged organ regeneration and serving as a universal platform therapy for stem cell and gene therapy.
Addressed loss of key investigator in a multidisciplinary project for development of stem cell therapy. Identified
expert in stem cell therapy testing and recruited scientist to assist in the testing and validation process.
Served as a key member of Executive Strategic Planning Committee and develop intellectual portfolio, fostered new
collaborations with academic and industrial partner to develop multi-institutional and multi-specialty consortium.

GENESYS RESEARCH INSTITUTE Brighton, Massachusetts 10/2010 9/2015

Director of Cardiovascular Research Center, Chief Scientific Officer
Drug-development research projects from conception to pre-clinical testing. Designed in vitro and in vivo experiments
leading research team and guiding project clinical direction, pathways and data analysis. Prepared study research
presentations for national and international scientific conferences. Wrote executive summaries, investor presentations,
scientific manuscripts, and grant proposals for government agencies, private foundations and medical associations.
Achievements:
Developed new anti-cancer treatment utilizing monoclonal antibodies to block the pro-survival receptor of the Tumor
Necrosis Factor Alpha. Potentially offers paradigm changing cancer treatment targeting proliferative and silent
cancer cells, cancer associated tumor stroma and endothelial cells providing an effective method to clean tumor
cells produce self-destructive cycle for tumors. Published initial pre-clinical proof of concept.
Researched cardiovascular disease risks for astronauts from low dose radiation exposures. Assisted NASA in
developing heart disease risk estimates and proposed measures to prevent Earth-bound population from radiationinduced cardiovascular diseases in cancer patients receiving standard of care conventional and particle
radiotherapy. Developed neutralizing antibody mitigation therapy to reduce cardiovascular disease risks.

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EDUCATION
Medical Doctor, Internal Medicine
Yerevan Medical University, Yerevan, Republic of Armenia

PhD in Genetics, Immunology, Dermatology

Central Advanced Training Institute for Physicians, Moscow, Russia

POSTDOCTORAL TRAINING CLINICAL

Internship Cardiology, Nephrology, Endocrinology
Yerevan Medical Institute, Yerevan, Armenia
Residency, Specialization in Dermatology
Belorussian Advanced Training Institute for Physicians, Minsk, Belarus
Clinical Fellowship, Dermatology for Primary Care Physicians
Belorussian Advanced Training Institute for Physicians, Belarus

POSTDOCTORAL TRAINING RESEARCH

Post-Doctoral Fellowship: Aging, Photo-aging, Gerontology, Cutaneous Oncology, Molecular and Cell Biology
Boston University School of Medicine, Boston, MA / National Institute of Aging T32 Training Grant
Post-Doctoral Fellowship: Aging, Endothelial Progenitor Cell Biology, Ischemia-induced Neovascularization,
Tissue Repair and Regeneration
Caritas St. Elizabeths Medical Center of Boston, Division of Cardiovascular Research, Boston, Massachusetts /
National Heart, Lung and Blood Institute
2010 NASA Space Radiation Summer School / Professional Auditor
NASA Space Radiation Laboratory, Brookhaven National Laboratory, Upton, New York

CERTIFICATIONS
Medical Doctor
Philosophy Doctor of Genetics, Immunology, Dermatology
Professional Auditor for NASA, Space Radiobiology

AWARDS AND RECOGNITION

World Congress Fund Award of the American Academy of Dermatology
Japanese Society of Investigative Dermatology International Fellowship Shiseido Award
Dermatology Foundation Research Award
The Skin Cancer Foundation Research Award
American Cancer Society Research Award
American Federation for Aging Research Award
Merck and Company, Inc., Research Award
American Cancer Society Research Award
Industrial Cantabria Farmaceutica, Research Award
American Heart Association, Scientist Development Award
NIH/NIA R21 Exploratory Developmental Research Grant
Industrial Farmaceutica Cantabria, Research Award
NASA Human Research Program Award, Ground-Based Studies in Space Radiobiology, 2011-2015
American Heart Association, Grant-in-Aid, 2014-2016
NASA Research and Technology Development to Support Crew Health and Performance in Space Missions, 2016-2017

AFFILIATIONS
American Federation for Aging Research, National Scientific Advisory Council
Center for Integration of Medicine and Innovative Technology
Brigham and Womans Hospital
Massachusetts Institute of Technology
Draper Laboratory
American Heart Association
Radiation Research Society

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PEER-REVIEW ACTIVITY
2000
2002
2003
2003
2004
2005
2005
2006
2006
2011
2013

Reviewer for Journal of Investigative Dermatology

Reviewer for Circulation
Reviewer for Circulation Research
Reviewer for Atherosclerosis Thrombosis and Vascular Biology
Reviewer for Journal of Cellular Physiology
Reviewer for FASEB Journal
Reviewer for Journal of Biological Chemistry
Reviewer for Proceeding of National Academy of Sciences, USA
Reviewer for Cancer Research and American Association of Cancer Research related 3 other Journals
Reviewer for Radiation Research
Reviewer for American Journal of Physiology Heart and Circulatory Physiology

GRANT PEER-REVIEW ACTIVITIES

2007 2008
2008
2005

Invited Program Project Grant reviewer for NIH/NHLBI, Special Emphasis Panel.
Reviewer for Basic and Translational grants, Italian Ministry of Health.
Reviewer for International Grant Review Committee, Russian Academy of Sciences and
Ministry of Health, Russian Federation.

2000
2003
2010

American Association for the Advancement of Science.

American Heart Association.
Radiation Research Society.

PROFESSIONAL SOCIETIES

HOSPITAL, MEDICAL SCHOOL, OR UNIVERSITY COMMITTEE ASSIGNMENTS

2013-2015
2010 2013
2005-2010
2006-2009
2001 2007

Chair, Institutional Animal Care and Use Committee, GeneSys Research Institute, Brighton, MA, USA
Executive Member, Strategic Planning Committee, Steward Research and Specialty Projects
Corporation, Brighton, MA, USA
Member of Institutional Review Board, St. Elizabeths Medical Center of Boston, MA, USA.
Member, Committee on Faculty Affairs, Boston University School of Medicine, Boston, MA, USA
Executive Faculty Supervisor of Research Labs, Department of Dermatology, BUSM, Boston, MA, USA

TRAINING OF MDs, PhDs, GRADUATE STUDENTS and POST DOCTORAL FELLOWS

2015
2014
2013
2013
2013
2013
2013
2013
2012
2012
2012
2012
2011
2011
2010
2008
2007-2008
2004-2007
2006-2007
2006
2006
2005-2006
2005-2006
2004-2005
2003-2004

John Schwab, Masters Student, BUSM, GMS Division

Adam Taleb, MD, - Post-Doctoral Fellow, Medicine, Steward St Elizabeths Medical Center
Radu Hagau, MD, - Clinical Fellow, Steward St Elizabeths Medical Center
Begona Quintana, MD, Post-Doctoral Fellow, Visiting Scholar, Assistant Professor of
Medicine, Universidad Complutence, Madrid, Spain
Layla Rahimi - Masters Student, BUSM, GMS Division, (Honors for MS).
Jin Song Masters Student, BUSM, GMS Division, (Honors for MS).
Brittany Garrety Undergraduate Intern, UMASS, Worchester
Albert Kiladjian Undergraduate Intern, Trinity University
Raman Mehrzad, MD Cardiac Fellow, Steward St Elizabeths Medical Center
Sanggyu Bae, MD, - Clinical Resident, Medicine, St Elizabeths Medical Center
Hannah Gee Masters Student, BUSM, GMS Division, (Honors for MS)
Akhil Aggarwal Medical Student (USMI) class of 2016 summer Internship.
st
Justin Wage Medical Student, TUSM (1 year), Summer Internship.
Daniel Park Senior Internship, School-To-Career, Weston High School.
Daniel Park High School Internship, Weston High School.
rd
Danielle Levine Medical Student, TUSM (3 year), Research Rotation.
Joanna Rhodes Master Student, BUSM, GMS Division (Honors for MS).
Simin Arad, MD Post-Doctoral fellow, BUSM, GMS Division.
Christina Coleman Masters Student (Honors for MS), BUSM, Graduate Medical Sciences
(GMS) Division.
Edoardo Zattra, MD Medical Resident, Post-Doctoral Research, University de Padova, Italy.
st
Danielle Levine Medical Student TUSM (1 year), Research rotation.
rd
Alexandra Guillermo Medical Student TUSM (3 year), Research Rotation.
Hu-Ya Chen, MD Post-Doctoral Research Fellow, Taiwan.
Sepideh Bagheri, MD Post-Doctoral Research Fellow.
Laila El-Keeb, MD Post-Doctoral Research Fellow.

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TEACHING RESPONSIBILITY
2006
2001 2010
1999 2006

Graduate Faculty, Primary Mentor of Graduate Student, Clinical and Translational Science
Institute, BUSM, Boston, MA, USA
Lectures (2/semester), within the course of Special Topic in Pathology, GMS Division, BUSM.
Course of Integrated Clinical Problems/Evidence-Based Medicine for M.D./Ph.D. students, and
of 1st and 2nd year Medical School students, BUSM.

BIBLIOGRAPHY
#

(#denotes corresponding and or primary author, selected since 2005)

1. Goukassian D.A. Mending the Rift: DNA Repair and Aging. Geriatrics and Aging. 8(8): 57-60, 2005.
2. Kishore R, Qin G, Luedemann C, Bord E, Hanley A, Silver M, Gavin M, Yoon YS, Goukassian D.A., Losordo DW.
The Cytoskeletal Protein Ezrin Regulates EC Proliferation and Angiogenesis via TNF-alpha-induced Transcriptional
Repression of Cyclin A. J Clin Invest. Jul;115(7):1785-96, 2005.
3. Luedemann C, Bord E, Qin G, Zhu Y, Goukassian D.A., Losordo DW, Kishore R. Ethanol Modulation of TNF-alpha
Biosynthesis and Signaling in Endothelial Cells: Synergistic Augmentation of TNF-alpha Mediated Endothelial Cell
Dysfunctions by Chronic Ethanol. Alcohol Clin Exp Res. Jun;29(6):930-8, 2005.
#
4. Marwaha V, Chen YH, Helms E, Arad S, Inoue H, Bord E, Kishore R, Sarkissian RD, Gilchrest BA, Goukassian DA.
T-oligo Treatment Decreases Constitutive and UVB-induced COX-2 Levels Through p53- and NFkappaB-dependent
Repression of the COX-2 Promoter. J Biol Chem. 280(37):32379-88, 2005.
5. Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, Iwakura A, Shintani S, Ii M, Asai J, Tkebuchava T, Thorne T,
Takenaka H, Aikawa R, Goukassian D.A., von Samson P, Hamada H, Yoon YS, Silver M, Eaton E, Ma H, Heyd L,
Kearney M, Munger W, Porter JA, Kishore R, Losordo DW. Sonic Hedgehog Myocardial Gene Therapy: Tissue Repair
Through Transient Reconstitution of Embryonic Signaling. Nature Medicine. 11(11):1197-204, 2005.
6. Qin G, Ii M, Silver M, Wecker A, Bord E, Ma H, Gavin M, Goukassian DA, Yoon YS, Papayannopoulou T, Asahara T,
Kearney M, Thorne T, Curry C, Eaton L, Heyd L, Dinesh D, Kishore R, Zhu Y, Losordo DW. Functional Disruption of
{alpha}4 Integrin Mobilizes Bone Marrow-derived Endothelial Progenitors and Augments Ischemic Neovascularization.
J Exp Med. 203(1): 153-63, 2006.
7. Qin G, Kishore R, Dolan CM, Silver M, Wecker A, Luedemann CN, Thorne T, Hanley A, Curry C, Heyd L, Dinesh D,
Kearney M, Martelli F, Murayama T, Goukassian DA, Zhu Y, Losordo DW. Cell Cycle Regulator E2F1 Modulates
Angiogenesis via p53-dependent Transcriptional Control of VEGF. PNAS. 103(29): 11015-20, 2006.
#
8. Arad S., Konnikov N., Goukassian D.A. Gilchrest B.A. T-oligo Augment UV-induced Protective Responses in Human
Skin. FASEB J, 20(11): pp. 1895-7, 2006.
9. Rajasingh J., Bord E., Luedemann C., Asai J., Thorne T., Qin G., Goukassian D.A., Zhu Y., Losordo D.W., Kishore R.
IL-10-induced TNF-alpha mRNA Destabilization is Mediated via IL-10 Suppression of p38 MAP Kinase Activation and
Inhibition of HuR Expression. FASEB J, 20(12): pp. 2112-4, 2006.
#
10. Goukassian D.A., Qin G., Dolan C., Murayama T., Silver M., Curry C., Eaton E., Luedemann C., Ma H., Asahara T.,
Zak V., Mehta S., Burg A., Thorne T., Kishore R., Losordo D.W. Tumor Necrosis Factor-alpha Receptor p75 is
Required in Ischemia-induced Neovascularization. Circulation 115(6): pp. 752-62, 2007.
11. Rajasingh J., Bord E., Qin G., Ii M., Silver M., Hamada H., Ahluwalia D., Goukassian D.A., Zhu Y., Losordo D.W.,
Kishore R. Enhanced Voluntary Alcohol Consumption After Estrogen Supplementation Negates Estrogen-mediated
Vascular Repair in Ovariectomized Mice. Endocrinology 148(8): pp. 3618-24, 2007.
#
12. Arad S., Konnikov N., Goukassian D.A., Gilchrest B.A. Quantification of Inducible SOS-like Photoprotective
Responses in Human Skin. J of Investigative Dermatology, 127(11):2629-36. 2007.
13. Astner S, Wu A, Chen J, Philips N, Rius-Diaz F, Parrado C, Mihm MC, Goukassian D.A., Pathak MA, Gonzalez S.
Dietary Lutein/ Zeaxanthin Partially Reduces Photoaging and Photocarcinogenesis in Chronically UVB-Irradiated Skh1 Hairless Mice. Skin Pharmacol Physiol, 20: pp. 283-91, 2007.
14. Aprahamian T, Takemura Y, Goukassian D.A., Walsh K. Ageing is Associated with Diminished Apoptotic Cell
Clearance in Vivo. Clin Exp Immunol 152(3): 448-55, 2008.
#
15. Arad S, Zattra E, Hebert J, Epstein EH, Jr, Goukassian DA, Gilchrest BA. Topical pTT Treatment Reduces UVinduced BCC Development in Ptch-1 +/- Mice. American Journal of Pathology. 172(5):1248-55.2008.
16. Zattra E, Coleman C, Arad S, Helms E, Levine D, Bord E, Guillaume A, El-Hajahmad M, Zwart E, van Steeg H,
#
Gonzalez S, Kishore R, Goukassian DA. Polypodium Leucotomos Decreases UV-induced Cox-2 Expression and
Inflammation, Enhances DNA Repair, Decreases Mutagenesis in Hairless Mice. Am J Pathol. 175(5):1952-61, 2009.
#
17. Coleman C, Levine D, Kishore R, Qin R, Thorne T, Lambers E, Sasi SP, Yaar M, Gilchrest BA, Goukassian DA.
Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides. J of Oncology, 2010: 2010:928628.
18. Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, #Goukassian D.A.
Breaking the 'Harmony' of TNF- Signaling for Cancer Treatment. Oncogene, 567, pp 1-11, 2011.
19. #Goukassian D.A., Gilchrest B.A. Topical Application of Thymidine Dinucleotide to Newborn Mice Reduces and
Delays Development of UV-Induced Melanomas. Journal of Investigative Dermatology, 132: pp. 2664-6, 2012.

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20. Klement G.L., Goukassian D.A., Hlatky L., Carrozza J., Morgan J.P., Yan X. Cancer Therapy Targeting the HER2PI3K Pathway: Potential Impact on the Heart. Frontiers in Pharmacology, 3:113, 2012.
21. Shtifman A, Pezone MJ, Sasi SP, Agarwal A, Gee H, Song J, Perepletchikov A, Yan X, Kishore R, #Goukassian
DA. Divergent modification of low-dose (56)Fe-particle and proton radiation on skeletal muscle. Radiat Res.
Nov;180(5):455-64, 2013.
22. Zhou J, Cheng M, Liao YH, Hu Y, Wu M, Wang Q, Qin B, Wang H, Zhu Y, Gao XM, Goukassian D, Zhao TC, Tang
YL, Kishore R, Qin G. Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial
progenitor cells. PLoS One. May 21;8(5):e63126, 2013.
23. Bian Y, Silver M, Ho KKL, Marchionni MA, Kang PM, Goukassian DA, Carrozza J, Morgan JP, Yan X. Neuregulin1
Improved Cardiac function in Doxorubicin-Treated Mice with Cardiomyocyte-Specific Overexpression of a DominantNegative PI3Kp110. J Cardiovasc Dis Diagn 1:120, 2013.
24. Sasi SP, Gee H, Lee J, Yang Y, Song J, Carrozza J, Yan X., #Goukassian DA. Radiation-associated
cardiovascular risks for future deep-space missions. J Radiat Res. Mar 1;55 Suppl 1:i37-i39, 2014.
25. TNF- and IL-1 but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived
TNFR1/p55KO EPCs. Sasi SP, Song J, Enderling H, Yan X, #Goukassian DA. J Radiat Res. Mar 1;55 Suppl
1:i122-i123, 2014.
26. Sasi SP, Yan X, Lee J, Sisakyan H, Carrozza J, #Goukassian DA. Radiation-associated degenerative
cardiovascular risks during normal aging and after adverse CV event 10 months post-initial exposure. J Radiat Res.
Mar 1;55 Suppl 1:i111-i112, 2014
27. Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, #Goukassian
DA. Therapeutic non-toxic doses of TNF induce significant regression in TNFR2-p75 knockdown Lewis lung
carcinoma tumor implants. PLoS One. Mar 24;9(3):e92373, 2014
(18 months after publication there were more than 1870 views and 320 full downloads worldwide).
28. Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M,
Kishore R, #Goukassian DA. TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Non-Targeted
Effects in Bone Marrow-Derived Endothelial Progenitor Cells. J Biol Chem. May 16;289(20):14178-93, 2014.
29. Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan
J, Wilson PF, Carrozza J, Walsh K, Kishore R, #Goukassian DA. Cardiovascular risks associated with low dose
ionizing particle radiation. PLoS One. Oct 22;9(10):e110269, 2014
(one year after publication there were more than 1500 views and 300 full downloads worldwide).
30. Sasi SP, Rahimi L, Yan X, Silver M, Qin G, Losordo DW, Kishore R, #Goukassian DA. Genetic Deletion of TNFR2
Augments Inflammatory Response and Blunts Satellite Cell-Mediated Recovery Responses in Hind Limb Ischemia
Model. FASEB J, Apr;29(4):1208-19, 2015.
31. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao TC, Zhao M,
Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol.
Jun;225(3):181-9, 2015.
32. Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X, #Goukassian DA. Particle
Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells Int.
2015:496512, 2015.
33. Coleman MA, P Sasi S, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev
Y, Yan X, #Goukassian DA. Low Dose Radiation Affects Cardiac Physiology: Gene Networks and Molecular
Signaling in Cardiomyocytes. Am J Physiol - Heart Circ Physiol. Sep 25:ajpheart.00050, 2015 (Podcast)
34. Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh K, Yan X, #Goukassian DA.
Ionizing particle radiation as a modulator of endogenous bone marrow cell reprogramming: implications for
hematological cancers. Front. Oncol., 14 October 2015, http://dx.doi.org/10.3389/fonc.2015.00231 (in one month
there were more than 210 views and 65 downloads)
Chapters:
1. Suvorova X.N. and #Goukassian D.A.- Textbook for Physicians Complications of Atopic Dermatitis by Secondary
Infection and its Treatment. -Moscow, 1993.
2. Kishore R,Tkebuchava T, Sasi SP, Silver M, Gilbert H-Y, Yoon Y-S, Park H-Y, Thorne, T, Losordo W, #Goukassian
DA. Tumor Necrosis Factor- Signaling Via TNFR1/p55 is Deleterious whereas TNFR2/p75 Signaling is Protective in
Adult Infarct Myocardium. Publisher Springer, Adv Exp Med and Biol 691, Chapter 45: pp. 433-48, 2011.
3. #Goukassian D.A. Morgan J, Yan X. Neuregulin1-ErbB Signaling in Doxorubicin-Induced Cardiotoxicity. Publisher
Intech, Ed.: Manuela Fiuza, Book Chapter in: Cardiotoxicity of Oncologic Treatments. pp. 65-88, 2012. (18 months
after publication there were more than 1,500 full downloads worldwide).
International patent applications (non-provisional):
April 2008 Pub No.: US 2012/0014879 A1 - Use of Tumor Necrosis Factor- Receptor p75 for Treatment of
Ischemia-Induced Neovascularization. Inventors Losordo, DW, Goukassain DA.

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March 2010 Pub No.: US 2010/0150841 A1 - Use of Tumor Necrosis Factor-Alpha p75 Receptor for the Reduction
of Inflammation. Inventors Goukassian DA, Kishore R.
April 2013 Pub No.: US 2013/0195896 A1 - Composition and Methods for the Treatment of Neoplasia. Inventor
Goukassian DA.
August 2013 Compositions and Methods for the Treatment of Radiation Exposure. Inventor Goukassian DA.

Provisional patent applications:

January 2015 - Patent Application No.: 62102374; Title - Compositions and Methods for the detecting and treating
Cardiovascular Damage associated with ionizing radiation. Inventor - David A. Goukassian, MD, PhD.
January 2015 - Patent Application No.: 62102431; Title - Particle radiation-induced non-targeted effects in bone
marrow-derived endothelial progenitor cells. Inventor - David A. Goukassian, MD, PhD.
January 2015 - Patent Application No.: 62102306; Title - Compositions and methods for diagnosing and/or reducing
delayed cardiomyocyte response to total body particle radiation.
Inventor: David A. Goukassian, MD, PhD.
January 2015 - Patent Application No.: 62102500; Title - Different sequence of fractionated sequential proton and
single low dose iron radiation induce divergent biological responses in the heart. Inventor: David A. Goukassian,
MD, PhD.
January 2015 Patent Application No.: 62102439; Title Particle radiation induced long-lasting cyclical decreases
in the number of bone marrow progenitor cells is associated with up-regulation of several pluripotent stem cell
markers over 10 months post radiation. Inventor: David A. Goukassian, MD, PhD.
June 2015 Patent Application No.: 62185353; Title TNFR2/p75 neutralizing antibodies and uses thereof.
Inventor: David A. Goukassian, MD, PhD.

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