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http://www.kidney-international.org
& 2012 International Society of Nephrology
Department of Anesthesiology and Critical Care Medicine, George Washington University Medical Center, Washington,
District of Columbia, USA; 2Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University
Medical Center, Washington, District of Columbia, USA and 3National Institute of Diabetes, Digestive, and Kidney Disorders,
National Institutes of Health, Bethesda, Maryland, USA
LS Chawla and PL Kimmel: Acute kidney injury and chronic kidney disease
mini review
mini review
LS Chawla and PL Kimmel: Acute kidney injury and chronic kidney disease
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Tertile 1 (n = 767)
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Mean eGFR
Time
Figure 1 | Effect of severity of acute kidney injury (AKI) on outcomes. AKI patients who survived for 1 year. (a) Mean eGFR over time
(tertiles). (b) AKI patients who survived for 1 year. Mean serum creatinine (Scr) over time (tertiles). Tertiles were defined based on Scr at 15
years post admission. Error bars show the 95% confidence interval at each time point.
0.8
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No AKI
(P < 0.0001)
1 AKI
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LS Chawla and PL Kimmel: Acute kidney injury and chronic kidney disease
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AKI
Repair
Chronic
GFR
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mini review
mini review
LS Chawla and PL Kimmel: Acute kidney injury and chronic kidney disease
c
Normal repair
and regeneration
ATN
Neutrophils and
monocytes
Interstitium
Endothelial
injury
Maladaptive
response
Interstitial
fibrosis
Zones of
hypoxia
Peri-tubular
blood vessels
Cells
and casts
Depleted
blood supply
Cell cycle arrest
Epigenetic changes
Figure 4 | Tubule cross-section. (a) Cross section of normal renal tubule with intact epithelial cells, renal interstitium, and peri-tubular
blood vessels. (b) Cross section of renal tubule with acute tubular necrosis (ATN) with epithelial cell necrosis, intra-tubular cast formation,
endothelial injury of peri-tubular blood vessels, and migration of monocytes and macrophages into renal interstitium. (c) Cross section of
renal tubule after normal repair and regeneration showing restoration of normal renal architecture. (d) Cross section of renal tubule after
severe episode of AKI, resulting in maladaptive repair. Epithelial cells have evidence of cell cycle arrest and epigenetic changes that favor a
fibrosis phenotype. Renal interstitium shows evidence of fibrosis. Post-injury vascular supply is less dense than baseline. The combination
of decreased blood supply and fibrosis leads to zones of hypoxia wherein the combination of decreased vascular supply and fibrosis can
initiate a vicious cycle leading to ongoing fibrosis.
LS Chawla and PL Kimmel: Acute kidney injury and chronic kidney disease
mini review
mini review
LS Chawla and PL Kimmel: Acute kidney injury and chronic kidney disease
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mini review
LS Chawla and PL Kimmel: Acute kidney injury and chronic kidney disease
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