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Chemwatch: 21999
S.GHS.AUS.EN
SULFANILAMIDE
sulfanilamide
Albexon Albosol Ambeside, C6-H8-N2-O2-S, p-aminobenzene sulfamide, p-aminobenzene sulphamide,
sulfanilamide, sulfonamide, sulphanilamide
Not Applicable
Chemical formula
C6H8N2O2S
Not Available
CAS number
63-74-1
Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses
Antibacterial.
Telephone
Fax
Website
Email
http://au.vwr.com
csaus@au.vwr.com
Not Available
Flammability
Toxicity
Body Contact
Reactivity
Chronic
Max
1
2
2
1
3
Poisons Schedule
GHS Classification[1]
0 = Minimum
1 = Low
2 = Moderate
3 = High
4 = Extreme
None
Skin Corrosion/Irritation Category 2, Eye Irrit. 2, Germ Cell Mutagen Category 2, Reproductive Toxicity Category
2, STOT - SE (Resp. Irr.) Category 3
Continued...
Chemwatch: 21999
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sulfanilamide
Legend:
1. Classified by Chemwatch; 2. Classification drawn from HSIS ; 3. Classification drawn from EC Directive
1272/2008 - Annex VI
Label elements
SIGNAL WORD
WARNING
Hazard statement(s)
H315
H319
H341
H361
H335
P271
P280
P261
P337+P313
P302+P352
P304+P340
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P332+P313
P362+P364
%[weight]
Name
63-74-1
>=98
sulfanilamide
Mixtures
See section above for composition of Substances
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sulfanilamide
Eye Contact
Skin Contact
Inhalation
Ingestion
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as
ignition may result
Fire Fighting
Fire/Explosion Hazard
Alert Fire Brigade and tell them location and nature of hazard.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water courses.
Use water delivered as a fine spray to control fire and cool adjacent area.
Combustible solid which burns but propagates flame with difficulty; it is estimated that most organic dusts are
combustible (circa 70%) - according to the circumstances under which the combustion process occurs, such
materials may cause fires and / or dust explosions.
Organic powders when finely divided over a range of concentrations regardless of particulate size or shape and
suspended in air or some other oxidizing medium may form explosive dust-air mixtures and result in a fire or
dust explosion (including secondary explosions).
Avoid generating dust, particularly clouds of dust in a confined or unventilated space as dusts may form an
explosive mixture with air, and any source of ignition, i.e. flame or spark, will cause fire or explosion. Dust
clouds generated by the fine grinding of the solid are a particular hazard; accumulations of fine dust (420
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sulfanilamide
micron or less) may burn rapidly and fiercely if ignited - particles exceeding this limit will generally not form
flammable dust clouds; once initiated, however, larger particles up to 1400 microns diameter will contribute to
the propagation of an explosion.
Minor Spills
Major Spills
Safe handling
Other information
Suitable container
Storage incompatibility
TEEL-0
TEEL-1
TEEL-2
TEEL-3
sulfanilamide
1(ppm)
3(ppm)
20(ppm)
500(ppm)
Ingredient
Original IDLH
Revised IDLH
SULFANILAMIDE
Not Available
Not Available
Exposure controls
Appropriate engineering
controls
Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard.
Well-designed engineering controls can be highly effective in protecting workers and will typically be independent
of worker interactions to provide this high level of protection.
The basic types of engineering controls are:
Process controls which involve changing the way a job activity or process is done to reduce the risk.
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sulfanilamide
Personal protection
Skin protection
Hand protection
The selection of suitable gloves does not only depend on the material, but also on further marks of quality which
vary from manufacturer to manufacturer. Where the chemical is a preparation of several substances, the
resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the
application.
The exact break through time for substances has to be obtained from the manufacturer of the protective gloves
and
has to be observed when making a final choice.
Body protection
Other protection
Overalls.
P.V.C. apron.
Barrier cream.
Thermal hazards
Recommended material(s)
Respiratory protection
Required
Minimum
Protection
Factor
Half-Face
Respirator
Full-Face
Respirator
Powered Air
Respirator
up to 10 x ES
P1
Air-line*
PAPR-P1
-
up to 50 x ES
Air-line**
P2
PAPR-P2
P3
Air-line*
Air-line**
PAPR-P3
CPI
up to 100 x ES 100+ x ES
White, odourless powder. Solubility: 7.5gm/100gm water @25C. Soluble in glycerol, propylene glycol, alcohol,
ether and hydrochloric acid. Practically insoluble in chloroform, benzene, and petroleum ether.
Physical state
Divided Solid
Odour
Not Available
Not Available
Odour threshold
Not Available
Not available.
pH (as supplied)
Not applicable
Decomposition temperature
Not available.
Viscosity (cSt)
Not Applicable
165
1.08
Not Available
Not Available
Taste
Not Available
Evaporation rate
Not applicable
Explosive properties
Not Available
172.20
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sulfanilamide
Flammability
Not Available
Oxidising properties
Not Available
Not Available
Not applicable
Not Available
Not applicable.
Miscible
Not applicable.
Not applicable.
Gas group
Not Available
pH as a solution(1%)
Not available.
See section 7
Presence of incompatible materials.
Product is considered stable.
Hazardous polymerisation will not occur.
Possibility of hazardous
reactions
See section 7
Conditions to avoid
See section 7
Incompatible materials
See section 7
Hazardous decomposition
products
See section 5
Inhaled
Evidence shows, or practical experience predicts, that the material produces irritation of the respiratory system, in
a substantial number of individuals, following inhalation. In contrast to most organs, the lung is able to respond to
a chemical insult by first removing or neutralising the irritant and then repairing the damage. The repair process,
which initially evolved to protect mammalian lungs from foreign matter and antigens, may however, produce
further lung damage resulting in the impairment of gas exchange, the primary function of the lungs. Respiratory
tract irritation often results in an inflammatory response involving the recruitment and activation of many cell
types, mainly derived from the vascular system.
Accidental ingestion of the material may be damaging to the health of the individual.
Ingestion
Skin Contact
Eye
Sulfonamides and their derivatives may precipitate in kidney tubules causing extensive damage. Haemolytic
anaemia may also result from use or exposure. Overdose may cause acidosis or hypoglycaemia with confusion
and coma resulting.
Evidence exists, or practical experience predicts, that the material either produces inflammation of the skin in a
substantial number of individuals following direct contact, and/or produces significant inflammation when applied to
the healthy intact skin of animals, for up to four hours, such inflammation being present twenty-four hours or
more after the end of the exposure period. Skin irritation may also be present after prolonged or repeated
exposure; this may result in a form of contact dermatitis (nonallergic). The dermatitis is often characterised by
skin redness (erythema) and swelling (oedema) which may progress to blistering (vesiculation), scaling and
thickening of the epidermis. At the microscopic level there may be intercellular oedema of the spongy layer of the
skin (spongiosis) and intracellular oedema of the epidermis.
Evidence exists, or practical experience predicts, that the material may cause eye irritation in a substantial
number of individuals and/or may produce significant ocular lesions which are present twenty-four hours or more
after instillation into the eye(s) of experimental animals.
Repeated or prolonged eye contact may cause inflammation characterised by temporary redness (similar to
windburn) of the conjunctiva (conjunctivitis); temporary impairment of vision and/or other transient eye
damage/ulceration may occur.
Ophthalmic solutions containing sulfonamides are reported to produce local irritation, reactive hyperaemia, burning
and transient stinging, blurred vision and temporary impairment of depth perception. Hypersensitivity reactions
may occur in predisposed individuals.
Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and
related systemic problems.
Strong evidence exists that the substance may cause irreversible but non-lethal mutagenic effects following a
single exposure.
Chronic
Exposure to the material may cause concerns for humans owing to possible developmental toxic effects,
generally on the basis that results in appropriate animal studies provide strong suspicion of developmental toxicity
in the absence of signs of marked maternal toxicity, or at around the same dose levels as other toxic effects but
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sulfanilamide
TOXICITY
IRRITATION
Not Available
Not Available
sulfanilamide
SULFANILAMIDE
Acute Toxicity
Skin Irritation/Corrosion
Serious Eye Damage/Irritation
Respiratory or Skin
sensitisation
Mutagenicity
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This
may be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can
occur following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS
include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent
asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow
pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine
challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been
included in the criteria for diagnosis of RADS.
Not Applicable
Skin Corrosion/Irritation Category 2
Eye Irrit. 2
Not Applicable
Germ Cell Mutagen Category 2
Carcinogenicity
Not Applicable
Reproductivity
Not Applicable
Aspiration Hazard
Not Applicable
CMR STATUS
SECTION 12 ECOLOGICAL INFORMATION
Toxicity
Toxic to soil organisms.
The sulfonamides are bipolar substances due to their polar functional groups with two pKa-values in the environmentally relevant
pH-range. At low pH-values they are cationic due to protonation of the aniline group (pKa1). The isoelectric point is between pH 4 and 5,
resulting in neutral species under slightly acidic conditions (pH 3 to 6).
Persistence: Water/Soil
Persistence: Air
Not Available
Not Available
Not Available
Bioaccumulative potential
Ingredient
Bioaccumulation
Not Available
Not Available
Mobility in soil
Ingredient
Mobility
Not Available
Not Available
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sulfanilamide
Not Applicable
end of SDS