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PNASTMPL 2015/12/4 17:28 page 1 #1
University of Cambridge, Cambridge, United Kingdom, and Universidad de Murcia, Bioquimica y Biologia Molecular, Murcia, Spain
Submitted to Proceedings of the National Academy of Sciences of the United States of America
Z
(x, y, t)u(x, y, t) (x, y, t)dydxdt = 0 [ 4 ]
R+ R/Z R
monolayer
structure
x-ray reflectivity
molecular electronics
D
=
+ u = 0
[1]
Dt
t
where,
,
)
u = (u1 , u2 ) = (
y x
[2]
Discussion
Cylindrical Case. We are going to consider the cylindrical case
here. We consider a transition layer of thickness smaller than
2 in which changes from 0 to 1. (see Figure ??).That means
we are considering of the form
and,
1
(4) 2 = ,
(u2 + v 2 ) 2
y (x, t) +
= 1 if
[3]
bounded if
= 0 if
|(x, t) y|
y (x, t)
[5]
+ (u, v)
C0 ,
where (x, y)
(x, y) = 1 in |x y| r and supp is
contained in {|x y| R} with 0 < r < R < 21 . Also C0 ,
(0, 0) = 0.
The main mathematical interest in the quasi-geostrophic
equation lies in its strong similarities with the 3-Euler equations. These results were first proved by Constantin, Majda
and Tabak, see [?], [?] and [?] for more details. There are
several other research lines for this equation, both theoretical
and numerical. See [?], [?], and [?]. The question about the
regularity of the solutions for QG remains as an open problem.
Recently one of the authors has obtained the equation for
the evolution of sharp fronts (in the periodic setting), proving its local well-posedness for that equation. (see [?] and
[?] for more details). This is a problem in contour dynamics.
Contour dynamics for other fluid equations has been studied
extensively.
www.pnas.org/cgi/doi/10.1073/pnas.0709640104
Significance
RJSM and ACAC developed the concept of the study. RJSM
conducted the analysis, data interpretation and drafted the
manuscript. AGB contributed to the development of the statistical methods, data interpretation and drafting of the manuscript.
PNAS
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Volume
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PNASTMPL 2015/12/4 17:28 page 2 #2
(x, t)
t
Z
(x, t)
(u, t)
x
u
=
2
2 1
R/Z [(x u) + ((x, t) (u, t)) ] 2
(x u, (x, t) (u, t))du +
Z
i
h
(x, t)
(u, t)
+
u
R/Z x
Z
uf dxdydt =: A + B
t dxdydt +
IIIR
IIIR
Z
(x, y, t)u(x, y, t) (x, y, t)dydxdt = 0
+
IR
since is bounded and hence O(1), and the area of the region
II is O(). As for the second term
Z
udxdydt = O(log())
IIR
R2
1. M. Belkin and P. Niyogi, Using manifold structure for partially labelled classification,
Advances in NIPS, 15 (2003).
2. P. B
erard, G. Besson, and S. Gallot, Embedding Riemannian manifolds by their heat
kernel, Geom. and Fun. Anal., 4 (1994), pp. 374398.
3. R.R. Coifman and S. Lafon, Diffusion maps, Appl. Comp. Harm. Anal., 21 (2006),
pp. 530.
4. R.R. Coifman, S. Lafon, A. Lee, M. Maggioni, B. Nadler, F. Warner, and S. Zucker,
Geometric diffusions as a tool for harmonic analysis and structure definition of data.
Part I: Diffusion maps, Proc. of Nat. Acad. Sci., (2005), pp. 74267431.
5. P. Das, M. Moll, H. Stamati, L. Kavraki, and C. Clementi, Low-dimensional, freeenergy landscapes of protein-folding reactions by nonlinear dimensionality reduction,
P.N.A.S., 103 (2006), pp. 98859890.
6. D. Donoho and C. Grimes, Hessian eigenmaps: new locally linear embedding techniques for high-dimensional data, Proceedings of the National Academy of Sciences,
100 (2003), pp. 55915596.
7. D. L. Donoho and C. Grimes, When does isomap recover natural parameterization
of families of articulated images?, Tech. Report Tech. Rep. 2002-27, Department of
Statistics, Stanford University, August 2002.
8. M. Gr
uter and K.-O. Widman, The Green function for uniformly elliptic equations,
Man. Math., 37 (1982), pp. 303342.
www.pnas.org/cgi/doi/10.1073/pnas.0709640104
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PNASTMPL 2015/12/4 17:28 page 3 #3
figsamp-eps-converted-to.pdf
Fig.
1.
activity.
Age of onset,
years
Mean
SD
Range
Median
60.15
9.32
4386
60
Juvenile, 220
40
Typical, 2150
377
45.72
2.97
4058
45
26
41.85
1.56
4045
42
Late, >50
The no. of wells for all samples was 384. Genotypes were determined by
n
SM
AX
10
1
10
5
100
20
t1
4
50
2840975
r1
.0007
.0008
.0423
m1
4
8
95
Averaged Results
t2
r2
4
.0020
50
.0020
2871117
.1083
m2
4
12
521
tlb
4
49
t1 /t2
1.000
.999
.990
Comparisons
r1 /r2
m1 /m2
.333
1.000
.417
.698
.390
.182
t1 /tlb
1.000
1.020
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PNASTMPL 2015/12/4 17:28 page 4 #4
figsamp-eps-converted-to.pdf
Fig. 2.
LKB1 phosphorylates Thr-172 of AMPK in vitro and activates its kinase activity.
www.pnas.org/cgi/doi/10.1073/pnas.0709640104
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