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Pedro Freire da Silva, Supervisor(s): Dr. Giovanni Boero, Dr. Pedro Sebastio
The electrical and mechanical design for a non-magnetic, 2.5x2.5 cm2 setup with m-precision was simulated and
implemented to perform simultaneously EPR and DNP-NMR studies. The interaction coils were EM-FEM modelled
and verified against optimized EPR and NMR results for sub-nL samples of water, PDMS and TEMPO.
I Introduction
chemical
insight,
non-invasive
behaviour1.
was developed2:
selectiveness
and
smaller 2
13C,
than the
13C
SNR
B 0 7/411/4
TS
1 sin(1 )
(1)
equations
designed
in
(a)
(b)
Fig 1- Geometry simulated in Solidwork s and imported into COMS OL
(a) and transversal magnetic field in the xy plane on the bottom of the
capillary (b). Dimensions in m and magnetic field in Gauss.
= (Iz I0 ) ( Sz S0 )
(2)
must
Iz
I0
= 1sf
| e |
n
(3)
be optimized
and that
whereas
a vertical
displacement has induces a significant signal drop, onplane shift have little effect, even introducing a small
s=
S0 Sz
S0
, 1 660 s 1 + 330 s
(4)
TNMR B EPR
TEPR B NMR
i eti /Ti
(5)
IV Electrical implementation
thermal
expansion
coefficient was
used,
EX200,
m.
(b)
(d)
Fig 4- Solidwork s model of the system. Table system for the EPR (a)
and NMR (c) PCBs (in green), and the microfluidic system (c) and detail
of its attachment (d). Arrows indicate the correct placement of each part.
(a)
(b)
(c)
Fig 5- Final prototype seen from the back (a) and the front (b). M1. 6
screws used to control friction and to lock movement are shown as well
as the adjustment system and capillary interface. Image of the precision
achieved when aligning the capillary with the NMR coil.
(a) (b)
(c)
frequency.
EPR
VI Acknowledgements
This project used the resources of LMIS1 at EPFL under
the direct supervision of Dr. G. Boero and indirect from
Dr. P. Sebastio. The aid and guidance of E. Montinaro,
G. Gualco and M. Grisi was also highly appreciated.
VII Bibliography
Press, 2015).
2. Hoult, D. . & Richards, R. . The signal-to-noise ratio of the
nuclear magnetic resonance experiment. J. Magn. Reson. 24,
7185 (1976).
3. Stejskal, E. ., Schaefer, J. & Waugh, J. . Magic-angle spinning
and polarization transfer in proton-enhanced NMR. J. Magn.
Reson. 28, 105112 (1977).
4. Grisi, M., Gualco, G. & Boero, G. A broadband single-chip
transceiver for multi-nuclear NMR probes. Rev. Sci. Instrum. 86,
044703 (2015).
single spin, NMR amplitudes with respect to the time of the RF pulse.
(c)
Fig 10- NMR for PDMS at different characteristric times for the exponential filter (a) ,EPR results for 50 mM TEMPO at different field-modulations using a
field sweep (b) and for 200 Mm TEMPO using a controlled sweep of the VCOs oscillation frequency (c). Experimental conditions discribed on the pictures