1) Placenta pathology of conjoined twins?

Monoamniotic, one amnion one chorion

2) Complete hydatidiform mole genotype?
46, completely paternal in origin
3) 24F, physically described to have PID, elevated B-hcg, ultrasound
shows bulge in fallopian tube. Where is the most likely location
for ectopic pregnany?
Ampulla
4) DES exposure. What tumor is most likely and where is the most
likely location?
Vaginal Clear cell tumor(carcinoma)
i. FOR BOARDS most likely tumor/location in order:
vaginal CCC, 2nd vaginal adenosis, CCC of cervix
5) High grade dysplasia CIN 3? E6 and E7 proteins
6) Vulvar biopsies, lichen sclerosis et atrophicus. Which of these
statements is false?

White tissue paper appearance (true)

Histological features of dermal colonization (true)
1-4% risk of cancer over lifetime (true)
Most common in older women (true)
Never occurs in a woman under thirty FALSE

7) What type of virus is Molluscum contagiosum?

Pox virus
8) Vulvar biopsy, gives us a pathology report:
He wants us to know Pagets Profile: CEA,
cytokeratin +, P63-, S100- (S100 is the same as
Mark-1)
-FYI Pagets is PAS positive
distractor: Bowens disease- Sq cell carcinoma in situ- high
grade, anywhere in the skin
9) Will give us a report characteristic of Melanoma. Which stains will
be positive?
S100+ (aka Mark 1+)

10)

11)
this

Gartners duct cyst. What is its origin?

Wolffian or mesenephric(kidney) duct cyst (Commonly
located laterally)
Vaginal biopsy of embryorhabdomyosarcoma: Know all of
aka sarcomabotryoides
In children
Vaginal
Huge (NOT small)
Red hemorrhagic grape like mass extending from vagina
Characteristic histologic feature of sarcombotryoides is
Camnien layer a cellular layer just underneath
epithelium

12)
Small Cell Carcinoma in the cervix with neuroendocrine
differentiation (these markers will be positive with
neurosecretory SCC in any location):
NSE, synaptophysin, CD99, cytokeratin
13)

14)

Cervix with mild dysplasia, CIN 1:

Low grade intraepithelial lesion
Squamous cell carcinoma:
Do NOT pick serous papillary carcinoma if asked about
Squamous Cell Cancer. It is a distractor, an awful answer,
NOT true

15)
Endometrioid endometrial cancrinom vs endomedtrioid
endocervical carcinoma: How to differentiate? Be able to
recognize the staining patterns of endometrial and endocervical.
Endocervical = vimentin -, CEA+, P16+, estrogen rec -,
Progestin rec
Endometrial = vimentin+, CEA-, P16 -, ER+, PR+
16)
Early secretory phase endometrium. What is the
characteristic histologic appearance?
Subnuclear vacuoles
17)

Arias-Stella phenomenon. What does that tell you?

It is a gestational phenomenon. Arias-Stella on an
endometrial biopsy is either pregnancy, ectopic pregnancy,

or some kind of hormonal hyperexpression usually in pt on

fertility drugs
18)
Serous carcinoma of the endometrium. Going to give us
opposite of everything listed on slide and makes us pick out the
true statement:
TRUE: It is an aggressive tumor, characteristically
associated with intraperitoneal spreading
19)

Malignant mixed mesodermal tumor carcinosarcoma:

need to know it is like a dedifferentiated endometrial
carcinoma, has a very fulminant clinical course

20)
endometrial cancer staging summaries. PT-3B endometrial
adenocarcinoma:
tumor extends into the vagina - answer choice D

21)
Endometrial stromal sarcoma which immunohistochemical
marker:
CD10
22)
true

Diagnosis with Polycystic ovary disease. Which of these is

statement?
-Associated with Oligomenorrhea Stein Leventhal
Ovaries are big, not small. (false)
-Thick, not thin, outer tunica layer (false)
-Low FSH, high LH (false)

23)
Serous carcinoma, it is thought to be confined to the pelvis,
but there is positive pleural effusion(meaning pleural fluid). What
stage is this?
Stage 4.
Why? Bc its invasive. As soon as tumor cells get above the
diaphragm it is invasive. Considered M1. Clinically would
have been Stage 2 up until this point.
24) Serous cystadenocarcinoma LMP borderline tumor:
(From Ovary lecture slide 38)
Very similar biologically to micro invasive carcinoma
(answer D)

25) Teratoma with Struma Ovarii: What kind of Pteratoma is it:

Monodermal teratoma specialized (thyroid)
Ovary slide 80

26) Adult Granulosa small tumor: (Ovary slide 94)

Feminizing

Ovarian cancer with annular differentiation: tree like polyps

Workup bc higher incidence colorectal carcinoma (Peutz-jehger
syndrome?)
Adnexal tunmor of wolffian duct origin: mesenephric origin
Small cell cancer hypercalcemic type: Very bad, younger women >
older
Often bilateral, don't have neurosecrety granules(pulmonary type have
these)
Maternal floor infarctions:
Regurgitate TORCH titers:
Complete moles: roughly 1/10 pregnancies
Partial mole: triploid DNA content
Invasive moles: elevated B-HCG, can cause life threatening
hemorrhage, can metastasize but not aggressive
Choriocarcinoma of gestational type:
About 50% occur after molar preg
Placental site trophoblastic tumor unique trait:
Sirtoli tumor: _____hirsutism/masculinizing
Cancer outside uterus, extends outside cervix but not outside pelvis is
stage III

Placenta accrete: partial or complete absence of decidua with direct

Cancer of endometrium_: low gradre
Yolk sac tumor/endodermal sinus tumor: recognize all positive:
aggressive, young ppl, NOT a seminoma, alpha-feto protein high
Placenta over cervix: previa
Placental floor infarction: misnomer
Sertoli _____Leydig_Proliferative phase breakdown: anovulatory
Granulosa cell tumor: cal exner bodies, not a common tumor, but there
is a juvenile tumor, malignant, NOT androgen producing, estrogen
producing
____ premature rupture of membranes, E coli,
Clear cell cancer in 25 yo from vagina: DES
Simple hyperplasia without atypia:
Low grade hyperplasia