Drug Information
1.Epinephrine(adrenalin Epinephrine increases the
) "fight or flight" response of
the sympathetic division of
the autonomic nervous
system. Epinephrine is a
non-selective, direct-acting
agonist of all adrenergic
receptors. It activates α1, α2,
β1, and β2 receptors.
Along with epinephrine,
2.Norepinephrine norepinephrine also
underlies the fight-or-flight
response, directly increasing
heart rate, triggering the
release of glucose from
energy stores, and
increasing blood flow to
skeletal muscle.
Therapeutic class Receptors Indications
Bronchodilator, Cardio: Cardio:
vasopressor, A1 - vasoconstricton. - restoring cardiac
cardiac stimulant, B1 - increase blood pressure, by rhythm in cardiac
enhancing cardiac contractility & arrest
increasing heart rate. Respi:
Respi: - relieve
A1 - bronchial glands decease in respiratory distress
secretion. due to
B2 - bronchodilator. Tracheal and bronchospasm.
bronchial muscle relaxation & Ophthalmic:
bronchial glands increase in - treating
secretion. glaucoma.
Ophthalmic: Topical nasal:
A2 – decreases internal eye - treating mucosal
pressure. Dilates blood vessels in congestion of hay
the eye. fever, rhinitis, and
acute sinusitis.
Vasopressor Cardio: Cardio:
A1 - vasoconstricton. - blood pressure
B1 - increase blood pressure, by control in certain
enhancing cardiac contractility & acute hypotensive
increasing heart rate. states.
 Dopamine is the immediate Intropin, Cardio: Cardio:
3.Dopamine precursor of vasopressor D - vasodilator.(low dose) - correction of
norepinephrine. Dopamine B1 - increase in systolic blood and hemodynamic
is a CNS neurotransmitter pulse pressure with little effect on imbalances present
associated with the basal diastolic. Pressures increase in the shock
ganglia and motor control. myocardial contractility.(high syndrome.
dose)
A1 - vasoconstriction.(high dose)

A catecholemine. Activates Bronchodilator, Cardio: Cardio:

4.Isoproterenol beta adrenergic receptors cardiac stimulant B1 - enhances cardiac contractility - treats ventricular
(B1 & B2). & increases heart rate. arrhythmias.
Respi: - aids in diagnosing
B2 - relaxes bronchial muscles. mitral regurgitation
and CAD.
Respi:
- Treats
bronchospasm.

Cardio:
Is a synthetic catecholamine Cardiac stimulant Cardio: - increases cardiac
5.Dobutamine for B1 receptor. B1 - enhances cardiac contractility output in short-
term
decompensation.

Respi:
May be used for long-term Bronchodilator Respi: - treats bronchial
6.Metaproterenol and acute treatment of B2 - bronchodilator. Tracheal and asthma and
bronchospasm. A non bronchial muscle relaxation reversible
catecholmine direct acting bronchospasms.
B2 selective adrenergic drug Respi:
 A non catecholmine B2 Bronchodilator Respi: - treats bronchial
7.Terbutaline selective adrenergic drug. B2 - bronchodilator. Tracheal and asthma and
Terbuatline has a rapid bronchial muscle relaxation. reversible
onset of action. obstructive airway
disease &
bronchospasms

Respi:
A non catecholmine B2 Bronchodilator Respi: - bronchospasm in
8.Albuterol selective adrenergic drug . B2 - bronchodilator. Tracheal and patients 2 to 12
Usually given by the inhaled bronchial muscle relaxation years of age with
route for direct effect on asthma.
bronchial smooth muscle.
Cardio:
A non catecholmine direct- Vasopressor Cardio: - treat shock and
9.Phenylephrine acting A1 selective decongestant A1 - vasoconsriction. low blood
adrenergic drug. pressure.
Phenylephrine is used as a Nasal:
decongestant oral medicine, - Nasal
nasal spray, or as eye drops. decongestant.
Ophthalmic:
For pupil dilatation
in uveitis &
glaucoma.

Cardio:
A non catecholmine direct- Vasopressor Cardio: - Hypotension
10.Methoxamine acting A1 selective A1 - vasoconsriction. during anesthesia.
adrenergic drug. Which -Supraventricular
produces a prompt and paroxysmal
prolonged rise in blood tachycardia.
 pressure.
Cardio:
A non catecholmine Vasopressor Cardio: - treats shock and
11.Mephentermine indirect-acting A1 selective A1 - vasoconsriction. low blood
adrenergic drug. Used as a pressure.
nasal decongestant. Nasal:
- Nasal
decongestant.

Cardio:
A direct-acting A2 Antihypertensive Cardio: - treats
12.Clonidine(catapres) adrenergic agonist. A2 - decreases cardiac output and hypertension
peripheral vascular resistance,
lowering blood pressure.
Cardio:
A A2 adrenergic agonist, Antihypertensive Cardio: - treats
13.Guanfacine subtype of norepinephrine A2 - decreases cardiac output and hypertension
receptors. Significantly peripheral vascular resistance,
reduces hypertension not lowering blood pressure.
just in short-term, but also
as shown in long-term.
Cardio:
A A2 adrenergic agonist. Antihypertensive Cardio: - treats
14.Methyldopa Treats hypertension. A2 - decreases cardiac output and hypertension
peripheral vascular resistance,
lowering blood pressure.
Cardio:
Has direct and indirect Bronchodilator, Cardio: - treats
15.Ephedrine actions on the adrenergic vasopressor, nasal A1 - vasoconstricton. hypotension during
receptors. commonly used decongestant B1 - increase blood pressure, by spinal anesthesia.
as a stimulant, appetite enhancing cardiac contractility & Respi:
 suppressant, concentration increasing heart rate. - treats
aid, decongestant, and to Respi: broncoconstriction.
treat hypotension A1 - bronchial glands decease in Nasal:
associated with secretion. - for nasal
anaesthesia. B2 - bronchodilator. Tracheal and decongestion.
bronchial muscle relaxation &
bronchial glands increase in
secretion.
Ophthalmic:
It is a sympathomimetic Vasoconstrictor cardio: - decreases eye
16.Naphazoline agent with marked alpha A1 - constricts blood vessels in congestion.
adrenergic activity. It is a the conjunctiva.
vasoconstrictor with a rapid
action in reducing swelling
when applied to mucous
membrane.
Ophthalmic:
Is an over-the-counter eye Vasoconstrictor cardio: - decreases eye
17.Tetrahydrozoline drops and nasal spray. Is a A1 - constricts blood vessels in congestion.
sympathomimetic agent the conjunctiva. Nasal:
with marked alpha - for nasal
adrenergic activity. decongestion.

Nasal:
A selective alpha-1 agonist Decongestant, Cardio: - nasal
18.Oxymetazoline and partial alpha-2 agonist vasoconstrictor A1- contricts vessels via nasal decongestant
topical decongestant. If spray
overused it can cause a
"rebound congestion"
where the mucosal surface
of the sinuses are damaged
 due to ischemia, become
swollen, and therefore
become congested after the
drug wears off.
Respi:
A long-acting direct beta2- Bronchodilator Respi: - treatment of
19.Salmeterol adrenergic receptor agonist B2 - bronchodilator. Tracheal and asthma and
drug. For oral inhalation bronchial muscle relaxation. chronic obstructive
only. pulmonary disease
(COPD)

Cardio:
Alpha-1-sympathomimetic Vasopressor Cardio: - treats orthostatic
20.Midodrine drug. It is used to treat A1 – increases blood pressure by hypotension
hepatorenal syndrome and vasoconstriction
orthostatic hypotension.