Genome

Approx.
Family
size

Type

papovaviridae
(papillomapolyomavacuolating)

adenoviridae

dsDNA
(lytic!)

herpesviridae

Fragmentation

Capsid
shape

Coat
Capsid
size

Envelope

Example
species
polyomavirus

5-8kbp:
small

icosahedral

50nm

SV40
papillomavirus

35kbp:
medium

150kbp:
large

icosahedral

icosahedral

80nm

120nm

adenovirus

human
herpesvirus 8
viriola

200kbp:
large

dsDNA
with RNA
intermedi
ate

hepaDNAviridae
reversiviruses

3kbp:
small

icosahedral

20nm

ssDNA

parvo-virus

5kb:
small

icosahedral

20nm

C.Riedinger

complex

200300nm

Additional
proteins
present

tumours in
rodents
tumours in
rodents
warts,
carcinoma

resp disease

herpes simplex,
cold sores,
type 1 + 2
genital lesions
chicken pox,
varicella-zoster
shingles
glandular
epstein-barr
fever, burkitt
lymphoma
cytomegalovirus

pox-viridae

Resulting
disease

vaccina

Life cycle

Genome
infectious?

1. uncoating
2. DNA to nuc
3. replication
DNA
4. RNA to cp
infectious
5. prot.to nuc
6. Assembly
with DNA in nuc

cytomegalic
inclusion
disease in
neonates
kaposi's
sarcoma
smallpox
virion
transcriptase:
DNA-dependent
RNA
vaccine against
polymerase,
smallpox
capping and
polyadenylating
enzymes

1. uncoating
2. Make mRNA
3. translate
4. Assemble
and release

Replication

Other

* stimulate
cell into cell
cycle!
* herpes
viruses
incease the
prod of
nucleus dNTPS
* can cause
latent
infection
* consist of
extrachomos
omal circular
DNA

DNA not
infectious

cytoplasm

* produce
EGF that
stimulates
neighbouring cells into
cell cycle!

* DNA->RNA>cDNA

hepatitis B

acute and
chronic
hepatitis, liver
cancer

nucleus

human
parvovirus

childhood rash
(erythema
infectiosum)

* most
nucleus strands infect
animals

Overview of Viruses

Genome
Approx.
Family
size

Type

papovareo-viridae
(resp. enteric
viridae

dsRNA

orphan virus)
(papillomapolyomavacuolating)

picoRNAviridae
(small RNA virus)

calici-viridae
(calyx/goblet)

20kbp:
5-8kbp:
medium
small

Fragmentation

Capsid
shape

Coat
Capsid
size

10-11
fragments
-

icosahedral
icosahedral

70nm
50nm

7kb:
small

8kb:
small

icosahedral

icosahedral

25nm

35nm

Envelope

Example
species

Resulting
disease

Additional
proteins
present

human
rotavirus

acute infantile
gastro-enteritis

virion
transcriptase
-

lytic

lytic

poliovirus
poliomyelitis
hepatitis A
acute hepatitis
rhinovirus
common cold
foot and mouth foot and mouth
disease
disease
winter
norovirus
vomiting
disease
rubella

dsDNA
+ve
(lytic!)
ssRNA

toga11kb:
viridae, flavimedium
viridae

icosahedral

60nm

hepatitis C
yellow fever
(ZOONOTIC!)
west nile

coronaviridae

C.Riedinger

30kb:
medium

helical

140nm

SARS

german
measles
acute and
chronic
hepatitis
jungle yellow
fever
encephalitis
severe acute
respiratory
syndrome

Overview of Viruses

Life cycle

Genome
infectious?

Replication

1. uncoating
2. DNA to nuc
3. replication
DNA
nucleus
4. RNA to cp
infectious cytoplas
RNA-dependent 5. prot.to nuc
m,as +ve
RNA polymerase 6. Assembly
RNA
1. uncoating
with
DNA in nuc
direct
2. Translation
RNA
template,
into RNA pol
infectious
can
and capsid
replicate
proteins
in
3. Assembly
enucleate
and release
d cells

RNA-dependent
RNA polymerase

Other

* stimulate
cell into cell
cycle!
* negative
* herpes
strand is
viruses
made to
incease
the
generate
prodmore
of
dNTPS
template
* can
cause
* nonlatent
enveloped
infection
RNA-viruses
* consist
of
are lytic
extrachomos
* mRNA is
omal
circular
polycistronic
DNA
* picoRNA
viruses
stable
outside the
host
* an get
hepA from
food and
water

Genome
Approx.
Family
size

Type

papovaorthoviridae
myxoviridae
(papilloma(mxyo
- mucus)
polyomavacuolating)

-ve
ssRNA

paramyxoviridae

dsDNA
(lytic!)

rhabdoviridae
(rhabdo = rod)

+ve
ssRNA
with DNA
intermedi
ate

retroviridae
reversiviruses

dsDNA
with RNA
intermedi
ate

hepaDNAviridae
reversiviruses

underlined:

C.Riedinger

12kb:
5-8kbp:
medium
small

15kb:
medium

10kb:
small

8kb:
small

3kbp:
small

Fragmentation

Capsid
shape

8 fragments
-

helical
icosahedral

helical (but
pleiomorphi
c, i.e.
different
shapes)

helical
capsid,
bulletshaped

icosahedral

Coat
Capsid
size

80nm
50nm

Example
species

Envelope

+
-

influenza

measles
150m

100nm

20nm

influenza

Additional
proteins
present

virion
transcriptase

measles
virion
transcriptase

+
mumps
respiratory
synycytial virus

200x80n
m

Resulting
disease

rabies
(ZOONOTIC)

these viruses cause persisten infection that can lead to neoplasia

mumps
bronchitis

rabies

human
immunodeficie
ncy HIV

Acquired
immunodeficiency
syndrome
AIDS

hepatitis B

acute and
chronic
hepatitis, liver
cancer

Overview of Viruses

Life cycle
* HA envelope
protein binds
sialic acid
* enters by
endocytosis!

1. uncoating
* RNA not
2. DNA to nuc
1. Make mRNA
infectous
3. replication
DNA
from -ve strand
4. RNA to cp
infectious
2. translation
5. prot.to nuc
3. Assembly
6. Assembly
and release
with DNA in nuc

virion
transcriptase

virion
transcriptase

Genome
infectious?

* input RNA
converted to
dsDNA
(provirus) to be
integrated into
host
chromosome
* packaging in
cytoplasm as
RNA packed

Replication

Other

* stimulate
cell into cell
cycle!
* herpes
* influenza
viruses
virus unique:
incease
the
cytoplas
prod RNA
of
m
processing in
nucleus dNTPS
nucleus
* can
cause
latent
infection
* consist of
extrachomos
omal circular
DNA

* reverse
transcription!
Envelope
protein
GP120 +
CD4/coR on
T-cells/macro
* envelope
protein
enters by
FUSION!
* can spread
as cellassociated
virus
* can be
latent if
proviral DNA
not
transcribed