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by: Eric Bland, Discovery News
Dec. 31, 2008 -- It can take months for
bones to heal after even a small break. Now
a U.K. company, RegenTec, hopes to speed
up the healing process by injecting a white
powder designed to seal broken bones
together in minutes.
"You won't be able to just walk out of a
hospital with a broken leg," said Robin Quirk,
a professor at the University of Nottingham
who, along with Kevin Shakesheff in the United States, originally developed the
technology. "What we are trying to do in the short term is have something that fills
the void left by a break that acts like normal spongy bone and encourages natural
regeneration."
The proprietary mix of ceramic and polylactic acid is called, for now, Injectable
Bone.
At room temperature, it is an inert white powder. Once injected into a break site
with a needle stick, however, the body's higher temperature causes the two
materials to fuse together in a hard, spongy mass much like living bone.
Injectable Bone isn't the only bone glue out there. Others exist, although they have
some problems. In some cases they harden in a solid mass or raise body
temperature at the injection site enough to damage nearby tissue.
Injectable Bone could actually encourage bone growth, when bone-producing cells
and growth-encouraging drugs are mixed in with the powder mixture. The cells fill
up the holes with natural bone as the Injectable Bone degrades into lactic acid, a
compound produced naturally by the body.
"We can actually control the rate of degradation to tailor it to the individual's
healing," said Quirk.
Injectable Bone isn't meant to permanently replace natural bone, just give the body
time to repair.
Multiple fractures on the same bone can be difficult to set and heal property. To
hold the bone fragments in proper alignment, doctors place surgical pins and rods
that can be painful to remove. Injectable Bone could replace the metal surgical pins
currently used to help bone heal, its makers say.
It won't, however, allow patients to forego plaster casts. The glue binds bone
together but isn't strong enough to bear weight.
Injectable Bone should sell well, said Jennifer Elisseef, a professor at Johns Hopkins
University. Elisseef has her own company, Cartilix, that focuses on materials to
replace broken cartilage.
"There is a lot of interest in bone filler materials from clinicians and from the
military," said Elisseef.
RegenTec claims it will have Injectable Bone stateside within 18 months. That's an
optimistic number, said Elisseef, adding that FDA approval will likely take longer
than that.
In the long run, Injectable Bone could also become Injectable Heart, said Quirk:
"Following a heart attack...the appropriate cells could be delivered to help re-grow
tissue."
Source:
Discovery News: http://dsc.discovery.com/news/2008/12/31/injectable-bone.html
CALCIUM
It's widely known that consuming dairy products like yogurt and
cheese is good for your skeleton. Most of the bony benefits that
come from dairy's rich calcium content. As the cement that builds
the foundation of your bones, calcium is also needed for other
bodily functions like muscle contractions. If you don't get enough
from your diet, then your body leeches the calcium stored in your bones. In addition to
dairy, good sources of calcium include green leafy vegetables, broccoli and almonds.
Adults should aim for 1,200 mg of dietary calcium per day.
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MAGNESIUM
More than half of the magnesium stored inside your body is found in your skeletal
system. But the Office of Dietary Supplements adds that many people don't reach their
daily magnesium target of 400 mg for men and 310 mg for women. Magnesium is crucial
for healthy calcium metabolism. Sources of dietary magnesium include fatty fish, soy,
whole grains, yogurt and potatoes.
VITAMIN D
Vitamin D is crucial for skeletal system health, as it boosts your body's absorption and
utilization of calcium. Adequate blood levels of vitamin D also prevent the loss of calcium
in the urine. People who are dark skinned, live in the Northern Hemisphere or avoid
sunlight are at high risk of vitamin D deficiency. Adults should aim for 600 IU per day.
Besides supplements and sunlight, sources of vitamin D include seafood, mushrooms,
dairy and vitamin D fortified orange juice.
OMEGA-3 FATS
Omega-3 fatty acids from foods like oily fish and flaxseeds are well known for their antiinflammatory properties. A study on animals in the June 2003 "Prostaglandins,
Leukotrienes and Essential Fatty Acids" found that a diet rich in omega-3 fats boosted
bone formation by reducing inflammation, which interferes with the activity of cells called
osteoblasts that create new bone tissue. However, no human research has replicated
the results of this study.
REFERENCES
International Osteoporosis Foundation: Facts and statistics about osteoporosis and its
impact
Centers For Disease Controls and Prevention: Calcium and Bone Health
Office of Dietary Supplements: Magnesium
Office of Dietary Supplements: Vitamin D
"Prostaglandins, Leukotrienes and Essential Fatty Acids"; Modulatory effect of omega3 polyunsaturated fatty acids on osteoblast function and bone metabolism; B
Watkins et al.; June 2003
Article reviewed by CPerry Last updated on: Apr 8, 2011
Source: http://www.livestrong.com/article/417207-nutrition-for-the-skeletalsystem/#ixzz2IpdSabqx
STRESS FRACTURES
When high-impact athletes get to the point of constantly exercising without adequate rest
time, the bone rebuilding process becomes interrupted and the structure of the bone
weakens. According to the Stretching Institute, stress fractures can occur when a
repetitive or unnatural stress is placed on the bone, which can happen during increases
in intensity, time or frequency of sport participation. You need to allow yourself to rest
and recover and implement adequate transitions into higher intensity exercise in order to
preserve the density of the bone.
REFERENCES
Medical News Today: Impact Sports Increase Bone Strength in Senior Athletes
"Medicine and Science in Sport and Exercise"; Bone density comparisons in male
competitive road cyclists and untrained controls; Smathers AM, Bemben MG,
Bemben DA; February 2009
The Stretching Institute: Stress Fractures and Stress Fracture Treatments
The Female Athlete Triad Coalition: Female Athlete Triad
Article reviewed by GlennK Last updated on: Dec 23, 2010
Source: http://www.livestrong.com/article/341333-sports-effects-on-the-skeletalsystem/#ixzz2IpekIPgb