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Chewable tablets
Pleasant tasting have smooth, rapid disintegration
(chewed or allowed to dissolve in the mouth)
Have a creamy base, specially flavoured and colored
mannitol
Prepared by compression or wet granulation
Xylitol: may be used in the preparation of sugar-0free
chewable tablets
Effervescent tablets
Prepared by compressing granular effervescent salts
that release gas when in contact with water
Name:
Pharmaceutical Dosage
Chapter 8: Tablets
Tablets
Types of Tablets
Guides
formulation
and
product
development toward product optimization
The tablet must meet the stated monograph requirement for rate of
dissolution
Steps:
Tablet Thickness
Content Uniformity
Compressed Tablets
Categories:
Wet Granulation
Widely employed method for production of compressed
tablets
Advantages:
Thermolabile compounds
Expertise required
Steps:
Precision Granulation
Using microwave
Powder mix is mixed, wetted, agglomerated and dried
Results from use of a drug with a color from that of the tablet
excipients or from a drug with a colored degradation products
Tablet Coatings
Sugarcoating tablets
Divided into following steps:
Waterproofing and sealing: containing components
that may be adversely affected by moisture
Subcoating: 3 to 5 subcoat of a sugar-based syrup are
applied
Smoothing and final rounding: 5 to 10 additional
coating of a thick syrup and applied to complete the
rounding and smooth the coating
Finishing and coloring: performed in a clean pan free
from previous coating materials
Polishing
Enteric Coating
Film-Coating Tablets
Alloying substance
Water solubility or permeability to the film to ensure
penetration by body fluids and therapeutic availability
of the drug
Example: PEG (polyethylene glycol)
Plasticizer
To produce flexibility and elasticity of the coating and
thus provide durability
Example: castor oil
Surfactant
To enhance spreadability of the film during application
Example: polyoxyethylene sorbitan derivatives
Opaque and colorant
To make the appearance of the coated tablets handsome
and distinctive
Example:
Sweeteners: saccharin
Flo-Coater
Systems to provide the fastest possible spray rates and the most
efficient drying results
Providing benefits for both top spray granulation and fluid bed
drying processes
Wurster Process
Top sprays
Provides greater capacity up to 1500kg than the other
air suspension coating method
For taste masking, enteric release, and barrier films on
particles or tablets
Most effective when coatings are applied from aqueous
solutions, latexes, or hot melts
Tangential spray technique
Used in rotary fluid bed coater
Used for layering coating and for sustained-release and
enteric coated
Bottom Spray
For sustained-release and enteric-release products
Employed using a modified apparatus used for bed
coaters
Compression Coating
Anhydrous operation safely employed in the coating of tablets
containing a drug that is labile to moisture
Preparation of multiple compressed tablets having inner core and
outer shell of drug material, core tablets may be sugarcoated by
compression
Lozenges
Can be made by compression or molding
Compressed lozenges are made using a tablet machine
and large, flat punches
Have a special place in the delivery of medication
Lollipop
Fentanyl actiq: a raspberry lollipop that differs from the
fentanyl oralet
Sugar-based lozenge on a tstick and contain fentanyl
citrate
Provide almost immediate relief as the drug starts being
absorbed in the mouth and starts to work within
minutes
Effect lasts for only about 15 minutes
Pills
Small, round solid dosage forms containing a medicinal
agent and intended to be administered orally