Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
DrugProduct
Absorica
Accutane
AcipHex
Acticlate
ActiveIngredient(s)
(isotretinoin)
(isotretinoin)
(rabeprazole)
(doxycycline)
DosageForm(s)
Capsule
Capsule
Tablet
Tablet
Actiq
(fentaNYL)
Lozenge
Actonel
(risedronate)
Tablet
AdalatCC
AdderallXR
AeroHistPlus
AfeditabCR
Afinitor
Aggrenox
AlavertAllergy(Sinus12hour)
AllegraD
Alophen
ALPRAZolamER
Altoprev
AmbienCR
AmibidDM
Amitiza
Ampyra
Amrix
Aplenzin
Apriso
Aptivus
AquatabC
AquatabD
Aricept23mg
(NIFEdipine)
(amphetaminesalts)
(combination)
(NIFEdipine)
(everolimus)
(combination)
(combination)
(combination)
(bisacodyl)
(ALPRAZolam)
(lovastatin)
(zolpidem)
(combination)
(lubiprostone)
(dalfampridine)
(cyclobenzaprine)
(buPROPion)
(mesalamine)
(tipranavir)
(combination)
(combination)
(donepezil)
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet
Reasons/Comments
Mucousmembraneirritant
Mucousmembraneirritant
Slowrelease
Filmcoated(h)(Note:tabletscoredinthirdsrather
thanhalf)
Slowrelease(Note:thislollipopdeliverysystem
requiresthepatienttoslowlyallowdissolution)
Irritant(Note:chewed,crushed,orsuckedtabletsmay
causeoropharyngealirritation)
Slowrelease
Slowrelease(a)
Slowrelease(h)
Slowrelease
Mucousmembraneirritant
Slowrelease
Slowrelease
Slowrelease
Entericcoated
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease(Note:formerlyfampridineSR)
Slowrelease
Slowrelease
Slowrelease(a)(Note:maintainpHat<6.0)
Note:oilemulsionwithinspheres;taste
Slowrelease(h)
Slowrelease(h)
Note:crushingthe23mgtabletmaysignificantly
increasetherateofabsorption;the5mgand10mg
tabletsarenotaffected
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page1of15
OralDosageFormsThatShouldNotBeCrushed2015
Arthrotec
Asacol
Aspirinentericcoated
Atelvia
(diclofenac)
(mesalamine)
(aspirin)
(risedronate)
Tablet
Tablet
Tablet,Caplet
Tablet
Entericcoated
Slowrelease
Slowrelease;Entericcoated
Slowrelease(Note:tabletcoatingisanimportantpart
oftheslowrelease;chewed,cut,orcrushedtablets
maycauseoropharyngealirritation)
AugmentinXR
AVINza
Avodart
(combination)
(morphine)
(dutasteride)
Tablet
Capsule
Capsule
Slowrelease(b,h)
Slowrelease(a;notpudding)
Note:drugmaycausefetalabnormalities;women
whoare,ormaybecome,pregnant,shouldnothandle
capsules;allwomenshouldusecautioninhandling
capsules,especiallyleakingcapsules
AzulfidineENTabs
BayerEC
BayerRegular
Belsomra
(sulfaSALAzine)
(aspirin)
(aspirin)
(suvorexant)
Tablet
Caplet
Caplet
Tablet
Slowrelease(b)
Entericcoated
Entericcoated
Note:notscored;nostudiesavailablefromcompany
BiaxinXL
BidexA
BidhistD
Biltricide
BiohistLA
BisacEvac
Bisacodyl
BisaLax
Boniva
(clarithromycin)
(combination)
(combination)
(praziquantel)
(combination)
(bisacodyl)
(combination)
(combination)
(ibandronate)
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
BromfedPD
BudeprionSR
Bunavail
(combination)
(buPROPion)
(combination)
Capsule
Tablet
Buccalfilm
CalanSR
(verapamil)
Tablet
Slowrelease
Slowrelease
Slowrelease
Taste(h)
Slowrelease(h)
Entericcoated(c)
Entericcoated(c)
Entericcoated(c)
Note:chewed,crushed,orsuckedtabletsmaycause
oropharyngealirritation
Slowrelease
Slowrelease
Note:chewingorswallowingmayresultinlowerpeak
concentrationsandbioavailability
Slowrelease(h)
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page2of15
OralDosageFormsThatShouldNotBeCrushed2015
Carbatrol
CardeneSR
Cardizem
(carBAMazepine)
(niCARdipine)
(diltiazem)
Capsule
Capsule
Tablet
CardizemCD
CardizemLA
CarduraXL
CartiaXT
CefaclorER
Ceftin
Cefuroxime
CellCept
Cerdelga
CharcoalPlus
ChlorTrimeton12H
CiproXR
ClaritinD12Hour
ClaritinD24Hour
Colace
Colestid
Commit
(diltiazem)
(diltiazem)
(doxazosin)
(diltiazem)
(cefuroxime)
(mycophenolate)
(eliglustat)
(combination)
(ciprofloxacin)
(combination)
(combination)
(docusate)
(colestipol)
(nicotine)
Capsule
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule,Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Lozenge
Concerta
Contrave
(methylphenidate)
(combination)
Tablet
Tablet
CoregCR
(carvedilol)
Capsule
CotazymS
CoveraHS
Creon5,10,20
Crixivan
(pancrelipase)
(verapamil)
(pancrelipase)
(indinavir)
Capsule
Tablet
Capsule
Capsule
Slowrelease(a)
Slowrelease
Note:althoughnotinthepackageinsert,thedrughas
acoatingthatisintendedtoreleasethedrugover
approximately3hours
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease(b)
Taste(b)(Note:usesuspensionforchildren)
Taste(b)(Note:usesuspensionforchildren)
Teratogenicpotential(i)
Preferablytakenwithwater
Entericcoated
Slowrelease(b)
Slowrelease(b)
Slowrelease
Slowrelease
Taste(e)
Slowrelease
Note:integritycompromisedbychewingorcrushing
Slowrelease
Slowrelease(Note:chewing,dividing,orcrushing
tabletsmayalterreleaserate)
Slowrelease(a)(Note:mayaddcontentsofcapsule
tochilled,notwarm,applesauceandconsume
immediately)
Entericcoated(a)
Slowrelease
Slowrelease(a)
Taste(Note:capsulemaybeopenedandmixedwith
fruitpuree[e.g.,banana])
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page3of15
OralDosageFormsThatShouldNotBeCrushed2015
Cymbalta
(DULoxetine)
Capsule
Slowrelease(a)(Note:mayaddcontentsofcapsule
toapplejuiceorapplesaucebutNOTchocolate)
Cytovene
Cytoxan
(ganciclovir)
(cyclophosphamide)
Capsule
Tablet
Depakene
Depakote
DepakoteER
DetrolLA
Dexilant
Diclegis
DilacorXR
DilatrateSR
DiltCD
DiltiaXT
DitropanXL
DivalproexER
Doxidan
Drisdol
Droxia
(divalproex)
(divalproex)
(divalproex)
(tolterodine)
(dexlansoprazole)
(combination)
(diltiazem)
(isosorbide)
(diltiazem)
(diltiazem)
(oxybutynin)
(divalproex)
(bisacodyl)
(ergocalciferol)
(hydroxyurea)
Capsule
Tablet
Tablet
Capsule
Capsule
Tablet
Capsule
Capsule
Capsule
Capsule
Tablet
Tablet
Tablet
Capsule
Capsule
Dulcolax
DynaCircCR
E.E.S.400
Easprin
ECNaprosyn
EcotrinAdultLowStrength
EcotrinMaximumStrength
EcotrinRegularStrength
EfferK
EffervescentPotassium
EffexorXR
(bisacodyl)
(isradipine)
(erythromycin)
(aspirin)
(combination)
(aspirin)
(aspirin)
(aspirin)
(potassiumbicarbonate)
(venlafaxine)
Tablet;Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Skinirritant
Note:drugmaybecrushedbutcompanyrecommends
usinginjection
Slowrelease;mucusmembraneirritant(b)
Slowrelease
Slowrelease
Slowrelease
Slowrelease(a)
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Entericcoated(c)
Liquidfilled(d)
Note:exposuretothepowdermaycauseseriousskin
toxicities;healthcareworkersshouldwearglovesto
administer
Entericcoated(c);Liquidfilled
Slowrelease
Entericcoated(b)
Entericcoated
Entericcoated
Entericcoated
Entericcoated
Entericcoated
Effervescenttablet(f)
Effervescenttablet(f)
Slowrelease
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page4of15
OralDosageFormsThatShouldNotBeCrushed2015
Embeda
EMycin
Enablex
EntocortEC
Epanova
(morphinesulfate)
(erythromycin)
(darifenacin)
(budesonide)
(omega3carboxylicacids)
Capsule
Tablet
Tablet
Capsule
Capsule
Slowrelease(a)
Entericcoated
Slowrelease
Entericcoated(a)
Note:contentsofcapsulemayerodewallsof
Styrofoamorplasticmaterials
Slowrelease(a)
Sublingualform(g)
Note:packageinsertindicatespotentialteratogenic
effects;materialsafetydatasheetwarnsagainstskin
contact;healthcareworkersshouldtakeappropriate
precautions
Entericcoated
Entericcoated
Entericcoatedpellets(a)
Entericcoated
Taste;teratogenicpotential(i)
Slowrelease(Note:crushing,chewing,ordissolving
tabletscancauserapidreleaseandabsorptionofa
potentiallyfataldose)
Note:donotgiveaswholetablet,tabletsaremeant
tobegivenasoralsuspension;seecompanyinsert
Equetro
Ergomar
Erivedge
(carBAMazepine)
(ergotamine)
(vismodegib)
Capsule
Tablet
Capsule
EryTab
ErythromycinBase
ErythromycinDelayedRelease
ErythromycinStearate
Evista
Exalgo
(erythromycin)
(raloxifene)
(HYDROmorphone)
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Exjade
(deferasirox)
Tablet
ExtendrylJR
ExtendrylSR
Feenamint
Feldene
FentaNYL
(combination)
(combination)
(bisacodyl)
(piroxicam)
Capsule
Capsule
Tablet
Capsule
Lozenge
Slowrelease
Slowrelease(b)
Entericcoated(c)
Mucousmembraneirritant
Slowrelease(Note:thislollipopdeliverysystem
requiresthepatienttoslowlydissolveinmouth)
Fentora
Feosol
Feratab
Fergon
(fentaNYL)
(ferroussulfate)
(ferroussulfate)
(ferrousgluconate)
Tablet
Tablet
Tablet
Tablet
Note:buccaltablet;swallowwhole
Entericcoated(b)
Entericcoated(b)
Entericcoated
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page5of15
OralDosageFormsThatShouldNotBeCrushed2015
FeroGrad500mg
FerroSequels
FlagylER
FleetLaxative
Flomax
FocalinXR
Fortamet
Fosamax
Gleevec
(combination)
(combination)
(metroNIDAZOLE)
(bisacodyl)
(tamsulosin)
(dexmethylphenidate)
(metFORMIN)
(alendronate)
(imatinib)
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet
GlipiZIDEXR
GlucophageXR
GlucotrolXL
Glumetza
Gralise
Guaifed
GuaifedPD
GuaifenexDM
GuaifenexGP
GuaifenexPSE
GuaifFENesin/Pseudoephedrine
GuaiMAXD
Halfprin81
Hetlioz
(glipiZIDE)
(metFORMIN)
(glipiZIDE)
(metFORMIN)
(gabapentin)
(combination)
(combination)
(combination)
(combination)
(combination)
(combination)
(aspirin)
(tasimelteon)
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
HistaVentDA
Horizant
Hydrea
(combination)
(gabapentin)
(hydroxyurea)
Tablet
Tablet
Capsule
HysinglaER
(HYDROcodone)
Tablet
Slowrelease
Slowrelease
Slowrelease
Entericcoated(c)
Slowrelease
Slowrelease(a)
Slowrelease
Mucousmembraneirritant
Taste(h)(Note:maybedissolvedinwaterorapple
juice)
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease(h)
Slowrelease
Slowrelease(h)
Slowrelease
Slowrelease
Entericcoated
Note:notscored;nostudiesavailablefromcompany
Slowrelease(h)
Slowrelease
Note:exposuretothepowdermaycauseseriousskin
toxicities;healthcareworkersshouldwearglovesto
administer
Slowrelease(Note:crushing,chewing,ordissolving
tabletscancauserapidreleaseandabsorptionofa
potentiallyfataldoseofhydrocodone)
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page6of15
OralDosageFormsThatShouldNotBeCrushed2015
Imbruvica
(ibrutinib)
Capsule
Note:notscored;nostudiesavailablefromcompany
Imdur
Impavido
(isosorbide)
(miltefosine)
Tablet
Capsule
Slowrelease(h)
Note:notscored;nostudiesavailablefromcompany
InderalLA
IndocinSR
InnoPranXL
Intelence
(propranolol)
(indomethacin)
(propranolol)
(etravirine)
Capsule
Capsule
Capsule
Tablet
Intermezzo
Intuniv
Invega
IsoptinSR
IsordilSublingual
IsosorbideDinitrateSublingual
IsosorbideSR
Jakafi
(zolpidem)
(guanFACINE)
(paliperidone)
(verapamil)
(isosorbide)
(isosorbide)
(isosorbide)
(ruxolitinib)
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Jalyn
(combination)
Capsule
JanumetXR
Kadian
(combination)
(morphine)
Tablet
Capsule
Slowrelease
Slowrelease(a,b)
Slowrelease
Note:tabletshouldbeswallowedwholeandnot
crushed;tabletmaybedispersedinwater
Sublingualform(g)
Slowrelease
Slowrelease
Slowrelease(h)
Sublingualform(g)
Sublingualform(g)
Slowrelease
Note:seeprescribinginformationformakinga
suspension
Mucousmembraneirritant(Note:womenwhoare,or
maybecome,pregnant,shouldnothandlecrushedor
brokentablets[l])
Slowrelease
Slowrelease(a)(Note:donotgiveviaNGtubes)
Kaletra
KaonCL10
Kapidex
(combination)
(potassium)
(dexlansoprazole)
Tablet
Tablet
Capsule
Filmcoated
Slowrelease(b)
Slowrelease(a)(Note:namechangedtoDexilant)
Kapvay
Kazano
(cloNIDine)
(combination)
Tablet
Tablet
Slowrelease
Note:notscored;nostudiesavailablefromcompany
KDur
(potassium)
Tablet
Slowrelease
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page7of15
OralDosageFormsThatShouldNotBeCrushed2015
Keppra
(levETIRAcetam)
Tablet
KeppraXR
Ketek
Khedezla
KlorCon
KlorConM
Klotrix
KLyte
KLyteCL
KLyteDS
KombiglyzeXR
(levETIRAcetam)
(telithromycin)
(desvenlafaxine)
(potassium)
(potassium)
(potassium)
(potassium)
(potassium)
(potassium)
(combination)
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
KTab
LaMICtalXR
LescolXL
Letairis
Levbid
LevsinexTimecaps
Lialda
LiquibidPD
Lithobid
Lodrane24
Lodrane24D
LoHist12Hour
Lovaza
(potassium)
(lamoTRIgine)
(fluvastatin)
(ambrisentan)
(hyoscyamine)
(hyoscyamine)
(mesalamine)
(combination)
(lithium)
(brompheniramine)
(combination)
(brompheniramine)
(combination)
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Capsule
LuvoxCR
MaxifedDM
MaxifedDMX
MaxiphenDM
MedentDM
MestinonER
MetadateCD
(fluvoxaMINE)
(combination)
(combination)
(combination)
(combination)
(pyridostigmine)
(methylphenidate)
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Taste(b)(Note:someextemporaneousformulasare
pharmacyprepared)
Slowrelease(b)
Slowrelease(b)
Slowrelease
Slowrelease(b)
Slowrelease(b,h)
Slowrelease
Effervescenttablet(f)
Effervescenttablet(f)
Effervescenttablet(f)
Slowrelease(Note:tabletmatrixmayremaininstool)
Slowrelease(b)
Slowrelease
Slowrelease
Slowrelease
Slowrelease(h)
Slowrelease
Slowrelease
Slowrelease(h)
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Note:contentsofcapsulemayerodewallsof
Styrofoamorplasticmaterials
Slowrelease
Slowrelease(h)
Slowrelease(h)
Slowrelease(h)
Slowrelease
Slowrelease(b)
Slowrelease(a)
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page8of15
OralDosageFormsThatShouldNotBeCrushed2015
MetadateER
MethylinER
MetoprololER
MicroKExtencaps
MiraphenPSE
Morphinesulfateextendedrelease
Motrin
Movantik
Moxatag
MSContin
Mucinex
MucinexDM
Myfortic
Myrbetriq
NamendaXR
Naprelan
NexIUM
Niaspan
NicotinicAcid
NifediacCC
NifedicalXL
Nitrostat
NorflexER
Northera
NorpaceCR
Norvir
(methylphenidate)
(methylphenidate)
(potassiumchloride)
(combination)
(ibuprofen)
(naloxegol)
(amoxicillin)
(morphine)
(guaiFENesin)
(combination)
(mycophenolate)
(mirabegron)
(memantine)
(naproxen)
(esomeprazole)
(nicotinicacid)
(NIFEdipine)
(NIFEdipine)
(nitroglycerin)
(orphenadrine)
(droxidopa)
(disopyramide)
(ritonavir)
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Capsule;Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Noxafil
NucyntaER
(posaconazole)
(tapentadole)
Tablet
Tablet
OFEV
Oleptro
(nintedanib)
(traZODone)
Capsule
Tablet
Slowrelease
Slowrelease
Slowrelease
Slowrelease(a,b)
Slowrelease
Slowrelease
Taste(b,e)
Filmcoated
Slowrelease
Slowrelease(b)
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Slowrelease(a)
Slowrelease
Slowrelease(a)
Slowrelease
Slowrelease(h)
Slowrelease
Slowrelease
Sublingualform(g)
Slowrelease
Note:nostudiesavailablefromcompany
Slowreleaseformwithinaspecialcapsule
Note:crushingtabletshasresultedindecreased
bioavailabilityofdrug(b)
Slowrelease(b)
Slowrelease(Note:crushing,chewing,ordissolving
tabletsmayresultinoverdoseordeath)
Taste
Slowrelease(h)
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page9of15
OralDosageFormsThatShouldNotBeCrushed2015
Omtryg
(omega3acidethylestersA)
Capsule
Note:contentsofcapsulemayerodewallsof
Styrofoamorplasticmaterials
Slowrelease(Note:crushing,chewing,ordissolving
tabletsmayresultinoverdoseordeath)
OpanaER
(oxymorphone)
Tablets
Oracea
OramorphSR
Otezla
OxyCONTIN
(doxycycline)
(morphine)
(apremilast)
(oxyCODONE)
Capsule
Tablet
Tablet
Tablet
Slowrelease
Slowrelease(b)
Filmcoated
Slowrelease(Note:tabletdisruptionmaycausea
potentiallyfataloverdoseofoxyCODONE)
Pancreaze
Pancrecarb
Pancrelipase
PaxilCR
Pentasa
Pertyze
Plendil
Pradaxa
(pancrelipase)
(pancrelipase)
(PARoxetine)
(mesalamine)
(pancrelipase)
(felodipine)
(dabigatran)
Capsule
Capsule
Capsule
Tablet
Capsule
Capsule
Tablet
Capsule
PreHistD
Prevacid
PrevacidSoluTab
(combination)
(lansoprazole)
(lansoprazole)
Tablet
Capsule
Tablet
Entericcoated(a)
Entericcoated(a)
Entericcoated(a)
Slowrelease
Slowrelease
Slowrelease(a)
Slowrelease
Note:breaking,chewing,oremptyingcontentsofthe
capsulecanresultinincreasedexposure
Slowrelease(h)
Slowrelease
Note:orallydisintegratingdonotswallow;dissolvein
wateronlyanddispenseviadosingsyringeofNGtube
PrevacidSuspension
(lansoprazole)
Suspension
PriLOSEC
PriLOSECOTC
Pristiq
ProcardiaXL
Propecia
(omeprazole)
(omeprazole)
(desvenlafaxine)
(NIFEdipine)
(finasteride)
Capsule
Tablet
Tablet
Tablet
Tablet
Slowrelease(Note:containsentericcoatedgranules;
mixwithwateronly;notforNGuse)
Slowrelease
Slowrelease
Slowrelease
Slowrelease
Note:womenwhoare,ormaybecome,pregnant,
shouldnothandlecrushedorbrokentablets
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page10of15
OralDosageFormsThatShouldNotBeCrushed2015
ProquinXR
Proscar
(ciprofloxacin)
(finasteride)
Tablet
Tablet
Slowrelease
Note:womenwhoare,ormaybecome,pregnant,
shouldnothandlecrushedorbrokentablets
Protonix
PROzacWeekly
QDALL
QDALLAR
QudexyXR
Ranexa
Rapamune
(pantoprazole)
(FLUoxetine)
(combination)
(combination)
(topiramate)
(ranolazine)
(sirolimus)
Tablet
Tablet
Capsule
Capsule
Capsule
Tablet
Tablet
Rayos
(predniSONE)
Tablet
RazadyneER
Renagel
(galantamine)
(sevelamer)
Capsule
Tablet
Slowrelease
Entericcoated
Slowrelease
Slowrelease
Slowrelease(a)
Slowrelease
Note:pharmacokineticparametersmaybeaffected
(b)
Slowrelease(Note:delayedreleaseisdependenton
anintactcoating)
Slowrelease
Note:tabletsexpandinliquidifbrokenorcrushed
Renvela
(sevelamercarbonate)
Tablet
Note:tabletsexpandinliquidifbrokenorcrushed(b)
RequipXL
Rescon
ResconJR
ResconMX
Respahist
RespaireSR
Revlimid
(ropinirole)
(combination)
(combination)
(combination)
(combination)
(combination)
(lenalidomide)
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Capsule
Reyataz
(atazanavir)
Capsule
Slowrelease
Slowrelease(h)
Slowrelease(h)
Slowrelease(h)
Slowrelease(a)
Slowrelease
Note:Teratogenicpotential;healthcareworkers
shouldavoidcontactwithcapsulecontents/body
fluids
Note:anoralpowderisavailable,seeprescribing
informationforadministrationinstructions
RitalinLA
RitalinSR
RTanna
(methylphenidate)
(methylphenidate)
(combination)
Capsule
Tablet
Tablet
Slowrelease(a)
Slowrelease
Slowrelease
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page11of15
OralDosageFormsThatShouldNotBeCrushed2015
RythmolSR
Ryzolt
(propafenone)
(traMADol)
Capsule
Tablet
Slowrelease
Slowrelease(Note:crushingmaycauseoverdose)
Sensipar
(cinacalcet)
Tablet
SEROquelXR
SinemetCR
SINUventPE
SloNiacin
Solodyn
Somnote
Sprycel
(QUEtiapine)
(levo/carbidopa)
(combination)
(nicotinicacid)
(minocycline)
(chloralhydrate)
(dasatinib)
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Note:tabletsarenotscoredandcuttingmaycause
variabledosageaccuracy
Slowrelease
Slowrelease(h)
Slowrelease(h)
Slowrelease(h)
Slowrelease
Liquidfilled
Filmcoated(Note:activeingredientsaresurrounded
bywaxmatrixtopreventhealthcareexposure;
womenwhoare,ormaybecome,pregnant,should
nothandlecrushedorbrokentablet)
Strattera
(atomoxetine)
Capsule
Note:capsulecontentscancauseocularirritation
Sudafed12hour
Sudafed24hour
Sular
SymaxDuotab
SymaxSR
TarginiqER
(combination)
(combination)
(nisoldipine)
(hyoscyamine)
(hyoscyamine)
(combination)
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Slowrelease(b)
Slowrelease(b)
Slowrelease
Slowrelease
Slowrelease
Slowrelease(Note:crushing,chewing,ordissolving
tabletscancauserapidreleaseandabsorptionofa
potentiallyfataldoseofoxycodone)
Tasigna
(nilotinib)
Capsule
TaztiaXT
Tecfidera
TEGretolXR
(diltiazem)
(dimethylfumarate)
(carBAMazepine)
Capsule
Capsule
Tablet
Note:disruptionofcapsulemayyieldhighbloodlevels
causingenhancedtoxicity
Slowrelease(a)
Slowrelease
Slowrelease
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page12of15
OralDosageFormsThatShouldNotBeCrushed2015
Temodar
(temozolomide)
Capsule
TessalonPerles
(benzonatate)
Capsule
Theo24
(theophylline)
Capsule
Theochron
Tiazac
Topamax
ToprolXL
TouroCCLD
TouroLALD
Toviaz
Tracleer
(theophylline)
(diltiazem)
(topiramate)
(metoprolol)
(combination)
(combination)
(fesoterodine)
(bosentan)
Tablet
Capsule
Tablet;Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
TRENtal
Treximet
(pentoxifylline)
(combination)
Tablet
Tablet
Trilipix
TylenolArthritis
Uceris
(fenofibricacid)
(acetaminophen)
(budesonide)
Capsule
Tablet
Tablet
UltramER
(traMADol)
Tablet
Ultrase
Ultresa
Uniphyl
UrocitK
Uroxatral
Valcyte
VerapamilSR
(pancrelipase)
(pancrelipase)
(theophylline)
(potassiumcitrate)
(alfuzosin)
(valGANCiclovir)
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Slowrelease(Note:accidentallyopenedordamaged
capsulesrequirerigorousprecautionstoavoid
inhalationorcontactwiththeskinormucous
membranes[i])
Note:swallowwhole;localanesthesiaoftheoral
mucosa;chokingcouldoccur
Slowrelease(Note:containsbeadsthatdissolve
throughouttheGItract)
Slowrelease
Slowrelease(a)
Taste;Taste(a)
Slowrelease(h)
Slowrelease(h)
Slowrelease(h)
Slowrelease
Note:womenwhoare,ormaybecome,pregnant,
shouldnothandlecrushedorbrokentablets
Slowrelease
Note:uniquedrugmatrixenhancesrapiddrug
absorption
Slowrelease
Slowrelease
Slowrelease(Note:filmcoatingisdesignedtobreak
downatorabovepHof7.0)
Slowrelease(Note:tabletdisruptionmaycausea
potentiallyfataloverdoseofdrug)
Entericcoated
Slowrelease(a)
Slowrelease
Waxcoated;preventsupperGIrelease
Slowrelease
Teratogenicandirritantpotential(i,b)
Slowrelease(h)
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page13of15
OralDosageFormsThatShouldNotBeCrushed2015
Verelan
VerelanPM
VESIcare
VidexEC
Vimovo
Viokace
ViramuneXR
VoltarenXR
VoSpireER
Votrient
(verapamil)
(verapamil)
(solifenacin)
(didanosine)
(combination)
(pancrelipase)
(nevirapine)
(diclofenac)
(albuterol)
(pazopanib)
Capsule
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
WellbutrinSR,XL
XanaxXR
Xarelto
(buPROPion)
(ALPRAZolam)
(rivaroxaban)
Tablet
Tablet
Tablet
XartemisXR
(combination)
Tablet
XigduoXR
Zegerid
Zenpep
ZohydroER
(combination)
(combination)
(pancrelipase)
(HYDROcodone)
Tablet
Capsule
Capsule
Capsule
Zolinza
(vorinostat)
Capsule
Zortress
(everolimus)
Tablet
Zyban
Zydelig
ZyfloCR
(buPROPion)
(idelalisib)
(zileuton)
Tablet
Tablet
Tablet
Slowrelease(a)
Slowrelease(a)
Entericcoated
Slowrelease
Slowrelease
Mucousmembraneirritant
Slowrelease(b)
Slowrelease
Slowrelease
Note:crushingsignificantlyincreasestheAUCand
Tmax
Slowrelease
Slowrelease
Note:crushedtabletmustbegivenwithin4hours
Slowrelease(Note:crushing,chewing,ordissolving
tabletscancauserapidreleaseandabsorptionofa
potentiallyfataldose)
Slowrelease
Slowrelease(b)
Slowrelease(b)
Slowrelease(Note:crushing,chewing,ordissolving
capsulesmayresultinoverdoseordeath)
Note:irritant;avoidcontactwithskinormucous
membranes;avoidcontactwithcrushedorbroken
tablets
Note:crushedpowdermaycausemucousmembrane
irritation
Slowrelease
Note:notscored;filmcoated
Slowrelease
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page14of15
OralDosageFormsThatShouldNotBeCrushed2015
(a)
(b)
(c)
(d)
(e)
(f)
(g)
(h)
(i)
Capsulemaybeopenedandthecontentstakenwithoutcrushingorchewing;softfoodsuchasapplesauceorpuddingmayfacilitateadministration;contents
Liquiddosageformsoftheproductareavailable;however,dose,frequencyofadministrationandmanufacturersmaydifferfromthatofthesoliddosageform.
Antacidsand/ormilkmayprematurelydissolvethecoatingofthetablet.
Capsulemaybeopenedandtheliquidcontentsremovedforadministration.
Thetasteofthisproductformwouldlikelybeunacceptabletothepatient;administrationvianasogastrictubeshouldbeacceptable.
Effervescenttabletsmustbedissolvedintheamountofdiluentrecommendedbythemanufacturer.
Tabletsaremadetodisintegrateunderthetongue.
Tabletisscoredandmaybebrokeninhalfwithoutaffectingreleasecharacteristics.
Skincontactmayenhancetumorproduction;avoiddirectcontact.
Disclaimer:Thislistisnotmeanttorepresentallproducts,eitherbygenericortradename.Whileeveryefforthasbeenmadetoensuretheaccurcayandcompleteness
oftheinformationpresentedinthischart,thereaderisadvisedthattheauthors,editor,orpublishercannotberesponsiblefortehcurrencyoftehinformation,forany
errorsoromissions,orforanyconsequencesthatmayarrise.
TwoofficialUSPtermsareusedtodesignatespecialreleasemedicationforms:"extendedrelease"and"delayedrelease".Others(e.g.,sustainedrelease,controlled
release)arecommonlyusedonpackagelabeling.Theterm"Slowrelease"isbeingusedheretosignifyallsuchdrugswithaspecialreleasemechanism.
ISMP2015.Permissionisgrantedtoreporducematerialforinternalusewithinhealthcareorganizations.
Youmaypurchaseawallchartversionofthislistat:
http://onlinestore.ismp.org/shop/item.aspx?itemid=133
Page15of15