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Dominus Testimonium
Please use a dark pencil/pen to complete the test. Read the instructions at the
begining carefully. This is an Sample Test Paper for DOTES Entry Level Examination
toward DOTES Cert. Level A. This series contains questions in Pharmacology. This
is an entry level examination to be eligible to appear for DOTE Certification Levels.
Please Note: There is a Negative Marking of (-1) for each incorrect response.
1. Drugs that reduces the bioavailability and absorption of warfarin
A acetaminophen
C phenothiazine
B cholestyramine
D benzodiazepine
C d-Arg[Hyp3,Thi5,
D-Tic7,Oic8]bradykinin
B [Leu8]des-Arg9
-bradykinin
D DArg[Hyp3,DPhe7,
Leu8]bradykinin
3. Drugs that inhibit metabolism of Warfarin include all of the following except:
A amiodarone
C cimetidine
B disulfiram
D aspirin
C febuxostat
B allopurinol
D probenecid
C cefaclor
B cefepime
D cefadroxil
-1-
Pharmacology
7. Which of the following agents is not an immunosuppressant?
A IFN- 2
C mercaptopurine
B azathioprine
D infliximab
D decreases IL-10
C Tacrolimus
B Chenodeoxycholic acid
D Macrokine
pyrazolones
A. phenylbutazone
orange discoloration of urine
B. pyrazinamide
nicotinamide
C. oxaprozin
niacinamide
D. rifampin
propionic acid derivative NSAID E. energy metabolism
C losartan
B metamizol
D fenofibrate
C fluoride
B loop diuretics
D -agonists
C methothrexate
B cyclosporin
D azathioprine
-2-
Pharmacology
15. Match the following on the left with their correct options on the right:
A.
B.
C.
D.
E.
Glycopeptide anitibiotic
Polyene antibiotic
3rd Generation Cephalosporin
2nd Generation Cephalosporin
Quinolone antibiotic
A.
B.
C.
D.
E.
Cefotaxime
Nalidixic acid
Vancomycin
Cefuroxime
Amphotericin-B
C hyperkalemia
B hypokalemia
D hypernatremia
C digitalis glycoside
B -agonists
D spironolactone
18. Factors that increase drug metabolism includes all of the following except
A administration of Phenobarbital
C heavy smoking
B charcoal-boiled foods
19. Which Leukotriene is a potent chemo attractant for eosinophils and T lymphocytes?
A Leukotriene C4
C Leukotriene D4
B Leukotriene B4
20. Drugs that are absorbed intact from the small intestine include all of the following
except
A pentazocine
C meperidine
B morphine
D clonazepam
C aromatase enzyme
B 5a-reductase
D xanthine oxidase
-3-
Pharmacology
23. Match the following with their correct alternatives:
A.
B.
C.
D.
E.
Hepatolenticular degeneration
Cysteinyl LT1 receptor antagonist
Diabetes insipidus
-lactams
Aminoglycosides
A.
B.
C.
D.
E.
Carbapenems
Desmopressin
Penicillamine
Gentamicin
Montelukast
C IL-1
B IL-1a
D Leukotriene C4
C Ezetimibe
B Gemfibrozil
D Flurbiprofen
C Leflunomide
B Lenalidomide
D Tolazamide
C lisinopril
B fosinopril
D enalapril
28. Drug which should not be used for analgesia in patients with gout
A indomethacin
C oxaprozin
B aspirin
D glucocorticoid
C metformin
B thiazides
D diazoxide
C suppress hepatic
gluconeogenesis
-4-
Pharmacology
31. Mechanism of action and indications not common to both diazoxide and
sulfonylureas
A both cause membrane
depolarization
D used in coagulopathy in
Hemophilia B
C postural hypotension
34. Drugs that should not be suddenly withdrawn after prolonged treatment include all
of the following except:
A -adrenergic blockers
C procyclidine
B clozapine
D fluoxetine
cyclophosphamide
nafcillin
ondansetron
A. neutropenia
B. torsades de pointes
C. acute myeloid leukemia
D.
E.
ampicillin
cisplatin
D. nephrotoxicity
E. pseudomembranous colitis
C methotrexate
B cyclophosphamide
D Glatiramer
37. Match the following classes of interferons & interleukins with their correct sources:
A.
B.
C.
D.
E.
IFN-
IFN-
IFN-
interleukin-2
interleukin -3
A.
B.
C.
D.
E.
-5-
mast cells
lectin or antigen stimulated T cells
white cells
fibroblasts
lymphocytes
Pharmacology
38. What is not true regarding the actions of clonidine?
A has no effect on cardiac output
C propanolol
B guanethidine
D prazosin
C amphotericin B
B chloramphenicol
D gentamicin
C ethosuximide
B nicorandil
D cisplatin
C Fluoxetin
B Bedaquiline
D Amiodarone
Doxycycline
Salbutamol
Digoxin
Morphine
chlorpropamide
A.
B.
C.
D.
E.
1.6 hrs
32 hrs
40 hrs
2-3 hrs
20 hrs
C chlorthiazide
B amitriptyline
D clomethiazole
C Amiloride
B Quinidine
D Nifedipine
-6-
Pharmacology
46. Mechanism of action of amiloride
A antagonize the effect of
aldosterone in collecting tubules
C zolpidem
B Lithium
D carbamazepine
C eszopiclone
B zaleplon
D ziprasidone
C -hydroxy metabolites
B desmomethyldiazepam
D demoxepam
C propylthiouracil
B methimazole
D amiodarone
-7-