Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
BRAIN
HEALTH
Guide
third edition
ii
CONTENTS
Table of Contents
Chapter 1:
Chapter 2:
Chapter 3:
13
What is Prevagen?
15
18
26
Researchers Discover
A Gift From The Sea
31
Chapter 4:
Chapter 5:
Chapter 6:
Chapter 7:
Epilogue:
Appendix I:
Memory Test
33
Appendix II:
Madison Memory Study
35
iii
Foreword
~
Did you hear about the elderly woman who was pulled over
for speeding? She explained to the young officer, I had to
hurry up before I forgot where I was going.
iv
Foreword
Chapter 1
America's State of Brain Health
here is good news and bad news when it comes to brain health.
The good news is that people are living longer than any other
time in history. Major nutritional and medical advancements have
been made to help keep the body physically healthy. The bad news is
we are seeing an unprecedented number of mild brain health issues
affecting our families and our friends. When life spans were shorter,
people simply were not living long enough to see the effects of natural
brain aging that are
common today.
Scientists estimate
we lose between
30,000 and 50,000
brain cells every
single day. This leads
not only to common
occurrences like the
misplacement
of
car keys and reading
glasses, but difficulty with management of our time and household
tasks. A recent study by the Natural Marketing Institute ranked
healthy mental function as the number one health concern among
those over 60 years old.
As we age, mild memory problems result in more than difficulty
remembering. It also leads to an inability to focus, pay attention
or stay on task. With increasing age comes increasing stress that
can affect the brain. The health of the brain is arguably the most
important part of overall health because it controls all organ systems
in the body.
The problems with mild memory problems in the United States are
mainly due to the aging of our society. In the year 1900, the average
Chapter 1
QUINCY BIOSCIENCE
~~
Chapter 1
Chapter 2
Nutrition Tips for Memory Fitness
Research suggests that a healthy diet can help keep your major
organs functioning at a high level. A diet consisting of the right
blend of proteins and complex carbohydrates has proven to be the
most beneficial. The brain and nervous system are comprised of
60% fat, so ensure your diet is rich in the Omega 3 essential fatty
Chapter 2
QUINCY BIOSCIENCE
Chapter 2
New research has found that to retain the health benefits associated
with eating broccoli or other cruciferous veggies (like cabbage,
turnips, cauliflower, kale and broccoli), you must consume the real
thingbecause of a phytochemical inside them thats missing in
supplements.
The study, published by the Pauling
Institute at Oregon State University and
supported by the National Institutes of
Health, is one of the first of its type
to determine whether the healthy
compounds found in cruciferous
vegetables can be just as easily obtained
through supplements.
The answer is no.
You need the whole foods and must go easy on cooking them. While
some nutrients, like folic acid, can be better absorbed via supplement,
the compounds that give vegetables like broccoli their health value
comes from the real thing.
The reason is that an enzyme that must be there to provide the
maximum nutrient kick is absent in supplements of this type.
Without these enzymes, the absorption rate is five to eight times less.
Intensive cooking also impedes delivery. If broccoli is cooked until
it's mushy, its health value plummets.
Instead, cook for 2-3 minutes, or steam until it's still a little crunchy.
(Broccoli was highlighted because it contains the highest levels of a
class of phytochemicals that may reduce the risk of prostate, breast,
lung and colorectal cancer.)
Bottom line: Eat your vegetables! And consume the real thing, prepared
correctly.
Tip #4 - Try Coconut Oil:
QUINCY BIOSCIENCE
Chapter 2
Soon after beginning (and logging) his daily dosage, he began to feel
much better, and found himself waking up feeling more vigorous,
armed with a greater confidence in facing the challenges ahead.
Supported by the supplements, and without realizing it fully, he
began changing his eating habitsgoing off his low in calorie/
high in protein diet to one including junk food, causing an 8-pound
weight gain over the five month test.
At the end of his singular study, the physicians who examined him
said that his vitamin-induced euphoria and subsequent straying from
making good lifestyle choices was a form of compensation, but poor
excuse for falling off the food wagon. And their advice?
Dont do that.
Like every other life plan, moderation and balance should be the key,
and while its okay to over-indulge now and then, staying on course,
eating right and exercising to fit your age and general health, then
backing things up with a realistic daily dosage of vitamins, minerals,
(and supplements) is the prescription for success.
Tip #6 Practice Moderation
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~~
Chapter 2
Chapter 3
Lifestyle Tips for Memory Fitness
QUINCY BIOSCIENCE
solver. Increasing scientific evidence is showing that you can fight aging
by challenging your mind.
Chapter 3
11
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Chapter 3
Chapter 4
Jellyfish & the Nobel Prize...
What's the Connection?
13
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~~
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
14
Chapter 4
ChapTer 5
WhaT is prevagen?
f you could help support the health of your brain, what kind of
health impact would that have on the rest of your body? How
would thinking and decision-making abilities improve? Would the
quality of your life improve also? Quincy
Bioscience has seen first-hand how the
daily use of Prevagen has helped the
lives of many people (if youre eager to see
how, jump ahead to Chapter 7).
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
ChapTer 5
15
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*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
16
Chapter 5
Quincy Bioscience has been on the cutting edge of the research and the
development of Prevagen for years. It has taken the original research to
its next logical level--application. By supplementing our proteins with
Prevagen, we may be able to support our brain function, as demonstrated
in the research.* The replenishment of these proteins supports healthy
brain function, a sharper mind and clearer thinking.*
Visit
www.freeonlinememorytest.com
to evaluate and track your memory.
~~
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
Chapter 5
17
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ChapTer 6
The laTesT sCienCe
18
ChapTer 6
-1.50%
-4.60%
-5%
-6.59%
-10.59%
-10%
-9.84%
-15%
-18.81%
-20%
30
*
90
Testing Day
Apoaequorin
Placebo
p< .05
In 90 days, the Prevagen group significantly reduced the number of errors that were
made compared to placebo in the Groton Maze. This task measures executive function,
learning and memory.
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
Chapter 6
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Short-Term Memory
Chapter 6
Executive Function
Have you ever made a plan? You used your Executive Function,
which loosely means your brains ability to put an order to the things
in your world. You use it to do things like setting goals and priorities,
and identifying what to accomplish during our day.
Executive function is an extremely important function of the brain.
Should it falter, tasks become more difficult.
One of the tests in the Madison Memory Study is the Groton Maze
Learning (GML) task, used to measure participants executive
function. Looking at a tile-like grid on a computer screen, subjects
repeatedly learn to work their way through a maze that takes them
from an identified start to a marked ending. Errors are expected, but
if executive function is present, each time its taken, mistakes are
fewer. Those on Prevagen showed an almost double decrease in
errors over a specific time than those on the placebo.
So if setting goals or prioritization is a problem for you, thats likely
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
Chapter 6
21
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Delayed Recall
22
Chapter 6
Youll know the next time you try to think of the name of someone
who figures in your thoughts. If it comes to you quickly, then
everythings clicking.
A Life of Quality
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
Chapter 6
23
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*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
24
ChapTer 6
~~
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
Chapter 6
25
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Chapter 7
What People Are Saying
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
26
Chapter 7
Prevagen has given me the ability to feel actually getting back to what
I would consider normal for me. And thats very comforting for me.
It relieves a lot of stress. Whether it works on everybody, I dont know,
but I had such a positive experience from it that I would urge anybody
to at least try it and see if itll work for you, because it sure helped me."
Chapter 7
27
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Chapter 7
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure or prevent any disease.
Chapter 7
29
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Visit
www.freeonlinememorytest.com
to evaluate and track your memory.
~~
30
Chapter 7
Epilogue
Researchers Discover Key to Brain Health
Mark Underwood, President and Co-Founder
Quincy Bioscience
How could the jellyfish have this poison inside of it, without
suffering from any effects? What was it in the jellyfish, could this
jellyfish protein help to protect support our brains in the same way
as the jellyfish? This sounded a lot like the snake and its venomwhy
doesnt the snake get killed by its own bite?
The brain and how it works became a topic of interest to me at a
young age because I was forced to face what happens when the brain
doesnt work. A family history of memory problems has led me to a
lifelong study of the brain and how we can help to keep it working.
In college, as a student at the University of Wisconsin at Milwaukee,
I focused my studies on neurochemistry and neuropsychology. What
I found was really exciting. Extensive research on a rare species
of jellyfish had been done and the amazing properties a protein
produced in its body gave it its ability to glow in the dark.
Recently, this experience inspired me to write a book titled, Gift from
the Sea How a Protein from Jellyfish Fights the Aging Process. I hope that
people will find the connection between our brain health and these
unique sea creatures that glow in the dark to be as fascinating as I do.
Together with Mike Beaman we founded Quincy Bioscience in 2004
to further develop the jellyfish technology to be used for supporting
the brain.*
The great secret unlocked through the study of this rare protein,
Epilogue
31
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32
~~
Epilogue
Appendix I
Take this short Memory Test to see how
Your brain is performing.
5.
6.
7.
8.
9.
10.
Da
ily
Re
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lar
ly
Oc
ca
sio
Ra
na
re
lll
y
Ne ly
ve
r
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
33
Da
ily
Re
gu
lar
ly
Oc
ca
sio
Ra
na
re
lll
y
Ne ly
ve
r
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14.
15.
16.
17.
18.
19.
20.
34
88
30's
82
40's
78
50's
70
60's
62
70's
60
80's
45
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
1 2 3 4 5
Your Total
Score
1 2 3 4 5
Appendix I
Appendix II
The Effects of the Calcium Binding Protein
Apoaequorin on Memory and Cognitive
Functioning in Older Adults
Mark Y. Underwood, Peggy A. Sivesind, Taylor A. Gabourie, Kenneth C. Lerner
Quincy Bioscience, LLC, Madison, WI, USA
QUINCY BIOSCIENCE
http://www.quincybioscience.com/research
35
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Methods
36
Appendix II
The primary efficacy variable measured the change from the Baseline/
Day 0 to Day 90 as recorded by the CogState software. The measurements
included speed of performance, total number of correct moves per second,
total errors, and the accuracy of performance. The secondary efficacy
variables were self-reported improvements defined by positive changes
from Baseline/Day 0 to Day 90 on the qualitative survey instruments.
Data Analysis: Analysis was conducted using the IBM Statistical Package
for the Social Sciences (SPSS) version 19 (IBM, Inc.). Data from all 218
participants were included in the analysis. The qualitative survey data
were analyzed to find descriptive statistics, the Mann-Whitney U Test and
the Wilcoxon Signed Rank Test. Group means and standard deviations
were found for each cognitive assessment. Each cognitive assessment was
analyzed using paired and independent t-tests, and the Mixed-Model
Repeated Measures Analysis of Covariance (ANCOVA). The Baseline/
Day 0 test scores served as the covariate for the Mixed-Model Repeated
Measure ANCOVA. Participant data was segregated for analysis based
upon self-reported level of impairment as measured by the AD8 score prior
to Baseline/Day 0.
Participants: The Madison Memory Study sample was comprised of
218 participants (148 females and 70 males) aged 40 to 91 (= 62.48) years.
Eligible participants were randomized, by a 2:3 ratio, into the Placebo arm
(n=92) or the Apoaequorin arm (n=126) respectively.
Inclusion Criteria:
Healthy males and females that were not excluded by the
predetermined exclusion criteria
Appendix II
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Exclusion Criteria:
Methods
P articipant Characteristics
nA
ge Range
Group Characteristics
Apoaequorin arm
40 - 90
62.54 1
92 (27 male)
40 - 91
62.39
Placebo arm
40 - 91
62.48 1
SD
1.43
1.79
10.98
38
Appendix II
-1.50%
-4.60%
-5%
-6.59%
-10.59%
-10%
-9.84%
-15%
-18.81%
-20%
30
*
90
Testing Day
Apoaequorin
Placebo
p< .05
39
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5.76%
10%
8.15%
5%
0%
-4.35%
-5%
-10%
-15%
-15.31%
-20%
-18.09%
-25%
-30%
-29.12%
-35%
30
90
Testing Day
Apoaequorin AD8 0-1
Placebo AD8 0-1
p< .001
40
Appendix II
Accuracy of Performance
1.02
1.01
1.00
0.99
0.98
0.97
0.96
0.95
30
90
Testing Day
Apoaequorin
Placebo
p< .05
Appendix II
41
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9.2
9.0
8.8
8.6
8.4
8.2
8.0
7.8
30
90
Testing Day
Apoaequorin AD8 0-1
Apoaequorin AD8 2-5
42
p< .05
Appendix II
Appendix II
43
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Notes:
Notes
Notes:
Notes
Quincy Bioscience
~
301 S Westfield Road Suite 200
Madison, Wisconsin 53717
1.888.814.0814