DRUG STUDIES

Drawing

Generic Name
Brand Name
Classification
Action
Dosage
Indication
Contraindication

Side Effects

Adverse Effects

Drug Interaction

Nursing
Interventions

Drawing

Co-amoxiclav: Amoxicillin and Clavulanicacid

Amoclav
Bactericidal, Pregnancy Category B
Inhibits enzymes involved in formation of peptidoglycan layer of bacterial cell wall.
625mg PO TID x 7 days
Lower respiratory tract infection, sinusitis, skin and soft tissue, UTI, dental infection
History of penicillin hypersensitivity and jaundice, pregnancy and lactation, candida.
Itchiness
Fever
Rasher
Fever
Diarrhea
Vomiting
Fatigue
Abdominal pain
Agitation
Depression
Dizziness
Jaundice
Drug-Drug:
o Allopurinol increased risk of rash
o Chloramphenicol decreased amoxicillin effect
o Probenecid decreased renal excretion and increase blood level of amoxicillin
Drug-Food:
o Any food delayed or reduced drug absorption
Drug-Herb:
o Khat decreased antimicrobial effect
Instruct client to immediately report signs or symptoms of hypersensitivity.
Tell client he can take drug without food.
Inform client that drug lowers resistance to some types of infections.
Teach patient to minimize GI upset by eating small, frequent servings of food and drinking plenty
of fluids.

Generic Name
Brand Name
Classification

Action
Dosage

Indication

Contraindication

Side Effects

Adverse Effects

Drug Interaction

Celecoxib
Celebrex
NSAID, Analgesic (nonopioid), Specific COX-2 enzyme blocker, Pregnancy Category C (first and
second trimester), Pregnancy Category D (third trimester)
Analgesic and anti-inflammatory activities related to inhibition of the COX-2 enzyme, which is
activated in inflammation to cause the signs and symptoms associated with inflammation; does
not affect the COX-1 enzyme, which protects the lining of the GI tract and has blood clotting and
renal functions.
200mg PO BID
Acute and long-term treatment of signs and symptoms of rheumatoid arthritis and
osteoarthritis
Reduction of the number of colorectal polyps in familial adenomatous polyposis (FAP)
Management of acute pain
Treatment of primary dysmenorrhea
Contraindicated with allergies to sulfonamides, celecoxib, NSAIDs, or aspirin;
significant renal impairment; pregnancy (third trimester); lactation.
Use cautiously with impaired hearing, hepatic, and CV conditions.
chest pain, weakness, shortness of breath, slurred speech, problems with vision or
balance;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
swelling or rapid weight gain;
urinating less than usual or not at all;
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored
stools, jaundice (yellowing of the skin or eyes);
skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your
eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face
or upper body) and causes blistering and peeling.
CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness,
tinnitus, ophthamologic effects
Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
GI: Nausea, abdominal pain, dyspepsia, flatulence, GI bleed
Hematologic: Neutropenia, eosinophilia, leukopenia, pancytopenia,
thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased
hemoglobin or hematocrit, bone marrow depression,menorrhagia
Other: Peripheral edema, anaphylactoid reactions to anaphylactic shock
Drug-drug
Increased risk of bleeding if taken concurrently with warfarin. Monitor patient closely and
reduce warfarin dose as appropriate
Increased lithium levels and toxicity

Nursing
Interventions

Increased risk of GI bleeding with long-term alcohol use, smoking

o
Administer drug with food or after meals if GI upset occurs.
Establish safety measures if CNS, visual disturbances occur.
Arrange for periodic ophthalmologic examination during long-term therapy.
WARNING: If overdose occurs, institute emergency proceduresgastric lavage,
induction of emesis, supportive therapy.
Provide further comfort measures to reduce pain (eg, positioning, environmental
control), and to reduce inflammation (eg, warmth, positioning, rest).
Take only the prescribed dosage.
You may experience these side effects: Dizziness, drowsiness (avoid driving or the
use of dangerous machinery while using this drug).
Report sore throat, fever, rash, itching, weight gain, swelling in ankles or fingers;
changes in vision.