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INTRODUCTION
The lungs constitute the largest organ in the respiratory system. They play
an important role in respiration, or the process of providing the body with
oxygen and releasing carbon dioxide. The lungs expand and contract up to
20 times per minute taking in and disposing of those gases.
Air that is breathed in is filled with oxygen and goes to the trachea, which
branches off into one of two bronchi. Each bronchus enters a lung. There are
two lungs, one on each side of the breastbone and protected by the ribs.
Each lung is made up of lobes, or sections. There are three lobes in the right
lung and two lobes in the left one. The lungs are cone shaped and made of
elastic, spongy tissue. Within the lungs, the bronchi branch out into minute
pathways that go through the lung tissue. The pathways are called
bronchioles, and they end at microscopic air sacs called alveoli. The alveoli
are surrounded by capillaries and provide oxygen for the blood in these
vessels. The oxygenated blood is then pumped by the heart throughout the
body. The alveoli also take in carbon dioxide, which is then exhaled from the
body.
Inhaling is due to contractions of the diaphragm and of muscles between the
ribs. Exhaling results from relaxation of those muscles. Each lung is
DISCHARGE PLANNING
Drink lots of fluids, especially water. Liquids will keep patient from
becoming dehydrated and help loosen mucus in the lungs.
germs enter ones body when he touch his eyes or rub his nose.
Washing hands thoroughly and often can help reduce the risk.
Protect others from infection. Try to stay away from anyone with a
compromised immune system. When that isnt possible, a person can
help protect others by wearing a face mask and always coughing into a
tissue.
Drug Name
Dosage &
Route
Action
Indication
Adverse Effects
Contraindicatio
n
Nursing Responsibility
LOSARTAN
POTASSIUM
(lo-sar'tan)
Cozaar
Classifications
: cardiovascular
agent;
angiotensin ii
receptor
antagonist;
antihypertensive
Hypertensio
n
Adult: PO 25
50 mg in 12
divided doses
(max: 100
mg/d); start
with 25 mg/d
if volume
depleted (i.e.,
on diuretics)
Angiotensin II
receptor
(type AT1)
antagonist
acts as a
potent
vasoconstrict
or and
primary
vasoactive
hormone of
the renin
angiotensin
aldosterone
system.
Hypertension
CNS: Dizziness,
insomnia,
headache. GI:
Diarrhea,
dyspepsia.
Musculoskeleta
l: Muscle cramps,
myalgia, back or
leg pain.
Respiratory:
Nasal
congestion,
cough, upper
respiratory
infection,
sinusitis.
Hypersensitivity to
losartan, pregnancy
[category C (first
trimester), category
D (second and third
trimesters)], lactation
Monitor BP at
drug trough
(prior to a
scheduled
dose).
Monitor drug
effectiveness,
especially in
AfricanAmericans when
losartan is used
as monotherapy.
Inadequate
response may
be improved by
splitting the
daily dose into
twice-daily dose.
Lab tests:
Monitor CBC,
electrolytes,
liver & kidney
function with
long-term
therapy.
Drug Name
FUROSEMIDE
(fur-oh'se-mide)
Fumide ,
Furomide , Lasix,
Luramide
Classifications
: ELECTROLYTIC
AND WATER
BALANCE
AGENT; LOOP
DIURETIC
Dosage &
Route
Edema
Adult: PO 2080
mg in 1 or more
divided doses up
to 600 mg/d if
needed IV/IM 20
40 mg in 1 or
more divided
doses up to 600
mg/d
Child: PO 2
mg/kg, may be
increased by 12
mg/kg q68h
(max: 6
mg/kg/dose) IV/I
M 1 mg/kg, may
be increased by
1 mg/kg q2h if
needed (max:
mg/kg/dose)
Neonate: PO 14
mg/kg q12
24h IV/IM 12
mg/kg q1224h
Hypertension
Adult: PO 1040
mg b.i.d. (max:
480 mg/d)
Action
Rapid-acting
potent
sulfonamide
"loop" diuretic
and
antihypertensi
ve with
pharmacologic
effects and
uses almost
identical to
those of
ethacrynic
acid. Exact
mode of action
not clearly
defined;
decreases
renal vascular
resistance and
may increase
renal blood
flow
Indication
Treatment of
edema
associated
with CHF,
cirrhosis of
liver, and
kidney
disease,
including
nephrotic
syndrome. May
be used for
management
of
hypertension,
alone or in
combination
with other
antihypertensi
ve agents, and
for treatment
of
hypercalcemia.
Has been used
concomitantly
with mannitol
for treatment
of severe
cerebral
edema,
particularly in
meningitis.
Adverse
Effects
CV: Postural
hypotension,
dizziness with
excessive
diuresis, acute
hypotensive
episodes,
circulatory
collapse.
Metabolic:
Hypovolemia,
dehydration,
hyponatremia
hypokalemia,
hypochloremia
metabolic
alkalosis,
hypomagnesemi
a, hypocalcemia
(tetany),
hyperglycemia,
glycosuria,
elevated BUN,
hyperuricemia.
GI: Nausea,
vomiting, oral
and gastric
burning,
anorexia,
diarrhea,
constipation,
abdominal
cramping, acute
pancreatitis,
jaundice.
Urogenital:
Allergic
interstitial
nephritis,
irreversible
renal failure,
urinary
frequency.
Hematologic:
Anemia,
leukopenia,
thrombocytopen
ic purpura;
aplastic anemia,
agranulocytosis
(rare). Special
Senses: Tinnitus,
Contraindicatio
n
History of
hypersensitivity
to furosemide or
sulfonamides;
increasing
oliguria, anuria,
fluid and
electrolyte
depletion states;
hepatic coma;
pregnancy
(category C),
lactation.
Nursing
Responsibility
Assessment &
Drug Effects
Observe
patients
receiving
parenteral drug
carefully;
closely monitor
BP and vital
signs. Sudden
death from
cardiac arrest
has been
reported.
Monitor BP
during periods
of diuresis and
through period
of dosage
adjustment.
Observe
older adults
closely during
period of brisk
diuresis.
Sudden
alteration in
fluid and
electrolyte
balance may
precipitate
significant
adverse
reactions.
Report
symptoms to
physician.
Lab tests:
Obtain frequent
blood count,
serum and
urine
electrolytes,
CO2, BUN, blood
sugar, and uric
acid values
during first few
months of
therapy and
periodically
thereafter.
Monitor for
S&S of
hypokalemia.
vertigo, feeling
of fullness in
ears, hearing
loss (rarely
permanent),
blurred vision.
Skin: Pruritus,
urticaria,
exfoliative
dermatitis,
purpura,
photosensitivity,
porphyria
cutanea tarde,
necrotizing
angiitis
(vasculitis).
Body as a Whole:
Increased
perspiration;
paresthesias;
activation of
SLE, muscle
spasms,
weakness;
thrombophlebiti
s, pain at IM
injection site.
Monitor I&O
ratio and
pattern. Report
decrease or
unusual
increase in
output.
Excessive
diuresis can
result in
dehydration
and
hypovolemia,
circulatory
collapse, and
hypotension.
Weigh patient
daily under
standard
conditions.
Monitor urine
and blood
glucose & HbA1C
closely in
diabetics and
patients with
decompensated
hepatic
cirrhosis. Drug
may cause
hyperglycemia.
Intensive
Care
Unit
Drug Name
PHENOBARBITAL
SODIUM
Luminal Sodium
Classifications:
CENTRAL
NERVOUS SYSTEM
AGENT;
ANTICONVULSANT
; SEDATIVEHYPNOTIC;
BARBITURATE
Dosage &
Route
Anticonvulsa
nt
Adult: PO 100
300 mg/d IV/IM
200600 mg up
to 20 mg/kg
Child: PO/IV 38
mg/kg or 125
mg/m2/d
Neonate: PO/IV
34 mg/kg/d
(max: 5
mg/kg/d)
Status
Epilepticus
Adult/Child: IV
1518 mg/kg in
single or
divided doses
(max: 20
mg/kg)
Neonate: IV 15
20 mg/kg in
single or
divided doses
Sedative
Adult: PO 30
120 mg/d IV/IM
100200 mg/d
Child: PO 6
mg/kg/d or 180
mg/m2 in 3
divided
doses IV/IM 16
100 mg/d (13
Action
Indication
Long-acting
barbiturate.
Sedative and
hypnotic
effects of
barbiturates
appear to be
due primarily
to
interference
with impulse
transmission
of cerebral
cortex by
inhibition of
reticular
activating
system. CNS
depression
may range
from mild
sedation to
coma,
depending on
dosage, route
of
administratio
n, degree of
nervous
system
excitability,
and drug
tolerance.
Initially,
barbiturates
suppress REM
sleep, but
with chronic
therapy REM
sleep returns
to normal.
Long-term
managemen
t of tonicclonic
(grand mal)
seizures and
partial
seizures;
status
epilepticus,
eclampsia,
febrile
convulsions
in young
children.
Also used as
a sedative
in anxiety or
tension
states; in
pediatrics as
preoperative
and
postoperativ
e sedation
and to treat
pylorospasm
in infants.
Adverse
Effects
Body as a Whole:
Myalgia,
neuralgia, CNS
depression,
coma, and
death. CNS:
Somnolence,
nightmares,
insomnia,
"hangover,"
headache,
anxiety, thinking
abnormalities,
dizziness,
nystagmus,
irritability,
paradoxic
excitement and
exacerbation of
hyperkinetic
behavior (in
children);
confusion or
depression or
marked
excitement
(older adult or
debilitated
patients); ataxia.
CV: Bradycardia,
syncope,
hypotension. GI:
Nausea,
vomiting,
constipation,
diarrhea,
epigastric pain,
liver damage.
Contraindicatio
n
Sensitivity to
barbiturates;
manifest hepatic
or familial history
of porphyria;
severe
respiratory or
kidney disease;
history of
previous
addiction to
sedative
hypnotics;
uncontrolled
pain; pregnancy
(particularly
early pregnancy)
(category D),
lactation;
sustained
release
formulation for
children <12 y of
age.
Nursing
Responsibility
Assessment &
Drug Effects
Observe
patients
receiving large
doses closely
for at least 30
min to ensure
that sedation is
not excessive.
Keep patient
under constant
observation
when drug is
administered
IV, and record
vital signs at
least every
hour or more
often if
indicated.
Lab tests:
Obtain liver
function and
hematology
tests and
determinations
of serum folate
and vitamin D
levels during
prolonged
therapy.
Monitor
serum drug
levels. Serum
concentrations
>50 mcg/mL
may cause
coma.
Therapeutic
mg/kg)
Hematologic:
Megaloblastic
anemia,
agranulocytosis,
thrombocytopeni
a. Metabolic:
Hypocalcemia,
osteomalacia,
rickets.
Musculoskeletal:
Folic acid
deficiency,
vitamin D
deficiency.
Respiratory:
Respiratory
depression. Skin:
Mild
maculopapular,
morbilliform
rash; erythema
multiforme,
Stevens-Johnson
syndrome,
exfoliative
dermatitis (rare).
.
serum
concentrations
of 1540
mcg/mL
produce
anticonvulsant
activity in most
patients. These
values are
usually
attained after
2 or 3 wk of
therapy with a
dose of 100
200 mg/d.
Expect
barbiturates to
produce
restlessness
when given to
patients in
pain because
these drugs do
not have
analgesic
action.
Be prepared
for paradoxical
responses and
report
promptly in
older adult or
debilitated
patient and
children (i.e.,
irritability,
marked
excitement
[inappropriate
tearfulness
and aggression
in children],
depression,
and confusion).