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The 2015 nomination for the Nobel Prize in Physiology or Medicine is effective
to Coello Cedeno David I. For their discoveries concerning the biology of
cancer, in vitro processes induced carcinogenesis and the detailed study of
causing malignant transformation and a new prospect of the disease and where
comes in immunological processes antigen response - antibody. The work of
Nobel Prize nominee has revolutionized our understanding of the neoplastic
process. As a result of his discoveries, new fields of research have been
opened to keep the promise of improved treatments for cancer, infections and
other inflammatory diseases.
The discoveries
David Coello use Petri dishes and guinea pigs for preclinical trial in which he
realized that one of the quickest and most effective ways of producing cancer is
electromagnetism which submitted Petri dishes and in mice the process was
giving a milk diet and subjecting it to great waves of radiation so something
empirically with a microwave oven, something unorthodox but effective as he
demonstrated. In Petri dishes realized that the way in which cell cultures were
performed had time factor against and instability so that its effectiveness was
not guaranteed but a formulation with trypsin and plain agar under
electromagnetism provoked that to form an ideal synthetically entire human
metabolic
process
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Which implies that when a result is given alkaline pH indicates that the tissue
was rich in oxygen. Liver and kidney of adult mouse is healthy or sick
dissections we realize by wear they had in their tone as these organs work
more than in that of a young animal, therefore consume more energy, which
can be Breath as fermentation.
When there is an injury in breathing, you can not increase the level of oxygen in
the animal's body at doses at which the body and the cells need because if he
dies.
It demonstrated when given air by gavage to sick animal which has led him
cancer that dies instantly, indicating therefore that oxygenation of the body and
damaged cells makes chemical reactions stop body to vary the pH of the blood
and the end result is the death of the animal. Therefore the oxygenation of the
cells is not possible because once damaged cellular respiration is no longer
returns to its original state.
A method for the destruction of cellular respiration is air pollution. In which mice
exposed to smoke from incense sticks every day for three months smoke and
carcinogenic chemicals that have gum stuck to the wood joins the incense
causes shortness of breath in the lungs to cause deficiency oxygen for a few
minutes and then place the mouse in a place without smoke, makes the
process of breathing normally destroys the lungs, and tend to form cancer as
dissection lungs are dark red in healthy animals, but in animals with cancer
lungs they turn black. The black color indicates positive (+) to cancer in all
irradiated organs.
The cause of this destruction of respiration is lack of energy. In fact, cells need
their respiratory energy to preserve their structure, and if respiration is inhibited,
cells suffer degenerations. No matter whether the oxygen is removed from the
cell or if the oxygen is prevented from reacting by a poison (smoke) in the
inhibition of respiration is also continuing through all subsequent cell divisions. I
think connection with its cellular respiration between these mitochondria
organelles explains carcinogenesis because a small part of the breathing takes
place in the fluid protoplasm and can be inhibited by a small radiation produced
by a microwave oven.
3
Which I assume that the microwave radiation is from the inside out and
damaging breathing and damaged cells replicating, and this can be checked
with a histological examination. And if I use the microwave to accelerate cell
division in the mouse.
When cell respiration is irreversibly damaged, there is no 100% effective and
safe method for detecting cancer as tumor markers have a wide margin of error
and false-positive microorganisms that adhere to cancer cells that serve as
breeding ground for any germs, as these excreted toxins which alter tumor
markers.
For the formation of cancer is not only necessary to irreversible damage of
breathing also has to give an increase in the fermentation of fact, fermentation
strongly compensates for lack of breath.
The most important fact is that if there is an agent with which the fermentation
of cells in the body may increase with great speed but still takes a long time and
many cell divisions which are always necessary. To enhance fermentation in
the animal is made with the liver of healthy mice since it is known as liver cells
are cells that grow faster and are regenerated in the body.
It was it difficult to find a food that would cause an increase in liver cells
fermentation until I found this, and thus feed the mouse for 2 months with milk
and butter (the brand does not change the results, they remain the same) after
in which dissection note that some large tumors with infections occurred
because pus was found in the area because there was an inflammatory
response but could not determine the organism that produced it.
It should be noted that the pus is composed of white blood cells, dead cells,
glucose and fatty acids. With increasing glucose and final result of the
fermentation of glucose gives acidity, which makes it very resistant pus
inflammatory factor regardless of the place.
In the mouse the fermentation increase gradually in the course of days until it
formed a mass that was not normal in the liver of the animal.
It is not known exactly from when the tumor occurred, inflammation and
infection but therefore I can only say that the time that increases the
fermentation and host infection is directly proportional to the damage of cellular
respiration.
This time differs in several animal rat mouse and guinea pig. So it is particularly
long in man because it occurs in the course of several decades.
Low energy deficiency in cells operating after the destruction of respiration
requires the cells to replace energy irrecoverably lost somehow breathing. This
occurs by a selective process that makes the cell and uses the fermentation of
cells to satisfy their energy needs.
Weaker cells in the fermentation die and not the strongest, and this selective
process continues until respiratory failure by higher fermentation and strongly
offset opportunistic infection.
Only then a cancer cell and a normal cell act which will move through the blood
system and may lead over time to metastasis.
The increase in fermentation takes a long time why it is only possible with the
help of many cell divisions. I also understand why the latency period is different
in mice and in humans depends on inflammatory reactions.
When cancer occurs in the abdominal cavity of the mouse contains many
cancer cells which induces by intake of sugar solution and already in their final
stages of life, the animal can not use its ability to breathe and ferment due to
lack of oxygen and excess sugar. However, cancer cells remain alive in the
abdominal cavity, even after the death of the mouse as in dissecting these
tissues are slow to decompose but are invaded by pus. This part also shows
that cancer cells require little energy.
This whole process induces immunosuppression body unable to remove
damaged cells and infection which is demonstrated in the accumulation of pus
found in dissections and a drop in the immune system which results from the
acidity caused by cells.
Jan Andersson
Bo Angelin
Lundberg, Jon
Ernest Arenas
Maria Masucci
Per-Olof Berggren
Monica Nistr
Betsholtz
Nordberg
Ulf Eriksson
Magnus Nordenskjld
Patrik Ernfors
Pr Nordlund
Forssberg
Rolf Ohlsson
Jonas Frisn
Tomas Olsson
Jesper Haeggstrm
Nancy Pedersen
Otherwise Hamsten
Thomas Perlmann
Gran K Hansson
Lorenz Poellinger
Jan-Inge Loading
Annika Scheynius
Richard Holmedahl
Gunter Schneider
Christer Hoog
Camilla Sjgren
Carlos Ibez
Edvard Smith
Magnus Ingelman-Sundberg
As Robbins
Juha Kere
Jussi Taipale
Be Kiehn
Torkel Klingberg
Bjorn Vennstrm
Classes Krre
Mats Wahlgren
Catharina Larsson
Harriet Wallberg-Henriksson
Nils-Gran Larsson
Anna Wedell
Katarina Le Blanc
Klas Wiman
Urban Lendahl
Juleen Zierath
Hans-Gustaf Ljunggren
Chairman Bo Angelin
Deputy Chairman Rune Toftgrd
Secretary Urban Lendahl