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286
Classification of studies
If a publication met the above criteria, individuals were classified
into one of three groups: first-episode schizophrenia, youth-onset
schizophrenia and late-onset schizophrenia. To be classified into
youth-onset schizophrenia, individuals with schizophrenia had
to have a maximum age at onset of 19 years. To be classified into
late-onset schizophrenia, people with schizophrenia had to have a
minimum age at onset of 40 years. For any other age at onset, a
selected publication was classified into the first-episode schizophrenia category provided that the study included and analysed
separately those individuals with first-episode schizophrenia.
Age at onset is defined differently in different studies. It is used
to refer to age at first behavioural changes (e.g. DeLisi et al 23),
age at first manifestation of positive symptoms (e.g. White et
al 16) or age at first admission to hospital (e.g. Bellgrove et al 24).
However, these different stages have been shown to be correlated
and typically within 618 months of each other.5,23,25 Thus, when
classifying a study, we accepted the definition of age at onset as
described in each individual study.
Extracted variables
After the selection and classification of a publication, the following
variables were extracted and recorded: journal name, title, first
author and year of publication. In addition, the following
variables were recorded for patients and controls separately:
number of participants and mean (s.d.) age. Some studies only
provided an age threshold (e.g. onset before age 14); when mean
(s.d.) age at onset was provided, it was recorded and mean
duration of illness was estimated based on the difference between
mean age at onset and mean age. Finally, the cognitive data were
recorded as follows.
Cognitive measures
The data from each cognitive test were extracted and classified
into one of 22 cognitive measures (see Online supplement). The
selection of these 22 measures followed a seminal quantitative
review of cognitive deficits in schizophrenia.11 As noted in that
review, organizing the myriad of neurocognitive test variables
reported in the literature into a coherent classification [is] a major
challenge. We adopted the strategy employed in that review
because it accounts for two opposing yet complementary
approaches. The first approach is to avoid aggregating cognitive
tests and to report results of individual tests. This approach is
supported by the fact that most individual tests are mediated by
multiple cognitive processes and tap into more than one cognitive
function. Thus, aggregation into a single cognitive measure could
result in misleading effect sizes that do not correspond to a
specific cognitive function. This is also relevant to our review
considering that in different groups (first-episode, youth-onset
and late-onset schizophrenia), different cognitive tests have been
used to assess particular cognitive measures. Consequently,
contrasting effect sizes that correspond to these cognitive
measures could be problematic. Thus, whenever possible, results
of individual tests were reported separately. The second approach
is to aggregate cognitive tests into a single measure based on
287
Rajji et al
6
605 publications reviewed in full text
7
6
109 publications included in the analysis
and classified into: 78 first-episode,a 23 youth-onseta
and 9 late-onset schizophrenia
Fig. 1
a. One publication contributed to both first-episode schizophrenia and youth-onset schizophrenia groups.
Discussion
We meta-analysed the results of 109 published studies that have
compared cognitive functions of 5010 people with schizophrenia
with that of healthy controls. To our knowledge, this is the first
meta-analysis that addresses the relationship between age at onset
and cognition in schizophrenia. When individuals were classified
based on their age at onset into those with adult-onset at their first
episode of schizophrenia, youth-onset schizophrenia and late-onset
Descriptive data
Total, na
Age, years:
weighted means (s.d.)
First-episode schizophrenia
4057
24.0 (0.6)
23.7 (1.5)
0.3 (0.4)
Youth-onset schizophrenia
692
16.0 (0.3)
13.6 (0.7)
2.3 (0.2)
Late-onset schizophrenia
261
68.4 (2.6)
60.7 (4.2)
7.7 (2.3)
Group
a. For first-episode, youth-onset and late-onset schizophrenia the total number of individuals for whom age at onset was reported was 850, 187 and 74 respectively.
b. Duration of illness was calculated by subtracting age at onset from age at time of assessment.
288
(a)
FSIQ (n=29;
VIQ (n=7;
PIQ (n=5;
GLOBAL (n=7;
DIG SY (n=15;
TOWER (n=13;
VISM (n=55;
VER GM (n=42;
VOCAB (n=16;
ARTH (n=6;
FLUEN (n=32;
VIS ATT (n=52;
STROOP (n=21;
CPT (n=28;
VS (n=34;
TMB (n=17;
VER SM (n=54;
TMA (n=17;
WISC (n=45;
PSY MOT (n=62;
AUD ATT (n=7;
DIG SP (n=24;
d=0.86)
d=1.14)
d=1.95)
d=0.61)
d=1.51)
d=1.26)
d=1.09)
d=1.09)
d=1.04)
d=1.03)
d=1.03)
d=1.00)
d=0.93)
d=0.90)
d=0.88)
d=0.87)
d=0.86)
d=0.78)
d=0.77)
d=0.74)
d=0.69)
d=0.62)
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
(b)
FSIQ (n=15;
VIQ (n=4;
PIQ (n=3;
DIG SY (n=10;
TOWER (n=10;
VISM (n=8;
VER GM (n=12;
VOCAB (n=8;
ARTH (n=4;
FLUEN (n=6;
VIS ATT (n=11;
STROOP (n=4;
CPT (n=10;
VS (n=10;
TMB (n=6;
VER SM (n=15;
TMA (n=6;
WISC (n=13;
PSY MOT (n=17;
AUD ATT (n=6;
DIG SP (n=7;
d=2.13)
d=1.20)
d=1.27)
d=1.45)
d=0.61)
d=1.13)
d=0.96)
d=1.39)
d=1.28)
d=0.83)
d=0.67)
d=1.14)
d=0.70)
d=1.07)
d=1.33)
d=1.17)
d=0.70)
d=0.93)
d=0.84)
d=0.58)
d=0.88)
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
(c)
FSIQ (n=4; d=1.53)
1
2
Mean effect size (error bar: 95% CI)
289
Rajji et al
Table 2
Youth-onset
schizophrenia
(YOS)
Late-onset
schizophrenia
(LOS)
Qbetween
Full-scale IQ
0.89 (0.04)
1.77 (0.07)
1.61 (0.15)
121.64***
Verbal IQ
1.31 (0.08)
1.19 (0.13)
1.34 (0.16)
0.75
Performance IQ
1.73 (0.09)
1.25 (0.15)
2.07 (0.23)
11.75**
FES=YOS=LOS
Cognitive measure
0.67 (0.10)
1.67 (0.11)
45.74***
FES5LOS
1.46 (0.05)
1.46 (0.09)
0.29 (0.22)
27.18***
0.78 (0.05)
0.57 (0.08)
0.97 (0.15)
8.18*
FES=YOS=LOS
Visual memory
0.85 (0.03)
0.95 (0.10)
1.12 (0.09)
9.46**
FES=YOS=LOS
1.03 (0.03)
0.98 (0.07)
1.11 (0.13)
0.86
Vocabulary
1.02 (0.05)
1.18 (0.11)
0.42 (0.19)
11.76**
Arithmetic
0.99 (0.07)
1.37 (0.12)
0.24 (0.26)
17.74***
Fluency
0.87 (0.03)
0.96 (0.10)
1.47 (0.14)
17.50***
Visual attention
0.72 (0.03)
0.66 (0.08)
1.51 (0.15)
26.72***
Stroop test
0.86 (0.04)
1.14 (0.13)
1.76 (0.27)
14.20**
FES=YOS=LOS
0.83 (0.04)
0.73 (0.08)
1.17
Visuospatial construction
0.83 (0.03)
0.98 (0.08)
1.41 (0.18)
12.97**
FES=YOS=LOS
0.77 (0.05)
1.12 (0.10)
9.82**
0.94 (0.03)
1.18 (0.06)
1.20 (0.12)
15.04***
FES5YOS
0.66 (0.04)
0.70 (0.10)
8.82*
0.76 (0.03)
2.00 (0.08)
1.13 (0.12)
231.41***
0.65 (0.02)
0.92 (0.06)
1.01 (0.21)
19.68***
Auditory attention
0.61 (0.08)
0.53 (0.12)
1.95 (0.27)
23.47***
Digit span
0.64 (0.04)
0.85 (0.10)
0.87 (0.12)
6.69*
FES=YOS=LOS
Cognitive measure
a. Qbetween comparison when there are only two groups; post hoc pair-wise comparison using Bonferroni adjustments when there are three groups and Qbetween is statistically
significant. =, no significant difference between the weighted-mean effect sizes, X5Y, X weighted mean effect size is smaller than Y weighted mean effect size.
*P50.05, **P50.01, ***P50.001.
FSIQ
VIQ
PIQ
GLOBAL
DIG SY
TOWER
VISM
VER GM
VOCAB
ARTH
FLUEN
STROOP
VIS ATT
CPT
VS
TMB
VER SM
TMA
WISC
PSY MOT
AUD ATT
DIG SP
First-episode schizophrenia
Youth-onset schizophrenia
Late-onset schizophrenia
0.50
1.00
1.50
Weighted mean effect size
2.00
2.50
Fig. 3 Qualitative comparison of weighted mean effect sizes (weighted d-values) of cognitive deficits of participants with first-episode,
youth-onset schizophrenia and late-onset schizophrenia compared with healthy controls.
FSIQ, full-scale IQ; VIQ, verbal IQ; PIQ, performance IQ; GLOBAL, global measure of cognition; DIG SY, digit symbol coding; TOWER, Tower of London and similar tests; VISM, visual
memory; VER GM, verbal general memory; VOCAB, vocabulary; ARTH, arithmetic; FLUEN, fluency; VIS ATT, visual attention; STROOP, Stroop test; CPT, continuous performance test;
VS, visuospatial construction; TMB, trail making test B; VER SM, verbal special memory; TMA, trail making test A; WISC, Wisconsin card sorting and similar tests; PSY MOT,
psychomotor speed of processing; AUD ATT, auditory attention; DIG SP, digit span.
290
291
Rajji et al
Funding
9 Crow TJ, Colter N, Frith CD, Johnstone EC, Owens DGC. Developmental arrest
of cerebral asymmetries in early onset schizophrenia. Psychiatry Res 1989;
29: 24753.
10 Raz S, Raz N. Structural brain abnormalities in the major psychoses a
quantitative review of the evidence from computerized imaging. Psychol Bull
1990; 108: 93108.
11 Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a
quantitative review of the evidence. Neuropsychology 1998; 12: 42645.
12 Rajji TK, Mulsant BH. Nature and course of cognitive function in late-life
schizophrenia: a systematic review. Schizophr Res 2008; 102: 12240.
13 Green MF, Kern RS, Heaton RK. Longitudinal studies of cognition and
functional outcome in schizophrenia: implications for MATRICS. Schizophr
Res 2004; 72: 4151.
T.K.R. is supported by the Centre for Addiction and Mental Health (CAMH) and the
Canadian Institutes of Health Research (CIHR180087).
Acknowledgements
Appendix
Literature search: databases and search terms
A literature search of 29 databases was performed using CINAHL,
EMBASE, and the multi-database search engine, Scholars Portal that
includes MEDLINE, PsycARTICLES, PsycINFO, Psychology: A SAGE Full-Text
Collection, and the following: AGRICOLA, Aqualine, ASFA: Aquatic
Sciences and Fisheries Abstracts, Biological and Agricultural Index,
Biological Sciences, Biology Digest, Biotechnology and Bioengineering
Abstracts, Compendex, Conference Papers Index, Digital Dissertations,
E-Journals, EIS: Digests of Environmental Impact Statements, Environmental
Sciences and Pollution Mgmt, General Science Abstracts, Geobase,
GeoRef, GeoRef In Process, Meteorological & Geoastrophysical Abstracts
Oceanic Abstracts, Pharmaceutical News Index, Physical Education Index,
Plant Science, Science Citation Index Expanded, Scopus Natural Sciences,
TOXLINE and Zoological Record Plus.
The following search terms were used: schizophrenia, schizoaffective, psychotic disorder, age of onset, age at onset, childhood onset,
adolescent onset, late onset, first episode, cognition, neuropsychology,
memory, learning, Wechsler, complex figure, face recognition, spatial
perception, line orientation, Purdue, motor dexterity, finger tapping, motor
disorder, Stroop test, digit span, continuous performance test, backward
masking, trails, trail making, Wisconsin card sorting test, IQ, vocabulary,
block design, word fluency, token, comprehension, affect recognition,
dichotic listening.
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Cognitive measures and associated tests
1. Auditory attention (AUD ATT): Auditory Consonant
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