Metformin

Type 2 diabetes mellitus: (immediate-release tablets, oral solution)

initial, 500 mg ORALLY twice daily or 850 mg ORALLY once daily
Type 2 diabetes mellitus: (immediate-release tablets, oral solution)
maintenance, titrate in 500 mg increments weekly, or 850 mg
increments every 2 weeks; divided dose range, 1000 to 2550 mg
ORALLY daily in 2 to 3 divided doses, MAX 2550 mg/day

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Glybenclamide(Glyburide)
Type 2 diabetes mellitus: initial, 2.5 to 5 mg ORALLY once daily;
titrate in increments of no more than 2.5 mg weekly based on
glycemic response; MAX 5 mg/day; may consider initiating at 1.25
mg ORALLY once daily in patients more sensitive to hypoglycemic
drugs

Type 2 diabetes mellitus: maintenance, 1.25 to 20 mg ORALLY once

daily or in 2 divided doses; MAX 20 mg/day


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Glipizide
Type 2 diabetes mellitus: immediate-release: initial, 5 mg ORALLY
once daily
Type 2 diabetes mellitus: immediate-release: maintenance, titrate in
2.5- to 5-mg increments; allow several days between titration steps;
MAX 40 mg daily (doses above 15 mg should be divided)

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Gliclazide
Type 2 diabetes mellitus

a) Gliclazide has been administered in initial doses of 40 or 80

milligrams orally daily with breakfast. The dose is increased in

increments of 40 or 80 milligrams (usually weekly) until adequate

glycemic control is achieved. The drug can be given once daily,
although twice-daily therapy (with meals) may be indicated in some
patients.

b) In several studies, adequate control of blood glucose has been

achieved with average daily doses of 160 to 200 milligrams. In
general, lower doses are required in patients previously untreated with
sulfonylureas and/or biguanides

MAXIMUM DOSE

1) Maximum doses have usually been 320 milligrams daily

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rd

Drug information Handbook 23 edition usual dosage

range : 80-320 mg/day (maximum dose : 320 mg/day)

Glimepiride
Type 2 diabetes mellitus: initial, 1 to 2 mg ORALLY once daily

 Type 2 diabetes mellitus: maintenance, increase in increments of 1 to

2 mg ORALLY no more than every 1 to 2 weeks based on glycemic
response; MAX 8 mg/day

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Pioglitazone
Type 2 diabetes mellitus: initial, 15 or 30 mg ORALLY once daily;
titrate in 15-mg increments; MAX 45 mg daily

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Acarbose
Type 2 diabetes mellitus: initial, 25 mg ORALLY 3 times a day with
the first bite of each main meal; may initiate at 25 mg ORALLY once
daily with gradual dose titration to 25 mg ORALLY 3 times a day in
some patients to minimize gastrointestinal side effects
Type 2 diabetes mellitus: maintenance, dose may be increased at 4- to
8-week intervals to 50 to 100 mg ORALLY 3 times a day with the
first bite of each main meal; MAX 50 mg three times daily for
patients weighing 60 kg or less and MAX 100 mg three times daily
for those weighing more than 60 kg

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Sitagliptin
Type 2 diabetes mellitus: 100 mg ORALLY once daily with or
without food; when administered with a sulfonylurea or insulin, a
lower dose of sulfonylurea or insulin may be required


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