Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
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I.!!Hypoxia C!'2/&+D#/$+!(:4=+2/$'(2!()!$'66#+!?6/E+!&+)'2'$'(2!()!/6!68(<FB@!"++&!GH!)(0!
(:'&/$'(2!98(698(04*/$'(2!9/$8>/4!7!>8+0+!4(#!=+$!%IJ!)0(E!'22+0!K'$(!E+EL0/2+!?+*+<$0(2!
$0/269(0$!646$+E;!</**+&!(:'&/$'M+!98(698(04*/$'(2B@!I8+!*/6$!0:2!'6!GH!$(!0+<+'M+!$8+!+*+<$0(26@!
J0($(26!/0+!L+'2=!F'<F+&!());!=(!L/<F!'2$(!$8+!E+EL0/2+;!/2&!)(0E!%IJ;!/2&!%IJ!'2!)(0E+&!'2!$8+!
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A. Terms:
1. Oxygen content!C!NL!:!GH!6/$2!O!9/0$'/*!90+66#0+!()!/0$+0'/*!(:4=+2!
?$8+6+!/0+!$8+!P!E/'2!$8'2=6!$8/$!</004!GH!'2!(#0!L*((&B!
!
12!NL;!$8+!GH!/$$/<8+6!$(!8+E+!=0(#9!?GH!6/$Q2B!
J/0$'/*!90+66#0+!()!/0$+0'/*!GH!'6!GH!&'66(*M+&!'2!9*/6E/!
!
12!RS.;!)(#0!8+E+!=0(#96!?T+!E#6$!L+!OHU!')!T+O!'6!OP;!'$!</22($!</004!GHB!
I8+0+)(0+;!>8+2!/**!)(#0!8+E+!=0(#96!8/M+!/2!GH!(2!'$;!$8+!GH!6/$Q2!'6!,VVW@!
2. O2 satn '6!$8+!GH!1"!$8+!RS.!'6!/$$/<8+&!IG!$8+!8+E+!=0(#9!C!?E+/6#0+&!L4!/!9#*6+!
(:'E+$+0B!
!
3.!!Partial pressure of O2!'6!GH!&'66(*M+&!'2!JX%YK%!
!
GH!)*(>-!)0(E!/*M+(*'!$80(#=8!$8+!'2$+098/6+;!$8+2!&'66(*M+6!'2!9*/6E/;!/2&!'2<0+/6+6!$8+!
9/0$'/*!90+66#0+!()!GH;!&'))#6+6!$80(#=8!$8+!RS.!E+EL0/2+!/2&!/$$/<8+6!$(!$8+!8+E+!=0(#96!
(2!$8+!RS.!(2!$8+!NL;!>8'<8!'6!$8+!GH!6/$Q2!
!
I8+0+)(0+!7!')!9/0$'/*!90+66#0+!()!GH!'6!&+<0+/6+&;!GH!6/$Q2!N%Y!$(!L+!&+<0+/6+&!?SZ<!GH!</E+!
)0(E!/E(#2$!$8/$!>/6!&'66(*M+&!'2!9*/6E/B!
B. Causes of tissue hypoxia:
1. Ischemia!?&+<0+/6+!'2!%RI[R1%X!L*((&!)*(>!AA"GI!M+2(#6B!
!
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$8+0+)(0+!K1!'6!=((&!+:/E9*+!()!'6<8+E'/!LZ<!$80(EL#6!'6!L*(<F'2=!/0$+0'/*!L*((&!)*(>;!
90(&#<'2=!$'66#+!849(:'/B!
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</0&'(=+2'<!68(<FB!LZ<!$8+0+!'6!/!&+<0+/6+!'2!/0$+0'/*!L*((&!)*(>@!
2. 2nd MCC of tissue hypoxia = hypoxemia
Hypoxia!C!]L'=Q!$+0E!
Hypoxemia!C!</#6+!()!849(:'/!?$8+4!/0+!2($!$8+!6/E+BU!&+/*6!>'$8!$8+!9/0$'/*!90+66#0+!()!
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$8+6+!/0+!$8+!9'$$'2=!+&+E/!6$/$+6!7!'+!RNT;!<'008(6'6!()!$8+!*'M+0@!!g8+2!$($/*!L(&4!"/!'6!
'2<0+/6+&;!'$!/*>/46!90(&#<+6!9'$$'2=!+&+E/@!!g8/$!<(E9/0$E+2$!'6!$8+!$($/*!L(&4!"/!'2n!
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P@!!Hypertonic state!7!L4!&+)'2'$'(2;!8/M+!$((!E#<8!"/!?849+02/$0+E'/B!(0!8/M+!
849+0=*4<+E'/!?'+!9$!>'$8!_5%!8/6!/!849+0$(2'<!<(2&'$'(2;!>8'<8!'6!E(0+!<(EE(2!$8/2!
849+02/$0+E'/B@!!g'$8!849+02/$0+E'/;!>8/$!&(+6!1.T!*((F!*'F+n!1$!>'**!/*>/46!L+!<(2$0/<$+&!
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>/$+0!$8/2!6/*$!'2!$8+!#0'2+;!4(#!8/M+!(6E($'<!&'#0+6'6!7!E':$#0+@!!g8+2!$8+0+!'6!=*#<(6+!/2&!
E/22'$(*!'2!$8+!#0'2+;!4(#Q0+!*(6'2=!849($(2'<!6/*$!6(*#$'(2!'2!#0'2+@!!!
!
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L/L4!8/6!2(!/<<+66!$(!>/$+0!/2&!8/6!/!0($/M'0#6!'2)+<$'(2;!6+0#E!6(&'#E!68(#*&!L+!8'=8!
L+</#6+!*(6'2=!E(0+!>/$+0!$8/2!6/*$;!*+/&'2=!$(!849+02/$0+E'/@!!N(>+M+0;!E(6$!E(E6!='M+!
$8+!L/L4!>/$+0!$(!<(00+<$!$8+!&'/008+/U!$8+0+)(0+!$8+!L/L4!>'**!<(E+!'2!>'$8!2(0E/*!6+0#E!
"/!(0!+M+2!849(2/$0+E'/!LZ<!$8+!&+2(E'2/$(0!?NHGB!'6!'2<0+/6+&@!!I0+/$E+2$!'6!9+&'/*4$+!
/2&!l/$(0/&+!7!$8+6+!/0+!849($(2'<!6/*$!6(*#$'(2!?3#6$!='M+!$8+E!L/<F!>8/$!$8+4!*(6$B@!!g8/$!
8/6!$(!L+!'2!9+&'/*4$+!/2&!>8/$!8/6!$(!L+!'2!l/$(0/&+!$(!(0&+0!$(!0+/L6(0L!$8+!"/!'2!$8+!l1!
$0/<$n!!l*#<(6+!LZ<!()!$8+!<(d$0/269(0$@!!g'$8!$8+!<(d$0/269(0$;!$8+!"/!N%Y!$(!L+!0+/L6(0L+&!
>'$8!=*#<(6+!(0!=/*/<$(6+@!![:/E9*+-!<8(*+0/;!'2!(0/*!0+9*/<+E+2$;!2++&!=*#<(6+!$(!0+/L6(0L!
"/!LZ<!<(d$0/269(0$!9#E9!*(</$+&!'2!$8+!6E/**!'2$+6$'2+@!!l/$(0/&+!8/6!=*#<(6+!/2&!6#<0(6+!
?>8'<8!'6!<(2M+0$+&!$(!)0#<$(6+!/2&!=*#<(6+B@!
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E. Volume Compartments
%0$+0'/*!L*((&!M(*#E+!'6!6/E+!/6!6$0(F+!M(*#E+!/2&!.G!?</0&'/<!(#$9#$B@!!g8+2!.G!
&+<0+/6+6;!/**!9846'(*(='<!90(<+66+6!(<<#0!$(!0+6$(0+!M(*#E+@!!g'$8!&+<0+/6+!.G!?'+!
849(M(*+E'/B;!(:4=+2/$+&!L*((&!>'**!2($!=+$!$(!$'66#+6;!/2&!>+!</2!&'+@!I8+0+)(0+;!M(*#E+!'6!
+66+2$'/*!$(!(#0!L(&'+6@!!!
!
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M+2(#6!6'&+;!>8'*+!$8+!8'=8!90+66#0+!(2+6!/0+!(2!$8+!/0$+0'/*!6'&+!?'+!$8+!</0($'&6!/2&!/0<8!()!
/(0$/B@!!I8+4!/0+!#6#/**4!'22+0M/$+&!L4!."!r!/2&!,V!?$8+!8'=8!90+66#0+!(2+6B@!!g8+2!$8+0+!
'6!/!&+<0+/6+!'2!/0$+0'/*!L*((&!M(*#E+!?&+<0+/6+&!Yk!(0!.GB;!'$!>'**!#2&+0!)'**!$8+!/0<8!M+66+*6!
/2&!$8+!</0($'&U!'26$+/&!()!r$8!(0!,V$8!2+0M+!0+69(26+;!4(#!8/M+!/!64E9/$8+$'<!"Y!0+69(26+;!
$8+0+)(0+!</$+<8(*/E'2+6!/0+!0+*+/6+&@!!I8'6!'6!=((&!LZ<!$8+4!>'**!<(26$0'<$!$8+!M+2(#6!
646$+E;!>8'<8!>'**!'2<0+/6+!L*((&!0+$#02'2=!$(!$8+!0'=8$!6'&+!()!$8+!8+/0$!?&(!2($!>/2$!
M+2(&'*/$'(2!LZ<!'$!>'**!9((*!'2!4(#0!*+=6B@!!./$+<8(*/E'2+6!>'**!/<$!(2!$8+!L+$/!/&0+2+0='<!
0+<+9$(06!(2!$8+!8+/0$;!>8'<8!>'**!'2<0+/6+!$8+!)(0<+!()!<(2$0/<$'(2;!$8+0+!>'**!L+!/2!'2<0+/6+!
'2!6$0(F+!M(*#E+!?6*'=8$B!/2&!'$!>'**!'2<0+/6+!8+/0$!0/$+!?iOj!<80(2($0(9'<!+))+<$!(2!$8+!8+/0$;!
'2<0+/6+!'2!646$(*'<!SJB@!!%0$+0'(*+6!(2!$8+!646$+E'<!6'&+-!6$'E#*/$+!L+$/!0+<+9$(06!'2!6E(($8!
E#6<*+@!!_'/6$(*'<!90+66#0+!'6!0+/**4!&#+!$(!$8+!/E(#2$!()!L*((&!'2!$8+!/0$+0'/*!646$+E;!>8'*+!
4(#!8+/0$!'6!)'**'2=!>'$8!L*((&@!!g8(!<(2$0(*6!$8+!/E(#2$!()!L*((&!'2!/0$+0'(*+!646$+E;!>8'*+!
4(#0!8+/0$!'6!)'**'2=!'2!&'/6$(*+n!b(#0!9+0'98+0/*!0+6'6$/2<+!/0$+0'(*+6!7!$8/$!E/'2$/'26!4(#0!
&'/6$(*'<!L*((&!90+66#0+@!!Y(;!>8+2!$8+4!/0+!<(26$0'<$+&;!M+04!*'$$*+!L*((&!'6!=('2=!$(!$8+!
$'66#+6!?L/&!2+>6BU!=((&!2+>6-!F++9!#9!&'/6$(*'<!90+66#0+!7!$8'6!'6!'E9(0$/2$!LZ<!$8+!
<(0(2/04!/0$+0'+6!)'**!'2!&'/6$(*+6@!I8'6!'6!/**!&(2+!>'$8!</$+<8(*/E'2+6@!!R+2'2!646$+E!'6!
/<$'M/$+&!L4!</$+<8(*/E'2+6;!$((U!/2='($+26'2!11!</2!M/6(<(26$0'<$(0!$8+!9+0'98+0/*!/0$+0'(*+6!
?$8+0+)(0+!'$!8+*96!$8+!</$+<8(*/E'2+6B@!!%l!11!6$'E#*/$+6!,t!84&0(:4*/6+;!>8'<8!<(2M+0$6!
<(0$'<(6$+0(2+!'2$(!/*&(6$+0(2+;!/2&!6$'E#*/$+6!/*&(6$+0(2+!0+*+/6+;!>8'<8!*+/&6!$(!
0+/L6(09$'(2!()!6/*$!/2&!>/$+0!$(!=+$!</0&'/<!(#$9#$!#9@!!!
g'$8!&+<0+/6+&!Yk;!0+2/*!L*((&!)*(>!$(!$8+!F'&2+4!'6!&+<0+/6+&;!/2&!$8+!R%%!</2!L+!
6$'E#*/$+&!L4!$8'6!E+<8/2'6E;!$((@!!g8+0+!+:/<$*4!/0+!$8+!0+<+9$(06!)(0!$8+!3#:$/=*(E+0*#0!
/99/0/$#6n!%))+0+2$!/0$+0'(*+@!I8+0+!/0+!6+26(06;!>8'<8!/0+!E(&')'+&!6E(($8!E#6<*+!<+**6!
$8/$!6+26+!L*((&!)*(>@!!%_N!>'**!L+!0+*+/6+&!)0(E!/!2+0M+!0+69(26+;!/2&!9#0+!>/$+0!>'**!
'2<0+/6+!L#$!$8/$!&(+6!2($!8+*9!>'$8!'2<0+/6'2=!$8+!</0&'/<!(#$9#$@!!"++&!6/*$!$(!'2<0+/6+!.G@!!!
!
[:/E9*+-!L*++&'2=!$(!&+/$8!/2&!$8+0+!'6!/!*(66!()!P!XQ6!()!)*#'&!7!8(>!</2!4(#!F++9!SJ!#9n!
l'M+!2(0E/*!6/*'2+!'6!'6($(2'<!$8+0+)(0+!$8+!6/*'2+!>'**!6$/4!'2!$8+![.T!<(E9/0$E+2$@!!"(0E/*!
6/*'2+!'6!9*/6E/!>'$8(#$!$8+!90($+'2@!!%24!$'E+!4(#!8/M+!849(M(*+E'<!68(<F;!='M+!2(0E/*!
6/*'2+!$(!'2<0+/6+!SJ!LZ<!'$!6$/46!'2!$8+![.T!<(E9/0$E+2$@!!./22($!0/'6+!SJ!>'$8!w!2(0E/*!
6/*'2+!(0!eW!&+:$0(6+U!8/M+!$(!='M+!6(E+$8'2=!$8/$!0+6+EL*+6!9*/6E/!/2&!8/6!$8+!6/E+!
$(2'<'$4!()!9*/6E/@!"(0E/*!6/*'2+!'6!V@rW@!!!
!
J+0'$#L#*/0!</9'**/04!90+66#0+6-!4(#!0+/L6(0L!E(6$!()!$8+!6(&'#E!'2!$8+!90(:'E/*!$#L#*+!?aVd
tVWB@!!g8+0+!'6!$8+!0+6$!/L6(0L+&nU!'2!$8+!&'6$/*!/2&!<(**+<$'2=!$#L#*+!L4!/*&(6$+0(2+@!!I8+!
"/!'6!0+/L6(0L+&!'2$(!$8+!9+0'$#L#*/0!</9'**/0'+6@!!Y$/0*'2=!)(0<+6!'2!$8+!</9'**/0'+6!E#6$!L+!
/E+2/L*+!$(!'$@!!I>(!6$/0*'2=!)(0<+6-!(2<($'<!90+66#0+!?F++96!)*#'&6!'2!$8+!M+66+*B!/2&!
84&0(6$/$'<!?9#68+6!)*#'&6!(#$!()!M+66+*B@!!!
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35
36
37
38
39
B.!Compensation!C!L(&'+6!/$$+E9$!$(!$04!$(!E/'2$/'2!/!2(0E/*!9N!?>8'<8!'$!2+M+0!&(+6B@!!Y(!')!
4(#!>/2$!$(!F++9!9N!0(#=8*4!2(0E/*!?/66#E'2=!4(#!<(#*&B@!
!
,@!![:/E9*+-!')!4(#!8/M+!E+$/L(*'<!/*F/*(6'6!?'2<0+/6+!'2!L'</0L-!>8'<8!'6!'2!$8+!2#E+0/$(0B;!
$8+2!8/M+!$(!'2<0+/6+!&+2(E'2/$(0!?9.GHB!$(!F++9!'$!2(0E/*;!$8+0+)(0+;!<(E9+26/$'(2!'6!&#+!
$(!0+69'0/$(04!?9.GHB!/<'&(6'6@!!%!2'<+!>/4!()!E+E(0'c'2=!'$!'6!>8/$!'6!$8+!(99(6'$+!()!
E+$/L(*'<n!R+69'0/$(04!/2&!>8/$!'6!$8+!(99(6'$+!()!/<'&(6'6n!%*F/*(6'6;!/2&!M'<+!M+06/@!!!
!
H@!![:/E9*+-!')!4(#!8/M+!E+$/L(*'<!/<'&(6'6!?&+<0+/6+!L'</0LB!>8/$!&(!>+!8/M+!$(!&(!>'$8!
$8+!9.GHn!!g+!8/M+!$(!=+$!0'&!()!'$@!!1)!>+!&+<0+/6+!$8+!2(E'2/$(0;!>+!8/M+!$(!&+<0+/6+!$8+!
&(E'2/$(0!'2!(0&+0!)(0!$8+!+D#/$'(2!$(!6$/4!$8+!6/E+@!!I8+0+)(0+;!>+!8/M+!$(!L*(>!())!$8+!
.GH!?849+0M+2$'*/$'(2B@!
P@!k+2$'*/$'(2!'6!/!.GH!$+0Em!
N49+0M+2$'*/$'(2!C!12<0+/6+!'2!0+69'0/$(04!0/$+!/**(>6!)(0!$8+!L*(>'2=!())!()!.GH;!$8+0+)(0+!
0+6#*$6!'2!0+69'0/$(04!/*F/*(6'6@!T(0!$8+!$0+/$E+2$!()!0+69'0/$(04!/*F/*(6'6!'6!$(!='M+!$8+!9$!/!
9/9+0!L/=!/2&!/6F!$(!L0+/$8!'2!'$;!LZ<!$8+2!$8+4!/0+!0+dL0+/$8'2=!$8+'0!(>2!.GH@!!!
!
N49(M+2$'*/$'(2!C!_+<0+/6+!'2!0+69'0/$(04!0/$+!/**(>6!)(0!$8+!0+$+2$'(2!()!.GH;!$8+0+)(0+!
0+6#*$6!'2!0+69'0/$(04!/<'&(6'6@!!!
!
T#**!<(E9+26/$'(2!&(+6!2($!+:'6$U!4(#!2+M+0!L0'2=!L/<F!$8+!9N!$(!$8+!2(0E/*!0/2=+@!!I8+0+!'6!
(2+!+:<+9$'(2-!<80(2'<!0+69'0/$(04!/*F/*(6'6!'2!8'=8!/*$'$#&+U!'+!E(#2$/'2!6'<F2+66!?'+!9+0#B@!!!
!
C. Respiratory conditions: acidosis and alkalosis
,@!I8'2=6!$8/$!&+/*!>'$8!.GH-!!
!
/B!R+69'0/$(04!<+2$+0!'6!'2!E+&#**/!(L*(2=/$/;!>8'<8!<(2$0(*6!$8+!L0+/$8'2=!0/$+!!
!
LB!\99+0!/'0>/46!7!')!(L6$0#<$+&;!$8+0+!>'**!L+!/!90(L*+E!=+$$'2=!0'&!()!.GH@!!!
<B!.8+6$!L+**(>6!7!E(6$!'E9!E#6<*+!()!0+69'0/$'(2!'6!&'/980/=E@!!G2!'269'0/$'(2-!$8+!
&'/980/=E!=(+6!&(>2;!$8+!2+=/$'M+!'2$0/$80(/<'<!90+66#0+!'2<0+/6+6;!/2&!/'0!'6!6#<F+&!
'2$(!$8+!*#2=6!/2&!L*((&!'6!6#<F+&!'2$(!$8+!0'=8$!6'&+!()!$8+!8+/0$!?$8'6!'6!>84!2+<F!M+'26!
<(**/96+!(2!'269'0/$'(2B@!!"+=/$'M+!M/<##E!6#<F6!L*((&!/2&!/'0!'2$(!4(#0!<8+6$@!!G2!
+:9'0/$'(2;!$8+0+!'6!/!iOj!'2$0/$80(<'<!90+66#0+;!9#68'2=!$8'2=6!(#$@!!1$!8+*96!$8+!*+)$!8+/0$!
$(!9#68!L*((&!(#$!/2&!'$!/*6(!8+*96!$8+!*#2=6!L4!9#68'2=!(#$!/'0@!
!
H@!![:/E9*+6-!!
?/B!S/0L'$#0/$+6!(0!/24!&0#=!$8/$!&+90+66+6!$8+!0+69'0/$(04!<+2$+0!>'**!*+/&6!$(!
0+69'0/$(04!/<'&(6'6!
!
?LB!."Y!'23#04!$(!E+&#**/!(L*(2=/$/!7!0+69!/<'&(6'6!
!
?<B!%2:'+$4!C!K..!0+69!/*F/*(6'6@!!g8+2!4(#!$/F+!/!$+6$;!6(E+$'E+6!4(#!)++*!6$0/2=+;!
/2&!=+$!2#EL!/2&!$'2=*4;!+69+<'/**4!/0(#2&!E(#$8!/2&!(2!$8+!$'96!()!)'2=+06;!/2&!
L+<(E+!$>'$<84!?LZ<!4(#!/0+!'2!$+$/24B!'$6!/**!</#6+&!L4!L+'2=!/*F/*($'<!/2&!'(2'c'2=!
</*<'#E!*+M+*!=+$6!*(>+0!/2&!4(#!0+/**4!/0+!=+$$'2=!$+$/24@!!I8+0+)(0+!4(#!L+<(E+!
40
41
42
43
44
45
46
8@!I(:'<'$4ZN49+0M'$/E'2(6'6!()!M'$!_-!849+0</*<+E'/;!$8+0+)(0+!0'6F!()!8/M'2=!$((!E/24!
6$(2+6!'2!$8+!#0'2+;!/2&!6$(2+6!'6!/!K..!<(E9*'</$'(2@!
I49+!,!0'<F+$6!7!E'66'2=!$8+!,d/d84&0(:4*/6+!
I49+!H!0'<F+$6!7!E'66'2=!$8+!0+<+9$(0!)(0!M'$!_!
3. Vitamin E
/@!K/'2!)#2<$'(2-!E/'2$/'2!<+**!E+EL0/2+6!/2&!90+M+2$!*'9'&!9+0(:'&/$'(2!()!$8+!<+**!
E+EL0/2+6U!'2!($8+0!>(0&6;!'$!90($+<$6!$8+!<+**!E+EL0/2+6!)0(E!L+'2=!L0(F+2!&(>2!L4!
98(698(*'9/6+!%!?*'9'&!9+0(:'&/$'(2;!>8'<8!'6!)0++!0/&'</*!&/E/=+!(2!$8+!<+**!E+EL0/2+;!
/2&!'6!90+M+2$+&!>'$8!M'$![B@!!G$8+0!)#2<$'(2-!2+#$0/*'c+&!(:'&'c+&!X_X;!>8'<8!'6!)/0!E(0+!
/$8+0(=+2'<!$8/2!X_X!L4!'$6+*)@!!g8+2!X_X!'6!(:'&'c+&;!'$!'6!>/4!E(0+!'23#0'(#6!$(!$8+!<+**!
$8+2!>8+2!'$!'6!2($!(:'&'c+&@!!k'$![!>'**!2+#$0/*'c+!(:'&'c+&!X_X;!$8+0+)(0+!'6!/!
</0&'(90($+<$/2$!?M'$![!/2&!.!L($8!2+#$0/*'c+!(:'&'c+&!X_XB@!!12!6#EE/04-!M'$![!)#2<!C!,B!
90($+<$6!<+**!E+E!)0(E!)0++!0/&'</*!&/E/=+@!HB!G:'&'c+6!)0++!X_X!?$8'6!'6!$8+!X_X!$8/$!
E/<0(98/=+6!98/=(<4$(6+!$(!90(&#<+!)(/E!<+**6;!/2&!*+/&6!$(!/$8+0(6<*+0($'<!9*/D#+6B@!
!
L@!_+)'<'+2<4!()!M'$/E'2![-!16!6++2!L#$!'6!M+04!#2<(EE(2;!/2&!')!6++2!')!>(#*&!L+!'2!F'&6!
>'$8!<46$'<!)'L0(6'6U!)0(E!L'0$8;!F'&6!8/M+!0+69!90(L6!/2&!9/2<0+/6!90(L*+E6@!!?*((F!/$!'2!
0(LL'26;!$((B@!%!F'&!$8/$!8/6!<46$'<!)'L0(6'6!>'**!8/M+!E/*/L6(09$'(2!90(L*+E6U!$8+0+)(0+!
>8/$!)(#0!M'$/E'26!68(#*&!4(#!='M+!8'En!.46$'<!)'L0(6'6!9$!8/6!/!E/*/L6(09$'(2!()!)/$U!
$8+0+)(0+!$8+4!>'**!8/M+!E/*/L6(09$'(2!()!)/$!6(*#L*+!M'$/E'26!7!%;!_;![;!/2&!5@!!k'$![!&+)!
'2!\Y%!'6!#6#/**4!6++2!'2!<46$'<!)'L0(6'6!9/$'+2$6@!!!
!
<@!.*'2'</*!90+6+2$/$'(26-!!G2+!()!$8+!)+/$#0+6!()!M'$![!&+)!'6!8+E(*4$'<!/2+E'/!?M'$![!
2(0E/**4!E/'2$/'26!$8+!'2$+=0'$4!()!$8+!E+EL0/2+BU!$8'6!9$!'6!2(>!6#6<+9$'L*+!$(!)0++!
0/&'</*!&/E/=+;!&/E/=+&!E+E!()!RS.!*+/&6!$(!8+E(*46'6!()!RS.!/2&!8+E(*4$'<!/2+E'/@!!
%2($8+0!)+/$#0+!()!M'$![!/0+!$8'2=6!0+*/$+&!$(!E4+*'2-!9(6$+0'(0!<(*#E2!&c;!69'2/*!
<+0+L+**/0!90(L6@!!I8+0+)(0+;!>'$8!M'$![!&+);!8/M+!2+#0(*(='</*!90(L*+E6!/2&!8+E(*4$'<!
/2+E'/@!
!
&@!k'$/E'2![!$(:'<'$4-!/24$8'2=!E(0+!$8/2!,,VV!#2'$6!?/M+0/=+!</96#*+!'6!^VV!#2'$6;!
$8+0+)(0+;!')!$/F+!P!9'**6;!/*0+/&4!$(:'<B@!!k'$/E'2![!$(:'<'$4!>'**!'28'L'$!642$8+6'6!()!!
k'$!5!&+9+2&+2$!.(/=#*/$'(2!)/<$(06!?H;!`;!r;!,V;!90($+'2!.;!90($+'2!YBU!'2!($8+0!>(0&6;!
4(#!/0+!/2$'.(/=#*/$+&@!![:/E9*+-!9$!>'$8!K1!7!$/F+!/2$'(:'&/2$6;!/2&!/69'0'2U!>'$8!
/2$+0'(0!K1;!$8+4!/2$'.(/=#*/$+!$8+!9$;!/2&!9$!=(+6!8(E+!(2!$80++!E(2$86!()!>/0)/0'2@!
"(0E/*!1"R!0/$'(;!/2&!$/F+6!*($6!/2&!*($6!()!M'$![!/2&!($8+0!M'$/E'26@!!I/F+!/!*($!()!M'$![!
/2&!>'**!8+*9!>/0)/0'2;!*+/&'2=!$(!(M+0!/2$'.(/=#*/$+&!6$/$+;!?0+E+EL+0!$8/$!>/0)/0'2!
L*(<F6!=/EE/!</0L(:4*/$'(2!()!M'$/E'2!5!&+9!)/<$(06B@!!k'$![!>'**!90+M+2$!$8+!Yb"IN[Y1Y!
()!$8+6+!)/<$(06@!!I8+0+)(0+;!M'$![!$(:'<'$4!'6!642+0='6$'<!'2!/<$'M'$4!>'$8!>/0)/0'2@![:/E9*+-!
9$!(2!>/0)/0'2;!</E+!8(E+!)0(E!K1;!1"R!0/$'(!'6!8#=+U!>84n!I/F'2=!M'$![@!
!
4. Vitamin K
/@!Y(#0<+6-!!./2!<(E+!)0(E!>8/$!>+!+/$;!L#$!E(6$!'6!642$8+6'c+&!L4!(#0!<(*(2'<!L/<$+0'/!
?(#0!/2/+0(L+6!'2!(#0!=#$B!7!$8'6!'6!>84!>+!='M+!M'$!5!'23+<$'(26!$(!(#0!L/L4!>8+2!$8+4!
/0+!L(02U!$8+4!(2*4!8/M+!P!&/46!>(0$8!()!M'$!5!)0(E!E(E;!L#$!/)$+0!$8/$;!$8+4!>(2Q$!8/M+!
/24!LZ<!'$6!2($!'2!L0+/6$!E'*FU!$8+0+)(0+;!/!M+04!*(>!*+M+*!()!M'$!5!L+$>++2!&/46!PdeU!/*6(;!
$8+4!&(2Q$!8/M+!L/<$+0'/!$(!E/F+!$8+!M'$!5@!!I8+0+)(0+;!</2!=+$!8+E(008/='<!&c!()!$8+!
2+>L(02!?$8'6!'6!>84!>+!='M+!M'$!F!>8+2!$8+4!/0+!L(02BU!/)$+0!e!&/46;!$8+!L/<$+0'/!
<(*(2'c+;!/2&!M'$!'6!E/&+!L4!$8+!L/L4@!!!
47
!
C. Water Soluble Vitamins: /**!/0+!<()/<$(06!'2!E/3(0!L'(<8+E'</*!9/$8>/4!
1. Vitamin C:
/B!.*/66'<!+:/E9*+!()!k'$/E'2!.!&+)'<'+2<4-!(*&+0!9+06(2!(2!$+/!/2&!$(/6$!&'+$!7!
'2&'</$'2=!$8/$!$8+4!/0+!E/*2(#0'68+&U!9$!=+$6!L*++&'2=!()!$8+!=#E6!C!6<#0M4;!&#+!$(!M'$!
.!&+)@!!k'$!.!'6!0+69(26'L*+!)(0!84&0(:4*/$'(2!()!90(*'2+!/2&!*46'2+;!/2&!$8'6!(<<#06!'2!$8+!
l(*='!/99/0/$#6!LZ<!$8/$Q6!>8+0+!9(6$d$0/26*/$'(2/*!E(&')'</$'(2!(<<#06@!!J$6!8/M+!>+/F!
I49+!1!<(**/=+2!LZ<!</22($!<0(66L0'&=+!'$U!$8+0+)(0+;!SkQ6!/0+!#26$/L*+!/2&!=#E6!L*++&@!!!
l+$!L*++&'2=!()!$8+!=#E6;!'2)*/EE/$'(2;!/2&!E/4!*((6+!$++$8@!!!
!
LB!%66(<'/$+&!D#+6$'(2-!>8/$!<(E9*'</$'(2!'6!/66(<'/$+&!>'$8!6+M+0+!8+E(98'*'/!%n!
N+E+/0$80(6+6;!/2&!</#6+&!L4!k'$!.!&+)'<'+2<4!?LZ<!$8+!SkQ6!/0+!#26$/L*+!/2&!$8+4!
0#9$#0+B@!
!
<B!J846'</*!&'/=2(6'6!()!k'$/E'2!.!&+)'<'+2<4-!!%*(2=!>'$8!$8+!$+/!/2&!$(/6$!&'+$;!$8+0+!'6!
/*6(!9+0')(**'<#*/0!8+E(008/=+!?8+E(008/=+!/0(#2&!$8+!8/'0!)(**'<*+6B@!!Y++!0'2=!
6'&+0(L*/6$!?2#<*+/$+&!RS.;!/2&!8/6!$((!E#<8!'0(2!'2!$8+!E'$(<8(2&0'/B;!0'2=!/0(#2&!$8+!
8/'0!)(**'<*+!/2&!/*6(!6++!<(0F!6<0+>!8/'06!&#+!$(!M'$!.!&+)@!!I8+!$(2=#+!*((F6!*'F+!'$!8#0$6!
/2&!9/$'+2$6!>'$8!M'$!.!8/M+!/!6E(($8!$(2=#+!7!=*(66'$'6;!>'$8!F+*(6'6!/0(#2&!/2F*+6;!9*#6!
/!8+E(008/='<!&'/$8+6'6!C!6<#0M4@!
!
48
49
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74
PB!*+/&!9('6(2'2=!7!6(!*+/&!*+/&6!$(!6'&+0(L*/6$'<!/2+E'/@!!X+/&!'6!/!&+2/$#0+0@!!%**!8+/M4!
E+$/*6!&+2/$#0+!90($+'26!?+2c4E+6!/0+!90($+'26B@!!X+/&Q6!)/M(0'$+!+2c4E+!$(!&+2/$#0+!'6!
)+00(<8+*/$/6+;!6(!'$!>(2Q$!>(0F;!/2&!2(!8+E+!C!2(!NL;!*+/&'2=!$(!E'<0(<4$'<!/2+E'/@!!X+66!
()!'28'L'$(04!+))+<$;!L#$!&(+6!8/M+!/!*'$$*+!(2+!(2!/E'2(*+M#*'2'<!/<'&!&+84&0/$/6+@!!S#$!'6!
KGYI!<(EE(2*4!F2(<F6!())!)+00(<8+*/$/6+@!!Y(;!>8+2!T+!<(E+6!'2$(!E'$(;!'$!</22($!L'2&!$(!
90($(9(09840'2!$(!)(0E!8+E+@!!No heme = decreased Hb = microcytic anemia@!!!
[:/E9*+-!!')!)+00(<8+*/$/6+!'6!&+<0+/6+&Z'28'L'$+&;!8+E+!&+<0+/6+6;!L#$!>8/$!8/99+26!$(!
90($(9(09840'2!L+)(0+!$8+!L*(<Fn!1$!'2<0+/6+6!?#6+&!$(!L+!6<0++2'2=!$+6$!()!<8('<+!)(0!*+/&!
9('6(2'2=B@!"($!#6+&!/24E(0+@!g84n!SZ<!')!4(#!&(2Q$!8/M+!T+!LZ<!%._cZT+!&+);!>8/$!>'**!
8/99+2!$(!$8+!90($(9(09840'2!'2!$8+!E'$(n!1$!>'**!'2<0+/6+@!!Y(;!$8+4!)(#2&!(#$!$8/$!E/24!
9+(9*+!8/&!/2!'2<0+/6+!'2!RS.!90($(9(09840'2;!/2&!=($!idi!$+6$!)(0!*+/&!9('6(2'2=;!/2&!$8+2!
F2+>!$8/$!$8+!9$6!8/&!+'$8+0!T+!&+)!(0!%._c;!/2&!<(2<*#&+&!$8/$!'$!>/6!2($!/!=((&!6<0++2'2=!
$+6$@!
!
Y(;!2(>!L*((&!*+/&!*+M+*!'6!$8+!6<0++2'2=!/2&!<(2)'0E/$(04!$+6$!)(0!*+/&!9('6(2'2=;!2($!RS.!
90($(9(09840'2!?$((!E/24!)/*6+!iOjQ6B!
!
G. Pathogenesis of Thalassemias: %#$(!0+<!&cQ6!
1. Alpha thalassemias!7!>8(!&(!>+!6++!/*98/!$8/*/66+E'/6!'2n!%6'/26!?T/0!+/6$+02B!/2&!
L*/<F6!?/**!=+2+$'<!8+E/$(*(='<!&cQ6!/0+!6++2!'2!$8+!L*/<F!9(9Q2!7!/*98/ZL+$/!$8/*;!laJ_!&+);!
Y._cB@!!!
,@!!NL!+*+<$0(98(0+6'6!7!6+9/0/$+6!$8'2=6!L/6+&!(2!6'c+!/2&!<8/0=+;!$8+0+)(0+!4(#!</2!
<*+/0*4!6+9/0/$+!NL%;!NLT;!/2&!NL%H!<*+/0*4!(2!<+**#*(6+!/<+$/$+!LZ<!$8+4!8/M+!&'))+0+2$!
E'=0/$'(26@!!Y(;!$8+4!)*#(0+6<+!'$;!/2&!NL%;!NLT!/2&!NL%H!/**!6+$$*+!&(>2@!I8+2!$8+4!
6$/'2!$8+!<+**#*(6+!/<+$/$+!$(!6++!8(>!E#<8!'6!$8+0+@!!I8+2;!'$!90(&#<+6!&+26'$4;!/2&!$8+!
&+26'$4!<(00+*/$+6!>'$8!$8+!<(2<+2$0/$'(2!()!+/<8!()!$8+!NLQ6@!!N(>!>'**!$8+4!F2(>!$8+!
9+0<+2$n!g'$8!/!&+26'$(E+$+0!7!'$!<(2M+0$6!$8+!&+26'$4!()!$8+!6$/'2!$(!$8+!9+0<+2$/=+@!!1$!
$#026!(#$!$8/$!NL%!?H H B!'6!$8+!90+&(E'2/2$!NL!'2!/2!/&#*$!?redreWB@!!NL%H!'6!,dHWU!
NLT!C!,W@!I8+6+!/0+!$8+!2(0E/*;!>8'<8!/0+!+:90+66+&!/6!/!9+0<+2$/=+@!!!
!
H@!!%*98/!$8/*/66+E'/6;!/#$(!0+<;!8/6!/!90(L*+E!'2!E/F'2=!/*98/!=*(L'2!<8/'26@!!_(!NL%H!
/2&!NLT!0+D#'0+!NL%!$(!L+!E/&+n!b+6@!!I8+0+)(0+;!/**!>'**!L+!+D#/**4!&+<0+/6+&@!!I8'6!
>'**!"GI!68(>!#9!(2!/2!+*+<$0(98(0+6'6;!LZ<!/**!/0+!+D#/**4!&+<0+/6+&;!$8+0+)(0+;!'$!
68(>6!$(!L+!$($/**4!2(0E/*@!!I8+0+!/0+!)(#0!=+2+6!$8/$!<(2$0(*!/*98/!=*(L'2!642$8+6'6@!!
_+*+$'(2!()!(2+!()!$8+6+!)(#0!>'**!2($!</#6+!/2+E'/@!!_+*+$'(2!()!H!=+2+6!C!90(L*+E!LZ<!
E'2'E/**4!&+<0+/6+&;!/2&!$8+0+)(0+!/!E'*&!/2+E'/@!!1$!'6!E'<0(<4$'<!LZ<!$8+!=*(L'2!9/0$!'6!
&+<0+/6+&;!E+/2'2=!4(#!>'**!=+$!/!E'<0(<4$'<!/2+E'/!?&+<0+/6+!'2!NL!<(2<Q2;!>8'<8!>'**!
L+!$8+!6$'E#*#6B@!!I8'6!</**+&!/*98/!$8/*/66+E'/!E'2(0;!6++2!'2!$8+!)/0!+/6$+02!9(9Q2!/2&!
L*/<F!9(9Q2@!!!
g'$8!/!$80++!=+2+!&+*+$'(2;!$8/$Q6!2($!=((&;!/2&!9$!'6!0+/**4!&+<0+/6+&!?$8+0+!'6!/*6(!/!
8+E(*4$'<!<(E9(2+2$!$(!'$B@!!I8+!L+$/!<8/'26!=+$!'00'$/$+&!$8/$!$8+0+!'6!2(!/*98/!<8/'26!
/0(#2&;!6(!$8+4!)0(E!$8+'0!(>2!L+$/!=*(L'2!<8/'26@!!Y(;!)(#0!L+$/!<8/'26!=+$!$(=+$8+0!
/2&!)(0E!NLN@!!1)!4(#!&(!/2!+*+<$0(98(0+6'6;!$8+0+!>'**!L+!/!&'))+0+2$!0+6#*$@!!NLN!'6!/!
&'))!NL;!/2&!$8+0+)(0+!>'**!2($!E'=0/$+!$(!$8+!6/E+!9*/<+!/6!($8+0!NLQ6@!!Y(;!4(#!</2!&:!
$8'6!/*98/!$8/*/66+E'/!>'$8!NL!+*+<$0(98(0+6'6!?>84!'$6!</**+&!NLN!&cB@!!T(#0!=+2+!
75
K.!'2!L*/<F!9(9Q2!7!L+$/d&+*$/!$8/*/66+E'/!?&+<0+/6+&!L+$/!<8/'26!/2&!&+<0+/6+&!&+*$/!<8/'26;!
6(!>8/$Q6!*+)$!/0+!/*98/!/2&!=/EE/!<8/'26B@!!g8/$!>'**!$8+!+*+<$0(98(0+6'6!68(>n!NLT@!!I8'6!
</**+&!8+0+&'$/04!9+06'6$+2<+!()!NLT@!!"(!/2+E'/;!3#6$!&(E'2/2$!NLT@!
!
T(0!$8/*/66+E'/6;!F2(>!$8+4!/0+!=+2+$'<;!>8/$!=0(#96!()!9+(9*+!$8+4!/0+!'2;!/2&!$8/$!4(#!_G"QI!
&(!/24$8'2=!$(!$8+E;!+69!='M'2=!T+!LZ<!/**!$8+'0!T+!6$#&'+6!/0+!2(0E/*@!!!
!
76
77
$80'M+@!!K+<8/2'6E!()!<+0+L0/*!+&+E/n!R+*/$+&!$(!'2<0+/6+&!M+66+*!9+0E+/L'*'$4!()!L0/'2!/2&!
L#'*	!()!&+*$/d*+E/M'24*'2'<!/<'&@!!!1)!4(#!L*(<F!)+00(<8+*/$/6+;!+M+04$8'2=!&'6$/*!$(!$8+!L*(<F!
>'**!'2<0+/6+!?90($(9(09840'2;!&+*$/*+E/M'24*'2'<!/<'&B!$8'6!'6!$(:'<!$(!2+#0(26;!*+/&'2=!$(!<+0+L0/*!
+&+E/@!
[:/E9*+-!=#4!/$!/2!/#$(E(L'*+!68(9;!<(E9*/'26!()!/L&(E'2/*!<(*'<!/2&!&'/008+/@!!I8'6!'6!*+/&!
9('6(2'2=!LZ<!+:9(6#0+!$(!L/$$+0'+6@!!12!9*/2$6;!$8+0+!'6!+:9(6#0+!$(!'2<'2+0/$'(2!()!L/$$+0'+6;!/2&!
9$6!/0+!+:9(6+&!$(!*+/&!'2!/#$(!)/<$(0'+6!
!
[:/E9*+-!E((268'2+!7!E/F+!/*<(8(*!'2!(*&!0/&'/$(06;!*+/&6!$(!*+/&!9('6(2'2=!
!
[:/E9*+-!9($$+04!9/'2$+0!7!9($$+04!'6!<(EE(2*4!9/'2$+&!>'$8!*+/&!L/6+&!9/'2$6@!!%!*($!$'E+6!$8+4!
*'<F!$8+!$'9!()!$8+!L0#68;!/2&!*+/&6!$(!*+/&!9('6(2'2=@!!!
!
[:/E9*+-!'2!<+0$/'2!<(#2$04;!$8+4!#6+!*+/&dL/6+&!9($$+04!)(0!&'68+6;!>8'<8!*+/&6!$(!*+/&!
9('6(2'2=@!!%&#*$6!>'**!=+$!$8+!2+#0(9/$8'+6!7!6*/99'2=!=/'$!?9+0'2+/*!9/*64B;!>0'6$!&0(9!?0/&'/*!
9/*64B;!<*/>!8/2&!?#*2/0!9/*64B;!*+/&!*'2+6!'2!$++$8!?#6#/**4!=+$!>'$8!<(*'<!/2&!&'/008+/B!
!
M. Fe/TIBC/%sat/ferritin:
T+!&+)-!*;!8;!*;!*!
%._c-!*;!*;!*;!8!
%*98/ZL+$/!$8/*-!2;!8;!8;!8;!&(!2($8'2=!/L(#$!'$!
X+/&!9('6(2'2=!?/2&!6'&+0(L*/6$'<!/2+E'/6!7!T+!(M+0*(/&!*'F+!8+E(<80(E/$(6'6B-!
N;!*;!8;!8!?I1S.!'6!*(>!LZ<!T+!6$(0+6!/0+!8'=8mB!7!'2!T+!(M+0*(/&!+M+04$8'2=!'6!8'=8;!I1S.!'6!
XGg!
!
Anemia
10(2!_+)'<'+2<4!%2+E'/!
%2+E'/!()!.80(2'<!_'6+/6+!
%*98/!/2&!S+$/!I8/*/66+E'/6!
X+/&!(M+0*(/&!>Z!8+E(<80(E/$(6'6!
Iron
XGg!
XGg!
"X!
N1lN!
TIBC
N1lN!
XGg!
N1lN!
XGg!
% saturation
XGg!
XGg!
N1lN!
N1lN!
Ferritin
XGg!
N1lN!
N1lN!
N1lN!
!
!
%#&'(!_/4!P-!N+E/$(*(=4!T'*+!P!
VIII. Macrocytic anemias
S,H!/2&!)(*/$+!/0+!'2M(*M+&!'2!_"%!642$8+6'6;!$8+0+)(0+;!')!4(#!/0+!S,H!/2&Z(0!)(*/$+!&+);!4(#!
</22($!E/F+!_"%;!69+<')'</**4!LZ<!4(#!8/M+!/!90(L!>'$8!E/F'2=!_KJ!?&+(:4$84E'&'2+!
E(2(98(698/$+B@!!I8+0+)(0+;!')!4(#!</22($!E/F+!$8/$;!4(#!</22($!E/$#0+!$8+!2#<*+#6!
?'EE/$#0+!2#<*+'!&(!2($!8/M+!/!*($!()!_"%!'2!$8+E;!L#$!/6!4(#!E/F+!E(0+!_"%;!$8+!2#<*+'!
L+<(E+!E(0+!E/$#0+&;!/2&!$8+!2#<*+#6!L+<(E+6!6E/**+0!/2&!E(0+!<(2&+26+&B@!!SZ<!_"%!
</22($!L+!E/&+;!$8+2!4(#!8/M+!*/0=+!2#<*+#6;!/2&!/**!2#<*+/$+&!$8+!<+**6!'2!4(#0!L(&4!/0+!L'=!7!
>84!$8+4!/0+!</**+&!MEGAloblastic anemias@!!%!=((&!9/$8(*(='6$!</2!&:!S,H!/2&!)(*/$+!&+)!'2!
/!<+0M'</*!9/9!6E+/0;!>8+2!*((F'2=!/$!$8+!6D#/E(#6!<+**6!?<+**6!*((F!L'=!7!/24!<+**!>'$8!/!
2#<*+#6!8/6!_"%!'2!'$;!6(!/24!<+**!>'$8!_"%!>'**!L+!L'=!7!2($!3#6$!$8+!8+E/$(9(+'$'<!<+**6!$8/$!/0+!
8#=+;!%XX!2#<*+/$+&!<+**6!'2!$8+!L(&4!/0+!L'=!7!'+!l1;!6D#/E(#6!<+**6B!
!
S,H!/F/!<(L/*/E'2U!S,H!8/6!<(L/*$!'2!'$@!!.'0<#*/$'2=!)(0E!()!)(*/$+!'6!E+$84*$+$0/84&0()(*/$+!
?$+$0/!C!)(#0B@!!J#09(6+!()!<(L/*/E'2!?S,HB!'6!$(!$/F+!$8+!E+$84*!=0(#9!())!()!
E+$84*$+$0/84&0()(*/$+@!!I8+2!'$Q6!</**+&!$+$0/84&0()(*/$+@!!1)!4(#!&(2Q$!=+$!$8+!E+$84*!=0(#9!())!
78
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J*/$+*+$!.(#2$!
"X!
XGg!
XGg
"X!
"X!
"X!
XGg!
S*++&'2=!I'E+!
N1lN!
N1lN!
N1lN
"X!
N1lN!
"X
N1lN!
JI!
"X!
"X!
"X
"X!
"X!
N1lN!?gB!
N1lN!
JII!
"X!
"X!
"X!
N1lN!
N1lN!
N1lN!?NB
N1lN!
g8'<8!'6!/66(<'/$+&!>'$8!=a6$0'<!</2<+0n!%!
g8'<8!'6!/66(<'/$+&!>'$8!&#o&+2/*!#*<+0n!G!
\2'M+06/*!&(2(0n!G!?</2!='M+!$8+'0!L*((&!$(!/24(2+!LZ<!8/M+!"G!/2$'d%!(0!/2$'dS!%=B@!
g8/$!'6!$8+!(2*4!L*((&!=0(#9!G!</2!=+$n!G!
\2'M+06/*!0+<'9'+2$n!%S!LZ<!$8+4!8/M+!2(!%LQ6!$(!/$$/<F!$8(6+!<+**6!
!
C. Other Antigens:
,@!R8!O!/2$'=+2!E+/26!$8/$!4(#!/0+!iOj!)(0!_!/2$'=+2!
!
H@!_#))4!%=!'6!E'66'2=!'2!L*/<F!9(9Q2U!$8+0+)(0+!2($!/6!*'F+*4!$(!=+$!9*/6E(&'#E!M'M/:!
?E/*/0'/B!LZ<!$8+!%=!$8+!J@!M'M/:!2++&6!$(!9/0/6'$'c+!$8+!RS.Q6!'6!$8+!_#))4!/=!/2&!')!4(#!
&(2Q$!8/M+!$8+!%=!$8+!J@!M'M/:!</2Q$!=+$!'$@!?laJ_!&+);!$8/*/66+E'/6;!Y._c!9$6!90($+<$+&!)0(E!
)/*<'9/0#E!7!$8+4!/0+!90($+<$+&!LZ<!$8+4Q0+!RS.Q6!8/M+!/!68(0$+0!*')+69/2!7!6(;!$8+!9/0/6'$+!
</22($!*'M+!(#$!$8+'0!<4<*+;!/2&!RS.Q6!/!68(0$+0!*')+69/2B!
!
D. Major crossmatch:!9$!=(22/!=+$!L*((&U!$8+'0!6+0#E!'6!'2!/!$+6$!$#L+;!>'$8!$8+!L*((&!()!$8+!
&(2(0!#2'$!/2&!$8+4!E':!$8+!H!$(=+$8+0!7!6(!$8+4!E':!$8+!9$Q6!6+0#E!>'$8!$8+!&(2(0Q6!RS.Q6!$(!
6++!')!$8+4!/0+!<(E9/$'L*+U!*((F'2=!)(0!/24$8'2=!'2!$8+!9$6!6+0#E!$8/$!>'**!/$$/<F!$8+!/2$'=+26!'2!
$8+!&(2(0Q6!RS.Q6@!!%2($8+0!9/0$!()!$8+!>(0F#9!)(0!<0(66E/$<8'2=!'6!$(!&(!/2!/2$'L(&4!6<0++2!
>8'<8!'6!/2!'2&'0+<$!<((ELQ6!L+)(0+!E':'2=!?0+E+EL+0!$8/$!'$!&+$+<$6!$8+!%"I1SG_bB@!!1)!$8'6!
$+6$!'6!2+=/$'M+;!$8+!<0(66E/$<8!'6!<(E9/$'L*+!?6(;!$8+0+!'6!2(!%L!'2!$8+!9$6!6+0#E!$8/$!>'**!
/$$/<F!$8+!&(2(0Q6B@!!I8'6!&(+6!2($!90+M+2$!/!$0/26)#6'(2!0:2;!(0!$8/$!%LQ6!>'**!&+M+*(9!*/$+0!
/=/'26$!$8+!&(2(0@!!g8/$!'6!$8+!<8/2<+!$8/$!/24(2+!8/6!$8+!6/E+!%=!E/F+#9!/6!/2($8+0n!q+0(@!!
108
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126
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128
129
130
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140
!
B. Adult Respiratory Distress Syndrome (ARDS)
12!$+0E6!()!%R_Y;!+66+2$'/**4!'$!'6!$8+!6/E+!/6!R_Y!'2!9/$8(9846;!L#$!'6!"[\IRGJN1X!0+*/$+&!
'23#04@!!12!R_Y!4(#Q0+!2($!E/F'2=!6#0)/<$/2$!LZ<!4(#!/0+!$((!90+E/$#0+!(0!8/M+!$((!E#<8!
'26#*'2!/2&!3#6$!8/M+!<(**/96+&!/*M+(*'@!!S\I!'2!%R_Y!'$6!LZ<!4(#!8/M+!$((!E#<8!
'2)*/EE/$'(2U!$8+0+!'6!2(!'2)*/EE/$'(2!'2!R_Y@!!!
!!
MCC ARDS = septic shock (MCC septic shock = E coli from sepsis from an
indwelling catheter; MCC DIC = septic shock).!![:/E9*+-!!12!$8+!1.\!7!')!/!9$!<(E+!'2!
>'$8!&4692+/!/2&!'$6!>'$8'2!H^!806!()!8/M'2=!6+9$'<!68(<F;!9$!8/6!%R_Y@!!1)!9$!'6!'2!6+9$'<!
68(<F!/2&!>'$8'2!^t!806!()!/&E'66'(2!/2&!'6!L*++&'2=!)0(E!+M+04!(0')'<+;!8+!8/6!_1.@!!So,
first day = septic shock, second day = ARDS, third day = DIC.
Pathogenesis: "+#$0(98'*6!=+$!'2$(!$8+!*#2=!'2!6+9$'<!68(<F!/2&!6$/0$!&+6$0(4'2=!/**!$8+!
<+**6!()!$8+!*#2=!?$49+!1!/2&!11!92+#E(<4$+6B@!!Y(!6#0)/<$/2$!90(&#<$'(2!&+<0+/6+6!/2&!0+6#*$!
'6!E/66'M+!/$+*+<$/6'6!?<(**/96+B@!!N(>+M+0;!$8'6!'6!2+#$0(98'*!0+*/$+&!?$8+!2+#$0(98'*6!/0+!
&+6$0(4'2=!$8+!$49+!11!92+#E(<4$+@!!!I8+!0+/6(2!>84!$8+4!=+$!84/*'2+!E+EL0/2+6!'2!$8+!
%R_Y!'6!LZ<!$8+!2+#$0(98'*6!8/M+!$(!=+$!'2!$8+!*#2=6!L4!=('2=!$80(#=8!$8+!9#*E(2/04!
</9'**/0'+6;!6(!$8+4!9#$!8(*+6!'2!$8+E!/6!$8+4!=+$!(#$!()!$8+!L*((&6$0+/E!/2&!'2$(!$8+!*#2=6!
?$8'6!'6!>84!'$!'6!</**+&!*+/F4!</9'**/04!642&0(E+B@!!%**!$8+!90($+'2!/2&!)'L0'2(=+2!=+$!'2!/2&!
90(&#<+!84/*'2+!E+EL0/2+6@!!I8+0+)(0+;!4(#!</2!/<$#/**4!6++!84/*'2+!E+EL0/2+6!'2!%R_Y@!!
141
142
143
144
145
D. Abscess
MCC abscess = aspiration of oropharyngeal material
Y++2!<(EE(2*4!'2!6$0++$!9+(9*+!$8/$!&(!2($!8/M+!=((&!&+2$'$'(2;!E/4!L+!&0#2F!/2&!)/**!/2&!
(0(98/042=+/*!E/$+0'/*!>'**!L+!/69'0/$+&@!!%69'0/$+!<(26'6$6!()!/+0(L+6!/2&!/2/+0(L+6;!
*+/&'2=!$(!9#$0'&Z6$/2<8!6E+**@!!!!I8+!/69'0/$+!'6!/!E':$#0+!()!/**!$8+6+!(0=/2'6E6-!K':+&!
/+0(L+6!/2&!/2/+0(L+6;!)#6(L/<$+0'#E;!L/<$+0('&+6@!!./2!=+$!/L6+<<+6!'2!$8+!*#2=!)0(E!
92+#E(2'/-!6$/98!/#0+#6;!5*+L6'+**/!?8(>+M+0;!K..!'6!/69'0/$'(2B;!6++!)*#'&!</M'$'+6!'2!*#2=!
(2!:d0/4@!!!
146
147
!
5. Hypersensitivity pneumonitis (farmers lung, silofillers dz, bysinosisB!
I8+6+!/0+!0+6$0'<$'M+!*#2=!&cQ6@!!_(2Q$!<(2)#6+!)/0E+0Q6!*#2=!/2&!6'*()'**+06!&c!7!$8+4!/0+!
SGIN!6++2!'2!)/0E+06@!!Y(;!0+E+EL+0!(2+;!$8+!($8+0!'6!$8+!($8+0m!
!
Silofillers dz 9#$!$8'2=6!'2!6'*(6;!>8'<8!'6!/!<*(6+&!69/<+;!/2&!)+0E+2$/$'(2!()!=/6!
(<<#06;!$8+!=/6!'6!2'$0(=+2!&'(:'&+!7![:/E9*+-!!)/0E+0!>+2$!'2$(!/!0((E!'2!8'6!L/02!
/2&!6#&&+2*4!&+M+*(9+&!>8++c'2=!/2&!&4692+/;!>84n!SZ<!8+!$((F!'2!2'$0(=+2!
&'(:'&+;!>8'<8!'6!/!)+0E+2$'2=!90(L*+E@!!?6'*(!</2!+:9*(&+!LZ<!=/6!)0(E!
)+0E+2$/$'(2B@!
!
148
149
150
151
152
153
!
E. Leukoplakia
g8'$+!*+6'(2;!9*/D#+!*'F+;!$04!$(!6<0/9!());!L#$!>(2Q$!<(E+!())!C!<*'2'</*!&:!()!*+#F(9*/F'/!7!
>8/$!'6!$8+!)'06$!6$+9!'2!E/2/=+E+2$n!S:!
!
I0#+!'2!$8+!M#*M/Z9+2'6!/0+/!7!>8'$+!(0!0+&&'68d>8'$+!9*/D#+!*'F+!*+6'(2!$8/$!&(+6!2($!6<0/9+!
())!7!)'06$!6$+9!'2!E/2/=+E+2$n!S:@!g84n!R#*+!(#$!&469*/6'/!/2&Z(0!'2M/6'M+!</2<+0@!
!
F. Cancer of the mouth
K..!6D#/E(#6!&469*/6'/!/2&!</2<+0!C!6E(F'2=!
H2&!K..!C!/*<(8(*!
1)!4(#!&(!L($8;!4(#!'2<0+/6+!$8+!0'6F!()!L($8@!
12M/6'M+!6D#/E(#6!</2<+0!C!<(*(0!<8/2=+!
154
k+0/<'(#6!</0<'2(E/!7!)0(E!<8+>'2=!$(L/<<(!?6D#/E(#6!</0<'2(E/BU!/*6(!8/6!/!NJk!M'0#6!
/66(<'/$+&!>'$8!'$@!!
!
G.!!N49+09'=E+2$/$'(2!7!&:n!Addisons!
%&&'6(2Q6-!&'))#6+!9'=E+2$/$'(2;!*(>!<(0$'6(*!*+M+*6;!'2<0+/6+&!%.IN!?%.IN!8/6!E+*/2(<4$+6!
6$'E#*/$'2=!90(9+0$'+6BU!M+04!)'06$!9*/<+!4(#!6++!849+09'=E+2$/$'(2!'6!'2!$8+!S#<</*!E#<(6/@!!!
!
H. Peutz-Jeghers
S*($<84!?2($!&'))#6+B!/0+/6!()!849+09'=E+2$/$'(2@ Polyps in small intestine.!!I8'6!'6!(2+!
()!$8+!+:<+9$'(26!$(!0#*+!)(0!9(*496!'2!$8+!6E/**!'2$+6$'2+@!!K(6$!9(*496!'2!$8+!l1!*(</$+&!'2!
$8+!6'=E('&!<(*(2U!8(>+M+0;!9(*496!()!J+#$c!f+=8+06!/0+!*(</$+&!'2!$8+!6E/**!'2$+6$'2+;!/2&!
$8+4!/0+!8/E/0$(E/6;!$8+0+)(0+!$8+4!/0+!2($!2+(9*/6$'<;!/2&!$8+'0!/L'*'$4!$(!<8/2=+!$(!</2<+0!
'6!q[RG@!
!
II. Diseases of the Salivary Glands
Pleomorphic adenoma aka Mumps / mixed tumor!?7!"GI!/!$+0/$(E/;!L#$!/!E':+&!$#E(0!
7!'$!8/6!$>(!&'))!$49+6!()!$'66#+6;!6/E+!<+**!*/4+0B@!!1$!'6!$8+!K.!6/*'M/04!=*/2&!$#E(0!(M+0/**;!/2&!
'6!'2!$8+!K.!*(</$'(2!7!$8+!9/0($'&@!
Mumps!7!9/0/E:4(M'0#6;!'2<0+/6+!'2!/E4*/6+U!'6!$8+!'2<'&+2<+!()!(0<8'$'6!8'=8n!"(U!&(+6!'$!
</#6+!'2)+0$'*'$4n!"(;!>84n!SZ<!'$6!#2'*/$+0/*!7!')!'$!>+0+!L'*/$+0/*!$8+2!'$!>(#*&!/!E#<8!=0+/$+0!
<8/2<+@!!\6#/**4!'2!(*&+0!$++2/=+!E/*+6!(0!E/*+!/&#*$6!'6!>8+0+!(0<8'$'6!>'**!(<<#0@!!./2!/*6(!
(<<#0!'2!)+E/*+6!d!((98(+0'$'6!7!K.!#2'*/$+0/*;!$8+0+)(0+!'2)+0$'*'$4!'6!0/0+@!
!
III. Diseases of the esophagus
155
!
Helpful hints with other diseases:
Palpable purpura = immune HPY type III = Henoch Schonlein (MC)
Epistaxis = platelet problem (dont think hemophilia)they give clues!
Pansystolic murmur increases on inspiration = tricuspid regurg
Pansystolic murmur increases on expiration = mitral regurg
!
B. Tracheoesophageal fistula
S*'2&*4!+2&'2=!+6(98/=#6!?90(:!+6(98/=#6!+2&6!L*'2&*4B!7!&'6$/*!+6(98/=#6!/00'M+6!)0(E!$8+!
$0/<8+/@!!g8/$!&(+6!$8+!E(E!8/M+n!J(*484&0/E2'(6!7!/E2'($'<!)*#'&!'6!L/L4!#0'2+;!6(!8/M+!
$(!0+<4<*+!'$;!(0!E(E!>'**!8/M+!L'=!L+**4@!!Y(;!$8+!L/L4!6>/**(>6!'$!/2&!'$!'6!0+/L6(0L+&!'2!$8+!
6E/**!'2$+6$'2+@!!Y(;!')!4(#!8/M+!(L6$0#<$'(2!'2!$8+!+6(98/=#6;!(0!90(:'E/*!9(0$'(26!()!$8+!
&#(&+2#E;!E(E!>'**!8/M+!9(*484&0/E2'(6@!!Y(;!$8+0+!/0+!H!/26>+06-!,B!I0/<8+(+6(98/=+/*!
)'6$#*/!HB!&#(&+2/*!/$0+6'/!'2!_(>2Q6!642&0(E+!7!$8+6+!H!/0+!/66(<'/$+&!>'$8!
9(*484&0/E2'(6@!!I8+4!L*(<F!$8+!/L'*'$4!$(!0+/L6(0L!/E2'($'<!)*#'&;!*+/&'2=!$(!
9(*484&0/E2'(6@!!%*6(;!>8+2!$8+6+!F'&6!+/$;!)((&!=+$6!</#=8$!/2&!F'&6!<(#=8!/2&!69#$$+0!
LZ<!$8+!&'6$/*!+6(98/=#6!/0'6+6!)0(E!$8+!$0/<8+/!/2&!*+/&6!$(!&'6$+26'(2!()!$8+!6$(E/<8@!!
I8'6!'6!M+04!<8/0/<$+0'6$'<@!
!
C. Zenkers diverticulum
%0+/!()!>+/F2+66!7!<0'<(98/042=+(#6!E#6<*+@!!1$!8/6!/!*'*!6*'$!'2!L+$>++2!$8+!)'L+06!()!'$@!!"($!
$8+!>8(*+!/0+/!'6!<#$!?>8'<8!>(#*&!L+!/!$0#+!&'M+0$'<#*#E!7!$8'6!'6!/!)/*6+!&'M+0$'<#*#EB@!!1$!
=(+6!(#$!/2&!=+$6!/!9(#<8@!!I8+!9(#<8!<(**+<$6!)((&!/2&!*+/&6!$(!8/*'$(6'6@!!I8+4!8/M+!/!
$+2&+2<4!()!0+=#0='$/$'2=!#2&'=+6$+&!)((&!(#$!()!$8+!2(6+@!
!
D. Achalasia
Peristalsis prob prob with relaxation of the LES;!$8+0+)(0+!'$!'6!'2!69/6E!/**!$8+!$'E+@!!
g84n!1)!4(#!L:!$8/$!/0+/;!$8'6!E+/26!$8/$!$8+!=/2=*'(2!<+**6!/0+!E'66'2=@!!g8/$!&c!&(+6!$8'6!
0+E'2&!4(#!()n!Hirschsprung dz@!!g8/$!'6!'2!$8(6+!=/2=*'(2!<+**6n!k/6('2$+6$'2/*!9+9$'&+!
?k1JB@!!g8/$!'6!'$6!)#2<$'(2n!I(!0+*/:!$8+!X[Y@!Y(;!>8+2!4(#!&+6$0(4!$8(6+!=/2=*'(2'<!<+**6;!
2($!(2*4!&(!4(#!&+6$0(4!$8+!E(M+E+2$!()!$8+!*(>+0!+6(98/=#6;!L#$!4(#!/*6(!0+&#<+!k1J!
*+M+*6@!!Y(;!4(#!8/M+!<(26$/2$!<(26$0'<$'(2!()!$8+!X[Y;!*+/&'2=!$(!L'0&!L+/F@!!J0(:!9(0$'(2!'6!
&'*/$+&@!!!
!
E. Parasites
_c!()!Y(#$8!%E+0'</!>8+0+!$8+!*+'68E/2'/!)(0E6!'2M/&+6!$8+!=/2=*'(2!<+**6!()!$8+!X[Y!/2&!
$8+!0+<$#E!77!90(&#<+!/<D#'0+&!/<8/*/6'/!/2&!N'06<8690#2=!&c!C!Chagas dz;!M+<$(0!C!
0+&#M'&!L#=!?/F/!F'66'2=!L#=BU!6>+**'2=!()!$8+!+4+!6'=2n!R(E/2/Q6@!!g8/$!&(+6!'$!&(!'2!$8+!
8+/0$n!./#6+6!E4(</0&'$'6!/2&!<80(2'<!8+/0$!)/'*#0+!7!<(2=+6$'M+!</0&'(E4(9/$84@!!I8'6!'6!
(2+!()!$8+!E(0+!<(EE(2!</#6+6!()!8+/0$!&c!'2!Y(#$8!%E+0'</@!
!
F. Barrett esophagus
\*<+0/$+&!E#<(6/!'2!$8+!&'6$/*!+6(98/=#6@!!S:-!6++!=*/2&#*/0!E+$/9*/6'/U!$8+0+)(0+!6++!
=(L*+$!<+**6!/2&!E#<(#6!<+**!?>8'<8!68(#*&2Q$!L+!$8+0+B@!!I8+4!/0+!$8+0+!LZ<!$8+!+6(98/=#6!
</22($!90($+<$!'$6+*)!)0(E!+6(98/=+/*!'23#04@!!I8+0+)(0+;!0#2!$8+!0'6F!()!/&+2(</0<'2(E/!()!
156
$8+!&'6$/*!+6(98/=#6@!![:/E9*+-!1)!$8+!*+6'(2!'2!+6(98/=#6;!&6498/='/!()!6(*'&6;!L#$!2($!
*'D#'&6;!*+6'(2!'2!2($+&!'2!&'6$/*!+6(98/=#6!7!&(!"GI!9'<F!6D#/E(#6!<+**!</0<'2(E/!7!$8'6!'6!
'2!$8+!K1_!+6(98/=#6@!!1)!'$!'6!&'6$/*;!'$!'6!/&+2(</0<'2(E/;!/2&!$8+!90+<#06(0!*+6'(2!'6!
S/00+$$Q6!+6(98/=#6@!!!
G. Esophageal varices
_'*/$+&!6#LE#<(6/*!+6(98/=+/*!M+'26!C!$8+0+)(0+!9$!8/6!<'008(6'6;!>8(!>/6!/2!/*<(8(*'<@!!J$!
/*6(!8/6!9(0$/*!NI"!7!$8+!*+)$!=/6$0'<!M+'2!'6!'2M(*M+&!?(2+!()!$8+!L0/2<8+6!())!$8+!9(0$/*!M+'2!
'6!*+)$!=/6$0'<!M+'2B@!!I8+!*+)$!=/6$0'<!M+'2!&0/'26!$8+!&'6$/*!+6(98/=#6!/2&!90(:'E/*!6$(E/<8@!!
g8/$!&0/'26!'2$(!$8+!*+)$!=/6$0'<!M+'2n!%c4=(#6!M+'2@!!g8+0+!&(+6!$8+!*+)$!=/6$0'<!M+'2!&0/'2!
'2$(n!J(0$/*!M+'2@!N(>+M+0;!LZ<!()!<'008(6'6;!9(0$/*!M+'2!</22($!+E9$4!L*((&!6#))'<'+2$*4!'2$(!
'$;!$8+!84&0(6$/$'<!90+66#0+!'2<0+/6+6U!4(#!0+M+06+!L*((&!)*(>!'2$(!$8+!*+)$!=/6$0'<!M+'2;!
69*+2'<!M+'2;!/2&!($8+0!M+'26;!/2&!+2&!#9!90(&#<'2=!M/0'<+6!$8/$!0#9$#0+@!!!
Hematemisis C!M(E'$'2=!L*((&
Hemoptysis C!<(#=8'2=!#9!L*((&
Hematochezia C!L*((&!9(#0'2=!(#$!()!/2#6!?/<$#/*!&0'99'2=!()!L*((&!7!2($!<(/$'2=!()!6$((*!
>'$8!L*((&;!$8/$!'6!6++2!'2!/2#6B@!!K..!C!&'M+0$'<#*(6'6U!2($!&'M+0$'<*#*'$'6!LZ<!$8+!M+66+*!'6!
2+:$!$(!$8+!&'M+0$'<#*/0!6/<;!6(!')!'$!>+0+!]d$'$'6Q;!'$!>(#*&!L+!6</00+&!())@!!g'$8!d(6'6;!'$!'6!
'2$/<$;!/2&!3#6$!8/M+!$(!+0(&+!'$;!*+/&'2=!$(!a!EX!L*++&@!!
157
158
159
160
B. Celiac Dz (sprue)
J'<!()!6E/**!L(>+*!*+6'(2!/2&!/!6F'2!c'$!$8/$!8/6!/2!/66(<'/$'(2!>'$8!'$@!!I8'6!'6!<+*'/<!&c!
?/#$('EE#2+!&cB;!/2&!$8+!6F'2!c'$!'6!dermatitis herpetiformis@!!Celiac dz is an
autoimmune dz against gluten wheat, esp. gliadin@!!1$!'6!M+04!<(EE(2!/2&!'6!$8+!K..!
()!E/*/L6(09$'(2!'2!$8'6!<(#2$04@!!Y(;!>8+2!4(#!+/$!>8+/$!90(&#<$6;!$8+!=*#$+2!'6!0+/L6(0L+&!
'2$(!$8+!M'**'!/2&!$8+0+!/0+!%LQ6!/=/'26$!=*'/&'2;!/2&!*+/&6!$(!&+6$0#<$'(2!()!$8+!M'**'!?3#6$!*'F+!
%LQ6!/=/'26$!9/0'+$/*!<+**6!(0!'2$0'26'<!)/<$(06;!>8'<8!&+6$0(4!+M+04$8'2=!/0(#2&!'$B@!Y(;!$8+!
%LQ6!/$$/<F!=*#$+2!$8/$!8/6!3#6$!L++2!0+/L6(0L+&!L4!$8+!)((&;!>8'<8!>'**!</#6+!&+6$0#<$'(2!()!
$8+!M'**#6@!%2&!$8+0+!/0+!2(!M'**'!8+0+!7!'$!'6!)*/$U!L*#2$'2=!()!M'**#6!7!6(!4(#!/0+!2($!/L*+!$(!
0+/L6(0L!)/$;!90($+'26;!(0!</0L6@!!I8+0+!'6!2(!M'**#6!6#0)/<+@!!!I8+!=*/2&6!#2&+02+/$8!/0+!)'2+;!
8(>+M+0@!!I8+!M'**'!/0+!/L6+2$@!!I8+0+!'6!/!100% chance of dermatitis herpetiformis
association with underlying celiac dz. Dermatitis herpetiformis is an autoimmune
dz, and it is a vesicular lesion of the skin 7*((F6!*'F+!8+09+6!()!$8+!6F'2@!!I8+4!>'**!68(>!
9'<!()!/!&+0E/$'$'6!8+09+$')(0E'6;!/2&!>'**!/6F!>8/$!$8+!</#6+!()!&'/008+/!'6n!%LQ6!/=/'26$!
=*#$+2!?=*'/&'2B@!
161
162
163
164
165
166
167
168
169
170
171
172
173
D. Review:
g8/$!>+!+:9+<$!'2!/<#$+!8+9/$'$'6!S!?>8/$!>(#*&!$8+!E/0F+06!L+Bn!!Y!%=;![!%=;!NSk!_"%;!
/2&!<(0+!1=K!
g8/$!')!$8+!9$!'6!'2!$8+!>'2&(>!9+0'(&n!.(0+!1=K!
g8/$!')!8/&!N+9!S;!L#$!8/M+!0+<(M+0+&!)0(E!'$n!.(0+!%L!1=l!/2&!6#0)/<+!%L!1=l!!
g8/$!')!9$!>/6!M/<<'2/$+&!?>8/$!'6!$8+!G"Xb!$8'2=!4(#!68(#*&!8/M+Bn!Y#0)/<+!%L!1=l!
g8/$!')!4(#!8/M+!/$!$8+!+2&!()!a!E(2$86!Y!%=;!<(0+!1=K;!>'$8!+M+04$8'2=!+*6+!2+=n!N+/*$84!
</00'+0!
g8/$!')!4(#!8/M+!/)$+0!a!E(2$86!6#0)/<+!%=;![!%=;!NSk!_"%!/2&!<(0+!%L!1=Kn!12)+<$'M+!
</00'+0@!!!
!
V. Inflammatory Liver Disorders
A. Amebiasis: Entamoeba histolytica
G0=/2'6E!'6!0+6'6$/2$!$(!/<'&!7!6>/**(>!'$!/2&!>'**!2($!&'+!'2!90+6+2<+!()!/<'&@!!1$!+:d<46$6!'2!
$8+!<+<#E;!>'$8'2!/2!/*F/*'2+!+2M'0(2E+2$@!!N/6!/!<8+E'</*!$8/$!</2!&0'**!/!8(*+!$80(#=8!$8+!
E#<(6/;!*+/&'2=!$(!)*/6F!68/9+&!#*<+06;!/2&!*+/&6!$(!bloody diarrhea@!!\2)(0$#2/$+*4;!LZ<!
$8+!<+<#E!'6!&0/'2+&!L4!$8+!9(0$/*!M+'2;!/2&!'6!)(0E'2=!/2!#*<+0;!$8+0+!'6!/!<8/2<+!$8/$!'$!</2!
&0'**!/2&!8(*+;!=+$!'2$(!$8+!9(0$/*!M+'2!$0'L#$/04!/2&!=+$!$(!$8+!0'=8$!*(L+!()!$8+!*'M+0;!>8+0+!'$!
>'**!90(&#<+!/2!/L6<+66@!!1$!>'**!6$/0$!&'66(*M'2=!$8+!*'M+0!7!8+2<+!$+0E!/2<8(M4!9/6$+!/L6<+66!
LZ<!'$!*((F6!*'F+!/2<8(M4!9/6$+!?/!L0(>2'68!*'D#'&B@!!1)!'$!>/2$6!$(;!'$!</2!&0'**!/!8(*+!$80(#=8!
$8+!0'=8$!&'/980/=E;!=(!$(!$8+!*#2=6;!/2&!90(&#<+!/2!+))#6'(2;!/2&!=(!/24>8+0+!'$!>/2$6!'2!
174
!
?K.!YZ[!()!</$/0/<$6!C!=*#<(<(0$'<('&6B!
VI. Nutmeg Liver
!
K..!C!RNT!
175
176
177
178
GALLBLADDER DZ
!
I. Ask about pathogenesis of stone too much cholesterol in bile or too little bile salts.
b(#!>'**!8/M+!/!6#9+06/$#0/$+&!6$(2+!>'$8!<8(*+6$+0(*!7!>'**!=+$!cholesterol stone (MC stone).
179
180
181
Carcinoma of the head of the pancreas MCC = smoker, 2nd MCC = chronic
pancreatitis, painless jaundice (mainly conjugated bilirubin), light colored stools,
palpable GB (Courvoisiers sign). .!6'=2!7!9+0E/2+2$*4!'2&+2$'2=!$8+!&#(&+2#E;!&(!L/0'#E!
6$#&4;!/*6(!/!6'=2!()!9/2<0+/$'<!</2<+0@!!!
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Acute pancreatitis with inflammation@!!g8/$!>'**!$8/$!&(!$(!9+0'6$/*6'6!()!$8/$!&#(&+2#E!
2+:$!$(!'$n!N(>!&(+6!$8+!L(>+*!0+/<$!$(!$8+!90+6+2<+!()!'2)*/EE/$'(2!2+:$!$(!'$n!It stops
peristalsing!?2($!$80(#=8!$8+!+2$'0+!L(>+*;!3#6$!$8+0+B@!!1)!$8'6!'6!$0#+;!$8+0+!>(#*&!3#6$!L+!/'0!'2!
$8+!/0+/!'$!&(+62Q$!9+0'6$/*6+6!7!>8/$!'6!$8'6!</**+&n!Sentinel sign!?6+2$'2+*!'6!6(E+(2+!$8/$!'6!
6#99(6+&!$(!F++9!>/$<8B!7!F++9!>/$<8!()!>8/$n!12)*/EE/$'(2!?6(;!the sentinel sign keeps
watch of inflammationBU!$8+!<*/66'<!/0+/!'6!$8+!9/2<0+/6@!!I8'6!is called localized ileus
(ileus, by definition is lack of peristalsis). Whenever the bowel lacks peristalsis, will
see air accumulate and will get distension. g8/$!')!4(#!8/M+!/!6+=E+2$!()!L(>+*!$8/$!'6!
&'6$+2&+&!'2!$8+!RXpn!N/6!$(!L+!'2)*/EE/$'(2;!$8+!<+<#E!'6!'2!$8+!RXp!/2&!/99+2&':!<(#*&!L+!
$8+!0+/6(2@!!Y(;!/99+2&'<'$'6!90(&#<'2=!6+2$'2+*Q6!6'=2@!!
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B. Nephrotoxic ATN:
l+2$/E4<'2;!%lQ6@!!1)!$8+4!/0+!2+980($(:'<;!>8/$!'6!$8+!)'06$!$8'2=!$8+4!>'**!)'*$+0+&!)0(E!$8+!
=*(E+0#*#6n!J0(:'E/*!$#L#*+@!!Y(;!nephrotoxic tubular necrosis related to drugs
involves the proximal tubule@!!%2&;!$8+!SK!0+E/'26!'2$/<$U!$8+0+)(0+!$8+!90(=2(6'6!()!
2+980($(:'<'$4!'6!>/4!L+$$+0!)(0!H!0+/6(26-!(2*4!/))+<$'2=!$8+!90(:'E/*!$#L#*+6!/2&!2($!
/))+<$'2=!$8+!SK@!!I8+!MCC nephrotoxicity = AGs (2nd MCC = intravenous
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Mg ammonium phosphate;!/2&!(2*4!&+M+*(96!'2!'2)+<$'(26!'2!9$6!$8/$!8/M+!#0+/6+!90(&#<+06@!!
[!<(*'!/0+!2($!#0+/6+!90(&#<+0!/2&!90($+#6!69+<'+6!/0+!/2&!$8+4!90+&'69(6+!$(!$8+6+!6$(2+6@!!_(!
2($!9/66!$8+6+!6$(2+6!?$((!L'=B;!$8+0+)(0+!2++&!$(!+:$0/<$!$8+6+!?6#0=+04B@!!Y(;!urease
producer, alkaline pH, ammonia smell to the urine.
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Bone Disorders
Osteogenesis imperfecta!
Y*'&+-!5'&!>'$8!/2!+4+L/**;!L*#+!6<*+0/-!%_!&'6(0&+0!>'$8!&+)+<$!'2!642$8+6'6!()!$49+!1!<(**/=+2;!2($+!$8+!
L*#+!6<*+0/d!*(66!()!<(**/=+2!'2!6<*+0/!/**(>6!L*#'68!<(*(0!()!<8(0('&/*!M+66+*6!$(!68'2+!$80(#=8-!
Osteogenesis imperfecta ?"GI!)(0+'=2!L(&4mB!iL0'$$*+!L(2+!&'6+/6+j!</2$!L0+/F!L(2+!&(>2!
!
p#+6$'(2-!>8/$Q6!$8+!&+)+<$n!_+)+<$'M+!642$8+6'6!()!$49+!,!<(**/=+2!
!
p#+6$'(2-!>8/$Q6!$8+!E+<8/2'6E!()!&+M+*(9E+2$!()!L*#+!6<*+0/n!!
.(**/=+2!'2!6<*+0/;!$49+!,!'6!&+)+<$'M+;!6(!'$!'6!6(!$8'2;!6(!4(#!</2!6++!$8+!#2&+0*4'2=!<8(0('&/*!M+'26!
$8/$!='M+6!$8+!L*#+!<(*(0@!
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Osteogenic sarcoma!!
Y*'&+-!"($+!E+$/9846+/*!(0'='2!()!$8+!</2<+0!/2&!+:$+26'(2!'2$(!$8+!E#6<*+;!2($+!$8+!69*'2$+0!()!
9+0'(6$+#E!$8/$!'6!+*+M/$+&!>8'<8!>(#*&!<(00+69(2&!$(!.(&E/26!$0'/2=*+!
!
Y*'&+-!hd0/4!()!90(:'E/*!8#E+0#6!68(>'2=!$8+!6#2L#06$!/99+/0/2<+!()!(6$+(=+2'<!6/0<(E/!$8/$!'6!
+:$+2&'2=!'2$(!$8+!E#6<*+;!(6$+(=+2'<!'E9*'+6!$8/$!$8+!</2<+0!'6!E/F'2=!L(2+!
!
%&(*+6<+2$;!6#2!L#06$!/99;!<(&E/26!$0'/2=*+;!F2++!/0+/CCG6$+(=+2'<!Y/0<(E+!
!
Suppressor Gene relationship: RL!6#990+66(0!.80(E(6(E+!,P!
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Muscular Disorders
Duchennes Muscular Dystrophy
l(>+0Q6!E/2+#M+0!
[*+M/$+&!Y+0#E!.5;!%L6+2<+!()!&46$0(98'2!90($+'2!
!
Y+:!*'2F+&!0+<+66'M+;!E'66'2=!_46$0(98'2!=+2+!
!
k/0'/2$-!S+<F+0Q6!&46$0(984-!E/F+!&46$0(98'2!L#$!'$!'6!&+)+<$'M+!
!
%2/*(=4-!/*)/!,!/2$'$0496'2!&+)-!K..!()!N..!'2!<8'*&0+2!
%&#*$6!=+$!9/2/<'2/0!+E9846+E/-!E/24!&'))!6#L!$49+6!()!/*)/!,!/2$'d$0496'2-!!
!
,B!%L6+2$!/*)/!,!/2$'d$0496'2-!=+$!9/2!/<'2/0!+E9846+E/@!
!
HB!%*)/!,!/2$'d$0496'2!'6!90+6+2$!L#$!'$!</22($!=+$!G\I!()!$8+!8+9/$(<4$+6-!6(!=+$!N..!
!
%#&'(!)'*+!_/4!e!se!YF'2!
Myotonic dystrophy - MC adult dystrophy, AD
I0'9*+$!0+9+/$!&c!7!0+9+$'$'(2!()!$0'd2$Q6!?$8+0+!/0+!^!&cQ6!>'$8!$8'6!/L2(0E/*'$4!7!N_;!T0/='*+!h!7!8/M+!
E/<0(0<8'&'6E!?L'=!$+6$+6!'2!/&(*+6<+2$6B;!T0'+&0'<8Q6!/$/:'/;!K4($(2'<!&46$0(984B@!!!
!
12!)#$#0+!=+2+0/$'(26;!&c!=+$6!>(06+!7!/2$'<'9/$'(2@!!I8+0+)(0+;!</2!/2$'<'9/$+!$8/$!'2!)#$#0+!&cQ6!'$!>'**!
=+$!>(06+@!!T(0!+/<8!=+2+0/$'(2;!$8+0+!/0+!E(0+!$0'9*+$!0+9+/$6!/&&+&!(2;!*+/&'2=!$(!/!E(0+!&+)+<$'M+!
90($+'2!/2&!$8+!&c!=+$6!>(06+!/2&!>(06+@!
!!!
[:/E9*+-!=+2+$'<!<(#26+*(0!$+**'2=!<(#9*+!$8/$!$8+4!8/M+!/!&c;!>8+0+!')!/0+!$(!8/M+!<8'*&0+2;!$8+!&c!>'**!
L+!)/$/*!'2!$8+'0!<8'*&0+2@!!I8+!<(#9*+!&'&2Q$!*'6$+2!$(!$8+'0!<(#26+*+0;!8/&!/!<8'*&!/2&!$8+!<8'*&!&'+&!(2*4!
/)$+0!,!E(2$8@!!g8/$!>/6!'$!/2&!>8/$!'6!$8'6-!/2!'+!$0'9*+$!0+9+/$!&'6(0&+0!?/2$'<'9/$'(2B!K#6<*+!
>+/F2+66!'2!)/<+!?6(!E(#$8!'6!&0((9+&!(9+2B@!!
!!
[:/E9*+-!9$!>'$8!)/'*#0+!$(!0+*+/6+!=0'9!(2!=(*)!6$'<F!?(0!>8+2!68/F'2=!8/2&B!7!$8+4!</22($!0+*/:!$8+'0!
E#6<*+!=0'9;!&'/L+$+6;!</0&'/<!/L2(0E/*'$4!
!
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