Documenti di Didattica
Documenti di Professioni
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Criteria
#
1
2
Efficacy
Points
3
4
Safety
Points
2
3
4
When considering the use of DTG/ABC/3TC, dat from the SINGLE
trial showed very reassuring results in ART-nave patients. Grade 3-4
adverse effects events were reported in 10% of patients on DTG in
comparison with 16% of subjects receiving EFV. DTG arm reported 43%
versus the EFV arm with 66% of all-grade drug-related side effects,
with significantly lower incidence of neuropsychiatric and skin adverse
events. Most commonly reported adverse events in DTG arm were
diarrhea, insomnia, nasopharyngitis and nausea (Fernandez-Montero,
et al, 2014).
Criteria
1
Necessity
Points
2
3
Convenience
schedule)
of
and
4
Minimal resistance to the drug
Criteria
1
Affordability
PHP 1 P 19,999 per month
Points
++++
2
PHP 20,000 39,999 per month
+++
++
3
4
PHP > 60,000
The cost of a month-treatment of DTG/ABC/3TC is approximately
___ for 1 tablet intake once a day.
Reference:
1. http://www.researchgate.net/publication/261799495_Dolutegravir
_abacavir_and_lamivudine_as_HIV_therapy
TENOFOVIR/EMITRCITABINE
Criteria
#
1
Efficacy
Points
3
4
+
+
In the study conducted in India for both ART nave and ART experienced
patients, the median change in CD4 counts at 6 and 12 months among ARV-naive patients was
+168 cells/microliter (mcL) and +368 cells/mcL, respectively.
Criteria
1
Safety
Points
2
3
4
Criteria
1
Necessity
Points
2
3
Convenience
schedule)
of
and
4
+
Approved by the FDA in 2001, Tenofovir is a nucleotide analog of deoxyadenosine
monophosphate, with activity against HIV-1, -2 and Hepatitis B virus (HBV) (Mulato and
Cherrington 1997; Robbins et al 1998). Because of its long half-life (17 hours), it is
administered once daily with other antiretroviral drugs.
Criteria
1
Affordability
PHP 1 P 19,999 per month
Points
++++
2
PHP 20,000 39,999 per month
+++
++
3
4
PHP > 60,000
Criteri
a#
Necessity
Points
++++
+++
++
+