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Fluorine
From Wikipedia, the free encyclopedia
Euskara readily forms compounds with most other elements. It has an Heat of (F 2 ) 6.62 kJ·mol−1
oxidation number -1, except when bonded to another fluorine in vaporization
Français F2 which gives it an oxidation number of 0. Fluorine combines Specific heat (25 °C) (F 2 )
Frysk with the noble gases argon, krypton, xenon, and radon. Even in capacity 31.304 J·mol −1 ·K −1
Furlan dark, cool conditions, fluorine reacts explosively with hydrogen.
Vapor pressure
Gaeilge The reaction with hydrogen can occur at extremely low
Gaelg temperatures, using liquid hydrogen and solid fluorine. It is so
Galego P/Pa 1 10 100 1k 10 k 100 k
reactive that metals, water, as well as most other substances,
Hak-kâ-fa burn with a bright flame in a jet of fluorine gas. In moist air, it at T/K 38 44 50 58 69 85
ionic salts. Fluorine compounds with metals are among the most (Weaklyacidic oxide)
Hrvatski
Ido stable of salts. Electronegativity 3.98 (Pauling scale)
Bahasa Indonesia Hydrogen fluoride is a weak acid when dissolved in water, but Ionization energies 1st: 1681.0 kJ·mol−1
Íslenska
is still very corrosive and attacks glass. Consequently, fluorides (more) 2nd: 3374.2 kJ·mol−1
Italiano
of alkali metals produce basic solutions. For example, a 1 M
עברית 3rd: 6050.4 kJ·mol−1
solution of NaF in water has a pH of 8.59 compared to a 1 M
Covalent radius 57±3 pm
solution of NaOH, a strong base, which has a pH of 14.00. [2]
Kiswahili (see covalent radius of fluorine)
Kreyòl ayisyen
Kurdî /
Isotopes Van der Waals 147 pm
radius
Latina
Main article: Isotopes of fluorine
Latviešu Miscellanea
Lëtzebuergesch Although fluorine (F) has multiple isotopes, only one of these
Crystal structure cubic
Lietuvių isotopes (F-19) is stable, and the others have short half-lives
and are not found in nature. Fluorine is thus a mononuclidic Magnetic ordering nonmagnetic
Líguru
Lojban element. Thermal (300 K) 27.7 m W·m −1 ·K −1
Magyar
The nuclide 18 F is the radionuclide of fluorine with the longest conductivity
Македонски
half life (about 110 minutes), and commercially is an important CAS registry 7782-41-4
source of positrons, finding its major use in positron emission number
Māori
tomography scanning. Most stable isotopes
Novial
Industrial use of fluorine-containing 19 F 100% 19 F is stable with 10 neutrons
Occitan
compounds
O'zbek
This box: view • talk • edit
Atomic fluorine and molecular fluorine are used for plasma
etching in semiconductor manufacturing, flat panel display
Plattdüütsch production and MEMS (microelectromechanical systems)
Polski fabrication. [4] Xenon difluoride is also used for this last purpose.
Português Hydrofluoric acid (chemical formula HF) is used to etch glass in
Română light bulbs and other products.
Runa Simi Tetrafluoroethylene and perfluorooctanoic acid (PFOA) are
Русский
directly used in the production of low friction plastics such as
Seeltersk
Teflon (or polytetrafluoroethylene).
Shqip
Fluorine is used indirectly in the production of halons such as
Sicilianu
freon.
Simple English
Slovenčina
Along with some of its compounds, fluorine is used in the
Because of the difficulty of biological systems in dealing with metabolism of fluorinated molecules,
fluorinated antibiotics and antidepressants are among the major fluorinated organics found in treated city
sewage and wastewater.
Compounds containing 18 F, a radioactive isotope that emits positrons, are often used in positron emission
tomography, because its half-life of 110 minutes is long by the standards of positron-emitters. One such
species is fluorodeoxyglucose.
Chemistry of fluorine
Fluorine forms a variety of very different compounds, owing to its small atomic size and covalent behavior.
Elemental fluorine is a dangerously powerful oxidant, reflecting the extreme electronegativity of fluorine.
Hydrofluoric acid is extremely dangerous, whereas in synthetic drugs incorporating an aromatic ring (e.g.
flumazenil), fluorine is used to help prevent toxication or to delay metabolism [citation needed] .
The fluoride ion is basic, therefore hydrofluoric acid is a weak acid in water solution. However, water is not an
inert solvent in this case: when less basic solvents such as anhydrous acetic acid are used, hydrofluoric acid
is the strongest of the hydrohalogenic acids. Also, owing to the basicity of the fluoride ion, soluble fluorides
give basic water solutions. The fluoride ion is a Lewis base, and has a high affinity to certain elements such
as calcium and silicon. For example, deprotection of silicon protecting groups is achieved with a fluoride. The
fluoride ion is poisonous.
Fluorine as a freely reacting oxidant gives the strongest oxidants known.
The reactivity of fluorine toward the noble gas xenon was first reported by Neil Bartlett in 1962. Fluorides of
krypton and radon have also been prepared. Argon fluorohydride has been observed at cryogenic
temperatures.
The carbon-fluoride bond is covalent and very stable. The use of a fluorocarbon polymer,
poly(tetrafluoroethene) or Teflon, is an example: it is thermostable and waterproof enough to be used in frying
pans. Organofluorines may be safely used in applications such as drugs, without the risk of release of toxic
fluoride. In synthetic drugs, toxication can be prevented. For example, an aromatic ring is useful but presents
a safety problem: enzymes in the body metabolize some of them into poisonous epoxides. When the para
position is substituted with fluorine, the aromatic ring is protected and epoxide is no longer produced.
The substitution of fluorine for hydrogen in organic compounds offers a very large number of compounds. An
estimated fifth of pharmaceutical compounds and 30% of agrochemical compounds contain fluorine. [8] The -
CF 3 and -OCF 3 moieties provide further variation, and more recently the -SF5 group.[9]
Production
Industrial production of fluorine entails the electrolysis of hydrogen
fluoride in the presence of potassium fluoride. This method is
based on the pioneering studies by Moissan (see below). Fluorine
gas forms at the anode, and hydrogen gas at the cathode. Under
these conditions, the potassium fluoride (KF) converts to potassium
bifluoride (KHF 2 ), which is the actual electrolyte. This potassium
bifluoride aids electrolysis by greatly increasing the electrical
conductivity of the solution.
HF + KF → KHF2
2 KHF2 → 2 KF + H 2 + F2 Fluorine cell room at F2 Chemicals Ltd,
The HF required for the electrolysis is obtained as a byproduct of Preston, UK
History
The mineral fluorspar (also called fluorite), consisting mainly of calcium fluoride, was described in 1530 by
Georgius Agricola for its use as a flux.[11] Fluxes are used to promote the fusion of metals or minerals. The
etymology of the element's name reflects its history: Fluorine is pronounced /'fl əri n/, /'fl ər n/, or
commonly /'fl r-/; from Latin: fluere, meaning "to flow". In 1670 Schwanhard found that glass was etched
when it was exposed to fluorspar that had been treated with acid. Carl Wilhelm Scheele and many later
researchers, including Humphry Davy, Caroline Menard, Gay-Lussac, Antoine Lavoisier, and Louis Thenard
all would experiment with hydrofluoric acid, easily obtained by treating fluorite with concentrated sulfuric acid.
Owing to its extreme reactivity, elemental fluorine was not isolated until many years after the characterization
of fluorite. Progress in isolating elemental fluorine was slowed because it could only be prepared
electrolytically and even then under stringent conditions since the gas attacks many materials. In 1886, the
isolation of elemental fluorine was reported by Henri Moissan after almost 74 years of effort by other
chemists.[12] The generation of elemental fluorine from hydrofluoric acid is exceptionally dangerous, killing or
blinding several scientists who attempted early experiments on this halogen. These individuals came to be
referred to as "fluorine martyrs". [13] For Moissan, it earned him the 1906 Nobel Prize in chemistry. [14]
The first large-scale production of fluorine was undertaken in support of the Manhattan project, where the
compound uranium hexafluoride (UF6 ) had been selected as the form of uranium that would allow separation
of its 235 U and 238 U isotopes. Today both the gaseous diffusion process and the gas centrifuge process use
gaseous UF 6 to produce enriched uranium for nuclear power applications. In the Manhattan Project, it was
found that UF 6 decomposed into UF 4 and F2 . The corrosion problem due to the F2 was eventually solved by
electrolytically coating all UF 6 carrying piping with nickel metal, which forms a nickel difluoride that is not
attacked by fluorine. Joints and flexible parts were made from teflon, then a very recently discovered
fluorocarbon plastic which is also not attacked by F2 .
Biological role
Though F2 is too reactive to have any natural biological role, fluorine is incorporated into compounds with
biological activity. Naturally occurring organofluorine compounds are rare, the most notable example is
fluoroacetate, which functions as a plant defence against herbivores in at least 40 plants in Australia, Brazil
and Africa.[15] The enzyme adenosyl-fluoride synthase catalyzes the formation of 5'-deoxy-5'-
fluoroadenosine. Fluorine is not an essential nutrient, but its importance in preventing tooth decay is well-
recognized. [16] The effect is predominantly topical, although prior to 1981 it was considered primarily
systemic (occurring through ingestion).[17]
Precautions
Elemental fluorine
Elemental fluorine (fluorine gas) is a highly toxic, corrosive oxidant, which can cause ignition of organic
material. Fluorine gas has a characteristic pungent odor that is detectable in concentrations as low as 20 ppb.
As it is so reactive, all materials of construction must be carefully selected and metal surfaces must be
passivated.
Fluoride ion
Main article: Fluoride poisoning
Fluoride ions are toxic: the lethal dose of sodium fluoride for a 70 kg human is estimated at 5–10 g. [18]
Organofluorines
Organofluorines are naturally rare compounds. They can be nontoxic (perflubron and perfluorodecalin) or
highly toxic (perfluoroisobutylene and fluoroacetic acid). Many pharmacueticals are organofluorines, such as
the anti-cancer fluorouracil. Perfluorooctanesulfonic acid (PFOS) is a persistent organic pollutant.
See also
Fluorocarbon
Isotopes of fluorine
Halide minerals
Water fluoridation
References
1. ^ Theodore Gray. "Real visible fluorine" . The Wooden Periodic Table.
2. ^ "pKa's of Inorganic and Oxo-Acids" . Evans Group. Retrieved 2008-11-29.
3. ^ M. Jaccaud, R. Faron, D. Devilliers, R. Romano (2005). Fluorine, in Ullmann’s Encyclopedia of Industrial Chemistry.
Weinheim: Wiley-VCH. ISBN 3527310975.
4. ^ Leonel R Arana, Nuria de Mas, Raymond Schmidt, Aleksander J Franz, Martin A Schmidt and Klavs F Jensen (2007).
"Isotropic etching of silicon in fluorine gas for MEMS micromachining". J. Micromech. Microeng. 17: 384. doi:10.1088/0960-
1317/17/2/026 .
5. ^ "Class I Ozone-Depleting Substances" . Ozone Depletion. U.S. Environmental Protection Agency.
6. ^ compiled by Alexander Senning. (2007). Elsevier's dictionary of chemoetymology : the whies and whences of chemical
nomenclature and terminology . Amsterdam: Elsevier. p. 149. ISBN 9780444522399.
7. ^ Steve S Lim. "eMedicine - Corticosteroid-Induced Myopathy" .
8. ^ "Fluorine's treasure trove" . ICIS news. 2006-10-02. Retrieved 2008-11-29.
9. ^ Bernhard Stump, Christian Eberle, W. Bernd Schweizer, Marcel Kaiser, Reto Brun, R. Luise Krauth-Siegel, Dieter Lentz,
François Diederich (2009). "Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase
Inhibition and Antiprotozoal Activities of Diarylamines". ChemBioChem 10 (1): 79. doi:10.1002/cbic.200800565 . PMID
19058274 .
10. ^ K. Christe (1986). "Chemical synthesis of elemental fluorine". Inorg. Chem. 25: 3721–3724. doi:10.1021/ic00241a001 .
11. ^ "Discovery of fluorine" . Fluoride History.
12. ^ H. Moissan (1886). "Action d'un courant électrique sur l'acide fluorhydrique anhydre" . Comptes rendus hebdomadaires
des séances de l'Académie des sciences 102: 1543–1544.
13. ^ Richard D. Duncan. (2008). Elements of faith : faith facts and learning lessons from the periodic table . Green Forest,
Ark.: Master Books. p. 22. ISBN 9780890515471.
14. ^ "The Nobel Prize in Chemistry 1906" . Nobelprize.org. Retrieved 2009-07-07.
15. ^ Proudfoot AT, Bradberry SM, Vale JA (2006). "Sodium fluoroacetate poisoning". Toxicol Rev 25 (4): 213–9.
doi:10.2165/00139709-200625040-00002 . PMID 17288493 .
16. ^ Olivares M and Uauy R (2004). "Essential nutrients in drinking-water (Draft)" . WHO. Retrieved 2008-12-30.
17. ^ Pizzo G, Piscopo MR, Pizzo I, Giuliana G (September 2007). "Community water fluoridation and caries prevention: a
critical review". Clin Oral Investig 11 (3): 189–93. doi:10.1007/s00784-007-0111-6 . PMID 17333303 .
18. ^ Aigueperse, Jean; Paul Mollard, Didier Devilliers, Marius Chemla, Robert Faron, Renée Romano, Jean Pierre Cuer
(2005). "Fluorine Compounds, Inorganic". in Ullmann. Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH.
19. ^ "Recommended Medical Treatment for Hydrofluoric Acid Exposure" (PDF). Honeywell Specialty Materials. Retrieved
2009-05-06.
External links
WebElements.com – Fluorine
Wikimedia Commons has media
It's Elemental – Fluorine related to: Fluorine
Picture of liquid fluorine – chemie-master.de
Chemsoc.org
Look up fluorine in Wiktionary,
the free dictionary.
v• d • e Periodic table
H He
Li Be B C N O F Ne
Na Mg Al Si P S Cl Ar
K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr
Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe
Cs Ba La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn
Uue Ubn
Categories: Chemical elements | Halogens | Fluorine | Fluorinating agents | Biology and pharmacology of
chemical elements
Chlorine
From Wikipedia, the free encyclopedia
This article is about the chemical element. For the bleach, see Sodium hypochlorite.
Chlorine (pronounced /'kl əri n/ KLOR-een, from the Greek
sulfur ← chlorine → argon
navigation word 'χλωρóς' (khlôros, meaning 'pale green'), is the chemical
F
element with atomic number 17 and symbol Cl. It is a halogen, 17 Cl
Main page ↑
Contents
found in the periodic table in group 17 (formerly VII, VIIa, or
Cl
Featured content VIIb). As the chloride ion, which is part of common salt and
↓
Current events other compounds, it is abundant in nature and necessary to Periodic table
Br
Random article most forms of life, including humans. In its elemental form (Cl2
or "dichlorine") under standard conditions, chlorine is a powerful Appearance
search
oxidant and is used in bleaching and disinfectants, as well as an pale yellow-green gas
essential reagent in the chemical industry. As a common
Go Search
disinfectant, chlorine compounds are used in swimming pools to
keep them clean and sanitary. In the upper atmosphere,
interaction
chlorine-containing molecules such as chlorofluorocarbons have
About Wikipedia
been implicated in the destruction of the ozone layer.
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Recent changes Contents [hide]
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1 Characteristics
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1.1 Isotopes General properties
Help
1.2 Occurrence Name, symbol, chlorine, Cl, 17
toolbox 2 History number
What links here 3 Production
Element category Halogen
Related changes 3.1 Electrolysis
Upload file 3.2 Other methods Group, period, 17, 3, p
Special pages 3.3 Industrial production block
Printable version 4 Compounds Standard atomic 35.453(2) g·mol−1
Permanent link 4.1 Oxidation states weight
Cite this page 5 Applications and uses
Electron [Ne] 3s 2 3p 5
languages 5.1 Production of industrial and consumer products
configuration
5.2 Purification and disinfection
Afrikaans
Electrons per shell 2, 8, 7 (Image)
5.3 Chemistry
5.4 Use as a weapon Physical properties
Asturianu
Azərbaycan 5.5 Chlorine cracking Phase gas
5.6 Other uses
Density (0 °C, 101.325 kPa)
Беларуская 6 Health effects
3.2 g/L
Bosanski 7 See also
Български 8 References Melting point 171.6 K, -101.5 °C, -
between the two atoms is relatively weak (only of 242.580 Specific heat (25 °C) (Cl 2 )
Eesti
±0.004 kJ/mol) which makes the Cl 2 molecule highly reactive. capacity 33.949 J·mol −1 ·K −1
Ελληνικά
Español Along with fluorine, bromine, iodine and astatine, chlorine is a Vapor pressure
Esperanto member of the halogen series that forms the group 17 of the
Euskara periodic table—the most reactive group of elements. It P/Pa 1 10 100 1k 10 k 100 k
combines readily with nearly all elements. at T/K 128 139 153 170 197 239
Français
Compounds with oxygen, nitrogen, xenon, and krypton are
Furlan
known, but do not form by direct reaction of the elements. [2] Atomic properties
Gaeilge
Chlorine, though very reactive, is not as extremely reactive as Oxidation states 7, 6, 5, 4, 3, 2, 1, -1
Gaelg
Galego
fluorine. Pure chlorine gas does, however, support combustion (strongly acidic oxide)
Hak-kâ-fa of organic compounds such as hydrocarbons, although the
Electronegativity 3.16 (Pauling scale)
carbon component tends to burn incompletely, with much of it
Ionization energies 1st: 1251.2 kJ·mol−1
Hawai`i remaining as soot. [3] At 10 °C and atmospheric pressure, one
liter of water dissolves 3.10 L of gaseous chlorine, and at 30 °C
(more) 2nd: 2298 kJ·mol−1
(86 °F), 1 L of water dissolves only 1.77 liters of chlorine. [4] 3rd: 3822 kJ·mol−1
Hrvatski
Chlorine is a member of the salt-forming halogen series and is Covalent radius 102±4 pm
Ido
extracted from chlorides through oxidation often by electrolysis. Van der Waals 175 pm
Bahasa Indonesia
With metals, it forms salts called chlorides. As the chloride ion, radius
Íslenska
Italiano
Cl − , it is also the most abundant dissolved ion in ocean water.
Miscellanea
עברית
Isotopes Crystal structure orthorhombic
Bahasa Melayu large amounts of 36 Cl were produced by irradiation of seawater 36 Cl trace 3.01×10 5 y β− 0.709 36 Ar
Chlorine was first used to bleach textiles in 1785. [15] In 1826, silver chloride was used to produce
photographic images for the first time. [16] Chloroform was first used as an anesthetic in 1847. [16] A chlorine
solution in lime-water (hypochlorite) was first used as a germicide to prevent the spread of puerperal fever in
the maternity wards of Vienna General Hospital in Austria in 1847, [17] and in 1850 by John Snow to disinfect
the water supply in London after an outbreak of cholera. The US Department of Treasury called for all water
to be disinfected with chlorine by 1918. [16] Polyvinylchloride (PVC) was invented in 1912, initially without a
purpose. [16] Chlorine gas was first introduced as a weapon on April 22, 1915 at Ypres by the German
Army,[18][19] and the results of this weapon were disastrous because gas masks had not yet been invented.
Production
Main article: Chlorine production
Electrolysis
of the concentrated sodium hydroxide solution leaving the cell is diverted as product, while the remainder is
diluted with deionized water and passed through the electrolysis apparatus again.
This method is more efficient than the diaphragm cell and produces very pure sodium (or potassium)
hydroxide at about 32% concentration, but requires very pure brine.
Other electrolytic processes
Although a much lower production scale is involved, electrolytic diaphragm and membrane technologies are
also used industrially to recover chlorine from hydrochloric acid solutions, producing hydrogen (but no caustic
alkali) as a co-product.
Furthermore, electrolysis of fused chloride salts (Downs process) also enables chlorine to be produced, in this
case as a by-product of the manufacture of metallic sodium or magnesium.
Other methods
Before electrolytic methods were used for chlorine production, the direct oxidation of hydrogen chloride with
oxygen or air was used in the Deacon process:
4 HCl + O 2 → 2 Cl2 + 2 H 2 O
This reaction is accomplished with the use of copper(II) chloride (CuCl 2 ) as a catalyst and is performed at
high temperature (about 400 °C). The amount of extracted chlorine is approximately 80%. Due to the
extremely corrosive reaction mixture, industrial use of this method is difficult and several pilot trials failed in
the past. Nevertheless, recent developments are promising. Recently Sumitomo patented a catalyst for the
Deacon process using ruthenium(IV) oxide (RuO 2 ).[28]
Another earlier process to produce chlorine was to heat brine with acid and manganese dioxide.
2 NaCl + 2 H 2 SO4 + MnO 2 → Na2 SO4 + MnSO4 + 2 H 2 O + Cl 2
Using this process, chemist Carl Wilhelm Scheele was the first to isolate chlorine in a laboratory. The
manganese can be recovered by the Weldon process.[29]
In the latter half of the 19th century, prior to the adoption of electrolytic methods of chlorine production, there
was substantial production of chlorine by these reactions to meet demand for bleach and bleaching powder
for use by textile industries; by the 1880s the UK, as well as supporting its own (then not inconsiderable)
domestic textile production was exporting 70,000 tons per year of bleaching powder. [30] This demand was
met by capturing hydrochloric acid driven off as a gas during the production of alkali by the Leblanc process,
oxidizing this to chlorine (originally by reaction with manganese dioxide), later by direct oxidation by air using
the Deacon process (in which case impurities capable of poisoning the catalyst had first to be removed), and
subsequently absorbing the chlorine onto lime.
Small amounts of chlorine gas can be made in the laboratory by putting concentrated hydrochloric acid in a
flask with a side arm and rubber tubing attached. Manganese dioxide is then added and the flask stoppered.
The reaction is not greatly exothermic. As chlorine is denser than air, it can be collected by placing the tube
inside a flask where it will displace the air. Once full, the collecting flask can be stoppered.
Another method for producing small amounts of chlorine gas in a lab is by adding concentrated hydrochloric
acid (typically about 5M) to sodium hypochlorite or sodium chlorate solution.
Industrial production
Large-scale production of chlorine involves several steps and many pieces
of equipment. The description below is typical of a membrane plant. The
plant also simultaneously produces sodium hydroxide (caustic soda) and
hydrogen gas. A typical plant consists of brine production/treatment, cell
operations, chlorine cooling & drying, chlorine compression & liquefaction,
liquid chlorine storage & loading, caustic handling, evaporation, storage &
loading and hydrogen handling.
Brine
Several methods of compression may be used: liquid ring, reciprocating, or centrifugal. The chlorine gas is
compressed at this stage and may be further cooled by inter- and after-coolers. After compression it flows to
the liquefiers, where it is cooled enough to liquefy. Non condensable gases and remaining chlorine gas are
vented off as part of the pressure control of the liquefaction systems. These gases are routed to a gas
scrubber, producing sodium hypochlorite, or used in the production of hydrochloric acid (by combustion with
hydrogen) or ethylene dichloride (by reaction with ethylene).
Storage and loading
Liquid chlorine is typically gravity-fed to storage tanks. It can be loaded into rail or road tankers via pumps or
padded with compressed dry gas.
Caustic handling, evaporation, storage and loading
Caustic, fed to the cell room flows in a loop that is simultaneously bled off to storage with a part diluted with
deionized water and returned to the cell line for strengthening within the cells. The caustic exiting the cell line
must be monitored for strength, to maintain safe concentrations. Too strong or too weak a solution may
damage the membranes. Membrane cells typically produce caustic in the range of 30% to 33% by weight.
The feed caustic flow is heated at low electrical loads to control its exit temperature. Higher loads require the
caustic to be cooled, to maintain correct exit temperatures. The caustic exiting to storage is pulled from a
storage tank and may be diluted for sale to customers who require weak caustic or for use on site. Another
stream may be pumped into a multiple effect evaporator set to produce commercial 50% caustic. Rail cars
and tanker trucks are loaded at loading stations via pumps.
Hydrogen handling
Hydrogen produced may be vented unprocessed directly to the atmosphere or cooled, compressed and dried
for use in other processes on site or sold to a customer via pipeline, cylinders or trucks. Some possible uses
include the manufacture of hydrochloric acid or hydrogen peroxide, as well as desulfurization of petroleum
oils, or use as a fuel in boilers or fuel cells. In Porsgrunn the byproduct is used for the hydrogen fueling
station at Hynor.
Energy consumption
Production of chlorine consumes a large amount of energy. [31] Energy consumption per unit weight of product
is not far below that for iron and steel manufacture [32] and greater than for the production of glass [33] or
cement. [34]
The amount of electrical energy required to produce a given amount of chlorine is fixed by the nature of the
electrochemical reaction. Any energy savings, therefore, can only be made by improving the efficiency of the
process and reducing ancillary energy use.
Compounds
See also: Category:Chlorine compounds
For general references to the chloride ion (Cl− ), including references to specific chlorides, see chloride. For
other chlorine compounds see chlorate (ClO −3 ), chlorite (ClO −2 ), hypochlorite (ClO− ), and perchlorate (ClO −4 ),
and chloramine (NH 2 Cl). [35]
Other chlorine-containing compounds include:
Fluorides: chlorine monofluoride (ClF), chlorine trifluoride (ClF 3 ), chlorine pentafluoride (ClF 5 )
Oxides: chlorine dioxide (ClO2 ), dichlorine monoxide (Cl 2 O), dichlorine heptoxide (Cl 2 O 7 )
Acids: hydrochloric acid (HCl), hypochlorous acid (HOCl), chloric acid (HClO 3 ) and perchloric acid.
Oxidation states
Oxidation
Name Formula Example compounds
state
−1 chlorides Cl − ionic chlorides, organic chlorides, hydrochloric acid
Chlorine exists in all odd numbered oxidation states from −1 to +7, as well as the elemental state of zero.
Progressing through the states, hydrochloric acid can be oxidized using manganese dioxide, or hydrogen
chloride gas oxidized catalytically by air to form elemental chlorine gas. The solubility of chlorine in water is
increased if the water contains dissolved alkali hydroxide. This is due to disproportionation:
Cl 2 + 2 OH − → Cl − + ClO − + H 2 O
In hot concentrated alkali solution disproportionation continues:
2 ClO − → Cl − + ClO −2
ClO − + ClO −2 → Cl − + ClO −3
Sodium chlorate and potassium chlorate can be crystallized from solutions formed by the above reactions. If
their crystals are heated, they undergo the final disproportionation step.
4 ClO −3 → Cl − + 3 ClO −4
This same progression from chloride to perchlorate can be accomplished by electrolysis. The anode reaction
progression is:[36]
Electrode
Reaction
potential
Cl − + 2 OH − → ClO − + H 2 O + 2 e − +0.89 volts
ClO − + 2 OH − → ClO −2 + H 2 O + 2 e − +0.67 volts
ClO −2 + 2 OH − → ClO −3 + H 2 O + 2 e − +0.33 volts
ClO −3 + 2 OH − → ClO −4 + H 2 O + 2 e − +0.35 volts
It is often impractical to store and use poisonous chlorine gas for water treatment, so alternative methods of
adding chlorine are used. These include hypochlorite solutions, which gradually release chlorine into the
water, and compounds like sodium dichloro-s-triazinetrione (dihydrate or anhydrous), sometimes referred to
as "dichlor", and trichloro-s-triazinetrione, sometimes referred to as "trichlor". These compounds are stable
while solid and may be used in powdered, granular, or tablet form. When added in small amounts to pool
water or industrial water systems, the chlorine atoms hydrolyze from the rest of the molecule forming
hypochlorous acid (HOCl) which acts as a general biocide killing germs, micro-organisms, algae, and so on.
Chemistry
Elemental chlorine is an oxidizer. It undergoes halogen substitution reactions with lower halide salts. For
example, chlorine gas bubbled through a solution of bromide or iodide anions oxidizes them to bromine and
iodine respectively.
Like the other halogens, chlorine participates in free-radical substitution reactions with hydrogen-containing
organic compounds. This reaction is often—but not invariably—non-regioselective, and hence, may result in a
mixture of isomeric products. It is often difficult to control the degree of substitution as well, so multiple
substitutions are common. If the different reaction products are easily separated, e.g. by distillation,
substitutive free-radical chlorination (in some cases accompanied by concurrent thermal dehydrochlorination)
may be a useful synthetic route. Industrial examples of this are the production of methyl chloride, methylene
chloride, chloroform and carbon tetrachloride from methane, allyl chloride from propylene, and
trichloroethylene and tetrachloroethylene from 1,2-dichloroethane.
Like the other halides, chlorine undergoes electrophilic additions reactions, most notably, the chlorination of
alkenes and aromatic compounds with a Lewis acid catalyst. Organic chlorine compounds tend to be less
reactive in nucleophilic substitution reactions than the corresponding bromine or iodine derivatives, but they
tend to be cheaper. They may be activated for reaction by substituting with a tosylate group, or by the use of
a catalytic amount of sodium iodide.
Chlorine is used extensively in organic and inorganic chemistry as an oxidizing agent and in substitution
reactions because chlorine often imparts many desired properties to an organic compound, due to its
electronegativity.
Chlorine compounds are used as intermediates in the production of a number of important commercial
products that do not contain chlorine. Examples are: polycarbonates, polyurethanes, silicones,
polytetrafluoroethylene, carboxymethyl cellulose and propylene oxide.
Use as a weapon
World War I
Main article: Poison gas in World War I
Chlorine gas, also known as bertholite, was first used as a weapon in World War I by Germany on April 22,
1915 in the Second Battle of Ypres. As described by the soldiers it had a distinctive smell of a mixture
between pepper and pineapple. It also tasted metallic and stung the back of the throat and chest. Chlorine
can react with water in the mucosa of the lungs to form hydrochloric acid, an irritant which can be lethal. The
damage done by chlorine gas can be prevented by a gas mask, or other filtration method, which makes the
overall chance of death by chlorine gas much lower than those of other chemical weapons. It was pioneered
by a German scientist later to be a Nobel laureate, Fritz Haber of the Kaiser Wilhelm Institute in Berlin, in
collaboration with the German chemical conglomerate IG Farben, who developed methods for discharging
chlorine gas against an entrenched enemy. It is alleged that Haber's role in the use of chlorine as a deadly
weapon drove his wife, Clara Immerwahr, to suicide. After its first use, chlorine was utilized by both sides as
a chemical weapon, but it was soon replaced by the more deadly gases phosgene and mustard gas.[40]
Iraq War
Main article: 2007 chlorine bombings in Iraq
Chlorine gas has also been used by insurgents against the local population and coalition forces in the Iraq
War in the form of chlorine bombs. On March 17, 2007, for example, three chlorine filled trucks were
detonated in the Anbar province killing two and sickening over 350. [41] Other chlorine bomb attacks resulted
in higher death tolls, with more than 30 deaths on two separate occasions. [42] Most of the deaths were
caused by the force of the explosions rather than the effects of chlorine, since the toxic gas is readily
dispersed and diluted in the atmosphere by the blast. The Iraqi authorities have tightened up security for
chlorine, which is essential for providing safe drinking water for the population.
Chlorine cracking
The element is widely used for purifying water owing to its powerful
oxidizing properties, especially potable water supplies and water
used in swimming pools. Several catastrophic collapses of
swimming pool ceilings have occurred owing to stress corrosion
cracking of stainless steel rods used to suspend them. [43] Some
polymers are also sensitive to attack, including acetal resin and
polybutene. Both materials were used in hot and cold water
domestic supplies, and stress corrosion cracking caused
widespread failures in the USA in the 1980s and 90s. One example
Chlorine "attack" of an acetal resin
shows an acetal joint in a water supply system, which when it
plumbing joint.
fractured, caused substantial physical damage to computers in the
labs below the supply. The cracks started at injection molding
defects in the joint and grew slowly until finally triggered. The fracture surface shows iron and calcium salts
which were deposited in the leaking joint from the water supply before failure.
Other uses
Chlorine is used in the manufacture of numerous organic chlorine compounds, the most significant of which in
terms of production volume are 1,2-dichloroethane and vinyl chloride, intermediates in the production of PVC.
Other particularly important organochlorines are methyl chloride, methylene chloride, chloroform, vinylidene
chloride, trichloroethylene, perchloroethylene, allyl chloride, epichlorohydrin, chlorobenzene, dichlorobenzenes
and trichlorobenzenes.
Chlorine is also used in the production of chlorates and in bromine extraction.
Health effects
Chlorine is a toxic gas that irritates the respiratory system. Because it is heavier than NFPA 704
air, it tends to accumulate at the bottom of poorly ventilated spaces. Chlorine gas is a
strong oxidizer, which may react with flammable materials. [44] 0
Chlorine is detectable in concentrations of as low as 0.2 ppm. Coughing and vomiting may
3 0
OX,₩
occur at 30 ppm and lung damage at 60 ppm. About 1000 ppm can be fatal after a few deep
breaths of the gas. [4] Breathing lower concentrations can aggravate the respiratory system,
and exposure to the gas can irritate the eyes. [45]
Chlorine's toxicity comes from its oxidizing power. When chlorine is inhaled at concentrations above 30ppm it
begins to react with water and cells which change it into hydrochloric acid (HCl) and hypochlorous acid
(HClO).
When used at specified levels for water disinfection, although chlorine reaction with water itself usually doesn't
represent a major concern for human health, other materials present in the water can generate disinfection
by-products that can damage human health. [46][47]
See also
Polymer degradation
References
1. ^ Magnetic susceptibility of the elements and inorganic compounds , in Handbook of Chemistry and Physics 81st edition,
CRC press.
2. ^ Windholz, Martha et al., ed (1976). Merck Index of Chemicals and Drugs, 9th ed.. Rahway, N.J.: Merck & Co.. ISBN
0911910263.
3. ^ a b Hammond, C. R. (2000). The Elements, in Handbook of Chemistry and Physics 81st edition. CRC press. ISBN
0849304814.
4. ^ a b "WebElements.com – Chlorine" . Mark Winter [The University of Sheffield and WebElements Ltd, UK]. Retrieved
2007-03-17.
5. ^ "Risk assessment and the cycling of natural organochlorines" . Euro Chlor. Retrieved 2007-08-12.
6. ^ "The earliest salt production in the world: an early Neolithic exploitation in Poiana Slatinei-Lunca, Romania" . Retrieved
2008-07-10.
7. ^ Pereira, Jonathan (1854). The elements of materia medica and therapeutics, Volume 1 . Longman, Brown, Green, and
Longmans. p. 387.
8. ^ Hoover, Herbert Clark (2003). Georgius Agricola de Re Metallica . Kessinger Publishing. p. 354. ISBN 0766131971.
9. ^ a b c d e f "17 Chlorine" . Elements.vanderkrogt.net. Retrieved 2008-09-12.
10. ^ Ihde, Aaron John (1984). The development of modern chemistry . Courier Dover Publications. p. 158. ISBN
0486642356.
11. ^ Gay-Lussac, Joseph Louis; Thénard, Louis-Jacques (1809). "On the nature and the properties of muriatic acid and of
oxygenated muriatic acid" . Mémoires de Physique et de Chimie de la Société d'Arcueil 2: 339–358 .
12. ^ Sir Humphry Davy (1811). "On a Combination of Oxymuriatic Gas and Oxygene Gas" . Philosophical Transactions of
the Royal Society 101: 155–162. doi:10.1098/rstl.1811.0008 .
13. ^ Snelders, H. A. M. (1971). "J. S. C. Schweigger: His Romanticism and His Crystal Electrical Theory of Matter" . Isis 62
(3): 328.
14. ^ "Discovery of Chlorine" . Retrieved 2008-07-10.
15. ^ "History of Chlorine" . Retrieved 2008-07-10.
16. ^ a b c d Jacqueline Brazin. "Chlorine & its Consequences" . Retrieved 2008-07-10.
17. ^ "Chlorine Story" . americanchemistry. Retrieved 2008-07-10.
18. ^ "Chlorine - History" . Retrieved 2008-07-10.
19. ^ "Weaponry: Use of Chlorine Gas Cylinders in World War I" . historynet.com. Retrieved 2008-07-10.
20. ^ Pauling, Linus (1970). General Chemistry. Dover publications. ISBN 0-486-65622-5.
21. ^ "Electrolytic Processes for Chlorine and Caustic Soda" . Lenntech Water treatment & air purification Holding B.V.,
Rotterdamseweg 402 M, 2629 HH Delft, The Netherlands. Retrieved 2007-03-17.
22. ^ "Mercury cell" . Euro Chlor. Retrieved 2007-08-15.
23. ^ "Regional Awareness-raising Workshop on Mercury Pollution" . UNEP. Retrieved 2007-10-28.
24. ^ "Diaphragm cell" . Euro Chlor. Retrieved 2007-08-15.
25. ^ "The Electrolysis of Brine" . Salt Manufacturers' Association. Retrieved 2007-03-17.
26. ^ a b Kiefer, David M.. "When the Industry Charged Ahead" . Chemistry Chronicles. Retrieved 2007-03-17.
27. ^ "Membrane cell" . Euro Chlor. Retrieved 2007-08-15.
28. ^ Lopez, N; Gomezsegura, J; Marin, R; Perezramirez, J (2008). "Mechanism of HCl oxidation (Deacon process) over
RuO2". Journal of Catalysis 255: 29. doi:10.1016/j.jcat.2008.01.020 .
29. ^ "The Chlorine Industry" . Lenntech Water treatment & air purification Holding B.V., Rotterdamseweg 402 M, 2629 HH
Delft, The Netherlands. Retrieved 2007-03-17.
30. ^ Reader W J (1970 SBN 19 215937 2). Imperial Chemical Industries; A History. Volume 1. The Forerunners 1870-1926.
Oxford University Press. p. 102. citing Haber L F (1958). The Chemical Industry during the Nineteenth Century. Oxford:
Clarendon Press.
31. ^ "Integrated Pollution Prevention and Control (IPPC) - Reference Document on Best Available Techniques in the Chlor-
Alkali Manufacturing Industry" . European Commission. Retrieved 2007-09-02.
32. ^ "Integrated Pollution Prevention and Control (IPPC) - Best Available Techniques Reference Document on the Production
of Iron and Steel" . European Commission. Retrieved 2007-09-02.
33. ^ "Integrated Pollution Prevention and Control (IPPC) - Reference Document on Best Available Techniques in the Glass
Manufacturing Industry" . European Commission. Retrieved 2007-09-02.
34. ^ "Integrated Pollution Prevention and Control (IPPC) - Reference Document on Best Available Techniques in the Cement
and Lime Manufacturing Industries" . European Commission. Retrieved 2007-09-02.
35. ^ "Chlorine compounds of the month" . Euro Chlor. Retrieved 2007-08-29.
36. ^ Cotton, F. Albert and Wilkinson, Geoffrey (1966). Advanced Inorganic Chemistry, 2nd ed.. John Wiley & sons. p. 568.
37. ^ "Uses" . Euro Chlor. Retrieved 2007-08-20.
38. ^ "Chlorine Tree" . Chlorine Tree. Retrieved 2007-08-20.
39. ^ Koski TA, Stuart LS, Ortenzio LF (1966). "Comparison of chlorine, bromine, iodine as disinfectants for swimming pool
External links
Electrolytic production
Wikimedia Commons has media
Computational Chemistry Wiki related to: Chlorine
Chlorine Production Using Mercury, Environmental
Considerations and Alternatives
Look up chlorine in Wiktionary,
National Pollutant Inventory - Chlorine the free dictionary.
National Institute for Occupational Safety and Health - Chlorine
Page
WebElements.com — Chlorine
Chlorine Institute - Trade association and lobby group representing the interests of the chlorine industry
Chlorine Online - Chlorine Online is an information resource produced by Eurochlor - the business
association of the European chlor-alkali industry
v• d • e Chlorine compounds
Equipment Chemical Agent Identification Set · M93 Fox · MOPP · People sniffer
Al-Shifa pharmaceutical factory · Chlorine bombings in Iraq · Herbicidal warfare · List of topics ·
Related topics
Poison gas in World War I · Tyler poison gas plot
v• d • e Chemical agents
Blood Cyanogen chloride (CK) · Hydrogen cyanide (AC)
Novichok agents
Pulmonary Chlorine · Chloropicrin (PS) · Phosgene (CG) · Diphosgene (DP)
v• d • e E numbers
Colours (E100–199) • Preservatives (E200–299) • Antioxidants & Acidity regulators (E300–399) • Thickeners, stabilisers &
emulsifiers (E400–499) • pH regulators & anti-caking agents (E500–599) • Flavour enhancers (E600–699) • Miscellaneous
(E900–999) • Additional chemicals (E1100–1599)
Waxes (E900–909) • Synthetic glazes (E910–919) • Improving agents (E920–929) • Packaging gases (E930–949) •
Sweeteners (E950–969) • Foaming agents (E990–999)
L-cysteine (E920) • L-cystine (E921) • Potassium persulfate (E922) • Ammonium persulfate (E923) • Potassium bromate
(E924) • Chlorine (E925) • Chlorine dioxide (E926) • Azodicarbonamide (E927) • Carbamide (E927b) • Benzoyl peroxide (E928)
v• d • e Periodic table
H He
Li Be B C N O F Ne
Na Mg Al Si P S Cl Ar
K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr
Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe
Cs Ba La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn
Uue Ubn
Categories: Chemical elements | Chlorine | Halogens | Hazardous air pollutants | Highly Hazardous
Chemicals | Occupational safety and health | Pulmonary agents | Swimming pool equipment
Bromine
From Wikipedia, the free encyclopedia
Physical properties
Azərbaycan
History [edit]
Phase liquid
Беларуская Bromine was Density (near r.t.) (Br 2 , liquid) 3.1028
Bosanski discovered g·cm−3
Български independently by two
Melting point 265.8 K, -7.2 °C, 19 °F
Català chemists Antoine
Ч вашла Boiling point 332.0 K, 58.8 °C,
Balard [4] and Carl
Česky 137.8 °F
Jacob Löwig[5] in
Corsu
1825 and 1826. [6] Critical point 588 K, 10.34 MPa
Cymraeg
Balard found bromide Heat of fusion (Br 2 ) 10.571 kJ·mol−1
Dansk
Deutsch chemicals in the ash Heat of vaporization (Br 2 ) 29.96 kJ·mol−1
Eesti of sea weed from the Specific heat capacity (25 °C) (Br 2 )
Ελληνικά salt marshes of 75.69 J·mol −1 ·K −1
Español Montpellier in 1826.
Esperanto Illustrative and secure bromine sample Vapor pressure
The sea weed was
Euskara for teaching
used to produce
Allotropes [edit]
At a pressure of 55 GPa bromine converts to a metal. At 75 GPa it converts to a face centered orthorhombic
structure. At 100 GPa it converts to a body centered orthorhombic monoatomic form.[13]
Similar alternatives, such as the use of dilute hydrochloric acid with sodium hypochlorite, are also available.
The most important thing is that the anion of the acid (in the above examples, sulfate and chloride,
respectively) be more electronegative than bromine, allowing the substitution reaction to occur.
Reaction involving a strong oxidizing agent, such as potassium permanganate, on bromide ions in the
presence of an acid also gives bromine. An acidic solution of bromate ions and bromide ions will also
disproportionate slowly to give bromine.
Bromine is only slightly soluble in water. But the solubility can be increased by the presence of bromide ions.
However, concentrated solutions of bromine are rarely prepared in the lab as they will continually give off
toxic red-brown bromine gas due to its very high vapor pressure. Sodium thiosulphate is an excellent reagent
for getting rid of bromine completely including the stains and odor.
Compounds [edit]
Bromine is an oxidizer, and it will oxidize iodide ions to iodine, being itself reduced to
bromide: Oxidation states
of bromine
Br2 + 2 I− → 2 Br− + I2
-1 HBr
Bromine will also oxidize metals and metalloids to the corresponding bromides.
Anhydrous bromine is less reactive toward many metals than hydrated bromine, 0 Br2
however. Dry bromine reacts vigorously with aluminium, titanium, mercury as well as +1 BrCl
alkaline earths and alkali metals.
+3 BrF3
If bromine is dissolved in hydroxide containing water not only bromide (Br − ) is formed, +5 BrF5
but also the hypobromite (OBr − ). This hypobromite is responsible for the bleaching
+5 BrO −3
abilities of bromide solutions. In warm solutions the disproportion reaction of the
hypobromite is quantitative. The resulting bromate is a strong oxidising agent and very +7 BrO −4
similar to the chlorate.
BrO 3 − + H 2 O + F2 → BrO −4 + 2 HF
− −
BrO 3 + O 3 → BrO 4 + O 2
Applications [edit]
A wide variety of organobromine compounds are used in industry. Some are prepared from bromine and
others are prepared from hydrogen bromide, which is obtained by burning hydrogen in bromine. [3]
Illustrative of the addition reaction [21] is the preparation of 1,2-Dibromoethane, the organobromine compound
produced in the largest amounts:
C 2 H 4 + Br2 → CH2 BrCH2 Br
Pesticide [edit]
Methyl bromide was widely used as pesticide to fumigate soil. The Montreal Protocol on
Substances that Deplete the Ozone scheduled the phase out for the ozone depleting
chemical until 2005. In 1991, an estimated 35,000 metric tonnes of the chemical were
used to control nematodes, fungi, weeds and other soil-borne diseases.[26][27]
Methyl bromide
Medical and veterinary [edit]
(bromomethane)
Bromide compounds, especially potassium bromide, were frequently used as
sedatives in the 19th and early 20th century. Bromides in the form of simple salts are still used as
anticonvulsants in both veterinary and human medicine.
Bromine has no known essential role in human or mammalian health, but inorganic
bromine and organobromine compounds do occur naturally, and some may be of use to
higher organisms in dealing with parasites. For example, in the presence of H 2 O 2
formed by the eosinophil, and either chloride or bromide ions, eosinophil peroxidase
provides a potent mechanism by which eosinophils kill multicellular parasites (such as,
for example, the nematode worms involved in filariasis); and also certain bacteria (such
as tuberculosis bacteria). Eosinophil peroxidase is a haloperoxidase that preferentially
uses bromide over chloride for this purpose, generating hypobromite (hypobromous Tyrian purple
acid).[31]
Marine organisms are the main source of organobromine compounds. Over 1600 compounds were identified
by 1999. The most abundant one is methyl bromide with estimated 56,000 metric tonnes produced by marine
algae. [32] The essential oil of the Hawaiian alga Asparagopsis taxiformis consists of 80% methyl bromide.[33]
A famous example of a bromine-containing organic compound that has been used by humans for a long time
is Tyrian purple.[32][34] The brominated indigo is produced by a medium-sized predatory sea snail, the
marine gastropod Murex brandaris. It took until 1909 before the organobromine nature of the compound was
discovered by Paul Friedländer.[35] Most organobromine compounds in nature arise via the action of
vanadium bromoperoxidase.[36]
Safety [edit]
References [edit]
1. ^ Magnetic susceptibility of the elements and inorganic compounds , in Handbook of Chemistry and Physics 81st edition,
CRC press.
2. ^ Gemoll W, Vretska K (1997). Griechisch-Deutsches Schul- und Handwörterbuch ("Greek-German dictionary"), 9th ed..
öbvhpt. ISBN 3-209-00108-1.
3. ^ a b Jack F. Mills (2002). Bromine: in Ullmann's Encyclopedia of Chemical Technology. Weinheim: Wiley-VCH Verlag.
doi:10.1002/14356007.a04_391 .
4. ^ a b Balard, Antoine (1826). "Memoire of a peculire Substance contained in Sea Water" . Annals of Philosophy: 387–
and 411–.
5. ^ a b Landolt, Hans Heinrich (1890). "Nekrolog: Carl Löwig" . Berichte der deutschen chemischen Gesellschaft 23: 905.
doi:10.1002/cber.18900230395 .
6. ^ Weeks, Mary Elvira (1932). "The discovery of the elements: XVII. The halogen family.". Journal of Chemical Education 9:
1915.
7. ^ Balard, A.J. (1826). Annales de Chimie et Physique 32: 337.
8. ^ Wisniak, Jaime (2004). "Antoine-Jerôme Balard. The discoverer of bromine" . Revista CENIC Ciencias Químicas 35.
9. ^ Barger, M. Susan; White, William Blaine (2000). "Technological Practice of Daguerreotypy". The Daguerreotype:
Nineteenth-century Technology and Modern Science. JHU Press. pp. 31–35. ISBN 9780801864582.
10. ^ Shorter, Edward (1997). A History of Psychiatry: From the Era of the Asylum to the Age of Prozac. John Wiley and Sons.
p. 200. ISBN 9780471245315.
11. ^ GE (1989). Chart of the Nuclides, 14th Edition. Nuclear Energy.
12. ^ Audi, Georges (2003). "The NUBASE Evaluation of Nuclear and Decay Properties". Nuclear Physics A (Atomic Mass
Data Center) 729: 3. doi:10.1016/j.nuclphysa.2003.11.001 .
13. ^ Duan, Defang (2007-09-26). "Ab initio studies of solid bromine under high pressure". Pysical Review B 76.
doi:10.1103/PhysRevB.76.104113 .
14. ^ Tallmadge, John A.; Butt, John B.; Solomon Herman J. (1964). "Minerals From Sea Salt". Ind. Eng. Chem. 56: 44.
doi:10.1021/ie50655a008 .
15. ^ Oumeish, Oumeish Youssef (1996). "Climatotherapy at the Dead Sea in Jordan". Clinics in Dermatology 14: 659.
doi:10.1016/S0738-081X(96)00101-0 .
16. ^ Al-Weshah, Radwan A. (2008). "The water balance of the Dead Sea: an integrated approach". Hydrological Processes
14: 145. doi:10.1002/(SICI)1099-1085(200001)14:1<145::AID-HYP916>3.0.CO;2-N .
17. ^ Emsley, John (2001). "Bromine". Nature's Building Blocks: An A-Z Guide to the Elements. Oxford, England, UK: Oxford
University Press. pp. 69–73. ISBN 0198503407.
18. ^ Lyday, Phyllis A.. "Comodity Report 2007: Bromine" . United States Geological Survey. Retrieved 2008-09-03.
19. ^ a b c d Lyday, Phyllis A.. "Mineral Yearbook 2007: Bromine" . United States Geological Survey. Retrieved 2008-09-03.
20. ^ "Bromine:An Important Arkansas Industry" .
21. ^ N. A. Khan, F. E. Deatherage, and J. B. Brown (1963), "Stearolic Acid" , Org. Synth.; Coll. Vol. 4: 851
22. ^ Green, Joseph (1996). "Mechanisms for Flame Retardancy and Smoke suppression -A Review". Journal of Fire Sciences
14: 426. doi:10.1177/073490419601400602 .
23. ^ Kaspersma, Jelle; Doumena, Cindy; Munrob Sheilaand; Prinsa, Anne-Marie (2002). "Fire retardant mechanism of
aliphatic bromine compounds in polystyrene and polypropylene". Polymer Degradation and Stability 77: 325.
doi:10.1016/S0141-3910(02)00067-8 .
24. ^ Weil, Edward D.; Levchik, Sergei (2004). "A Review of Current Flame Retardant Systems for Epoxy Resins". Journal of
Fire Sciences 22: 25. doi:10.1177/0734904104038107 .
25. ^ Alaeea, Mehran; Ariasb, Pedro; Sjödinc, Andreas; Bergman, Åke (2003). "An overview of commercially used brominated
flame retardants, their applications, their use patterns in different countries/regions and possible modes of release".
Environment International 29: 683. doi:10.1016/S0160-4120(03)00121-1 .
26. ^ Messenger, Belinda; Braun, Adolf (2000). "Alternatives to Methyl Bromide for the Control of Soil-Borne Diseases and
Pests in California" . Pest Management Analysis and Planning Program. Retrieved 2008-11-17.
27. ^ Decanio, Stephen J.; Norman, Catherine S. (2008). "Economics of the "Critical Use" of Methyl bromide under the
Montreal Protocol". Contemporary Economic Policy 23: 376. doi:10.1093/cep/byi028 .
28. ^ Darley, H. C. H.; Gray, George Robert (1988). Composition and Properties of Drilling and Completion Fluids. Gulf
Professional Publishing. pp. 61–62. ISBN 9780872011472.
29. ^ Kaufman, Vered R.; Garti, Nissim (1984). "Effect of cloudy agents on the stability and opacity of cloudy emulsions for soft
drinks". International Journal of Food Science & Technology 19: 255. doi:10.1111/j.1365-2621.1984.tb00348.x .
30. ^ Horowitz, B. Zane (1997). "Bromism from Excessive Cola Consumption',Clinical Toxicology". Clinical Toxicology 35: 315.
doi:10.3109/15563659709001219 .
31. ^ Mayeno AN, Curran AJ, Roberts RL, Foote CS (April 1989). "Eosinophils preferentially use bromide to generate
halogenating agents". J. Biol. Chem. 264 (10): 5660–8. PMID 2538427 .
32. ^ a b Gordon W. Gribble (1999). "The diversity of naturally occurring organobromine compounds". Chemical Society
Reviews 28: 335. doi:10.1039/a900201d .
33. ^ Burreson, B. Jay; Moore, Richard E.; Roller, Peter P. (1976). "Volatile halogen compounds in the alga Asparagopsis
taxiformis (Rhodophyta)". Journal of Agricultural snd Food Chemistry 24: 856. doi:10.1021/jf60206a040 .
34. ^ Gordon W. Gribble (1998). "Naturally Occurring Organohalogen Compounds". Acc. Chem. Res. 31: 141.
doi:10.1021/ar9701777 .
35. ^ Friedländer, P. (1909). "Über den Farbstoff des antiken Purpurs aus murex brandaris". Berichte der deutschen
chemischen Gesellschaft 42: 765. doi:10.1002/cber.190904201122 .
36. ^ Butler, Alison; Carter-Franklin, Jayme N. (2004). "The role of vanadium bromoperoxidase in the biosynthesis of
halogenated marine natural products". Natural Product Reports 21: 180. doi:10.1039/b302337k .
WebElements.com – Bromine
Wikimedia Commons has media
Theodoregray.com – Bromine related to: Bromine
USGS Minerals Information: Bromine
Bromine Science and Environmental Forum (BSEF)
Look up bromine in Wiktionary,
Thermal Conductivity of BROMINE the free dictionary.
Viscosity of Bromine
Chemistry in its element podcast (MP3) from the Royal Society of Chemistry's Chemistry World:
Bromine
v• d • e Periodic table
H He
Li Be B C N O F Ne
Na Mg Al Si P S Cl Ar
K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr
Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe
Cs Ba La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn
Uue Ubn
Iodine
From Wikipedia, the free encyclopedia
Eesti 11.3 Iodine in salivary glands and oral health Heat of vaporization (I2 ) 41.57 kJ·mol−1
Ελληνικά 11.4 Human dietary intake Specific heat (25 °C) (I2 ) 54.44
Español 11.5 Deficiency capacity J·mol −1 ·K −1
Esperanto 12 Radioiodine in biology
Euskara Vapor pressure (rhombic)
12.1 Radioiodine and the thyroid
עברית compounds with many elements, but is less reactive than the Van der Waals 198 pm
Basa Jawa other members of its Group VII (halogens) and has some radius
Kiswahili metallic light reflectance. Miscellanea
Kreyòl ayisyen
Elemental iodine dissolves easily in most Crystal structure orthorhombic
Latina
organic solvents such as hexane or
Latviešu Magnetic ordering diamagnetic [1 ]
chloroform due to its lack of polarity, but is
Lëtzebuergesch
only slightly soluble in water. However, the Electrical resistivity (0 °C) 1.3×107 Ω·m
Lietuvių
Líguru solubility of elemental iodine in water can Thermal (300 K) 0.449 W·m −1 ·K −1
Lojban be increased by the addition of potassium conductivity
Magyar iodide. The molecular iodine reacts Bulk modulus 7.7 GPa
Македонски In the gas reversibly with the negative ion, generating
CAS registry 7553-56-2
the triiodide anion I 3 − in equilibrium, which
phase iodine
shows its violet number
color. is soluble in water. This is also the
Nederlands formulation of some types of medicinal Most stable isotopes
(antiseptic) iodine, although tincture of iodine classically Main article: Isotopes of iodine
Norsk (bokmål) dissolves the element in aqueous ethanol.
Norsk (nynorsk)
Solutions of elemental iodine have the unique property of iso NA half-life DM DE (MeV) DP
Occitan
O'zbek
exhibiting dramatically different colors depending on the polarity 123 I syn 13 h ε, γ 0.16 123 Te
of the solvent. When dissolved in nonpolar solvents like hexane, 127 I 100% 127 I is stable with 74 neutrons
Structure [edit]
Production [edit]
From the several places in which iodine occurs in nature only two
are used as source for iodine: the caliche, found in Chile and the
iodine containing brines of gas and oil fields, especially in Japan Structure of solid iodine
and the United States.
The caliche, found in Chile contains sodium nitrate, which is the main product of the mining activities and
small amounts of sodium iodate and sodium iodide. During leaching and production of pure sodium nitrate the
sodium iodate and iodide is extracted. [7] The high concentration of iodine in the caliche and the extensive
mining made Chile the largest producer of iodine in 2007.
Most other producers use natural occurring brine for the production
of iodine. The Japanese Minami Kanto gas field east of Tokyo and
the American Anadarko Basin gas field in northwest Oklahoma are
the two largest sources for iodine from brine. The brine has a
temperature of over 60°C due to the depth of the source. The brine
is first purified and acidified using sulfuric acid, then the iodide
present is oxidized to iodine with chlorine. An iodine solution is Iodine output in 2005
Cu2+ + 2 I– → CuI 2
2 CuI 2 → 2 CuI + I2
There are also other methods of isolating this element in the laboratory, for example the method used to
isolate other halogens: oxidation of the iodide in hydrogen iodide (often made in situ with an iodide and
sulfuric acid) by manganese dioxide (see below in Descriptive chemistry).
Isotopes [edit]
There are 37 known (characterized) isotopes of iodine, but only one, 127 I, is stable.
In many ways, 129 I is similar to 36 Cl. It is a soluble halogen, fairly non-reactive, exists mainly as a non-
sorbing anion, and is produced by cosmogenic, thermonuclear, and in-situ reactions. In hydrologic studies,
129 I concentrations are usually reported as the ratio of 129 I to total I (which is virtually all 127 I). As is the case
with 36 Cl/Cl, 129 I/I ratios in nature are quite small, 10 −14 to 10 −10 (peak thermonuclear 129 I/I during the
1960s and 1970s reached about 10 −7 ). 129 I differs from 36 Cl in that its half-life is longer (15.7 vs. 0.301
million years), it is highly biophilic, and occurs in multiple ionic forms (commonly, I− and IO3 − ) which have
different chemical behaviors. This makes it fairly easy for 129 I to enter the biosphere as it becomes
incorporated into vegetation, soil, milk, animal tissue, etc.
Excesses of stable 129 Xe in meteorites have been shown to result from decay of "primordial" iodine-129
produced newly by the supernovas which created the dust and gas from which the solar system formed. 129 I
was the first extinct radionuclide to be identified as present in the early solar system. Its decay is the basis of
the I-Xe Iodine-xenon radiometric dating scheme, which covers the first 85 million years of solar system
evolution.
Effects of various radioiodine isotopes in biology are discussed below.
History [edit]
Iodine was discovered by Bernard Courtois in 1811. [9][10] He was born to a manufacturer of saltpeter (a vital
part of gunpowder). At the time of the Napoleonic Wars, France was at war and saltpeter was in great
demand. Saltpeter produced from French niter beds required sodium carbonate, which could be isolated from
seaweed washed up on the coasts of Normandy and Brittany. To isolate the sodium carbonate, seaweed was
burned and the ash then washed with water. The remaining waste was destroyed by adding sulfuric acid.
One day Courtois added too much sulfuric acid and a cloud of purple vapor rose. Courtois noted that the
vapor crystallized on cold surfaces making dark crystals. Courtois suspected that this was a new element but
lacked the money to pursue his observations.
However he gave samples to his friends, Charles Bernard Desormes (1777–1862) and Nicolas Clément
(1779–1841), to continue research. He also gave some of the substance to Joseph Louis Gay-Lussac (1778–
1850), a well-known chemist at that time, and to physicist André-Marie Ampère (1775–1836). On 29
November 1813, Dersormes and Clément made public Courtois’s discovery. They described the substance to
a meeting of the Imperial Institute of France. On December 6, Gay-Lussac announced that the new
substance was either an element or a compound of oxygen. [11][12][13] Ampère had given some of his sample
to Humphry Davy (1778–1829). Davy did some experiments on the substance and noted its similarity to
chlorine. [14] Davy sent a letter dated December 10 to the Royal Society of London stating that he had
identified a new element.[15] A large argument erupted between Davy and Gay-Lussac over who identified
iodine first but both scientists acknowledged Courtois as the first to isolate the chemical element.
Applications [edit]
Elemental iodine is used as a disinfectant in various forms. The iodine exists as the element, or as the water
soluble triiodide anion I 3 - generated in situ by adding iodide to poorly-soluble iodine (the reverse chemical
reaction makes some free elemental iodine available for antisepsis). Alternatively, iodine may come from
iodophors, which contain iodine complexed with a solubilizing agent (iodide ion may be thought of loosely as
the iodophor in triiodide water solutions). Examples of such preparations include:[16]
Tincture of iodine (iodine in ethanol, or iodine and sodium iodide in a mixture of ethanol and water)
Lugol's iodine (iodine and iodide in water, forming mostly triiodide)
Povidone iodine (an iodophor)
Staining [edit]
Radioiodine [edit]
Some radioactive iodine isotopes can be used to treat thyroid
cancer. The body accumulates iodine in the thyroid, thus
radioactive iodine can selectively damage growing thyroid cancer
Diatrizoic acid, a radiocontrast
cells while the radioactive dose to the rest of the body remains
small.
convenient source of the iodide anion; it is easier to handle than sodium iodide because it is not hygroscopic.
Sodium iodide is especially useful in the Finkelstein reaction, because it is soluble in acetone, while
potassium iodide is poorly so. In this reaction, an alkyl chloride is converted to an alkyl iodide. This relies on
the insolubility of sodium chloride in acetone to drive the reaction:
R-Cl (acetone) + NaI (acetone) → R-I (acetone) + NaCl (s)
Iodic acid (HIO 3 ) and its salts are strong oxidizers. Periodic acid (HIO 4 ) cleaves vicinal diols along the C-C
bond to give aldehyde fragments. 2-Iodoxybenzoic acid and Dess-Martin periodinane are hypervalent iodine
oxidants used to specifically oxidize alcohols to ketones or aldehydes. Iodine pentoxide is a strong oxidant as
well.
Interhalogen compounds are well known; examples include iodine monochloride and trichloride; iodine
pentafluoride and heptafluoride.
HI He
IF,
I2 O 4 ,
IF 3 ,
LiI BeI 2 BI 3 CI4 NI3 I2 O 5 , Ne
IF 5 ,
I4 O 9
IF 7
PI 3 , ICl,
NaI MgI2 AlI 3 SiI 4 S Ar
P2 I4 ICl3
GeI2 ,
KI CaI 2 Sc TiI 4 VI 3 Cr MnI2 Fe CoI 2 NiI2 CuI ZnI2 Ga 2 I6 AsI3 Se IBr Kr
GeI4
SnI 4 ,
RbI SrI2 Y ZrI4 Nb Mo Tc Ru Rh Pd AgI CdI 2 InI 3 SbI 3 TeI4 I Xe
SnI 2
Hg 2 I2 ,
CsI BaI 2 Hf Ta W Re Os Ir Pt AuI TlI PbI 2 Bi Po At Rn
HgI 2
Fr Ra Rf Db Sg Bh Hs Mt Ds Rg Uub Uut Uuq Uup Uuh Uus Uuo
↓
La Ce Pr Nd Pm SmI 2 Eu Gd TbI3 Dy Ho Er Tm Yb Lu
Ac ThI4 Pa U Np Pu Am Cm Bk Cf Es Fm Md No Lr
Biologically active substances like the thyroid hormones are naturally occurring organoiodine compounds.[18]
Chemistry [edit]
Elemental iodine is poorly soluble in water, with one gram dissolving in 3450 ml at 20 °C and 1280 ml at
50 °C. By contrast with chlorine, the formation of the hypohalite ion (IO – ) in neutral aqueous solutions of
iodine is negligible.
ethanol solutions are brown. Solutions in chloroform, carbon tetrachloride, and carbon disulfide are violet.
Molecular iodine can be prepared by oxidizing iodides with chlorine:
2 I− + Cl 2 → I2 + 2 Cl −
2 I− + 4 H + + MnO 2 → I2 + 2 H 2 O + Mn 2+
or by chlorates: [22]
I2 + 2 ClO 3 − → 2 IO3 − + Cl 2
Iodine is converted in a two stage reaction to iodide and iodate in solutions of alkali hydroxides (such as
sodium hydroxide):[19]
I2 + 2 OH − → I− + IO− + H 2 O (K = 30)
3 IO− → 2 I− + IO3 − (K = 10 20 )
Despite having the lowest electronegativity of the common halogens, iodine reacts violently with some metals,
such as aluminum:
3 I2 + 2 Al → 2 AlI3
This reaction produces 314 kJ per mole of aluminum, comparable to thermite's 425 kJ. Yet the reaction
initiates spontaneously, and if unconfined, causes a cloud of gaseous iodine due to the high heat.
When dissolved in fuming sulfuric acid (65% oleum), iodine forms an intense blue solution. This has been
shown to be due to the formation of the I+2 cation, the result of iodine being oxidised by SO3 :[23]
2 I2 + 2 SO3 + H 2 SO4 → 2 I+2 + SO2 + 2 HSO −4
The I+2 cation is also formed in the oxidation of iodine by SbF5 or TaF 5 . The resulting I+2Sb2 F−11 or I+2Ta 2 F−11
can be isolated as deep blue crystals. The solutions of these salts turn red when cooled below −60 °C, due to
the formation of the I2+
4 cation:
[23]
2 I+2 I2+
4
With phosphorus, iodine is able to replace hydroxyl groups on alcohols with iodide. For example, the
synthesis of methyl iodide from methanol, red phosphorus, and iodine. [24] The iodinating reagent is
phosphorus triiodide that is formed in situ:
3 CH3 OH + PI 3 → 3 CH3 I + H 3 PO3
Phosphorous acid is formed as a side-product.
The iodoform test uses an alkaline solution of iodine to react with methyl ketones to give the labile
triiodomethide leaving group, forming iodoform which precipitates.
Iodine is sometimes used to activate magnesium when preparing Grignard reagents; aryl and alkyl iodides
both form Grignard reagents. Alkyl iodides such as iodomethane are good alkylating agents. Some drawbacks
to use of iodo-organics in chemical synthesis are:
iodine compounds tend to be more expensive than the corresponding bromides and chlorides, in that
order
iodides tend to be much stronger alkylating agents, and so are more toxic (e.g. methyl iodide is very toxic
(T+) [25]
low molecular weight iodides tend to have a much higher equivalent weight, compared with other
alkylating agents (e.g. methyl iodide versus dimethyl carbonate), due to the atomic mass of iodine.
In the United States, the Drug Enforcement Agency (DEA) regards iodine and compounds containing iodine
(ionic iodides, iodoform, ethyl iodide, and so on) as reagents useful for the clandestine manufacture of
methamphetamine. Persons who attempt to purchase significant quantities of such chemicals without
establishing a legitimate use are likely to find themselves the target of a DEA investigation. Persons selling
such compounds without doing due diligence to establish that the materials are not being diverted to
clandestine use may be subject to stiff penalties, such as expensive fines or even imprisonment.[26][27]
Iodine accounts for 65% of the molecular weight of T4 and 59% of the T3. 15–20 mg of iodine is
concentrated in thyroid tissue and hormones, but 70% of the body's iodine is distributed in other tissues,
including mammary glands, eyes, gastric mucosa, the cervix, and salivary glands. In the cells of these tissues
iodide enters directly by sodium-iodide symporter (NIS). Its role in mammary tissue is related to fetal and
neonatal development, but its role in the other tissues is unknown.[28] It has been shown to act as an
antioxidant in these tissues. [28]
Iodine may have a relationship with selenium, and iodine supplementation in selenium-deficient populations
may pose risks for thyroid function. [28]
The US Food and Nutrition Board and Institute of Medicine recommended daily allowance of iodine ranges
from 150 micrograms /day for adult humans to 290 micrograms /day for lactating mothers. However, the
thyroid gland needs no more than 70 micrograms /day to synthesize the requisite daily amounts of T4 and T3.
These higher recommended daily allowance levels of iodine seem necessary for optimal function of a number
of body systems, including lactating breast, gastric mucosa, salivary glands, oral mucosa, thymus, epidermis,
choroid plexus, etc.[29][30][31]
*Breast cancer. It is known that a diet lacking in iodine is connected with adverse health effects collectively
referred as iodine deficiency diseases or disorders. Studies also indicate that iodine deficiency, either dietary
or pharmacologic, can lead to breast atypia and increased incidence of malignancy in animal models, while
iodine treatment can reverse dysplasia.[32][33][34] Laboratory evidences demonstrate that the effect of iodine
on breast cancer is in part independent of thyroid function and that iodine inhibit cancer promotion through
modulation of the estrogen pathway. Gene array profiling of estrogen responsive breast cancer cell line shows
that the combination of iodine and iodide alters gene expression and inhibits the estrogen response through
up-regulating proteins involved in estrogen metabolism. Whether iodine/iodide will be useful as an adjuvant
therapy in the pharmacologic manipulation of the estrogen pathway in women with breast cancer has not
been determined clinically. [32]
*Iodine and stomach cancer. Some researchers have found an epidemiologic correlation between iodine
deficiency, iodine-deficient goitre and gastric cancer;[35] [36][37] a decrease of the incidence of death rate
from stomach cancer after implementation of the effective iodine-prophylaxis was reported too.[38] The
proposed mechanism of action is that iodide ion can function in gastric mucosa as an antioxidant reducing
species that can detoxify poisonous reactive oxygen species, such as hydrogen peroxide.
Iodine has important actions in the immune system. The high iodide-concentration of thymus suggests an
anatomical rationale for this role of iodine in immune system.[39][40][41][42][43][44]
Deficiency [edit]
Due to preferential uptake of iodine by the thyroid, isotopes with short half lives such as I131 can be used for
thyroid ablation, a procedure in which radioactive iodine is administered intravenously or orally following a
diagnostic scan. This procedure is generally performed on patients with thyroid cancer or hyperfunctioning
thyroid tissue. After uptake, the iodine undergoes degeneration via beta decay, destroying its associated
thyroid tissue. Normally thyroidectomy is performed prior to ablation to avoid side effects of epilation and
radiation toxicity. The purpose of radioablation is to destroy remnant tissue that was unable to be removed
with surgery.
Lower energy isotopes such as iodine-123, and less commonly iodine-125, are used as tracers to evaluate
the anatomic and physiologic function of the thyroid. Abnormal results may be caused by disorders such as
Graves' Disease or Hashimoto's thyroiditis.
Potassium iodide has been distributed to populations exposed to nuclear fission accidents such as the
Chernobyl disaster. The iodide solution SSKI, a saturated solution of potassium (K) iodide in water, has
been used to block absorption of the radioiodine (it has no effect on other radioisotopes from fission). Tablets
containing potassium iodide are now also manufactured and stocked in central disaster sites by the
governments for this purpose. In theory, many harmful late-cancer effects of nuclear fallout might be
prevented in this way, since an excess of thyroid cancers, presumably due to radioiodine uptake, is the only
proven radioisotope contamination effect after a fission accident, or from contamination by fallout from an
atomic bomb (prompt radiation from the bomb also cases other cancers, such as leukemias, directly). Taking
large amounts of thyroid saturates iodide receptors prevents uptake of most radioactive iodine-131 that may
be present from fission product exposure (although it does not protect from other radioisotopes, nor from any
other form of direct radiation). The protective effect of KI lasts approximately 24 hours, so must be dosed daily
until a risk of significant exposure to radioiodines from fission products no longer exists.[57][58] Iodine-131
(the most common radioiodine contaminant in fallout) also decays relatively rapidly with a half-life of 8 days,
so that 99.95% of the original radioiodine is gone after three months.
Iodine-125 is also commonly used by radiation oncologists in low dose rate brachytherapy in the treatment of
cancer at sites other than the thyroid, especially in prostate cancer. The radioiodine is encapsulated in
titanium seeds and implanted in the area of tumor involvement. In contrast to the blood-borne dissemination
of radioiodine used in the thyroid, the radioiodine acts only locally in the area where it is implanted.
Iodine-129 ( 129 I; half-life 15.7 million years) is a product of cosmic ray spallation on various isotopes of
xenon in the atmosphere, in cosmic ray muon interaction with tellurium-130, and also uranium and plutonium
fission, both in subsurface rocks and nuclear reactors. Artificial nuclear processes, in particular nuclear fuel
reprocessing and atmospheric nuclear weapons tests, have now swamped the natural signal for this isotope.
Nevertheless, it now serves as a groundwater tracer as indicator of nuclear waste dispersion into the natural
environment. In a similar fashion, 129 I was used in rainwater studies to track fission products following the
Chernobyl disaster.
Elemental iodine is an oxidizing irritant and direct contact with skin can cause lesions, so iodine crystals
should be handled with care. Solutions with high elemental iodine concentration such as tincture of iodine are
capable of causing tissue damage if use for cleaning and antisepsis is prolonged.
Elemental iodine (I2 ) is poisonous if taken orally in larger amounts; 2–3 grams of it is a lethal dose for an
adult human.
Iodine vapor is very irritating to the eye, to mucous membranes, and in the respiratory tract. Concentration of
iodine in the air should not exceed 1 mg/m³ (eight-hour time-weighted average).
When mixed with ammonia and water, elemental iodine forms nitrogen triiodide which is extremely shock
sensitive and can explode unexpectedly.
Excess iodine has symptoms similar to those of iodine deficiency. Commonly encountered symptoms are
abnormal growth of the thyroid gland and disorders in functioning and growth of the organism as a whole.
Iodides are similar in toxicity to bromides.[citation needed]
Some people develop a sensitivity to iodine. Application of tincture of iodine can cause a rash. Some cases of
reaction to Povidone-iodine (Betadine) have been documented to be a chemical burn.[59] Eating iodine-
containing foods can cause hives. Medical use of iodine (i.e. as a contrast agent, see above) can cause
anaphylactic shock in highly iodine sensitive patients. Some cases of sensitivity to iodine can be formally
classified as iodine allergies. Iodine sensitivity is rare but has a considerable effect given the extremely
widespread use of iodine-based contrast media [60] .
Iodide as an antioxidant
Chemical oxygen iodine laser
Nutrition facts label
Starch indicator
References [edit]
1. ^ Magnetic susceptibility of the elements and inorganic compounds , in Handbook of Chemistry and Physics 81st edition,
CRC press.
2. ^ J McMaster and John H Enemark (1998). "The active sites of molybdenum- and tungsten-containing enzymes". Current
Opinion in Chemical Biology 2: 201. doi:10.1016/S1367-5931(98)80061-6 .
3. ^ Russ Hille (2002). "Molybdenum and tungsten in biology". Trends in Biochemical Sciences 27: 360. doi:10.1016/S0968-
0004(02)02107-2 .
4. ^ Guan, L; Suenaga, K; Shi, Z; Gu, Z; Iijima, S (Jun 2007). "Polymorphic structures of iodine and their phase transition in
confined nanospace.". Nano letters 7 (6): 1532. doi:10.1021/nl070313t . PMID 17477579 .
5. ^ a b Dissanayake, C. B.; Chandrajith, Rohana; Tobschall, H. J. (1999). "The iodine cycle in the tropical environment —
implications on iodine deficiency disorders". International Journal of Environmental Studies 56: 357.
doi:10.1080/00207239908711210 .
6. ^ a b N. Bell, L. Hsu, D. J. Jacob, M. G. Schultz, D. R. Blake, J. H. Butler, D. B. King, J. M. Lobert, and E. Maier-Reimer
(2002). "Methyl iodide: Atmospheric budget and use as a tracer of marine convection in global models". Journal of
GeophysicalResearch 107: 4340. doi:10.1029/2001JD001151 .
7. ^ a b Jessica Elzea Kogel, Nikhil C. Trivedi, James M. Barker, Stanley T. Krukowski (2006). Industrial Minerals & Rocks:
Commodities, Markets, and Uses . SME. pp. 541–552. ISBN 9780873352338.
8. ^ Tatsuo Maekawa, Shun-Ichiro Igari and Nobuyuki Kaneko (2006). "Chemical and isotopic compositions of brines from
dissolved-in-water type natural gas fields in Chiba, Japan". Geochemical Journal 40: 475. doi:10.2343/geochemj.40.475 .
9. ^ Bernard Courtois (1813). "Découverte d'une substance nouvelle dans le Vareck". Annales de chimie 88: 304. In French,
seaweed that had been washed onto the shore was called "varec", "varech", or "vareck", whence the English word "wrack".
Later, "varec" also referred to the ashes of such seaweed: the ashes were used as a source of iodine and salts of sodium
and potassium.
10. ^ Patricia A. Swain (2005). "Bernard Courtois (1777-1838) famed for discovering iodine (1811), and his life in Paris from
1798" . Bulletin for the History of Chemistry 30 (2): 103.
11. ^ J. Gay-Lussac (1813). "Sur un nouvel acide formé avec la substance décourverte par M. Courtois". Annales de chimie
88: 311.
12. ^ J. Gay-Lussac (1813). "Sur la combination de l'iode avec d'oxigène". Annales de chimie 88: 319.
13. ^ J. Gay-Lussac (1814). "Mémoire sur l'iode". Annales de chimie 91: 5.
14. ^ H. Davy (1813). "Sur la nouvelle substance découverte par M. Courtois, dans le sel de Vareck". Annales de chemie 88:
322.
15. ^ Humphry Davy (January 1, 1814). "Some Experiments and Observations on a New Substance Which Becomes a Violet
Coloured Gas by Heat" . Phil. Trans. R. Soc. Lond. 104: 74. doi:10.1098/rstl.1814.0007 .
16. ^ Block, Seymour Stanton (2001). Disinfection, sterilization, and preservation. Hagerstwon, MD: Lippincott Williams &
Wilkins. p. 159. ISBN 0-683-30740-1.
17. ^ R. Toreki. "Peroxide" . The MSDS HyperGlossary.
18. ^ Gribble, G. W. (1996). "Naturally occurring organohalogen compounds - A comprehensive survey". Progress in the
Chemistry of Organic Natural Products 68: 1–423. PMID 8795309 .
19. ^ a b c F. A. Cotton and G. Wilkinson (1988). Advanced Inorganic Chemistry, 5th ed.. John Wiley & Sons. ISBN
0471849979.
20. ^ Martha Windholz, editor ; Susan Budavari, associate editor ; Lorraine Y. Stroumtsos, assistant editor ; Margaret Noether
Fertig, assistant editor. (1976). Merck Index of Chemicals and Drugs, 9th ed. S.l.: J A Majors Company. ISBN 0911910263.
21. ^ N.L. Glinka (1981). General Chemistry (volume 2). Mir Publishing.
22. ^ a b Linus Pauling (1988). General Chemistry. Dover Publications. ISBN 0486656225.
23. ^ a b c Egon Wiberg; Nils Wiberg; Arnold Frederick Holleman (2001). Inorganic chemistry. Academic Press. p. 419-420.
ISBN 0123526515.
24. ^ King, C. S.; Hartman, W. W. (1943), "Methyl Iodide" , Org. Synth.; Coll. Vol. 2: 399
25. ^ "Safety data for iodomethane" . Oxford University.
26. ^ 21 "USC Sec. 872 01/22/02" .
27. ^ "Chemical Supplier Convicted of Diversion of Iodine" .
28. ^ a b c d e f Patrick L (2008). "Iodine: deficiency and therapeutic considerations" . Altern Med Rev 13 (2): 116. PMID
18590348 .
29. ^ Brown-Grant, K. (1961). "Extrathyroidal iodide concentrating mechanisms" . Physiol Rev. 41: 189.
30. ^ Spitzweg, C., Joba, W., Eisenmenger, W. and Heufelder, A.E. (1998). "Analysis of human sodium iodide symporter gene
expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acid from salivary gland, mammary
gland, and gastric mucosa". J Clin Endocrinol Metab. 83: 1746. doi:10.1210/jc.83.5.1746 .
31. ^ Banerjee, R.K., Bose, A.K., Chakraborty, t.K., de, S.K. and datta, A.G. (1985). "Peroxidase catalysed iodotyrosine
formation in dispersed cells of mouse extrathyroidal tissues". J Endocrinol. 2: 159.
32. ^ a b Stoddard II, F. R.; Brooks, A. D.; Eskin, B. A.; Johannes, G. J. (2008). "Iodine Alters Gene Expression in the MCF7
Breast Cancer Cell Line: Evidence for an Anti-Estrogen Effect of Iodine" . International Journal of Medical Science 5 (4):
189. PMID 18645607 . PMC 2452979 .
33. ^ Eskin, B. A.; Grotkowski, C. E.; Connolly, C. P.; Ghent W. R.; (1995). "Different tissue responses for iodine and iodide in
rat thyroid and mammary glands". Bioligal Trace Elements Research 49 (5): 9. doi:10.1007/BF02788999 . PMID
14965610 .
34. ^ Venturi, S.; Grotkowski, CE; Connolly, CP; Ghent, WR (2001). "Is there a role for iodine in breast diseases?". The Breast
10 (1): 379. doi:10.1054/brst.2000.0267 . PMID 7577324 .
35. ^ Josefssson M, Ekblad E. (2009). Victor R. Preedy, Gerard N. Burrow MD, Ronald Watson. ed. Sodium Iodide Symporter
(NIS) in Gastric Mucosa: Gastric Iodide Secretion. In: Comprehensive Handbook of Iodine: Nutritional, Biochemical,
Pathological and Therapeutic Aspects.
36. ^ Abnet CC, Fan JH, Kamangar F, Sun XD, Taylor PR, Ren JS, Mark SD, Zhao P, Fraumeni JF Jr, Qiao YL, Dawsey SM
(2006). Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large
population-based Chinese cohort.. 119. p. 1508.
37. ^ Behrouzian R, Aghdami N. (2004). East Mediterr Health J.. 10. p. 921.
38. ^ Golkowski F, Szybinski Z, Rachtan J, Sokolowski A, Buziak-Bereza M, Trofimiuk M, Hubalewska-Dydejczyk A, Przybylik-
Mazurek E, Huszno B. (2007). "Iodine prophylaxis--the protective factor against stomach cancer in iodine deficient areas".
Eur J Nutr. 46: 251. doi:10.1007/s00394-007-0657-8 .
39. ^ Venturi S, Venturi M (September 2009). "Iodine, thymus, and immunity". Nutrition 25 (9): 977–9.
doi:10.1016/j.nut.2009.06.002 . PMID 19647627 .
40. ^ Venturi S.; Venturi A, Cimini D, Arduini C, Venturi M, Guidi A. (1993). "A new hypothesis: iodine and gastric cancer.".
Europ. J. Cancer. Prev. 2: 17.
41. ^ Marani L; Venturi S, Masala R (1985). "Role of iodine in delayed immune response.". Isr. J. Med. Sci. 21: 864.
42. ^ Ma F; Zhao W, Kudo M, Aoki K, Misumi J. (2002). "Inhibition of vacuolation toxin activity of Helicobacter pylori by iodine,
nitrite and potentiation by sodium chloride, sterigmatocystin and fluoride.". Toxicol in Vitro 16: 531. doi:10.1016/S0887-
2333(02)00045-0 .
43. ^ Klebanoff S.J. (1967). "Iodination of bacteria: A bacterial mechanism.". J Exp Med 126: 1063.
doi:10.1084/jem.126.6.1063 .
44. ^ "Iodine enhances ig-G-synthesis by human peripheral blood Iyphocytes in vitro.". Acta Endocr 103: 103. 1983.
45. ^ Venturi S.; Venturi M. (2009). "Iodine in evolution of salivary glands and in oral health". Nutrition and Health 20 (2): 119–
134. PMID 19835108 .
46. ^ Bahar, G.; Feinmesser, R.; Shpitzer, T.; Popovtzer, A.; Nagler, R.M. (2007). "Salivary analysis in oral cancer patients:
DNA and protein oxidation, reactive nitrogen species, and antioxidant profile". Cancer 109 (1): 54–59.
doi:10.1002/cncr.22386 . PMID 17099862 .
47. ^ Banerjee, R.K.; Bose, A.K.; Chakraborty, T.K.; De, S.K.; Datta, A.G. (1985). "Peroxidase-catalysed iodotyrosine formation
in dispersed cells of mouse extrathyroidal tissues". J Endocrinol 2: 159–165.
48. ^ Banerjee, R.K.; Datta, A.G. (1986). "Salivary peroxidases". Mol Cell Biochem 70 (1): 21–29. PMID 3520291 .
49. ^ Bartelstone, H. J. (1951). "Radioiodine penetration through intact enamel with uptake by bloodstream and thyroid gland".
J Dent Res 5: 728–733.
50. ^ Bartelstone, H.J.; Mandel, I.D.; Oshry, E.; Seidlin, S.M. (1947). "Use of radioactive iodine as a tracer in the Study of the
Physiology of teeth". Science 106: 132.
51. ^ a b United States National Research Council (2000). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron,
Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc . National Academies
Press. pp. 258–259.
52. ^ "Sources of iodine" . International Council for the Control of Iodine Deficiency Disorders.
53. ^ a b "MedlinePlus Medical Encyclopedia: Iodine in diet" .
54. ^ Wu T, Liu GJ, Li P, Clar C (2002). "Iodised salt for preventing iodine deficiency disorders". Cochrane Database Syst Rev
(3): CD003204. doi:10.1002/14651858.CD003204 . PMID 12137681 .
55. ^ Felig, Philip; Frohman, Lawrence A. (2001). "Endemic Goiter" . Endocrinology & metabolism. McGraw-Hill Professional.
ISBN 9780070220010.
56. ^ "Micronutrients - Iodine, Iron and Vitamin A" . UNICEF.
57. ^ "Frequently Asked Questions on Potassium Iodide" . Food and Drug Administration. Retrieved 2009-06-06.
58. ^ "Potassium Iodide as a Thyroid Blocking Agent in Radiation Emergencies" . Food and Drug Administration. Retrieved
2009-06-06.
59. ^ D. O. Lowe, S. R. Knowles, E. A. Weber, C. J. Railton, and N. H. Shear (2006). "Povidone-iodine-induced burn: case
report and review of the literature". Pharmacotherapy 26: 1641-5. doi:10.1592/phco.26.11.1641 .
60. ^ Katelaris, Constance (2009). "'Iodine Allergy' label is misleading". Australian Prescriber, Vol. 32, 125-128. Available at
http://www.australianprescriber.com/magazine/32/5/125/8/
v• d • e Iodine compounds
v• d • e Periodic table
H He
Li Be B C N O F Ne
Na Mg Al Si P S Cl Ar
K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr
Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe
Cs Ba La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn
Uue Ubn
Categories: Dietary minerals | Iodine | Halogens | DEA List I chemicals | Biology and pharmacology of
chemical elements | Chemical elements
Astatine
From Wikipedia, the free encyclopedia
Беларуская
spectrometers to behave chemically much like other halogens,
especially iodine (it would probably accumulate in the thyroid Atomic properties
Bosanski
Български gland like iodine), though astatine is thought to be more metallic Oxidation states ±1, 3, 5, 7
Català than iodine. Researchers at the Brookhaven National
Electronegativity 2.2 (Pauling scale)
Ч вашла Laboratory have performed experiments that have identified
Ionization energies 1st: 890±40 kJ·mol−1
Česky and measured elementary reactions that involve astatine; [2]
Corsu however, chemical research into astatine is limited by its Covalent radius 150 pm
Dansk extreme rarity, which is a consequence of its extremely short Van der Waals radius 202 pm
Deutsch half-life. Its most stable isotope has a half-life of around 8.3
Miscellanea
Eesti hours. The final products of the decay of astatine are isotopes
Ελληνικά of lead. The halogens get darker in color with increasing Magnetic ordering no data
Español
molecular weight and atomic number. Thus, following the trend, Thermal conductivity (300 K) 1.7 W·m −1 ·K −1
Esperanto
astatine would be expected to be a nearly black solid, which, CAS registry number 7440-68-8
Euskara
when heated, sublimes into a dark, purplish vapor (darker than
Most stable isotopes
iodine). Astatine is expected to form ionic bonds with metals
Français Main article: Isotopes of astatine
Hak-kâ-fa acid. Astatine is the least reactive of the halogens, being less α 5.631 206 Bi
Norsk (bokmål) Astatine occurs naturally in three natural radioactive decay series, but because of its short half-life is found
Norsk (nynorsk) only in minute amounts. Astatine-218 ( 218 At) is found in the uranium series, 216 At is in the thorium series,
Occitan and 215 At as well as 219 At are in the actinium series[12] . The most long-lived of these naturally-occurring
astatine isotopes is 219 At with a half-life of 56 seconds.
Polski
Astatine is the rarest naturally-occurring element, with the total amount in Earth's crust estimated to be less
Português
than 1 oz (28 g) at any given time. This amounts to less than one teaspoon of the element. Guinness World
Română
Runa Simi
Records has dubbed the element the rarest on Earth, stating: "Only around 0.9 oz (25 g) of the element
Русский astatine (At) occurring naturally". Isaac Asimov, in a 1957 essay on large numbers, scientific notation, and the
Seeltersk size of the atom, wrote that in "all of North and South America to a depth of ten miles", the number of
Sicilianu astatine-215 atoms at any time is "only a trillion". [13]
Simple English
Slovenčina Production [edit]
Slovenščina Astatine is produced by bombarding bismuth with energetic alpha particles to obtain the relatively long-lived
Српски / Srpski isotopes 209 At through 211 At, which can then be distilled from the target by heating in the presence of air.
Srpskohrvatski /
The energy of the alpha particles determine which isotopes are produced:
Српскохрватски
Suomi Reaction Energy of alpha particle
Svenska 209 4 211 1
Tagalog 83 Bi + 2α → 85 At +2 0n 26 MeV[14]
209
83 Bi + 42 α → 210
85 At + 3 10 n 40 MeV[14]
Türkçe 209
83 Bi + 42 α → 209
85 At + 4 10 n 60 MeV[15]
Українська
Yorùbá possible before their inevitable radioactive disintegration. The reactions are normally tested with dilute
solutions of astatine mixed with larger amounts of iodine. The iodine acts as a carrier, ensuring that there is
sufficient material for laboratory techniques such as filtration and precipitation to work. [14][16]
While these compounds are primarily of theoretical interest, they are being studied for potential use in nuclear
medicine.[17] Astatine is expected to form ionic bonds with metals such as sodium, like the other halogens,
but it can be displaced from the salts by lighter, more reactive halogens. Astatine can also react with
hydrogen to form hydrogen astatide (HAt), which when dissolved in water, forms hydroastatic acid.
Some examples of astatic compounds are:
Sodium astatide (NaAt)
Magnesium astatide (MgAt 2 )
Carbon tetraastatide (CAt4 )
Isotopes [edit]
Applications [edit]
The least stable isotopes of astatine have no practical applications other than scientific study due to their
extremely short life, but heavier isotopes have medical uses. Astatine-211 is an alpha emitter with a physical
half-life of 7.2 h. These features have led to its use in radiation therapy.[19] An investigation of the efficacy of
astatine-211–tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this
alpha-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison,
beta-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most
compelling explanation for this striking difference is the dense ionization and short range of action associated
with alpha-emission. These results have important implications for the development and use of alpha-emitters
as radiocolloid therapy for the treatment of human tumors. [20]
Precautions [edit]
Since astatine is extremely radioactive, it should be handled with extreme care. Because of its extreme rarity,
it is not likely that the general public will be exposed.
Astatine is a halogen, and standard precautions apply. It is reactive, sharing similar chemical characteristics
with iodine.
There are toxicologic studies of astatine-211 on mice indicating that radioactive poisoning is the major effect
on living organisms. [21]
References [edit]
1. ^ Close, Frank. Particle Physics: A Very Short Introduction. Oxford University Press: New York, 2004. Page 2.
2. ^ C. R. Hammond (2004). The Elements, in Handbook of Chemistry and Physics 81st edition. CRC press. ISBN
0849304857.
3. ^ Anders, E. (1959). "Technetium and Astatine Chemistry". Annual Review of Nuclear Science 9: 203–220.
doi:10.1146/annurev.ns.09.120159.001223 .
4. ^ D. R. Corson, K. R. MacKenzie, and E. Segrè (1940). "Artificially Radioactive Element 85". Phys. Rev. 58: 672–678.
doi:10.1103/PhysRev.58.672 .
5. ^ Fred Allison, Edgar J. Murphy, Edna R. Bishop, and Anna L. Sommer (1931). "Evidence of the Detection of Element 85 in
Certain Substances". Phys. Rev. 37: 1178–1180. doi:10.1103/PhysRev.37.1178 .
6. ^ "Alabamine & Virginium" . time. Retrieved 2008-07-10.
7. ^ Trimble, R. F. (1975). "What happened to alabamine, virginium, and illinium?". J. Chem. Educ. 52: 585.
8. ^ 85 Astatine
9. ^ Alice Leigh-Smith, Walter Minder (1942). "Experimental Evidence of the Existence of Element 85 in the Thorium Family".
Nature 150: 767–768. doi:10.1038/150767a0 .
10. ^ Karlik, Berta; Bernert, Traude (1943). "Eine neue natürliche α-Strahlung". Naturwissenschaften 31 (25–26): 298–299.
doi:10.1007/BF01475613 .
11. ^ Karlik, Berta; Bernert, Trande (1943). "Das Element 85 in den natürlichen Zerfallsreihen". Zeitschrift für Physik 123 (1–2):
51–72. doi:10.1007/BF01375144 .
12. ^ "astatine (At)" . Encyclopedia Britannica online. Retrieved 2008-06-22.
13. ^ http://ia331335.us.archive.org/1/items/onlyatrillion017765mbp/onlyatrillion017765mbp_djvu.txt
14. ^ a b c Nefedov, V. D.; Norseev, Yu V; Toropova, M A; Khalkin, Vladimir A (1968). "Astatine". Russ. Chem. Rev. 37: 87–
98. doi:10.1070/RC1968v037n02ABEH001603 .
15. ^ Barton, G. W.; Ghiorso, A.; Perlman, I. (1951). "Radioactivity of Astatine Isotopes". Physical Reviews 82 (1): 13–19.
doi:10.1103/PhysRev.82.13 .
16. ^ Aten Jun., A. H. W.; Doorgeest, T.; Hollstein, U.; Moeken, H. P. (1952). "Section 5: radiochemical methods. Analytical
chemistry of astatine". Analyst 77: 774–777. doi:10.1039/AN9527700774 .
17. ^ Boyd, Jade (1007-08-27). "Nuclear Nanocapsules, The New Cancer Weapon" . Medical News Today. Retrieved 2008-
11-05.
18. ^ Audi, Georges (2003). "The NUBASE Evaluation of Nuclear and Decay Properties". Nuclear Physics A (Atomic Mass
Data Center) 729: 3–128. doi:10.1016/j.nuclphysa.2003.11.001 .
19. ^ Wilbur, D. S. (1 October 2001). "Overcoming the Obstacles to Clinical Evaluation of 211At-Labeled
Radiopharmaceuticals." . Journal Nuclear Medicine 42 (10): 1516–1518.
20. ^ Bloomer, W. D.; McLaughlin, WH; Neirinckx, RD; Adelstein, SJ; Gordon, PR; Ruth, TJ; Wolf, AP (1981). "Astatine-211--
tellurium radiocolloid cures experimental malignant ascites" . Science 212 (4492): 340–341.
doi:10.1126/science.7209534 . PMID 7209534 .
21. ^ Cobb, L.M.; Harrison, A.; Butler, S.A. (1988). "Toxicity of Astatine-211 in the Mouse". Human & Experimental Toxicology
7: 529. doi:10.1177/096032718800700602 .
WebElements.com - Astatine
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Look up astatine in Wiktionary,
the free dictionary.
v• d • e Periodic table
H He
Li Be B C N O F Ne
Na Mg Al Si P S Cl Ar
K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr
Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe
Cs Ba La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn
Uue Ubn