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Intracranial hematoma (ICH) occurs when a blood vessel ruptures within a persons
brain or between the skull and the brain, causing increased intracranial pressure (ICP)
as the collection of blood compresses brain tissue. This can occur when an external
force causes the brain to slide forcefully against the inner wall of the skull and become
injured. ICH can be categorized according to which layer of the brain the rupture occurs.
Diagnosing ICH can be difficult as symptoms can vary in type and severity from milder
symptoms such as headaches, vomiting, and dizziness, to more severe symptoms such
as loss of consciousness, seizures, and weakness in the limbs on one side of the body.
Diagnosis can further be complicated by a complete absence of symptoms in the period
immediately following the trauma, termed the lucid interval, with symptoms appearing
several weeks later. Imaging techniques such as CT scans and MRI scans are
commonly used to define the position and size of the hematoma. Depending on the size
of the hematoma, surgery may be required in the acute response to remove the pooled
blood. The prolonged chronic stage of treatment may require anticonvulsant
medications to control post-traumatic seizures. If ICH is left untreated, possible medical
complications can result including herniation, cerebral edema, cerebral ischemia, and
cerebral infarction.[1] The mortality rate of patients with ICH is high and as a result, ICH
has been the focus of growing medical research into the short-term and long-term
implications of increased ICP on the structures and functions of the brain.
Figure 1: Multicompartmental hematoma. The white and black arrows show the different
hematoma locations.
Figure 2: Cross section showing epidural and subdural hematoma. (Taken from:
http://www.merckmanuals.com/home/injuries_and_poisoning/head_injuries/intracranial_hemato
mas.html)
Figure 3: CT scan of intraparenchymal hematoma indicated by the arrow. (Taken from: Naidech,
A. Concise Clinical Review: Intracranial Hemorrhage. American Journal of Respiratory and
Critical Care Medicine. 184, 998-1006 (2011).)
pupil size, increased blood pressure, weak limbs on one side of the body, drowsiness, and progressive
loss of consciousness. At higher levels of intracranial pressure, other signs and symptoms become
apparent such as: lethargy, seizures, and unconsciousness[8] . Headaches of variable intensity are the
most prevalent clinical feature to occur. Studies have shown seizures to occur in approximately 10% of all
patients.[9] Seizures will likely occur at onset of hemorrhaging or within the first 24 hours. Patients with
large hematomas may present in coma resulting from elevated intracranial pressure and decreased
cerebral perfusion (blood flow to brain), or due to distortion of diencephalic or brainstem structures. The
severity and occurrence of these symptoms will depend on the size and location of the hematoma.
2.2 Severity
Assessing severity of neurological trauma is significant for guiding diagnostic studies, guiding
resuscitation, and planning surigical and non-surgical intervention. Examinations are generally performed
off sedation.[10]
widely available. MRI scans rely on magnets and radio waves to produce a computerized image of the
hematoma. MRI is capable of detecting hyperacute intracerebral hemorrhage and microhemorrhages
(see Figure 4).[14] MRI as well as cerebral angiography can be used to detect secondary causes of ICH
such as aneurisms, arteriovenous malformations, dural venous thromboses, and vasculitis. Cranial
ultrasound is used as the first imaging modality for newborns suspected of hematoma resulting from head
injury due to its instrument transportability, low cost of operation, and absence of exposure to radiation. [15]
Figure 4: Microhemorrhage is shown in the MRI scan (left) but not in the CT scan (right).
Figure 5: An example of connecting consecutive hematoma regions from the CT data set in a
case of subdural hematoma (SDH). The hematoma regions are shown in black. The key
hematoma slice is labeled with a thick square and other hematoma slices are labeled with thin
squares. The type of the hematoma is labeled at the left upper part of each slice, and the final
diagnosis derived from the voting process is displayed after the last slice.
3. Treatment
Initial evaluation begins with obtaining a thorough patient history of proceeding or initiating events and a
thorough general physical and neurologic examination. Previous or current drug use, hemorrhages, or
known structural lesions can provide important information about a potential source of hemorrhage. [17]
Diringer et al, suggest that aggressive medical management and specialist care show statistical
significance in improving the overall outcome in patients with ICH. Trials addressing a single severity
factor for positive clinical outcome have been unsuccessful, suggesting that a single treatment approach
might accomplish its physiological goal but be insufficient to produce clinical benefit, thus calling for a
Figure 6: Cerebral Compliance Curve. Initially, volume added to the cranial vault results in no
increase in intracranial pressure (ICP) due to compensatory mechanisms. However, once these
mechanisms are exhausted, ICP increases rapidly as volume is added. (Taken from:
Vanderheyden, B., Buck, B. Management of Elevated Intracranial Pressue. Journal of Pharmacy
Practice. 15 (2), 167-185 (2002).)
epidural hematoma larger than 30 cm cubed will require surgical evacuation regardless of other clinical
features of the patient.[20] Surgical evacuation is generally required to prevent expansion of the hematoma
and increases in local ICP, decrease harmful mass-effects on brain structures, and block the release of
neurotoxic products from the pooled fluid, and thus prevent harmful pathological processes from occuring.
[21]
3.2.1 Craniotomy
Craniotomy is a surgical procedure that involves making a surgical cut through the scalp in the location of
the hematoma to remove the bone flap. This is performed using a high-speed drill to create a pattern of
holes through the cranium and a fine wire saw to connect the holes until a segment of bone can be
removed, thus giving the surgeon access to the inside of the skull to remove or suction out the hematoma
(see Video 1).[22] Despite being a common surgical procedure to treat ICH, craniotomy can result in certain
complications such as neural damage and recurrence of bleeding in deep lesions. A trial involving 1033
patients randomly assigned to either early surgery or non-invasive treatment showed early surgery carried
no significant benefit compared with initial conservative treatment: 24% versus 26% showed good
recovery or moderate disability after treatment.[23]
( Video 1: Surgical procedure for removal of epidural hematoma. The hematoma is seen being removed
after gaining access to inside the skull.)
One study has shown that stereotactic evacuation was associated with lower mortality and better
functional recovery than surgical procedures in patients with neurological Grade 3 hemorrhage (mildly
reduced consciousness).[26] The ASA Stroke Council 88 and EUSI Guidelines do not recommend surgical
evacuation of ICH by craniotomy within 96 hours of the initial trauma. These guidelines state that removal
within 12 hours with minimally-invasive methods has the most evidence for beneficial effect and could
even be considered for deep hemorrhages.[27]
develop seizures.[29] Patients who have a seizure more than 2 weeks after ICH onset are at greater risk of
recurrent seizures than those who do not, and may require long-term prophylactic treatment with
anticonvulsants.[30]
4. Possible Complications
If left untreated, certain complications can result from increased intracranial pressure. These include brain
herniation (movement of brain structures, CSF, and blood vessels from their usual position in the skull),
cerebral edema (accumulation of water in the intracellular and extracellular spaces of the brain), cerebral
ischemia (inadequate oxygen and blood flow to brain tissue) and subsequent cerebral infarction
(neurological deterioration).
Studies have shown that areas surrounding an ICH have decreased blood flow close to ischemic levels. [31]
Patients with large hematomas showed increased cerebral oxygen extraction, suggestive of early
ischemia.[32] This is further supported by numerous cerebral blood flow (CBF) studies showing decreased
perfusion in the areas surrounding a cerebral hemorrhage. [33]
Observational studies have shown that a large percentage of patients will develop hematoma expansion.
26% of patients evaluated within the first 3 hours after the initial trauma showed ICH expansion. [34] ICH
volume can increase by as much as 40% and is likely to result in increased ICP and low cerebral
perfusion pressure and subsequent neurologic deterioration. [35] One study has suggested that poorly
controlled diabetes mellitus and systolic blood pressure greater than 200 mm Hg are major predictors of
hematoma volume expansion.[36]
Neurological deterioration can also result from cerebral edema, supported by evidence in which patients
with a larger amount of cerebral edema show worse clinical outcomes. [37] Peak edema generally occurs 3
to 7 days after the initial hemorrhage and correlates with lysis of red blood cells. Hemoglobin and its
degradation products have been implicated in direct and indirect neural toxicity.[38]