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Gianotti-Crosti Syndrome

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Gianotti-Crosti Syndrome
Author: Sren A Craig-Mller; Chief Editor: Dirk M Elston, MD more...
Updated: Aug 1, 2014

Background
Gianotti-Crosti syndrome (GCS) is a distinct infectious exanthem with associated lymphadenopathy and acute
anicteric hepatitis.[1] Gianotti and Crosti initially described GCS as associated with a hepatitis B virus exanthem,
which they termed papular acrodermatitis of childhood. A similar constellation of characteristics was later found to
be associated with several infectious agents and immunizations that were called papulovesicular acrolocated
syndromes. Subsequent retrospective studies have shown that these 2 entities are indistinguishable from one
another, and they are now consolidated under the unifying title of GCS.[2]

Contributor Information and Disclosures


Author
Sren A Craig-Mller The Commonwealth Medical College
Sren A Craig-Mller is a member of the following medical societies: American Medical Association
Disclosure: Nothing to disclose.
Coauthor(s)
Dirk M Elston, MD Director, Ackerman Academy of Dermatopathology, New York
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.
Specialty Editor Board
Kevin P Connelly, DO Clinical Assistant Professor, Department of Pediatrics, Division of General Pediatrics
and Emergency Care, Virginia Commonwealth University School of Medicine; Medical Director, Paws for Health
Pet Visitation Program of the Richmond SPCA; Pediatric Emergency Physician, Emergency Consultants Inc,
Chippenham Medical Center
Kevin P Connelly, DO is a member of the following medical societies: American Academy of Pediatrics,
American College of Osteopathic Pediatricians, and American Osteopathic Association

http://emedicine.medscape.com/article/911275-overview

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Gianotti-Crosti Syndrome

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Disclosure: Nothing to disclose.


Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of
Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Nothing to disclose.
Robert A Schwartz, MD, MPH Professor and Head, Dermatology, Professor of Pathology, Pediatrics,
Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School
Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American
Academy of Dermatology, American College of Physicians, New York Academy of Medicine, and Sigma Xi
Disclosure: Nothing to disclose.
Merrily P M Poth, MD Professor, Department of Pediatrics and Neuroscience, Uniformed Services University
of the Health Sciences
Merrily P M Poth, MD is a member of the following medical societies: American Academy of Pediatrics,
Pediatric Endocrine Society, and The Endocrine Society
Disclosure: Nothing to disclose.
Chief Editor
Dirk M Elston, MD Director, Ackerman Academy of Dermatopathology, New York
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.
Additional Contributors
Howard Pride, MD Associate Physician, Departments of Pediatrics and Dermatology, Geisinger Medical Center
Howard Pride is a member of the following medical societies: American Academy of Dermatology and Society
for Pediatric Dermatology
Disclosure: Nothing to disclose.

References
1. Baleviciene G, Maciuleviciene R, Schwartz RA. Papular acrodermatitis of childhood: the Gianotti-Crosti
syndrome. Cutis. Apr 2001;67(4):291-4. [Medline].
2. Caputo R, Gelmetti C, Ermacora E, et al. Gianotti-Crosti syndrome: a retrospective analysis of 308 cases.
J Am Acad Dermatol. Feb 1992;26(2 Pt 1):207-10. [Medline].
3. Caltabiano R, Vecchio GM, De Pasquale R, Loreto C, Leonardi R, Vasquez E. Human -defensin 4
expression in Gianotti-Crosti. Acta Dermatovenerol Croat. 2013;21(1):43-7. [Medline].
4. Tagawa C, Speakman M. Photo quiz. Papular rash in a child after a fever. Gianotti-Crosti syndrome. Am
Fam Physician. January 2013;87(1):59-60. [Medline].
5. Iorizzo LJ 3rd, Scott G, Tausk FA. Gianotti-Crosti syndrome: a case report in an adult. Cutis. April
2012;89(4):169-72. [Medline].
6. Brandt O, Abeck D, Gianotti R, Burgdorf W. Gianotti-Crosti syndrome. J Am Acad Dermatol. January
2006;54(1):136-45. [Medline].
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[Medline].
8. Yoshida M, Tsuda N, Morihata T, et al. Five patients with localized facial eruptions associated with
Gianotti-Crosti syndrome caused by primary Epstein-Barr virus infection. J Pediatr. Dec 2004;145(6):843http://emedicine.medscape.com/article/911275-overview

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4. [Medline].
9. Mendoza N, Diamantis M, Arora A, et al. Mucocutaneous manifestations of Epstein-Barr virus infection.
Am J Clin Dermatol. 2008;9(5):295-305. [Medline].
10. Draelos ZK, Hansen RC, James WD. Gianotti-Crosti syndrome associated with infections other than
hepatitis B. JAMA. Nov 7 1986;256(17):2386-8. [Medline].
11. Atanasovski M, Dele-Michael A, Dasgeb B, Ganger L, Mehregan D. A case report of Gianotti-Crosti post
vaccination with MMR and dTaP. Int J Dermatol. May 2011;50(5):609-10. [Medline].
12. Kroeskop A, Lewis AB, Barril FA, Baribault KE. Gianotti-Crosti syndrome after H1N1-influenza vaccine.
Pediatr Dermatol. Sep-Oct 2011;28(5):595-6. [Medline].
13. Retrouvey M, Koch LH, Williams JV. Gianotti-Crosti syndrome following childhood vaccinations. Pediatr
Dermatol. Jan-Feb 2013;30(1):137-8. [Medline].
14. Brandt O, Abeck D, Gianotti R, Burgdorf W. Gianotti-Crosti syndrome. J Am Acad Dermatol. 2006;54:136145. [Medline].
15. Chuh A, Lee A, Zawar V. The diagnostic criteria of Gianotti-Crosti syndrome: are they applicable to
children in India?. Pediatr Dermatol. Sep-Oct 2004;21(5):542-7. [Medline].
16. Chuh AA. Diagnostic criteria for Gianotti-Crosti syndrome: a prospective case-control study for validity
assessment. Cutis. Sep 2001;68(3):207-13. [Medline].
17. Magyarlaki M, Drobnitsch I, Schneider I. Papular acrodermatitis of childhood (Gianotti-Crosti disease).
Pediatr Dermatol. Sep 1991;8(3):224-7. [Medline].
18. Taieb A, Plantin P, Du Pasquier P, et al. Gianotti-Crosti syndrome: a study of 26 cases. Br J Dermatol. Jul
1986;115(1):49-59. [Medline].
Medscape Reference 2011 WebMD, LLC

http://emedicine.medscape.com/article/911275-overview

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