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8.8 million new cases and 1.5 million associated deaths, mostly occurring in developing countries.[5] The absolute
number of tuberculosis cases has been decreasing since 2006, and new cases have decreased since 2002.[5] The
distribution of tuberculosis is not uniform across the globe; about 80% of the population in many Asian and African
countries test positive in tuberculin tests, while only 510% of the United States population tests positive.[1] More
people in the developing world contract tuberculosis because of compromised immunity, largely due to high rates of
HIV infection and the corresponding development of AIDS.[6]
About 510% of those without HIV, infected with tuberculosis, develop active disease during their lifetimes.[8] In
contrast, 30% of those coinfected with HIV develop active disease.[8] Tuberculosis may infect any part of the body, but
most commonly occurs in the lungs (known as pulmonary tuberculosis).[9] Extrapulmonary TB occurs when
tuberculosis develops outside of the lungs. Extrapulmonary TB may coexist with pulmonary TB as well.[9] General
signs and symptoms include fever, chills, night sweats, loss of appetite, weight loss, and fatigue,[9] and significant
finger clubbing ay also occur.[8]
A number of factors make people more susceptible to TB infections. The most important risk factor globally is HIV;
13% of all TB cases are infected by the virus.[5] This is a particular problem in sub-Saharan Africa, where rates of HIV
are high. Tuberculosis is closely linked to both overcrowding and malnutrition, making it one of the principal diseases
of poverty.[6] Those at high risk thus include: people who inject illicit drugs, inhabitants and employees of locales where
vulnerable people gather (e.g. prisons and homeless shelters), medically underprivileged and resource-poor
communities, high-risk ethnic minorities, children in close contact with high-risk category patients, and health care
providers serving these clients.
Tuberculosis is the second most common cause of death from infectious disease (after those due to HIV/AIDS).[9] The
absolute number of tuberculosis cases ("prevalence") has been decreasing since 2005, while new cases ("incidence")
have decreased since 2002.[5] China has achieved particularly dramatic progress, with an approximate 80% reduction
in its TB mortality rate between 1990 and 2010.[85] Tuberculosis is more common in developing countries; about 80%
of the population in many Asian and African countries test positive in tuberculin tests, while only 510% of the US
population test positive.[1] Hopes of totally controlling the disease have been dramatically dampened because of a
number of factors, including the difficulty of developing an effective vaccine, the expensive and time-consuming
diagnostic process, the necessity of many months of treatment, the increase in HIV-associated tuberculosis, and the
emergence of drug-resistant cases in the 1980s
A Solution is point of care testing. The Development of noninvasive methods for tuberculosis (TB) diagnosis, with the
potential to be administered in field situations, remains as an unmet worldwide challenge so we need to revolutionize
the diagnostic evaluation for TB tests with an inexpensive hand held device testing for to discriminate tuberculosis
patients from healthy subjects primarily testing for the markers for this disease.