Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
I.
INTRODUCTION
A. Worldwide
B. Philippines
I.
INTRODUCTION
A. What is Cancer?
Cancer develops when cells in a part of the body begin to grow out of control. Instead of dying, they outlive normal
cells and continue to form new abnormal cells.
Cancer cells can develop because of any abnormal change and/or damage in the DNA. DNA, also known as the
blueprint of life, can be found in every cell which directs all activities.
Normally, when DNA takes damage and/or undergoes abnormal change/s, the body is able to repair it. Cancer can
develop in instances where the body cannot repair any change/s in the DNA. And this damage can be passed on to
the offsprings, which accounts for inherited cancers.
A persons DNA can be damaged by exposure to mutagenic agents in the environment, like radiation and nicotine.
Carcinogens though are the specific mutagens that lead to cancer. Take note that all carcinogens are mutagens, but
not all mutagens are necessarily carcinogens.
Cancer usually forms as a tumor. Some cancers, like leukemia, do not form tumors. Instead, these cancer cells
involve the blood and blood-forming organs and circulate through other tissues where they grow.
Often, cancer cells travel to other parts of the body where they begin to grow and replace normal tissue. This process
is called metastasis. Regardless of where a cancer may spread, however, it is always named for the place it began.
For instance, breast cancer that spreads to the liver is still called breast cancer, not liver cancer.
B. Cancer Wordwide
Cancer is one of the most common causes of death, with nearly 7 million deaths each year worldwide. Right now 24.6
million people are living with cancer, and by 2020 it is projected that there will be 16 million new cancer cases and 10
million cancer deaths every year, if we wont take action to prevent such from happening.
Cancers figure among the leading causes of death worldwide, accounting for 8.2 million deaths in 2012 and 1.2
million of these are in WHOs South-East Asia Region, where an estimated 1.7 million new cancer cases are
diagnosed each year. For women in the Region, cancer of the breast and cervix are the most common cancers, whilst
lung and oral cavity cancers are the most common for men.
Lung, liver, stomach, colorectal and breast cancers cause the most cancer deaths each year.
The most frequent types of cancer differ between men and women.
About 30% of cancer deaths are due to the five leading behavioral and dietary risks:
High body mass index
Low fruit and vegetable intake
Lack of physical activity
Tobacco use
Alcohol use
Tobacco use is the most important risk factor for cancer causing over 20% of global cancer deaths and about 70% of
global lung cancer deaths.
Cancer causing viral infections such as HBV/HCV and HPV are responsible for up to 20% of cancer deaths in lowand middle-income countries.
More than 60% of worlds total new annual cases occur in Africa, Asia and Central and South America. These regions
account for 70% of the worlds cancer deaths.
It is expected that annual cancer cases will rise from 14 million in 2012 to 22 million within the next two decades, if no
effective preventive measure is applied.
Seventy-five percent of cancer patients in the Philippines are 50 years old and above while 3.2% belong to the
pediatric age bracket (0 to 14 years). However, cancers can occur at any age.
It is responsible for 5 million deaths out of a total of 50 million deaths in the world every year.
The table below shows the number of new cases (both sexes) per cancer site in 2010, ranked
according to decreasing number of new cases.
Thyroid cancer is more common in women than in men. In fact, it is the most common cancer for women at age 15 to 24.
Risk factors include family history, exposure to radiation, and not having enough iodine in the diet. It is highly curable by
surgery alone.
7. Rectal cancer
Rectal cancer is caused by cancer cells that grow in the last 15 centimeters of the colon. These cancer cells become
deadly once they travel through the bloodstream and into the other internal organs such as the liver. A diet rich in red meat
and processed meats, lack of exercise, obesity, smoking, type-2 diabetes, and alcoholism is found to cause the disease.
8. Ovarian cancer
The Department of Health website cites ovarian cancer as the 5th most common cancer among women. It is considered
a silent killer as it is usually detected when the cancer cells have already spread to other organs such as the lungs and
the liver. In March 2010, the mother of actress Francine Prieto succumbed to Stage 3 ovarian cancer.
9. Prostate cancer
After lung cancer, prostate cancer is the most common cancer for men. According to Enrique Ona of the National Kidney
and Transplant Institute, prostate cancer develops in 19.3 out of every 100,000 Filipinos. The Department of Health has
already recognized this alarming number and declared June of every year as Prostate Cancer Awareness Month.
10. Non-Hodgkins lymphoma
Lymphoma is a type of cancer that affects the lymphoid tissues such as the lymph nodes or the spleen. It is considered as
the most common type of blood cancer in the United States. Meanwhile, non-Hodgkins lymphoma is a type of
lymphoma that commonly affects adults. Patients with non-Hodgkins lymphoma have a lower survival rate (63%)
compared to patients with Hodgkins lymphoma (90%).
Other Leading Cancer Sites
Ovary (2.9%)
Prostate (2.7%)
Oral (2.5%)
Lymphomas (2.3%)
Pancreas (1.8%)
Bladder (1.8%)
Corpus Uteri (1.6%)
Bone (1.4%)
Brain, Nervous System (1.3%)
Larynx (1.3%)
Kidney (1.3%)
Connective Tissues (1.3)
Esophagus (1.0%)
From www.cancerindex.com/philippines
Population in 2012:
96.5m
98,200
140.0
14.8%
59,000
3.
4.
5.
6.
Coughing of blood
Wheezing or shortness of breath
Weight loss and loss of appetite
Frequent lung infection (e.g. bronchitis or pneumonia).
2. Liver
Liver cancer will be the 3rd leading site for both sexes combined (9%) in 2010. It ranks 2nd among males (14%) and
6th among females (4%).
In 2010, there will be an estimated 7,331 new cases among both sexes, 5,522 cases among men and 1,809 cases
among women.
The incidence rates begin to rise at age 35 among males, and age 50 among females.
There was a slight decrease in incidence rates from 1980 to 2002, with an annual change of - 1.2% among males,
and -0.8 among females.
In 2008, the estimated age-standardized national incidence rates were 10.6 per 100,000 in both sexes, 16.5 among
males, and 5.1 among females.
In 2008, two (1.9) out of 100 men and one (0.6) out of 100 women would have had a likelihood of getting liver
cancer before age 75.
In 2010, there will be 6,819 deaths in both sexes, 5,102 in men and 1,717 in women.
In 2008, the estimated national standardized mortality rates were 10 per 100,000 in both sexes, 15.4 among males,
and 4.9 among females.
In 2008, two (1.8) out of 100 men, and one (0.5) out of 100 women would have died from liver cancer before
age 75.
For liver cancers (both sexes) diagnosed between 1993-2002 and using population-specific life tables, the 5-year
relative survival rate of Metro Manila residents (8.5%) was slightly lower compared to Filipino-Americans (11.7%) and
Caucasians (12.3%) in the United States.
For liver cancers (both sexes) diagnosed between 1995-1999 and also using population-specific life tables, survival of
Metro Manila residents (5.3%) was also lower compared to European residents (9.1%) in the Eurocare-4 study.
3. Colon/Rectum
In 2010 cancers of the colon and rectum combined will rank 4th for both sexes (7%), 3rd among males (8%) and 4th
among females (6%).
In 2010, there will be 5,787 new cases in both sexes, 3,208 in males and 2,579 in females.
The incidence rates begin to rise steeply at age 50 years in both males and females. The incidence rates rose
steadily from 1980 to 2002, with an annual change of 3% and 3.7% in males and females respectively.
In 2008, the estimated age-standardized national incidence rates for colon and rectum cancers were 8.6 per 100,000
in both sexes, 10.0 among males, and 7.3 among females.
In 2008, one (1.2) out of 100 men and one (0.8) out of 100 women would have had a likelihood of getting
colorectal cancer before age 75.
There will be 3,060 deaths in both sexes, 1,690 in males and 1,370 among females, in 2010.
In 2008, the estimated national standardized mortality rates were 4.7 per 100,000 in both sexes, 5.5 among males,
and 3.9 among females.
In 2008, one (0.6) out of 100 men and less than one (0.4) out of 100 women would have died from colorectal
cancer before age 75.
2. Cervix/Uteri
In 2010 cervix cancer will be the 5th leading site for both sexes combined (6%), and the 2nd among women (11%).
In 2010, an estimated 4,812 new cases will occur.
The incidence rate starts rising steeply at age 30. There was a slight decrease in incidence rate from 1980 to 2002,
with an annual change of -0.3%.
In 2008, the estimated age-standardized national incidence rate was 11.7 per 100,000.
In 2008, one (1.1) out of 100 women would have had a likelihood of getting cervix cancer before age 75.
There will be 1,984 deaths in 2010. In 2008, the estimated national standardized mortality rate was 5.3 per 100,000.
In 2008, one (0.6) out of 100 women would have died from cervix cancer before age 75.
For cervix cancers diagnosed between 1993-2002 and using population-specific life tables, the 5-year relative survival
rate of Metro Manila residents (45.4%) was lower compared to Filipino-Americans (67.2%) and Caucasians (67.4%) in
the United States.
For cervix cancers diagnosed between 1995-1999 and also using population-specific life tables, survival of Metro
Manila residents (38.8%) was also lower compared to European residents (62.6%) in the Eurocare-4 study.
3. Lungs
3rd leading cause of cancer (6% of all cases)
Increased incidence and mortality rates: prevalence of smoking
Risk factors:
1. Third-hand smokes
2. Air pollution
3. Family history of lung cancer
Incident rates increase at age 45 (highest in Metro Manila)
In 2008, estimated age-standardized national incidence rate: 1 out of 100 women likely gets lung cancer before age of
75.
Estimated national standardized mortality rate: 1 out of 100 women might die from lung cancer before age of 75.
Early detection and treatment is still difficult to achieve, survival is still poor.
In 1987, it surpassed breast cancer to become the leading cause of cancer deaths in women. It causes more deaths
than the next three most common cancers combined (colon, breast and pancreatic).
According to the Department of Health, a Filipino smoker puffs 1,073 cigarette sticks annually while other smokers in
the Southeast Asian region consume less than a thousand sticks yearly. Ten Filipinos die every hour because of
smoking, representing a clear picture of the extent of the tobacco epidemic in the country.
PEDIATRIC POPULATION
Cancer among children comprises 3.2% of all cancer cases.
Leukemias are the most common.
Other cancer sites include brain and nervous system, retina, lymph nodes, kidneys, bone and soft tissues, gonadal
and germ cell site.
3,500 new cancer cases in children <15 y/o
In 2008, 8 out 10 children died of cancer
Childhood cancer (0-14 y/o)- 3.5% of all cancer cases.
1. Acute
Lymphocytic/
Acute
Lymphoblastic
Leukemia
Symptoms:
1. Fever without a known cause
2. Easy bruising or bleeding
3. Petechiae (dark-red spots under the skin caused
by bleeding)
4. Bone or joint pain
5. Painless lumps in the neck, stomach, groin, or
underarm
6. Pain or feeling of fullness below the ribs
7. Weakness and fatigue
8. Pale appearance
9. Loss of appetite
10. Recurrent minor infections
11. Abdominal swelling
12. Poor healing of minor cuts
13. Uncontrolled bleeding
14. Vision changes (a rare symptom).
2. Retinoblastoma
Symptoms:
1. White appearance of pupil under direct light
(leukocoria)
2. Eyes that cannot move or focus in the same
direction
3. Eye pain
4. Constantly dilated pupil
5. Red eye or eyes
6. Lazy eye (i.e. squinting of one eye or both eyes)
7. Color change in the iris
8. Deterioration of vision.
3. Lymphoma
Symptoms:
1. Painless swelling of the lymph nodes in the neck,
underarm, groin and chest
2. Difficulty in breathing due to the enlarged nodes in
the chest
3. Fever due to unknown causes
4. Night sweats
5. Fatigue
6. Weight loss and decreased appetite
7. Itchy skin
8. Frequent viral infections (e.g. cold, flu, sinus
2 types:
1. Familial or Hereditary (Bilateral= 25% of cases)
2. Non-Hereditary (Unilateral= 75% of cases)
Common manifestations: Leucoria (whitening of
the pupil; cats eye).
Curable at early diagnosis
9.
10.
11.
12.
infection)
Wheezing
Coughing
High-pitched breathing sounds
Difficulty in swallowing.
2. Non-Hodgkin Lymphoma
More likely to occur in children
Rare in children < 3y/o
Accounts 50% of all lymphomas in children
45% of childhood lymphomas occur b/w ages 1014
5-year survival is only 50%
Malignancies in children are difficult to detect because it may present similarly as other common childhood diseases.
Parents should have their children undergo regular medical check-up and be alerted on the following symptoms which
may be associated with cancer in children: prolonged, unexplained fever or illness; unexplained pallor; increased
tendency to bruise; unexplained localized pain or limping; unusual masses or swelling; frequent headaches, often with
vomiting; sudden eye or visual changes; sudden or progressive weight loss.
Management of childhood cancers is usually by a combination of surgery, radiotherapy and chemotherapy.
A five-year survival rate markedly vary according to the sites of origin of the tumor.
III.
COMMON IDENTIFIED RISK FACTORS (AGENT, HOST, ENVIRONMENTAL)
A. Agent Factors
1. Chemical
Aromatic series: coal, tar, asphalt, aniline dyes and benzidine
Chemicals in insecticides, cosmetics, and food additives
Carcinogens - substances known to cause cancer
1. Direct carcinogens - can cause cancer by themselves
2. Procarcinogens - require actual metabolization and chemical change before they become
carcinogenic.
3. Co-carcinogens - only cause cancer when paired with other chemicals.
2. Physical
a. Radiation Energy
UV rays, alpha and beta rays, gamma or x-rays, and heat radiation (e.g. atomic bombs during wars
like Nagasaki and Hiroshima = many leukemias among affected survivors)
Leukemia: most common radiation-induced cancer.
Other types of cancer correlated with radiation exposure include lung cancer, skin cancer, multiple
myelomas, and stomach cancer.
b. Mechanical
Chronic irritation and trauma (e.g. projecting tooth, birth injuries, gallbladder stones, burn scars)
3. Nutritional
Vitamin deficiencies and other nutrient deficiencies
Low-fiber intake
High fat diet in breast and colorectal cancer
4. Biological
Viruses - Some viruses are linked with cancer in humans and are appropriately termed as oncoviruses.
Very common viruses today that are correlated with cancer include Hepatitis B (liver infection which may
cause hepatocellular cancer)
Epstein-Barr virus(mononucleosis/kissing disease may cause nasopharyngeal cancer, lymphomas,
stomach cancer)
human papilloma virus (from sexual practices may lead to cervical cancer).
B. Host Factors
1. Age
Cancer incidence is directly related with increasing age
However, some particular cancer types have characteristic age predilections such as:
o Nephroblastoma and retinoblastoma (children)
o Testicular cancer (adolescent males)
o Hodgkins disease (peak in childhood and young adulthood).
Two kinds of mechanisms have been suggested to explain the increase in cancer risk with age
1. Simple dose-duration- effects of carcinogenic exposures, regardless of any effects of aging.
2. Age-associated increase in cancer risk
Aging may increase susceptibility of an organism to cancer due to:
o Disturbance of hormonal balance
o An increase in the number of loci of chronic proliferation
o Decline in immune surveillance with age.
2. Sex
a. Sex hormones
Hepatocellular carcinoma or HCC is statistically more often found in males than in females.
Interleukin 6- found to aid in the progression of HCC. Higher in males. Lower in females due to protective
effect of estrogen.
Estrogen- protects females from Colorectal cancer
b. Chromosome related effect
Males have one copy of the X chromosome as part of their genetic make-up as opposed to females having
two. The X chromosome inactivation in females takes place in order to achieve gene dosage adjustment. As a
result, the same X chromosome is expressed in approximately half of the cells of females. If an X
chromosome gene has a mutation or a deleterious polymorphism, all male cells will lack its protein product,
but 50% of female cells may still have the functional protein provided that the other copy of the gene is
functional.
3. Race
Skin Cancer: Caucasian
Prostate Cancer: Black than whites (hormonal, dietary, genetic)
Pancreatic cancer: Ashkenazi Jews of European descent (also breast, ovarian, pancreatic, uterine, and
prostate cancer)
4. Heredity
With Down Syndrome (Trisomy 21): Acute Myeloid Leukemia
Colorectal and hereditary non-polyposis colon cancer (HNPCC) syndrome
Thyroid Cancer and Multiple Endocrine Neoplasia (MEN) syndrome
5. Habits and Customs
Circumcision- reducing STDs (males and females) thus reduced prostate cancer (males)
C. Environmental Factors
Cervical cancer is more common in the low income group
Lung cancer common among sugar cane farmers which may be due to exposure to fibers of biogenic
amorphous silica (BAS)
Rising lung cancer incidence with increased pollution of atmospheric air with smoke
1. Occupational risks are mainly concerned with the particular types of exposure to carcinogens an individual has
because of the nature of his or her work.
Lung cancer sugar cane farmers (increased pollution of atmospheric air with smoke)
Arsenic exposure mining, smelting, vineyard milling and pesticide production. These are known to be
associated with bladder and liver cancer.
Asbestos exposure shipbuilding as well as metal and cement industries. (mesothelioma)
Formaldehyde exposure medical technologists, pathologists and those involved in the textile and plywood
industry (nasal cavity cancer)
Benzene exposure is common in shoe production, pharmaceutical, rubber, printing and gasoline industries.
(lymphatic and hematopoietic types of cancer)
PREVENTIVE MEASURES FROM WHO AND DOH AGAINST MOST COMMON TYPES
LESSEN THE RISK OF DEVELOPING CANCER THROUGH HEALTH PROMOTION AND SPECIFIC PROTECTION:
There is no 100% guarantee that cancer can ever be prevented. However, being aware of the cancer risk factors will
help reduce the possibility of cancer.
(BY WHO)
1. Quit smoking.
Tobacco use is the single greatest avoidable risk factor for cancer mortality worldwide, causing an estimated
22% of cancer deaths per year. In 2004, 1.6 million of the 7.4 million cancer deaths were due to tobacco use.
Tobacco smoking causes many types of cancer, including cancers of the lung, oesophagus, larynx (voice
box), mouth, throat, kidney, bladder, pancreas, stomach and cervix. About 70% of the lung cancer burden can
be attributed to smoking alone. Second-hand smoke (SHS), also known as environmental tobacco smoke,
has been proven to cause lung cancer in nonsmoking adults. Smokeless tobacco (also called oral tobacco,
chewing tobacco or snuff) causes oral, oesophageal and pancreatic cancer.
2. Limit drinking of alcoholic beverages.
Alcohol use is a risk factor for many cancer types including cancer of the oral cavity, pharynx, larynx,
oesophagus, liver, colorectum and breast. Risk of cancer increases with the amount of alcohol consumed.
The risk from heavy drinking for several cancer types (e.g. oral cavity, pharynx, larynx and oesophagus)
substantially increases if the person is also a heavy smoker.
Attributable fractions vary between men and women for certain types of alcohol-related cancer, mainly
because of differences in average levels of consumption. For example, 22% of mouth and oropharynx
cancers in men are attributable to alcohol whereas in women the attributable burden drops to 9%. A similar
sex difference exists for oesophageal and liver cancers (Rehm et al., 2004).
3. Watch your diet.
Dietary modification is another important approach to cancer control. There is a link between overweight and
obesity to many types of cancer such as oesophagus, colorectum, breast, endometrium and kidney. Diets
high in fruits and vegetables may have a protective effect against many cancers. Conversely, excess
consumption of red and preserved meat may be associated with an increased risk of colorectal cancer. In
addition, healthy eating habits that prevent the development of diet-associated cancers will also lower the risk
of cardiovascular disease.
4. Do regular physical activity.
Regular physical activity and the maintenance of a healthy body weight, along with a healthy diet, will
considerably reduce cancer risk. National policies and programmes should be implemented to raise
awareness and reduce exposure to cancer risk factors, and to ensure that people are provided with the
information and support they need to adopt healthy lifestyles.
5. Have yourself immunized (Hepatitis B vaccine at birth up to 6 months old for prevention of liver cancer,
and human papilloma virus vaccine for the prevention of cervical cancer among women).
Infectious agents are responsible for almost 22% of cancer deaths in the developing world and 6% in
industrialized countries. Viral hepatitis B and C cause cancer of the liver; human papilloma virus infection
causes cervical cancer; the bacterium Helicobacter pylori increases the risk of stomach cancer. In some
countries the parasitic infection schistosomiasis increases the risk of bladder cancer and in other countries
the liver fluke increases the risk of cholangiocarcinoma of the bile ducts. Preventive measures include
vaccination and prevention of infection and infestation.
6. Maintain a clean environment.
Environmental pollution of air, water and soil with carcinogenic chemicals accounts for 14% of all cancers
(IARC/WHO, 2003). Exposure to carcinogenic chemicals in the environment can occur through drinking water
or pollution of indoor and ambient air.
In Bangladesh, 510% of all cancer deaths in an arsenic-contaminated region were attributable to arsenic
exposure (Smith, Lingas & Rahman, 2000). Exposure to carcinogens also occurs via the contamination of
food by chemicals, such as aflatoxins or dioxins. Indoor air pollution from coal fires doubles the risk of lung
cancer, particularly among non-smoking women (Smith, Mehta & Feuz, 2004). Worldwide, indoor air pollution
from domestic coal fires is responsible for approximately 1.5% of all lung cancer deaths. Coal use in
households is particularly widespread in Asia.
(BY DOH)
SPECIFIC PREVENTIVE MEASURES FOR THE MOST COMMON CANCERS:
Bone Cancer
o Prevention of bone cancer will require a better understanding of its causes than is currently available.
o Patients with persistent and progressive bone pain should have an x-ray study of the bone.
o Early detection is extremely difficult in asymptomatic patients.
o Careful screening may help detect and treat the cancer in its early stages, thereby improving the chances
for survival.
Breast Cancer
o Generally, breast cancer cannot be prevented, particularly if a woman has a family history of breast
cancer. To minimize contributing risk factors:
Eat a healthy diet consisting of high-fiber foods (cruciferous vegetables, foods rich in Vitamins A
and C);
Get enough exercise (Be active to maintain body muscles flexibility.);
Maintain ideal body weight;
Undergo mammography and BSE.
Breast Self-Examination
Cervical Cancer
o Cervical cancer, when detected early, is curable.
o Pap smear is the most reliable and practical way to diagnose early cervical cancer.
o Pap smear should be done 3 years after the first vaginal intercourse but not earlier than age 21. After that,
it should be done every year for 3 years.
o If the Pap smear test is negative for 3 consecutive years, then it can be done every 2 or 3 years. In
unmarried women who have never engaged in sexual activity, Pap smear should be done at age 35.
o Visual inspection with Acetic Acid Wash (VIA) is an acceptable alternative to Pap smear in low-resource
setting.
o The following preventive measures should be followed:
A one-partner sexual relationship should be observed;
A delay on the first sexual intercourse;
Consistent and correct use of barrier contraceptives, like condoms during sexual intercourse; and
Vaccination of anti-cervical cancer vaccine (HPV Vaccine).
Colon Cancer
o The most effective prevention of colon cancer is early detection and removal of precancerous colon
polyps before they turn cancerous.
o Barium enema or colonoscopy can be used for early diagnosis of symptomatic patients (particularly those
aged 50 years old and above).
Liver Cancer
o Lowering the prevalence of Hepatitis B through infant vaccination and improving sanitation nationwide is a
positive step.
o Unfortunately, there is no efficient early detection method yet for liver cancer.
Lung Cancer
o Unfortunately, there is no effective way of detecting lung cancer in its early stages.
o The best approach to lung cancer prevention is to stop smoking
o Also, the following may help prevent lung cancer:
Avoid secondhand smoke.
V.
SCREENING
Screening refers to the use of simple tests across a healthy population in order to identify individuals who have
disease, but do not yet have symptoms. Examples include breast cancer screening using mammography and cervical
cancer screening using cytology screening methods, including Pap smears.
Screening programmes should be undertaken only when their effectiveness has been demonstrated, when resources
(personnel, equipment, etc.) are sufficient to cover nearly all of the target group, when facilities exist for confirming
diagnoses and for treatment and follow-up of those with abnormal results, and when prevalence of the disease is high
enough to justify the effort and costs of screening.
SCREENING FOR VARIOUS CANCERS
Screening is the presumptive identification of unrecognized disease or defects by means of tests, examinations, or
other procedures that can be applied rapidly.
In advocating screening programmes as part of early detection of cancer, it is important for national cancer control
programmes to avoid imposing the high technology of the developed world on countries that lack the infrastructure
and resources to use the technology appropriately or to achieve adequate coverage of the population.
The success of screening depends on having sufficient numbers of personnel to perform the screening tests and on
the availability of facilities that can undertake subsequent diagnosis, treatment, and follow-up.
A number of factors should be taken into account when the adoption of any screening technique is being
considered:
Sensitivity: the effectiveness of a test in detecting a cancer in those who have the disease
Specificity: the extent to which a test gives negative results in those that are free of the disease
Positive predictive value: the extent to which subjects have the disease in those that give a positive test
result
Negative predictive value: the extent to which subjects are free of the disease in those that give a negative
test result
Acceptability: the extent to which those for whom the test is designed agree to be tested
Policies on early cancer detection will differ markedly between countries. An industrialized country may conduct
screening programmes for cervical and breast cancer.
Such programmes are not, however, recommended in the least developed countries in which there is a low
prevalence of cancer and a weak health care infrastructure. Further, only organized screening programmes are likely
to be fully successful as a means of reaching a high proportion of the at-risk population.
Agreement needs to be reached on guidelines to be applied in the national cancer control programme
concerning:
The frequency of screening and ages at which screening should be performed;
Quality control systems for the screening tests;
Defined mechanisms for referral and treatment of abnormalities;
An information system that can:
- send out invitations for initial screening
- recall individuals for repeat screening
- follow those with identified abnormalities
- monitor and evaluate the programme
VACCINES
Cancer vaccines are medicines that belong to a class of substances known as biological response modifiers.
Biological response modifiers work by stimulating or restoring the immune systems ability to fight infections and
disease. There are two broad types of cancer vaccines:
1. Preventive (or prophylactic) vaccines, which are intended to prevent cancer from developing in
healthy people
2. Treatment (or therapeutic) vaccines, which are intended to treat an existing cancer by
strengthening the bodys natural defenses against the cancer.
The International Agency for Research on Cancer (IARC) has classified several microbes as carcinogenic
(causing or contributing to the development of cancer in people:
Infectious Agents
Type OfAssociated Cancers
Vaccines or Screening Procedures
Organism
Hepatitis B Virus (Hbv)
Virus
Hepatocellular Carcinoma (A Type Of Hepa B Vaccine
Liver Cancer)
Hepatitis C Virus (Hcv)
Virus
Hepatocellular Carcinoma (A Type Of No Hepa C Vaccine.
Liver Cancer)
Prevention:
Don't share personal care items that
might have blood on them
Never share needles, syringes,
water
Get vaccinated against hepatitis A
and hepatitis B if you are a drug
user
Consider the risks of getting tattoos
or body piercings.
Human Papillomavirus (Hpv) Virus
Cervical Cancer; Vaginal Cancer; Vulvar HPV Vaccine
Types 16 And 18, As Well As
Cancer;
Oropharyngeal
Cancer Pap Smear
Other HPV Types
(cancers of the base of the tongue, Acetic Acid Wash
tonsils, or upper throat); Anal Cancer;
Penile
Cancer;
Squamous
Cell
Carcinoma Of The Skin
Epstein-Barr Virus
Virus
Burkitt
Lymphoma;
Non-Hodgkin EBV vaccine is still under development
Lymphoma;
Hodgkin
Lymphoma;
Nasopharyngeal Carcinoma (cancer of
the upper part of the throat behind the
nose)
Kaposi Sarcoma-Associated Virus
Kaposi Sarcoma
KSHV
vaccine
is
still
under
Herpes virus (KSHV), Also
development; under EBV vaccine
Known
As
Human
development study
Herpesvirus 8 (Hhv8)
Human T-Cell Lymphotropic Virus
Adult T-Cell Leukemia/Lymphoma
No developed vaccine
Virus Type 1 (HTLV1)
Helicobacter Pylori
Bacterium Stomach Cancer; Mucosa-Associated No developed vaccine
Lymphoid Tissue (Malt) Lymphoma
If infected with H. pylori, antimicrobial
treatment may avoid ulcer formation
and extension of disease
Schistosomes (Schistosoma Parasite Bladder Cancer
No official vaccine.
Hematobium)
Praziquantel The treatment of choice
for all schistosome species
Liver Flukes (Opisthorchis Parasite Cholangiocarcinoma (A Type Of Liver No developed vaccine
Viverrini)
Cancer)
VI.
CANCER TREATMENT
TREATMENT
Cancer treatment requires a careful selection of one or more intervention, such as surgery, radiotherapy, and
chemotherapy. The goal is to cure the disease or considerably prolong life while improving the patient's quality of life.
Cancer diagnosis and treatment is complemented by psychological support.
Treatment of early detectable cancers
Some of the most common cancer types, such as breast cancer, cervical cancer, oral cancer and colorectal cancer
have higher cure rates when detected early and treated according to best practices.
Treatment of other cancers with potential for cure
Some cancer types, even though disseminated, such as leukemias and lymphomas in children, and testicular
seminoma, have high cure rates if appropriate treatment is provided.
REHABILITATIVE CARE
The goal of rehabilitation is to help a person regain control over many aspects of their lives and remain as
independent and productive as possible. Rehabilitation can be valuable to anyone with cancer and those recovering
from cancer treatment.
How cancer rehabilitation can help
Rehabilitation can improve the quality of life for people with cancer and their families, including:
Improving physical strength to help offset any limitations from cancer and cancer treatment
Helping the person with cancer become more independent and less reliant on caregivers
Helping the person with cancer adjust to actual, perceived, and potential losses due to cancer and cancer
treatment
Reducing sleep problems
Lowering the number of hospitalizations
PSYCHOLOGICAL
Psychological stress alone has not been found to cause cancer, but psychological stress that lasts a long time may
affect a persons overall health and ability to cope with cancer.
People who are better able to cope with stress have a better quality of life while they are being treated for cancer, but
they do not necessarily live longer.
Emotional and social support can help patients learn to cope with psychological stress. Such support can reduce
levels of depression, anxiety, and disease- and treatment-related symptoms among patients. Approaches can include
the following:
1. Training in relaxation, meditation, or stress management
2. Counseling or talk therapy
3. Cancer education sessions
4. Social support in a group setting
5. Medications for depression or anxiety
6. Exercise
PALLIATIVE CARE
Palliative care is treatment to relieve, rather than cure, symptoms caused by cancer. Palliative care can help people
live more comfortably; it is an urgent humanitarian need for people worldwide with cancer and other chronic fatal
diseases. It is particularly needed in places with a high proportion of patients in advanced stages where there is little
chance of cure.
Relief from physical, psychosocial and spiritual problems can be achieved in over 90% of advanced cancer patients
through palliative care.
Palliative care strategies
Effective public health strategies, comprising of community- and home-based care are essential to provide pain
relief and palliative care for patients and their families in low-resource settings.
Improved access to oral morphine is mandatory for the treatment of moderate to severe cancer pain, suffered by
over 80% of cancer patients in terminal phase.
VII.
WHO RESPONSE
In 2013, WHO launched the Global Action Plan for the Prevention and Control of Noncommunicable Diseases 2013-2030
that aims to reduce by 25% premature mortality from cancer, cardiovascular diseases, diabetes and chronic respiratory
diseases.
WHO and the International Agency for Research on Cancer (IARC), the specialized cancer research agency of WHO,
collaborate with other United Nations organizations and partners to:
Coordinate and conduct research on the causes of human cancer and the mechanisms of carcinogenesis;
Generate new knowledge, and disseminate existing knowledge to facilitate the delivery of evidence-based
approaches to cancer control;
Develop standards and tools to guide the planning and implementation of interventions for prevention, early
detection, treatment and care;
Facilitate broad networks of cancer control partners and experts at global, regional and national levels;
Strengthen health systems at national and local levels to deliver cure and care for cancer patients; and
Provide technical assistance for rapid, effective transfer of best practice interventions to developing countries
VIII. REFERENCES:
1. International Agency for Research on Cancer (http://www.iarc.fr/)
2. Department of Health (http://www.doh.gov.ph/content/philippine-cancer-control-program.html)
3. World Health Organization (http://www.who.int)
4. National Cancer Institute at the National Institutes of Health (http://www.cancer.gov/)
5. Philippine Cancer Index (www.cancerindex.com/philippines)
6. Philippine Cancer Society (http://www.philcancer.org.ph/)
7. Review Notes and Manual in Disease Prevention and Control in the Family and the Community, 8 th Edition,
University of the East Ramon Magsaysay Memorial Medical Center, Inc.