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Clinical examination
CRITERIA
ESSENTIAL
THROMBOCYTHEMIA (ET)
Major criteria
Minor criteria
Major criteria
Minor criteria
Major criteria
Hemoglobin
> 18.5 g/dL in men,
> 16.5 g/dL in women
Presence of JAK2V617F
or other clonal markera
Not meeting WHO criteria for CML,
PV, MDS, or other myeloid neoplasm
Palpable splenomegaly
Proliferation and atypia of
megakaryocytes, with or without
b
Complete
blood count
Biochemistry
Increased serum LDH
Leukoerythroblastosis
Special assay
TOTAL NUMBER OF
HIGHLIGHTED CRITERIA
To meet WHO
diagnostic criteria
for this MPN
CML = chronic myelogenous leukemia; EPO = erythropoietin; LDH = lactate dehydrogenase; MDS = myelodysplastic syndrome; MPN = myeloproliferative neoplasm;
WHO = World Health Organization
For PV: or JAK2 exon 12 mutation; for ET: or other clonal marker or no evidence of reactive thrombocytosis; for PMF: or other clonal marker or no evidence of reactive marrow
fibrosis.
b
Presence of megakaryocyte proliferation and atypia (small to large megakaryocytes with an aberrant nuclear/cytoplasmic ratio and hyperchromatic, bulbous, or irregularly
folded nuclei and dense clustering). In the absence of significant reticulin fibrosis, the megakaryocyte changes must be accompanied by an increased bone marrow cellularity
characterized by granulocytic proliferation and often decreased erythropoiesis (ie, prefibrotic cellular-phase disease).
c
And no or little granulocyte or erythroid proliferation.
d
For PV: bone marrow trilineage myeloproliferation.
e
Or other evidence of increased red cell volume as follows: Hemoglobin or hematocrit >99th percentile of method-specific reference range for age, sex, altitude of residence, or
hemoglobin >17 g/dL in men, >15 g/dL in women if associated with a documented and sustained increase of at least 2 g/dL from a persons baseline value that cannot be attributed
to correction of iron deficiency or elevated red cell mass >25% above mean normal predicted value.
a
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