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Department of Psychiatry and Neurosexology, Haga Hospital Leyenburg, The Hague, The Netherlands
Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences,
Utrecht University, Utrecht, The Netherlands
Article info
Abstract
Keywords:
Premature ejaculation
IELT
Definition
Serotonin
Psychoanalysis
1.
Introduction
1569-9056/$ see front matter # 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
doi:10.1016/j.eursup.2007.04.009
clomipramine [57]. These studies have demonstrated a key role of central serotonin (5-hydroxytryptamine [5-HT]) neurotransmission and 5-HT
receptor subtypes in regulating ejaculation [4,8].
For many years there have been two separate and
rather contrasting approaches to PE: the medical
approach favoring drug treatment and the psychological approach focusing on behavioral therapy of
PE. A current challenge in PE treatment is to combine
psychological and neurobiological insights into an
evidence-based definition of PE. This review will
focus on the historical viewpoints and the current
neurobiological approach of PE.
2.
Historical perspectives of premature
ejaculation
2.1.
763
764
Definition of PE
There is accumulating evidence for a neurobiological basis of lifelong PE, despite the contrasting and
conflicting medical and psychological approaches
to PE that prevailed until the mid-1990s. However,
an official evidence-based definition of PE is still
lacking. The definition of PE as formulated in the
Diagnostic and Statistical Manual, Fourth Edition, Text
Revision (DSM-IV-TR) issued by the American Psychiatric Association (APA) is persistent or recurrent
ejaculation with minimal sexual stimulation before,
on, or shortly after penetration and before the
3.
Conclusion
765
Conflicts of interest
The author has nothing to disclose.
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