Wu Zi Yan Zong fluid was used as the main recipe for

reinforcement of the kidney in this study. 73 cases were

randomly divided into 2 groups: 53 cases in treatment group
with Wu Zi Yan Zong fluid oral take; 20 cases in control
group with no treatment. After 6 weeks treatment, the
abilities of instantaneous memory and the memory of the
segments of logical story were elevated, the time of upright
standing with one leg and closure of the eye was prolonged,
and the hand tremor and degree of kidney deficiency (TCM)
were improved. But the memory width (memory in sequence
and in reverse sequence of a figure) showed no significant
difference comparing with that before treatment.
Key Words: Reinforcement of kidney, Wu Zi Yan Zong,
Senile Brain Functions
Writer: Xuemei Wang, Zhufan Xie
Institute of Combination of Traditional Chinese and Western
Medicines, Beijing Medical University, Beijing 100034

Wu Zi Yan Zong Wan

Functions
The formula helps to replenish essence, supplement marrow,
reinforce the kidney, and strengthen yang. It is used to treat
body weakness, kidney deficiency, sexual impotence,
spermatorrhea, and dark, dense urine.
Dosage Info
Pill: orally taken, 30mg, once a day. Tablet: 6 tablets, 3
times a day.5:1 concentrated extract: 9grams/day.
Ingredients
Wu Wei Zi , Che Qian Zi, Fu Pen Zi, Gou Qi Zi, Tu Si Zi
Precautions
Patients with allergic reactions caused to alcohol should take
this formula with caution.
Pharmacology
Effect on lipid metabolism in rats with alcohol induced liver
injuries: Wu Zhi Yan Zong Wan (1-2g/kg) can significantly
protect alcohol-induced liver injuries by preventing the
reduction of serum total cholesterol and the increase of
serum and liver triglycerides in rats. It can also significantly

alleviate changes in fat degeneration of the liver and

necrosis of liver tissue (P<0.05-0.01). Wu Zi Yan Zong Wan
can correct metabolic disorders of lipids, triglycerides in
particular, in the liver.(1)
Strengthening immune function: Wu Zi Yan Zong Wan has
certain strengthening effects on some nonspecific immune
functions of normal mice and significant strengthening
effects on nonspecific and specific immune functions
(including cellular and humoral immunity) of immunityinhibited mice.(2)
Effect on drug induced diabetes: Stomach perfusion of Wu Zi
Yan Zong Wan 1000-2000mg/kg can significantly improve
the abnormal glucose tolerance in rats with diabetes induced
by Sai Geng Ding, a pharmaceutical medication. It can also
significantly reduce the levels of blood sugar 60 and 120
minutes after sugar has been administered to rats and
significantly reduce the ratio of blood sugar to serum insulin
120 minutes after sugar administration.(3) The formula is
effective in alcohol induced hepatic diabetes and can reduce
lipid peroxide in the blood and liver and decrease the
impairment of tissue cells.(4) Stomach perfusion of Wu Zi
Yan Zong Wan can reduce the blood sugar in mice with
diabetes induced by alloxan. It can also prevent weight loss
and improve appearance. It has no significant effect on
serum insulin levels.(5)
Effect on the reproductive system: Stomach perfusion of Wu
Zi Yan Zong Wan can increase serum levels of testosterone,
sperm mobility, and sperm count in juvenile male rats as
well as increase the weight of foreskin and secondary sexual
organs (prostate and seminal vesicle) of castrated rats. The
formula can also increase the sperm count and sperm
motility in rats with gossypol induced low sperm production,
and improve fertility in male mice.(6)
Clinical Applications
Treating sexual impotence
Lin Yu Qun, et al. used Wu Zi Yan Zong Wan to treat sexual
impotence caused by panic induced kidney injury. The
principles used for the treatment were warming and
recuperating the kidney-yang, regulating the flow of qi, and
tranquilizing the mind. They achieved satisfactory results.(7)
Treating recurrent mouth ulcers

Wu Zi Yan Zong Wan was used to treat 50 cases of recurrent

mouth ulcers at a dosage of 6g, 3 times a day. Fifteen days
constituted one course of treatment. The patients continued
to take the formula at the attack stage and at intermission.
During administration patients remained relaxed, restricted
eating and drinking, led a regular life, and did not eat
pungent, fatty, or sweet foods. The results showed recovery
in 38 cases, improvement in 8 cases, and no improvement in
4 cases. The total effectiveness rate was 92%.(8)
Treating uterine hypoplasia
Pang Yu Qin used Wu Zi Yan Zong Wan to treat hypoplasia of
uterus. The formula consisted of Sha Wan Zi (Flatstem), Tu
Si Zi (Dodder Seed), Gou Qi Zi (Wolfberry Fruit), Che Qian Zi
(Plantain Seed), and Fu Pen Zi (Rubus). Shan Zhu Yu
(Dogwood Fruit) and Dang Gui (Chinese Angelica Root) were
added for deficiency of yin and blood. Ren Shen (Ginseng)
was added for deficiency of qi. Xiang Fu (Cyperus Tuber) and
Yu Jin (Curcuma Root) were added for depression. The
decoction was taken orally one dose a day from the second
day of menstruation to the first day of the next
menstruation. After two menstrual cycles, the decoction was
then taken for 4 months as one course of treatment from
the 7th to 17th day of menstruation. 1 to 3 courses of
treatment resulted in full recovery in 68 cases, improvement
in 21 cases, and no improvement in 11 cases. The total
effectiveness rate was 89%.(9)
Treating infertility
Modified Wu Zi Yan Zong Wan and a medicinal meal for
promoting the generation of vital essence were used to treat
male infertility. The formula was modified according to the
individual's symptoms. This formula consisted of Gou Qi Zi
(Wolfberry Fruit), Tu Si Zi (Dodder Seed), Fu Pen Zi
(Raspberry), Wu Wei Zi (Schisandra Fruit), Che Qian Zi
(Plantain), Jin Yin Zi (Cherokee Rose-hip), Sang Shen Zi
(Mulberry), and Xian Lin Pi (Epimidium). The decoction was
taken orally daily for 1 month. The medicinal meal for
promoting the generation of vital essence was eaten in the
morning and in the evening. One month constituted one
course of treatment. The results showed full recovery for 28
cases, improvement in 13 cases, and no improvement in 8
cases. The total effectiveness rate was 83.7%.(10)