Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Abstract. The purpose of this paper is to examine the sets of model and literature review to prove that
strategy of applying free chemical usage in purified water system for pharmaceutical industry would be
help the existing and new pharmaceutical companies to comply with part of Natioanal Agency of Drug
and Food Control / Badan Pengawas Obat dan Makanan (NADFC/BPOM) regulation in order to achieve
Cara Pembuatan Obat yang Baik (CPOB) of Indonesia pharmaceutical industry. One of the main
reasons is when we figured out the number of Indonesian pharmaceutical industries in 2012 are kept
reducing compare to the increasing numbers of Indonesian population growth. This strategy concept also
might help the industries to reducing environmental pollution, and operational cost in pharmaceutical
industries, by reducing of the chemical usage for water treatment process in floculation and cougulation
and chlorination for sterillization. This new model is free usage of chemicals for purified water
generation system process and sterilization. The concept offering of using membrane technologyReverse Osmosis (RO) membrane base treatment to replace traditional chemical base treatment,
following enhance Electrodeionization (EDI) as final polisher for controlling conductivity, and finally
Ultra Violet (UV) disinfectant technology as final guard for bacteria controls instead of chemical base
system in purified water generation system.
Key wordsPurified water system, pharmaceutical industry, free chemical, membrane base treatment
and enviromental pollution.
1 Introduction
As the world fourth largest population country, the
numbers of population in Indonesia is estimated around
220 millions, with an annual growth rate of 1.5% per
annum (International Trade Centre, 2005). While, based
on Gabungan Perusahaan Farmasi (Indonesian
Association of Pharmaceutical Companies), the numbers
of pharmaceutical company keep decreasing from year to
year. In the earlier 2005, there are around 250
manufacturers of pharmaceutical company and today
there are only 199 manufacturers of pharmaceutical
company spread around major city in Indonesia in the
year 2012. Supposedly, there should be huge potential
market for pharmaceutical industry to growth in
Indonesia when we compare the numbers of population
and the numbers of pharmaceutical company but the fact
is the other way round.
Based on the Business Monitor International (2010)
report, the main regulatory in Indonesia pharmaceutical
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.
2 Literature Review
The pharmaceutical manufactures are awash in
information of data [5]. Laboratory and manufacturing
information, non-conformance data and corrective and
preventive action (CAPA) plans, clinical trial reports,
supplier audits and correspondence with regulatory
agencies, customers and other stake holders, including
the Goverment policies, all flow into the ever increasing
information. When data and information meets the CPOB
3 Discussions
3.1 Methodology Approach
Based on the literature review offering the basic
model of technology in purified water system for
pharmaceutical industry as per Fig.1 [7].
Every pharmaceutical, chemical and bio
technological plant related to health products must rely
on appropriate water purification system, permitting it to
meet its particular requirements, especially as to the
problems related to storage and internal distribution. This
procedure must guarantee supply according to the volume
required and pursuant to the demanded quality
consumption points [7].
The system has pretreatment, particel filter, and the
main water treatment is a Reverse Osmosis (RO), with
the conductivity control after Rom and sterilized by
UltraViolet ( UV).
00039-p.2
ICASCE 2013
00039-p.3
00039-p.4
ICASCE 2013
00039-p.5
ICASCE 2013
References
Business Monitor International (2010) Indonesia Pharmaceuticals
& Healthcare Report Q3 2010, Business Monitor International
Ltd. ISSN 1748-1945
[2] Dian Risdianto, Optimisasi Proses Koagulasi Floculasi Untuk
Pengolahan Air Limbah Industri Jamu, Disertation for Master of
Chemical Engineering, Diponegoro University, Semarang, 2007.
[3] International Trade Center (2005), Supply and demand survey on
pharmaceuticals and natural products-Indonesia, International
Trade Center, July 2005.
[4] Joshi, H. N. (2003), Analysis of the Indian Pharmaceutical
Industry with Emphasis on opportunities in 2005. Pharmaceutical
Technology North America; Jan 2003; 27,1; ProQuest Research
Library pg. 74.
[5] June, E. (2004), Information retrieval in the pharmaceutical
industry. Pharmaceutical Technology; 2004; ProQuest Research
Library pg. S8.
[6] Lin, B., & Dwyer, D.S. (1995) New product development in the
information age: pharmaceutical industry. The Journal of Business
& Industrial Marketing; 1995; 10, 3; ProQuest Research Library
pg. 6.
[7] Mazzola, et, al (2006) Chemical resistance of the gram-negative
bacteria to different sanitizers in a water purifications system.
BMC Infectious Disease.
[8] Paul, D. H. (2002) Electrodeionization in pharmaceutical water
treatment, Pharmaceutical Technology North America; Jul; 26, 7;
ProQuest Research Library pg. 36.
[9] Pfeffer, J., & Salancik, G. R. 2003. The external control of
organizations: A resource dependence perspective: Stanford, CA:
Stanford University Press.
[10] P. J. DiMaggio & W. Powell, "The iron cage revisited"
institutional isomorphism and collective rationality in
[1]
00039-p.7
Copyright of EPJ Web of Conferences is the property of EDP Sciences and its content may
not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's
express written permission. However, users may print, download, or email articles for
individual use.