DAFTAR PUSTAKA

Residu Nitrat/Nitrit dalam Daging Segar

Hill, MJ. 1991. Nitrates and Nitrite in Food and Water. Ellis horwood series in
food science and technology. England. ISBN 0-7476-0067-8.
Birdsall, J. J. (1981). Human dietary nitrite intake and results of animal feeding
studies of nitrite. Paper presented at the Public Meeting of the Committee
on Nitrite and Alternative Curing Agents in Food, 22 Jan, 1981, National
Research Council, National Academy of Sciences, Washington DC, USA,
pp. 16.
Buege. D. R.. Lee. M. H. and Cassens, R. G. (1978). Residual nitrite levels in
meat products manufactured by Wisconsin meat processors. University of
Wisconsin, Madison. Wisconsin, USA. Available as A2983.
Cassens, R. G., Sebranek, J. G., Kubberod, G. and Woolford, G. (1974) Where
does the nitrite go? Food Prod. Dev. 8, 50-56.
Cassens, R. G., Greaser, M. L., Ito, T. and Lee, M. (1979). Reactions of nitrite in
meat. Food Technol. Chicago 33, 46-57.
Kacmar, P. and Bartik, N. (1965). Certain quantitative relations of nitrate and
nitrite metabolism in farm animals, IV normal nitrate levels in the organs
and body liquids of swine. Folia Vet. 9,59-63.
Kemp, J. D., Langlois, B.E., Fox, J. D. and Varney, W. Y. (1975). Effects of curing
ingredients and holding times and temperatures on organoleptic and
microbiological properties of dry-cured sliced ham. J. Food Sci. 40,634636.
MAFF (1987). Nitrate, Nitrite and N-nitroso Compounds in Foods. 20th Report of
the Steering Group on Food Surveillance, Food Surveillance Paper No.
20, HMSO, London.
Nordin, H. R. (1969). The depletion of added sodium nitrite in ham. Canad. Inst.
Food Technol. J. 2,79-85.
Usher, C. D. and Telling, G. M. (1975).Analysis of nitrate and nitrite in foodstuffs
critical review,/. Sci. Food Agric. 26,1793-1805.

Walters, C. L.,Casselden, R. J. and Taylor, A. McM. (1967). Nitrite metabolism by

skeletal muscle mitochondria in relation to haem pigments. Biochim.
Biophys. Ada 143,310-318.
Walters, C. L., Edwards, M. W., Elsey, T. S. and Martin, M. (1976). The effect of
antioxidants on the production of volatile nitrosamines during the frying
of bacon. Z. fiir Lebensm. Unters. it. Forsch. 162,377-385.
Wright, M. J. and Davison, K. L. (1964) Nitrate accumulation on crops and nitrate
poisoning in animals. Adv. Agron. 16, 197-247.

Archer, M.C. (1989). Mechanisms of action of N-nitroso compounds. Cancer

Surveys, 8, 241250.
Bernini, R., Picconi, F., Iacovacci, V. & Abballe, F. (2001). Analisi di salumi
mediante cromatografia ionica II: nitrito e Nitrato. Industrie Alimentari,
XL, 741746.
Chichester, C.O. & Mrak, E.M. (1984). Cured meat flavour. In: Advances in Food
Research. (edited by Academic Press Inc). Pp. 1011. Orlando, Florida,
USA: Academic Press.
European Commission. (1995). Directive (EC) No. 2 1995. 20 February 1995.
Official Journal of the European Union, L61, 140.
European Commission. (2006). Regulation (EC) No. 1881/2006. 19 December
2006. Official Journal of the European Union, L364,5
European Commission. (2011). Commission Regulation (EU) No. 1129/2011 of
11 November 2011 amending Annex II to Regulation (EC) No.
1333/2008 of the European Parliament and of the Council by establishing
a Union list of food additives.Official Journal of the European Union,
L295.
Fan, A.M. & Steinberg, V.E. (1996). Health implications of nitrate and nitrite in
drinking water: an update on methemoglobinemia occurrence and
reproductive and developmental toxicity. Regulatory Toxicology
Pharmcology, 23, 3543.

Hansen, H. (1978). The content of nitrate and protein in lettuce (Lactuca sativavar.
capitata (Butterhead salad) grown under different conditions. Qualitas
Plantarum, 28, 1117.
Henritz, E. (2010). Online reference included in article: the effects of sodium
nitrate. http://www.livestrong.com/article/218891-the-effects-of-sodiumnitrate/. Accessed 12 04 2011.
Honikel, K.O. (2007). The use and control of nitrate and nitrite for the processing
of meat products.Meat Science, 78, 6876.
Hsu, J., Jayashree, A. & Lee, N.A. (2009). Nitrate and nitrite quantification from
cured meat and vegetables and their estimated dietary intake in
Australians. Food Chemistry, 115, 334339.
Iammarino, M. and Taranto, AD. 2012. Nitrite and nitrate in fresh meats: a
contribution to the estimation of admissible maximum limits to
introduce in directive 952EC. International Journal of Food Science and
Technology, 47, 18521858.
Iammarino, M., Taranto, AD., Cristino, M. 2013. Endogenous levels of nitrites
and nitrates in wide consumption foodstuffs: Results of five years of
official controls and monitoring. Food Chemistry, 140, 763771.
Kanner, J. (1994). Oxidative processes in meat and meat products: quality
implication.Meat Science, 36, 673676.
Keeton, J.T. (2011). History of nitrite and nitrate in food. In N. S. Bryan, & J.
Loscalzo, (Eds.), Nitrite and nitrate in human health and disease(pp. 6984). New York, USA: Springer Science+Business Media, LLC.
Martn, A., Coln, B., Aranda, E., Benito, M.J. & Co`rdoba, M.G. (2007).
Characterization of Micrococcaceaeisolated from Iberian dry-cured
sausages.Meat Science, 75, 696708.
Matteucci, O., Diletti, G., Principe, V., Di Giannatale, E., Marconi, M.M. &
Migliorati, G. (2008). Due casi di metaemoglobinemia acuta da sospetto
avvelenamento da sodio nitrito. Veterinaria Italiana, 44, 439445.
McKnight, G.M., Duncan, C.W., Leifert, C. & Golden, M.H. (1999). Dietary
nitrate in man: friend or foe?.British Journal of Nutrition, 81, 349358.
Mosier, A. R., Syers, J. K., & Freney, J. R. (2004). Nitrogen fertilizer: An essential
component of increased food, feed and fiber production. In A. R. Mosier,

J. K. Syers, & J. R. Freney (Eds.),Agriculture and the nitrogen cycle

Assessing the impact of fertilizer use on food production and the
environment (pp. 3). Washington DC, USA: Island Press.
National Research Council. (1989). Nutrient Requirements of Equines, 5th edn.
Chapter 4, Washington DC: National Research Council.
Noel, P., Briand, E. & Dumont, J.P. (1990). Role of nitrite in flavour development
in uncooked cured meat products: sensory assessment. Meat Science, 28,
18.
Pierson, M.D. & Smoot, L.A. (1982). Nitrite, nitrite alternatives and the control of
Clostridium botulinumin cured meats.Critical Reviews in Food Science
and Nutrition, 17, 141187.
Schuddeboom, L. J. (1993). Nitrates and nitrites in foodstuffs. Strasbourg,
Belgium: Council of Europe.
Skibsted, L.H. (1992). Cured meat products and their oxidative stability. In:The
Chemistry of Muscle-Based Foods. (edited by D.E. Johnston, M.K.
Knight & D.A. Ledward). Pp. 266286. Cambridge, UK: The Royal
Society of Chemistry.
Tanzi, E. & Saccani, G. (2005). Nitrati in carni e prodotti stagionati. Laboratorio
2000, 3, 4447.
Toldra, F. (2010). Chemical of nitrite and nitrate in meat. In: Handbook of Meat
Processing. Pp. 136381. Malden, USA: Blackwell Publishing.
Walters, C. L. (1996). Nitrite and nitrate in foods. In M. J. Hill (Ed.), Nitrates and
nitrites in food and water(pp. 93). Cambridge, UK: Woodhead Publishing
Ltd.
Nitrat/Nitrit Anorganik dan Organik
A. Daiber, T. Munzel, T. Gori, Organic nitrates and nitrate tolerancestate of the
art and future developments, Adv. Pharmacol. 60 (2010) 177227.
A. Dejam, C.J. Hunter, C. Tremonti, R.M. Pluta, Y.Y. Hon, G. Grimes, K. Partovi,
M.M. Pelletier, E.H. Oldfield, R.O. Cannon 3rd, A.N. Schechter, M.T.
Gladwin, Nitrite infusion in humans and nonhuman primates: endocrine
effects, pharmacokinetics, and tolerance formation, Circulation 116
(2007) 1821 1831.

A. Koenig, C. Roegler, K. Lange, A. Daiber, E. Glusa, J. Lehmann, NO donors.

Part 16: investigations on structureactivity relationships of organic
mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent
vasodilator, Bioorg. Med. Chem. Lett. 17 (2007) 58815885.
A. Milkowski, H.K. Garg, J.R. Coughlin, N.S. Bryan, Nutritional epidemiology in
the context of nitric oxide biology: a riskbenefit evaluation for dietary
nitrite and nitrate, Nitric Oxide 22 (2010) 110119.
A. Webb, R. Bond, P. McLean, R. Uppal, N. Benjamin, A. Ahluwalia, Reduction
of nitrite to nitric oxide during ischemia protects against myocardial
ischemia-reperfusion damage, Proc. Natl. Acad. Sci. U S A 101 (2004)
1368313688.
A.F. Vanin, L.M. Bevers, A. Slama-Schwok, E.E. van Faassen, Nitric oxide
synthase reduces nitrite to NO under anoxia, Cell. Mol. Life Sci. 64
(2007) 96103.
A.J. Webb, A.B. Milsom, K.S. Rathod, W.L. Chu, S. Qureshi, M.J. Lovell, F.M.
Lecomte, D. Perrett, C. Raimondo, E. Khoshbin, Z. Ahmed, R. Uppal, N.
Benjamin, A.J. Hobbs, A. Ahluwalia, Mechanisms underlying erythrocyte
and endothelial nitrite reduction to nitric oxide in hypoxia: role for
xanthine oxidoreductase and endothelial nitric oxide synthase, Circ. Res.
103 (2008) 957964.
A.M. Frydman, P. Chapelle, H. Diekmann, R. Bruno, J.J. Thebault, J. Bouthier, H.
Caplain, W. Ungethuem, C. Gaillard, A. Le Liboux, et al.,
Pharmacokinetics of nicorandil, Am. J. Cardiol. 63 (1989) 25J33J.
A.R. Butler, M. Feelisch, Therapeutic uses of inorganic nitrite and nitrate: from
the past to the future, Circulation 117 (2008) 21512159.
A.R. Butler, M. Feelisch, Therapeutic uses of inorganic nitrite and nitrate: from
the past to the future, Circulation 117 (2008) 21512159.
A.S. Pannala, A.R. Mani, J.P. Spencer, V. Skinner, K.R. Bruckdorfer, K.P. Moore,
C.A. Rice-Evans, The effect of dietary nitrate on salivary, plasma, and
urinary nitrate metabolism in humans, Free Radic. Biol. Med. 34 (2003)
576584.
B. Gago, T. Nystrom, C. Cavaleiro, B.S. Rocha, R.M. Barbosa, J. Laranjinha, J.O.
Lundberg, The potent vasodilator ethyl nitrite is formed upon reaction of
nitrite and ethanol under gastric conditions, Free Radic. Biol. Med. 45
(2008) 404412.
5

B. Spiegelhalder, G. Eisenbrand, R. Preussmann, Influence of dietary nitrate on

nitrite content of human saliva: possible relevance to in vivo formation of
N-nitroso compounds, Food Cosmet. Toxicol. 14 (1976) 545548.
B.A. Kilfoy, Y. Zhang, Y. Park, T.R. Holford, A. Schatzkin, A. Hollenbeck, M.H.
Ward, Dietary nitrate and nitrite and the risk of thyroid cancer in the
NIH-AARP diet and health study, Int. J. Cancer 129 (2011) 160172.
B.S. Zuckerbraun, P. George, M.T. Gladwin, Nitrite in pulmonary arterial
hypertension: therapeutic avenues in the setting of dysregulated arginine/
nitric oxide synthase signalling, Cardiovasc. Res. 89 (2011) 542552.
C. van Kessel, D.S. Powlson, T.M. Addisott, N. Benjamin, K.G. Cassman, T.M. de
Kok, H. van Grinsven, J.L. Lhirondel, A.A. Avery, When does nitrate
become a risk for humans?, J Environ. Qual. 37 (2008) 291295.
C.C. Hunault, A.G. van Velzen, A.J. Sips, R.C. Schothorst, J. Meulenbelt,
Bioavailability of sodium nitrite from an aqueous solution in healthy
adults, Toxicol. Lett. 190 (2009) 4853.
C.C. Hunault, A.G. van Velzen, A.J. Sips, R.C. Schothorst, J. Meulenbelt,
Bioavailability of sodium nitrite from an aqueous solution in healthy
adults, Toxicol. Lett. 190 (2009) 4853.
C.D. Leaf, J.S. Wishnok, S.R. Tannenbaum, L-Arginine is a precursor for nitrate
biosynthesis in humans, Biochem. Biophys. Res. Commun. 163 (1989)
10321037.
C.L. Duncan, E.M. Foster, Role of curing agents in the preservation of shelf-stable
canned meat products, Appl. Microbiol. 16 (1968) 401405.
D.A. Edwards, K. Fletcher, E.N. Rowlands, Antagonism between perchlorate,
iodide, thiocyanate, and nitrate for secretion in human saliva; analogy
with the iodide trap of the thyroid, Lancet 266 (1954) 498499.
D.A. Wagner, D.S. Schultz, W.M. Deen, V.R. Young, S.R. Tannenbaum,
Metabolic-fate of an oral dose of N-15-labeled nitrate in humans effect
of diet supplementation with ascorbic-acid, Cancer Res. 43 (1983) 1921
1925.
D.F. Assinder, L.F. Chasseaud, T. Taylor, Plasma isosorbide dinitrate
concentrations in human subjects after administration of standard and
sustained-release formulations, J. Pharm. Sci. 66 (1977) 775778.

D.F. Assinder, L.F. Chasseaud, T. Taylor, Plasma isosorbide dinitrate

concentrations in human subjects after administration of standard and
sustained-release formulations, J. Pharm. Sci. 66 (1977) 775778.
D.R. Janero, N.S. Bryan, F. Saijo, V. Dhawan, D.J. Schwalb, M.C. Warren, M.
Feelisch, Differential nitros(yl)ation of blood and tissue constituents
during glyceryl trinitrate biotransformation in vivo, Proc. Natl. Acad. Sci.
U S A 101 (2004) 1695816963.
E. Riboli, T. Norat, S. Bingham, P. Ferrari, N. Slimani, M. Jenab, M. Mazuir, K.
Overvad, A. Olsen, A. Tjonneland, F. Clavel, M.C. Boutron-Ruault, E.
Kesse, H. Boeing, M.M. Bergmann, A. Nieters, J. Linseisen, A.
Trichopoulou, D. Trichopoulos, Y. Tountas, F. Berrino, D. Palli, S.
Panico, R. Tumino, P. Vineis, H.B. Bueno-De-Mesquita, P.H.M. Peeters,
D. Engeset, E. Lund, G. Skeie, E. Ardanaz, C. Gonzalez, C. Navarro, J.R.
Quiros, M.J. Sanchez, G. Berglund, I. Mattisson, G. Hallmans, R.
Palmqvist, N.E. Day, K.T. Khaw, T.J. Key, M. San Joaquin, B. Hemon,
R. Saracci, R. Kaaks, Meat, fish, and colorectal cancer risk: The
European prospective investigation into cancer and nutrition, J. Natl.
Cancer Inst. 97 (2005) 906916.
E.A. Jansson, L. Huang, R. Malkey, M. Govoni, C. Nihlen, A. Olsson, M.
Stensdotter, J. Petersson, L. Holm, E. Weitzberg, J.O. Lundberg, A
mammalian functional nitrate reductase that regulates nitrite and
nitric oxide homeostasis, Nat. Chem. Biol. 4 (2008) 411417.
E.F. Binkerd, O.E. Kolari, History and use of nitrate and nitrite in curing of meat,
Food Cosmet. Toxicol. 13 (1975) 655661.
F.R. Greer, M. Shannon, Infant methemoglobinemia: the role of dietary nitrate in
food and water, Pediatrics 116 (2005) 784786.
G. Speijers, P.A.v.d. Brandt, Nitrate, Food Additives Series. Joint FAO/WHO
Expert Committee on Food Additives, 2003.
G.E. McVeigh, P. Hamilton, M. Wilson, C.G. Hanratty, W.J. Leahey, A.B. Devine,
D.G. Morgan, L.J. Dixon, L.T. McGrath, Platelet nitric oxide and
superoxide release during the development of nitrate tolerance. effect of
supplemental ascorbate, Circulation 106 (2002) 208213.
G.M. McKnight, L.M. Smith, R.S. Drummond, C.W. Duncan, M. Golden,
Benjamin, Chemical synthesis of nitric oxide in the stomach from dietary
nitrate in humans, Gut 40 (1997) 211214.

G.R. Thatcher, A.C. Nicolescu, B.M. Bennett, V. Toader, Nitrates and NO release:
contemporary aspects in biological and medicinal chemistry, Free Radic.
Biol. Med. 37 (2004) 11221143.
H. Bartsch, H. Ohshima, B. Pignatelli, Inhibitors of endogenous nitrosation
mechanisms and implications in human cancer prevention, Mutat. Res.
202 (1988) 307324.
H. Druckrey, A. Schildbach, D. Schmaehl, R. Preussmann, S. Ivankovic,
Quantitative analysis of the carcinogenic effect of diethylnitrosamine,
Arzneimittelforschung 13 (1963) 841851.
H. Li, H. Cui, T.K. Kundu, W. Alzawahra, J.L. Zweier, Nitric oxide production
from nitrite occurs primarily in tissues not in the blood: critical role of
xanthine oxidase and aldehyde oxidase, J. Biol. Chem. 283 (2008)
1785517863.
H. Li, T.K. Kundu, J.L. Zweier, Characterization of the magnitude and mechanism
of aldehyde oxidase-mediated nitric oxide production from nitrite, J.
Biol. Chem. 284 (2009) 3385033858.
H.H. Comly, Cyanosis in Infants Caused by Nitrates in Well Water, JAMA J.
Am. Med. Assoc. 129 (1945) 112116.
J. Sakshaug, E. Sognen, M.A. Hansen, N. Koppang, Dimethylnitrosamine; its
hepatotoxic effect in sheep and its occurrence in toxic batches of herring
meal, Nature 206 (1965) 12611262.
J. Sander, Can nitrites in the human diet be the cause of cancerogenesis through
formation of nitrosamines?, Arch Hyg. Bakteriol. 151 (1967) 2228.
J. Sander, Kann Nitrit in Der Menschlichen Nahrung Ursache Einer
Krebsentstehung Durch Nitrosaminbildung Sein, Arch. Hyg. Bakteriol.
151 (1967) 22.
J.G. Sebranek, J.N. Bacus, Cured meat products without direct addition of nitrate
or nitrite: what are the issues?, Meat Sci 77 (2007) 136147.
J.J. Doel, N. Benjamin, M.P. Hector, M. Rogers, R.P. Allaker, Evaluation of
bacterial nitrate reduction in the human oral cavity, Eur. J. Oral Sci. 113
(2005) 1419.
J.N. Lukens, The legacy of well-water methemoglobinemia, JAMA J. Am. Med.
Assoc. 257 (1987) 27932795.

J.O. Lundberg, E. Weitzberg, J.M. Lundberg, K. Alving, Intragastric nitric oxide

production in humans: measurements in expelled air, Gut 35 (1994)
1543 1546.
J.O. Lundberg, E. Weitzberg, M.T. Gladwin, The nitratenitritenitric oxide
pathway in physiology and therapeutics, Nat. Rev. Drug Discov. 7 (2008)
156167.
J.S. Kim, M.H. Nam, Y.S. Do, C.J. Lee, C.S. Kim, W.S. Sim, K.B. Park, S.H. Lee,
J.S. Han, B.S. Shin, H.Y. Kim, Efficacy of milrinone versus nitroglycerin
in controlling pulmonary arterial hypertension induced by intravenous
injections of absolute ethanol in anesthetized dogs, J. Vasc. Interv.
Radiol. 21 (2010) 882887.
J.W. Winter, S. Paterson, G. Scobie, A. Wirz, T. Preston, K.E.L. McColl, Nnitrosamine generation from ingested nitrate via nitric oxide in subjects
with and without gastroesophageal reflux, Gastroenterology 133 (2007)
164174.
K. Cosby, K.S. Partovi, J.H. Crawford, R.P. Patel, C.D. Reiter, S. Martyr, B.K.
Yang, M.A. Waclawiw, G. Zalos, X. Xu, K.T. Huang, H. Shields, D.B.
Kim-Shapiro, A.N. Schechter, R.O. Cannon 3rd, M.T. Gladwin, Nitrite
reduction to nitric oxide by deoxyhemoglobin vasodilates the human
circulation, Nat. Med. 9 (2003) 14981505.
L. Peri, D. Pietraforte, G. Scorza, A. Napolitano, V. Fogliano, M. Minetti, Apples
increase nitric oxide production by human saliva at the acidic pH of the
stomach: a new biological function for polyphenols with a catechol
group?, Free Radic Biol. Med. 39 (2005) 668681.
L.C. Green, K.R. Deluzuriaga, D.A. Wagner, W. Rand, N. Istfan, V.R. Young, S.R.
Tannenbaum, Nitrate Biosynthesis in Man, Proc. Natl. Acad. Sci. U S A
Biol. Sci. 78 (1981) 77647768.
L.M. Van Bortel, J.J. Spek, E.J. Balkestein, M. Sardina, H.A. Struijker Boudier, Is
it possible to develop drugs that act more selectively on large arteries?, J
Hypertens. 17 (1999) 701705.
M. Feelisch, B.O. Fernandez, N.S. Bryan, M.F. Garcia-Saura, S. Bauer, D.R.
Whitlock, P.C. Ford, D.R. Janero, J. Rodriguez, H. Ashrafian, Tissue
processing of nitrite in hypoxia: an intricate interplay of nitric oxidegenerating and -scavenging systems, J. Biol. Chem. 283 (2008) 33927
33934.

M. Gilchrist, P.G. Winyard, N. Benjamin, Dietary nitrate good or bad?, Nitric

Oxide 22 (2010) 104109.
M. Gilchrist, P.G. Winyard, N. Benjamin, Dietary nitrate good or bad?, Nitric
Oxide 22 (2010) 104109.
M. Wiseman, The second World Cancer Research Fund/American Institute for
Cancer Research expert report. Food, nutrition, physical activity, and the
prevention of cancer: a global perspective, Proc. Nutr. Soc. 67 (2008)
253 256.
M.H. Ward, B.A. Kilfoy, P.J. Weyer, K.E. Anderson, A.R. Folsom, J.R. Cerhan,
Nitrate intake and the risk of thyroid cancer and thyroid
disease, Epidemiology 21 (2010) 389395.
M.H. Ward, Too much of a good thing? Nitrate from nitrogen fertilizers and
cancer, Rev. Environ. Health 24 (2009) 357363.
M.S.B. Katzung, Trevor A.J., Basic and Clinical, Pharmacology, Section III.
Cardiovascular-Renal Drugs. Vasodilators & the Treatment of Angina
Pectoris, 10th ed., 2007. (Chapter 12) ISBN: 0071451536, ISBN-13:
9780071451536.
M.T. Gladwin, C.J. Hunter, A. Dejam, A.B. Blood, H. Shields, D. Kim-Shapiro,
R.F. Machado, S. Tarekegn, N. Mulla, A.O. Hopper, A.N. Schechter,
G.G. Power, Inhaled nebulized nitrite is a hypoxia-sensitive NOdependent selective pulmonary vasodilator, Nat. Med. 10 (2004) 1122
1127.
N. Marsh, A. Marsh, A short history of nitroglycerine and nitric oxide in
pharmacology and physiology, Clin. Exp. Pharmacol. Physiol. 27 (2000)
313319.
N.G. Hord, Y. Tang, N.S. Bryan, Food sources of nitrates and nitrites: the
physiologic context for potential health benefits, Am. J. Clin. Nutr. 90
(2009) 110.
N.H. Golwala, C. Hodenette, S.N. Murthy, B.D. Nossaman, P.J. Kadowitz,
Vascular responses to nitrite are mediated by xanthine oxidoreductase
and mitochondrial aldehyde dehydrogenase in the rat, Can. J. Physiol.
Pharmacol. 87 (2009) 10951101.
Omar, SA., Artime, E., Webb, AJ. (2012). A comparison of organic and inorganic
nitrates/nitrites. Nitric Oxide, 26, 229240.

10

P. Rhodes, A.M. Leone, P.L. Francis, A.D. Struthers, S. Moncada, P.M. Rhodes,
The L-arginine:nitric oxide pathway is the major source of plasma nitrite
in fasted humans, Biochem. Biophys. Res. Commun. 209 (1995) 590
596.
P. Santamaria, Nitrate in vegetables: toxicity, content, intake and EC regulation, J.
Sci. Food Agric. 86 (2006) 1017.
P.N. Magee, J.M. Barnes, The productionofmalignant primary hepatic tumours in
the rat by feeding dimethylnitrosamine, Br. J. Cancer 10 (1956) 114.
R. Aamand, T. Dalsgaard, F.B. Jensen, U. Simonsen, A. Roepstorff, A. Fago,
Generation of nitric oxide from nitrite by carbonic anhydrase: a possible
link between metabolic activity and vasodilation, Am. J. Phys.-Heart
Circulat. Physiol. 297 (2009) H2068H2074.
R. Bodo, The effect of the heart-tonics and other drugs upon the heart-tone and
coronary circulation, J. Physiol. 64 (1928) 365387.
R. Schoental, Carcinogenic activity of N-methyl-N-nitroso-N0-nitroguanidine,
Nature 209 (1966) 726.
R. Schoental, Induction of tumours of stomach in rats and mice by N-nitroso-Nalkylurethanes, Nature 199 (1963) 190.
R.L. Santarelli, F. Pierre, D.E. Corpet, Processed meat and colorectal cancer: a
review of epidemiologic and experimental evidence, Nutr. Cancer 60
(2008) 131144.
S. Carlsson, N.P. Wiklund, L. Engstrand, E. Weitzberg, J.O. Lundberg, Effects of
pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation
and bacterial growth in urine, Nitric Oxide 5 (2001) 580586.
S. Shiva, Z. Huang, R. Grubina, J. Sun, L.A. Ringwood, P.H. MacArthur, X. Xu,
E. Murphy, V.M. Darley-Usmar, M.T. Gladwin, Deoxymyoglobin is a
nitrite reductase that generates nitric oxide and regulates mitochondrial
respiration, Circ. Res. 100 (2007) 654661.
S. Shiva, Z. Huang, R. Grubina, J. Sun, L.A. Ringwood, P.H. MacArthur, X. Xu,
E. Murphy, V.M. Darley-Usmar, M.T. Gladwin, Deoxymyoglobin is a
nitrite reductase that generates nitric oxide and regulates mitochondrial
respiration, Circ. Res. 100 (2007) 654661.

11

S.B. King, Mechanisms and novel directions in the biological applications of

nitric oxide donors, Free Radic. Biol. Med. 37 (2004) 735736.
S.M. Bode-Boger, G. Kojda, Organic nitrates in cardiovascular disease, Cell Mol.
Biol. (Noisy-le-grand) 51 (2005) 307320.
S.R. Tannenbaum, M. Weisman, D. Fett, The effect of nitrate intake on nitrite
formation in human saliva, Food Cosmet. Toxicol. 14 (1976) 549552.
S.R. Tannenbaum, M. Weisman, D. Fett, The effect of nitrate intake on nitrite
formation in human saliva, Food Cosmet. Toxicol. 14 (1976) 549552.
T. Munzel, A. Daiber, A. Mulsch, Explaining the phenomenon of nitrate tolerance,
Circ. Res. 97 (2005) 618628.
T. Rassaf, U. Flogel, C. Drexhage, U. Hendgen-Cotta, M. Kelm, J. Schrader,
Nitrite reductase function of deoxymyoglobin: oxygen sensor and
regulator of cardiac energetics and function, Circ. Res. 100 (2007) 1749
1754.
T.L. Brunton, The action of nitrate of amyl on the circulation, J. Anat. Physiol. 5
(1870) 92101.
T.T. Mensinga, G.J. Speijers, J. Meulenbelt, Health implications of exposure to
environmental nitrogenous compounds, Toxicol. Rev. 22 (2003) 4151.
U.W. Abshagen, Pharmacokinetics of isosorbide mononitrate, Am. J. Cardiol. 70
(1992) 61G66G.
U.W. Abshagen, Pharmacokinetics of isosorbide mononitrate, Am. J. Cardiol. 70
(1992) 61G66G.
V. Kapil, A.B. Milsom, M. Okorie, S. Maleki-Toyserkani, F. Akram, F. Rehman,
S. Arghandawi, V. Pearl, N. Benjamin, S. Loukogeorgakis, R.
Macallister, A.J. Hobbs, A.J. Webb, A. Ahluwalia, Inorganic nitrate
supplementation lowers blood pressure in humans: role for nitrite-derived
NO, Hypertension 56 (2010) 274281.
Y.J. Yang, S.H. Hwang, H.J. Kim, S.J. Nam, G. Kong, M.K. Kim, Dietary intake
of nitrate relative to antioxidant vitamin in relation to breast cancer risk:
a case-control study, Nutr. Cancer 62 (2010) 555566.
Z. Chen, J. Zhang, J.S. Stamler, Identification of the enzymatic mechanism of
nitroglycerin bioactivation, Proc. Natl. Acad. Sci. U S A 99 (2002) 8306
8311.
12

Sirkulasi dan ekskresi nitrit dan nitrat endogen

A. Bhmer, S. Gambaryan, D. Tsikas, Human blood platelets lack nitric oxide
synthase activity, Platelets (2014) doi:10.3109/09537104.2014.974024.
C. Baylis, P. Vallance, Measurement of nitrite and nitrate levels in plasma and
urine what does this measure tell us about the activity of the
endogenous nitric oxide system?, Curr. Opin. Nephrol. Hypertens. 7
(1998) 5962.
D. Tsikas, J.C. Frlich, Determination of nitrite as pentafluorobenzyl derivative by
RP-HPLC and UV detection with and without ion-pair extraction,
Fresenius. J. Anal. Chem. 344 (1992) 256260.
D.B. Kim-Shapiro, M.T. Gladwin, Pitfalls in measuring NO bioavailability using
NOx, Nitric Oxide 44 (2015) 12.
L.J. Ignarro, J.M. Fukuto, J.M. Griscavage, N.E. Rogers, R.E. Byrns, Oxidation of
nitric oxide in aqueous solution to nitrite but not nitrate: comparison with
enzymatically formed nitric oxide from L-arginine, Proc. Natl. Acad. Sci.
U.S.A. 90 (1993) 81038107.
Aksi antimikroba Nitric oxide
Fang, FC. 2012. Antimicrobial actions of nitric oxide. Nitric Oxide, 27, S2S50

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