Name of Patient

F. S.

Age

35 y.o

Height

53

Diagnosis

G3P3 (3003) PU del. ceph. term live birth by 1oLSTCS +

BTL w/ variable deaceration; severe preeclampsia
M. M. Olmillo

Sex

Female

Weight

60 kg

Website

milkv.co.vu

A/N

youre welcome J

Author

DRUG DATA
Generic Name:
Hydralazine Hcl

CLASSIFICATION
Pharmacologic:
Peripheral
vasodilator

Trade name/s:
Apresoline
Patients dose:
50mg q15mins. x
2 doses for BP

MECHANISM OF
ACTION

Acts directly on
vascular smooth
muscle to cause
vasodilation, primarily
arteriolar, decreasing
peripheral resistance;
maintains or increases
renal and cerebral
blood flow

Therapeutic:
Antihypertensive

140/100

Maximum dose:
800mg repeated
as necessary

Pregnancy Category
Risk: C

Onset:
Rapid
Peak:
10-20mins

Minimum dose:
5-10mg

Duration:
2-4 hrs

Available forms:
Tablets 10, 25,
50, 100mg;
injection
20mg/mL

Metabolism:
Hepatic, 3-7 hr

Route: IVTT

Excretion: urine

Source: 2011
Lippincotts NDG

Distribution: crosses
placenta, may enter
breast milk

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

INDICATIONS

General:
> oral: essential
hypertension
alone or in
combination with
other drugs
> parenteral:
severe essential
hypertension
when drug cannot
be given orally or
when need to
lower BP is urgent
>unlabeled uses:
reducing afterload
in the treatment of
heart failure,
severe aortic
insufficiency, and
after valve
replacement
(doses up to
800mg TID)

Patients actual
indication:
Pregnancyinduced
hypertension

Source: 2011
Lippincotts NDG

CONTRAINDICATI
ON

Contraindicated with
hypersensitivity to
hydralazine, tartrazine;
CAD, mitral valvular
rheumatic heart disease
(implicated in MI)

Precaution:
Use cautiously with
CVAs, increased ICP,
severe hypertension with
uremia, advanced renal
damage, lactation,
pregnancy, pulmonary
hypertension

ADVERSE
EFFECTS

CNS: headace,
peripheral neuritis,
dizziness
CV: palpitations,
tachycardia,
angina pectoris

NURSING
RESPONSIBILITIE
S

Before:
> check doctors order
> wash hands before administering
the drug
> take the clients BP
> check the patency of the IV line
> educate the client about the
purpose and importance of the drug

GI: anorexia,
nausea, vomiting,
diarrhea
GU: difficult
micturation,
impotence
Hematologic: blood
dyscrasias
Hypersensitivity:
rash, urticaria,
pruritus

Interactions:
> drug-drug: increased
pharmacologic effect of
beta-adrenergic blockers
> drug-food: increased
bioavailability of oral
hydralazine given with
food

Other: nasal
congestion,
flushing, edema,
muscle cramps

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

During:
> Give drug exactly as prescribed
> Take with food
> discontinue if blood dyscrasias
> withdraw drug gradually and not at
once
> repeat the purpose of the drug

After:
> Monitor client for orthostatic
hypertension
> reevaluate therapy if patient
develops arthralgia, fever, chest pain,
or continued malaise.
> report persistent or severe
constipation
> report unexplained fever or
malaise, muscle or joint aching, rash,
numbness, tingling
> document and record.

Source: 2011 Lippincotts Nursing

Drug Guide