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BIOPHARMACEUTICS
PLASMA DRUG CONCENTRATION TIME
CURVE
Submitted To:
SIR MOOSA RAZA
Submitted By:
ZAIN HANIF
BPD-01093-263
NABEELA ANWAR
BPD-01101-007
IFRA EHSAN
HINA ZAINAB
BPD-01101-025
BPD-01101-
028
SEHAR ANJUM
BPD-01101-035
(Section 7th A)
GRAPH
The concentration of drug (mg/ml) in each plasma sample is plotted against time (hr.) at which
the plasma sample was removed.
Plasma Drug concentration = X-axis
Time = Y-axis
PURPOSE
It is a way to determine:
PHARMACOLOGIC PARAMETERS
The relationship of the drug level-time curve and various pharmacologic parameters for the drug
are:
MEC:
abbreviation for Minimum Effective Concentration
It is the Minimum concentration of drug needed at the receptors to produce the desired
pharmacologic effect.
For some drugs, such as those acting on autonomic nervous system, it is useful to know the
concentration of drug that will just barely produce a pharmacologic effect.
MTC:
abbreviation for Minimum Toxic Concentration
It is the concentration needed to just barely produce a toxic effect.
ONSET TIME:
It is the time required by the drug to reach the MEC
TERMINATION TIME:
It is time for the drug to decline back to the MEC.
DURATION OF ACTION:
It is the difference between the Onset time and the termination time.
It is also defined as the time at which the drug remains above the MEC.
THERAPEUTIC WINDOW:
It is the concentration between the MEC and MTC.
Drugs with the wide therapeutic window are generally considered safer than drugs with narrow
therapeutic window.
PHARMACOKINETIC TERMS:
Peak plasma level
AUC (Area under Curve)
It is the maximum drug concentration in the plasma and is a rough marker of average rate of drug
absorption.
tmax: It is the time of Peak plasma concentration
The time required to reach maximum drug concentration after drug administration.
At tmax Peak plasma drug absorption occurs and the rate of drug absorption exactly equals to rate
of drug elimination. The value for tmax will be smaller as the absorption rate for the drug
becomes more rapid. (Indicating less time required to reach peak plasma concentration)
UNIT: Units for tmax are units of time (e.g. hours, minutes)
Gastric Content
Gastrointestinal pH
REFRENCE:
Applied Bio-pharmaceutics & Pharmacokinetics (6th edition) by
Leon Shargel.