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Nuclear medicine scan could identify who

might benefit from aromatase inhibitor
treatment
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May 7, 2015

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Society of Nuclear Medicine

A new, noninvasive nuclear medicine test can be used to
determine whether aromatase inhibitor treatment will be
effective for specific cancer patients, according to a recent
study reported in The Journal of Nuclear Medicine. The
research shows that a PET scan with the ligand C-11-

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vorozole reliably detects aromatase in all body organs demonstrating the value of its future use to pre-determine
the effectiveness of the treatment for breast, ovarian,
endometrial and lung cancer patients.
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FULL STORY

A new, noninvasive nuclear medicine test can be

used to determine whether aromatase inhibitor
treatment will be effective for specific cancer
patients, according to a recent study reported in
The Journal of Nuclear Medicine. The research
shows that a PET scan with the ligand C-11vorozole reliably detects aromatase in all body
organs -- demonstrating the value of its future use
to pre-determine the effectiveness of the treatment
for breast, ovarian, endometrial and lung cancer
patients, potentially reducing unnecessary
treatment costs and adverse effects.
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May Help Prevent Lung Cancer

Jan. 9, 2012 A combination of
drugs that target estrogen
production significantly reduced the
number of tobacco carcinogeninduced lung tumors in mice,
according to results from a
preclinical ... read more
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Dec. 9, 2010 Postmenopausal
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Aromatase inhibitors are drugs that work by blocking the aromatase

enzyme, which turns the androgen hormone into cancer-stimulating
estrogen. They are widely used in the adjuvant treatment of breast cancer
and other endocrine conditions. However, no quantitative, noninvasive
studies had been done of the distribution and regulation of aromatase in
living humans.
Anat Biegon, PhD, corresponding author of the study, explains, "This is the
first study conducted in living human subjects that surveys the whole body,
comparing healthy young and old men and women."
For the study, 13 men and 20 women were injected intravenously with C11-vorozole (111-296 MBq/subject), with PET data acquired over a 90minute period. Each subject had four scans, two per day separated by two
to six weeks. Brain and torso or pelvic scans were included. Young women
were scanned at two discrete phases of the menstrual cycle (midcycle and
late luteal). Men and postmenopausal women were also scanned after
pretreatment with a clinical dose of the aromatase inhibitor letrozole. Timeactivity curves were obtained, and standardized uptake values (SUV) were
calculated for major organs, including brain, heart, lungs, liver, kidneys,
spleen, muscle, bone, and male and female reproductive organs. Organ
and whole-body radiation exposures were calculated using OLINDA
software.
The study shows for the first time that the body organ with the largest
stable capacity for estrogen biosynthesis is the male brain, closely followed
by the female brain. Aromatase availability is slightly but consistently higher
in all organs in men relative to women, with the exception of the ovary. In
addition, aromatase availability in the ovary is tightly linked to the ovulatory
phase of the menstrual cycle in young women, with increased levels
evident in one ovary/cycle around the time of ovulation. Also of interest is
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read more
PET Scans Reveal
Estrogen-Producing
Hotspots in Human
Brain
Nov. 3, 2010 A new study
demonstrated that a molecule
"tagged" with a radioactive form of
carbon can be used to image
aromatase, an enzyme responsible
for the production of estrogen, in
the human brain. ... read more

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the finding that aging and cigarette smoke reduce aromatase availability in
the brains of healthy men and women.
Dr. Biegon points out the significance of the study: "Research using in vitro
methods indicates aromatase over expression is not limited to breast
cancer and is evident in a considerable proportion of ovarian, endometrial,
and lung tumors. This study provides methodological, baseline and
dosimetry information supporting the use of PET and C-11 vorozole in the
non-invasive identification of individuals with disparate disorders who may
benefit from treatment with aromatase inhibitors." She notes, "It also offers
the ability to distinguish breast cancer patients who are not likely to benefit
from this treatment, reducing unnecessary treatment costs and adverse
effects. Finally, aromatase imaging can be used in monitoring efficacy of
treatment with aromatase inhibitors and aid in the development of new
drugs in this class."
Another key finding relates to the differences between men and women. Dr.
Biegon states, "Radiotracer uptake and the resultant radiation exposure
can be sex-dependent and strongly modulated by hormonal status. Nuclear
medicine procedures need to be adjusted for these factors when applied in
women."

Story Source:
The above story is based on materials provided by Society of Nuclear
Medicine. Note: Materials may be edited for content and length.

Journal Reference:
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1. A. Biegon, D. L. Alexoff, S. W. Kim, J. Logan, D. Pareto, D. Schlyer, G.J. Wang, J. S. Fowler. Aromatase Imaging with [N-Methyl11C]Vorozole PET in Healthy Men and Women. Journal of Nuclear
Medicine, 2015; 56 (4): 580 DOI: 10.2967/jnumed.114.150383

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Society of Nuclear Medicine. "Nuclear medicine scan could identify who

might benefit from aromatase inhibitor treatment." ScienceDaily.
ScienceDaily, 7 May 2015.
<www.sciencedaily.com/releases/2015/05/150507123027.htm>.

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