Pfizer Reviewer prepared by Ralph Gabriel Gutierrez

PFIZER DRUGS ( MIMS Philippines 2014 )

A Drug Study
1. Accupril
( Distributed by Zuellig; ACE Inhibitor; Rx only; Cat D; Quinapril HCL; tablet)
Indications and Dosage : HTN Px not on Diuretics initial 1020mg/day(maintenance 20-40mg(single or 2 doses
HTN Px on Concomitant diuretics initial 5g/day
CHF intial 5mg once/bid ;mainte 10-40mg in 2 divided
doses
Administration : taken on an empty stomach; before meals ; same time of day
Contraindications : Hypersensitivity; hx of angioedema r/t to previous tx w/ ACE;
pregnancy; co admin of aliskiren in px w/ diabetes
Special Precuations : renal & hepatic impairment; sx&anest; monitor wbc counts in
px with collagen vascular & or renal dse; Monitor K ;
angioedema;anyphylactoidrxns; hypogly; impaied ability to drive/operate
machinery; pregancy; children
Adverse Drug Reactions: headache, dizziness, cough, fatigue. Rhinitis, n & v,
myalgia
Drug Interactions: red. absorption of tetracylines; inc lithium conc; K sparing
diuretics; K supplements and K containing sal substitute; co admin with
NSAIDS,ACE,COX2 inhibitors; volume depleted or px with renal problems; Dual
blockage of RAS w/ angiotensin receptor blockers; ACE inhibitors; aliskerin
Storage : <25C; avoid moisture; protect from light; red brown triangular biconvex
2. Accuzide
( Distributed by Zuellig; Diuretics ACE inhibitor/Direct renin inhibitor; Quinapril HCL
20mg, HCLthiazode 12.5mg; rx only, cat d, tablet)
Indication and Dosage: HTN; combination therapy; px w/o diu initial tab;mainte
1tab
Concomitant diu initial 5mg
Administration : taken with/without food
Contraindications : Hypersensitivity to other sulfonamide derived drugs; hx of
angioedema r/t prev. tx w ACE; anuria; pregnancy; co admin of aliskerin w/ px w/
diabetes
Special Precautions: px w/ hx of angioedema unr/t ACE inc risk of angioedema;
symptomatic htn in salt/vol depleted px; px undergoing desensitization w/
hymenoptera venom; LDL apheresis; renal and hepatic pxs; SLE; major sx;
myopia;glaucoma; light headedness @ 1st few days;neutropenia
Adverse Drug Rxs: headache. Dizziness, cough, fatigue and myalgia
Drug Interactions: dec. tetra abxn; inc lithium levels; alcohol, barbis, narcotics may
potentiate orthohtn; NSAIDS can reduce diuretic effect; corticosteroids, pressor
amines, skeletal muscle relaxant, antidiabetic drugs, other antiHTN.; almost same
w/ Accupril
Storage : <30C; protect from light; film coated; pink scored triangular biconvex 50s
3. Adriblastina RD
( DoxorubicinHCL,Zuellig,Cytotoxic chemo, Ca drug, rx only, IV, CAT D)
Indications and Dosage : Acute Lymphoma, CAs : IV starting dose 60-90mg/m2 as
single or divided dose over 3 sucessive days or given on days 1 & 8.
- Combination w/ other cytotoxic drugs 30-60mg/m2/cycle
- Hepatic Dys Bilirubin 1 2-3mg/dl of starting dose
- ->3 mg/dl of starting dose

Administration : IV ; vesical/arterial - .9%nacl og d5glucosesolution for not < 3min

and not >10 min to minimize thrombosis and extravasation; direct push is not
recommended
Contraindication: myelosupression; hepatic impairment; myocardial insufficiency &
infarction; arryhtmias; prev max tx of doxorubicin bicins and other anthracyclines;
UTI; bladder and hematuria;pregnancy
Special Precautions: px should recover from prev toxicity; monitor cardiac fxn;
obese px,; myelosupression
Adverse Drug rxs: refer to MIMS: too many
Drug Interaction inc effect with cyp3a4.cyp2d6 or pgp inhibitors; dec in cyp34a
inducers like phenobarbi, phenytoin; potentiate toxicity of other anticancer; inc
plasma conc w paclitaxel
ATC classification- doxorubicin cytotoxic antibiotic
Storage <25C; red orange isotonic solution
4. Advil/ Advil Suspension for KIDS
(Zuellig; Ibuprofen; NSAIDs; non Rx; cat c 1st to 2nd trimester; cat D at 3rd trimester)
Indication : mild to moderate pain; inflammation in dysmenorrheal, h/a during
migraine. Post op and dental pain;muskoskeletal d/o, reduction of fever
Dosage : Softgel Adult 200-400mg 4-6hrly ; MAX 1200mg daily
Children
susp 11-12yr 15ml; 9 10yr 12.5ml ; 6 -8yr 10; 4 5yr 7.5;2-3yr 5ml QID
Administration : with food; taken immediately after meals
Contraindications: hypersensitivity to aspirin/NSAIDs; hx of GI ulcer/bleeding;
pregnancy last trimester
Special Precautions: Do not take > 10 days for pain or >3 days for fever ; severe
allergic rxn skin
Adverse Drug Reactions : Abdominal pain, diarrhea, n & v, GI bleeding and ulcer
Drug Interactions : Anticoagulants; diuretics; other antiHPN, corticosteroids, SSRIs.
Cyclosporine, tacrolimus. Lithium methotrexate
5. Aldactone
(Spironolactone;Diuretic antiHPN; Rx only; Cat c cat D in gestational HTN; zuellig)
Indication and Dosage : Essential HPN; preoptx for primary hyperaldosteronism;
establishing dx of primary hyperaldosternism; CHF; diuretic induced hypoK/hypoMG;
prophylaxis of hypoKtakinfdigitalis;mngt of hirsutism
- Essential HTN Adult 50 -100mg/day if svere increased at
2wk intercal up to 200mg/day
-CHF adult 100mg/day , maintenance 25100day
-Cirrhosis urinary Na/k ratio
>1:100mg/day --------<1:200-400mg/day
-nephrotic
syndrome 100-200mg day
- edema in children initial 3mg/kg bodywt in divided doses; reduced to 1 -2
mg/kg for mainte
- hypoK/hypoMG 25 -100mg daily
-dx &tx of primary aldosteronism : LONg test
400mg/day for 3-4wks
Short test : 400mg/day for 4 days
-Hirsutism 100200mg/day in divided doses
Administration: taken with food
Contraindications: hypersensivity; acute renal insufficiency; anuria; hyperkalemia;
renal failure; addisonsdse or other dse with hyperkalemial use of
eplerenone;pregnancy
Special Precautions: concominant use with k retaining druhs of K supplements;
renal impairment; anesth and lactation
Adverse Drug rxn: gynecomastia; GI upset; drowsiness; lethargy; h/a and mental
confusion; ataxia., impotence, stevens Johnson syndrome; toxic epidermal

necrolysis; drug rash and menstrual irregularities; post menopausal bleeding;

agranulocytoses, urticaria and fever
ATC Classification K sparing diuretic ; aldosterone antagonists
Drug Interactions : concominant use of drugs to cause hyperK -> sever hyperK; may
diminish vascular response in norepi; inhibits clearance of digoxin; k supplements;
carbonoxolone
Storage : <30C ; tab 25mg film coated round and buff colored with peppermint odor
; SEARLE engraved
6. Aldazide
(Pfizer; spironolactone25mg hydroflumethiazide 25mg; diuretics; low ceiling
diuretics ksparing diuretic; antiHPN; rx only)
Indication and Dosage Essential HTN, edema, CHF, liver cirrhosis,
nephritic syndrome, idiopathic edema; ESSENTIAL HTN 25/25
100/100mg/day
CHF & other
edema adult initial 100/100mg/day single/divided dose for 2weeks
-children 1.5 3mg spironolactone/kg
body wt
Administration taken with food
Contraindications: hypersensitivity to other sulfonamidederived drugs;
acute renal insufficiency; hypercalcemia, anuria, addisonsdse,
precomaassctd w/ liver dse. Hyperkalemia
Special Precautions : Concominant use w/ K sparing diuretics, ACE
inhibitors, aldosterone blockers, monitor K levels, hyponatremia, Inc in
blood uric acid and glucose, cholesterol and triglyceride; may impair
ability to drive; pregnancy and lactation
Adverse Drug Rxns: Anaphylactoidrxn, asthenia, fever,malaise, orthohtn,
benign breast neoplasm, breast and abdl pain, n & v, pancreatitis,
leucopenia , thrombocytopenia, abN hepatic fxn, electrolyte imb,
drowsiness, changes in libido, menstrual, photosensitivity, rash, acute
renal failure
Drug Interactions: other diuretics, antiHTN, norepi, anest, digoxin,
ammonium Cl or chlestyramine, colestipol. Lithium, muscle relaxants,
corticosteroids, acth, Nsaids
Storage : <30C; tab film coated, SEARLE 101,; peppermint odor
7. Alfadil XL
(Pfizer; doxazosinmesylate; cat c; rx only; drug for bladder & prostate d/o; class
of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents;
used in tx of HTN)
Indications: tx of clinical s&sy in benign prostatic hyperplasia (BPH & for
reduced urinary flow assctd w/ BPH
Dosage: max recommended dose: 8 mg once daily, usual maintenance
dose: 4mg/daily : optimal effect may take up to 4wks
Administration : may be taken or without food
Overdosage : htn = immediately place in a supine head down position
Contraindications : hypersensitivity to quinazolines, doxazosin or any
other aldadil XL
Special Precaution : Hepatic impairment & severe GI narrowing, postural
htn, intraoperative floppy iris syndrome (IFIS), may impair ability to drive
or operate; pregnancy & lactation
Adverse Drug Reactions : vertigo, asthenia, peripheral edema, abdl pain,
dyspepsia, nausea & flu like symptoms; bronchitis, dyspnea, rhinitis, htn&
postural, IFIS
Drug Interaction: PDE5 inhibitors; ACE inhibitors; adrenergic neuron
blockers, alcohol. Aldesleukin, general anest, AIIA, MAOis, antipsychotics,

anxiolytics & hypnotics, anth HPNs. Ldopa and methyldopa, moxonidine,

baclofen, nitrates, alprostadil, hydralazine, minoxidil&nitroprusside,
corticosteroids, estrogen & digoxin
Storage : <30C and protect from moisture CR tab 4mg
8. Aromasin
(Zuellig; Exemestane; Cancer Hormone Therapy; Rx only;CAT X; enzyme inhibitors; used in
endocrine therapy)
Indication and Dosage: adjuvant tx of postmenopausal women w/ estrogen receptor
or unknown early breast CA to reduce risk of reoccurrence (distant &locoregional;
1st line tx of ABCa in women w/ natural or induced postmenopausal status; 2 nd line if
with whose dse has progressed following anti estrogen therapy; 3 rd line tx if ABCa
following multiple hormone therapies
- 1 tab
once/day
Administration : taken with food/after meal
Contraindication : hypersensitivity, pregnancy
Special Precautions : women w/ premenopausal endocrine status.; monitor bone
density and tx of osteoporosis; concominant use w/ estrogen products
Adverse Drug Reactions : hot flushes, arthralgia, nausea, anorexia, insomnia,
depression, headache, dizziness, carpal tunnel syndrome, inc sweating, rash,
alopecia, muscoskeletal pain, osteoporosis, pain, leg edema, urticarial, pruritus
Storage: < 30C, sugar coated
9. Caltrate Plus
(metro drug; calcium with vitamins, minerals pre/post natal, antienemics; CA 600mg, vit D
200IU copper 1mg, mg 50mg Manganese 1.8mg, Zn 7.5mg; OTC)
Indication and Dosage : prevention and tx of osteoporosis ; 1 tab bid
Administration : taken with food
10.Celebrex
(zuellig; celecoxib; NSAIDs;rx only; cat c but cat d in 3 rd trimester; anti rheumatic coxibs)
Indication and Dosage :symptomatictx of OA&RA. Relief of ankylosing spondylitis;
acute pain; acute dysmenorrhea. Acute and chronic lower back pain
OA 200mg/day single dose or 100mg bid ;
max 400mg bid
RA - 100/200mgbid ; max
400mg
Ankylossing
Spondylitis 200mg/day as single dose or 100mg bid max : 400
Acute pain : initial 400mg followed by additional 200mg if needed on 1 st day;
then 200mgbid/400mg once daily
Primary Dysmenorrhea : initial 400mg followed by 200mg
st
if needed on 1 day; then 200mg bid
Administration : may be with or w/o food
Contraindications : hypersensitivity to celecoxib& sulfonamides; hx of aspirin or
NSAID induced asthma, urticaria; preop pain in CABG; hx of CVA. Mi,CABG,
uncontrolled HTN and CHF
Special Precautions : ischemic heart dse; hx of Gi problems; renal & liver
impairment; dehydration; risk of heart dse; edema; smoking; monitor anticoagulant
activity after initiating tx; not to be used as substitute tx of aspirin as prophylactic
tx in cv dse; pregnancy
Adverse Drug Rxns :Bronchitis, pharyngitis . URTI, UTI, anaphylaxis; dyspepsia. GI
upset
Drug Interactions : Fluconazole; ACE; AIIA diuretics & lithium
Storage : <25C CAP100 blue bands ; CAP200 gold bands ; CAP 400 green
bands
11.Centrum / Centrum Silver (50y/o + )
(metrodrug; vitamins; non rx)

Indication and Dosage : prevention and tx of vitamin and mineral defieciencies/ 1

tab a day; may be taken w/ or w/o meals; dietary supplement
12.Champix
(zuelli, varenicline tartrate; antidote or detox agent used in substance dependence; used
in nicotine dependence; cat C; rx only
Indication and Dosage : aid to smoking cessation tx
Adult : 1mg bid following 1 wk titration as 0.5mgonce/day on day 1-3
0.5 mg bid/day on day
47
1mg bid on day
8 to end tx
START dose 1 wk before the set date
to stop smoking or may adop a flexible approach; pt should be treated for 12
wks
Severe renal
st
impairment : start dose 0.5mg once daily for 1 3 days then inc to 1mg/day
Administration :maybe with or w/o food; swallow whole w/ a full glass of water, do
not chew/crush
Contraindications : hypersensitivity
Special Precautions : discontinue if hypersensitivity rxns; renal impairment; impair
ability to drive or operate machinery; pregnancy; children < 18 yr
Adverse Drug Rxns : SITISES ; decreased appetite , mood swings, insomnia,
palpitations, GI upset, malaise, chest pain etc
Drug Interactions : none as of the moment
Storage < 30 C
13.Childrens Clusivol
( metro drug; tx of & prevention of vit& mineral deficiency; non rx)
Indication and Dosage : tx& prevention of vit& mineral defieciency
Children 7 12 yr : 5 ml daily
1-6 yr : 2.5 ml daily
Administration : maybe with or without food if GI upset

14.Chloromycetin
( zuellig; chloramphenicol suspension : palmitate, injection : succinate; rx only; cat c;
amphenicols tx of systemic infection)
Indication and Dosage : acute infections caused by salmonella typhi / H influenza,
rickettia, lymphogranuloma psittacosis group, various gm ve bacteria causing
bacteremia, meningitis and other serious infections, cystic fibrosis regiments
Adult & Children 50 100mg/kg in 4
divided doses ; high doses as soon as possible
Full term Indant
<2wk 25 50mg/kg in 4 divided doses
premature and new born 25mg/kg in 4 equally divided 4 doses
Administration : taken on an empty stomach; 1 before meals or 2 hr after meals
Contraindications : hx of hypersensivity or toxic reaction
Special precautions : renal or hepatic impairment, g6pd, porphyria, clostridium
difficile assctd dirarrehea; pregnancy & lactation; premature and full term infants
Drug Interactions: retards biotransformation tolbutamide , phenytoin and
dicoumarol, rifampicin therapy can reduce chloramphenicol conc. Increases
tacrolimus serum conc
Storage : CAPSULE <30c; tight container; protected from moisture and heat
SUSPENSION : <30C; protect from freezing
POWDER for INJ : <25C ; solution is stable
for 30 days @ 25C upon reconstitution
15.Dalacin C HCL/Dalacin C Palmitate HCL/Dalacin C Phosphate

(zuellig; clindamycin ,cap HCL,granules palmitate, inj phosphate, antibiotic, class of

lincomides for systemic tx of infection; cat b, rx only)
Indication and Dosage : infection caused by anaerobic or gm+ve aerobic bacteria
and Chlamydia trachomitis; URTI, LRTI, skin and soft tissue, muskoloskeletal, gyne,
intraabdominal, septcimea, endocarditis. Dental infc, toxoplasmic encephalitis in
aids, pneumocystis jiroveci pneumonia
PROPHYLAXIS in endocarditis if
sensitive to penicillin
effective in
preventing peritonitis, intraabdminal abscess
Dosage : refer to MIMS
Administration : CAP maybe taken w or w/o food, swallow whole w/a full glass of
water in an upright position
GRANULES : taken with food
Contraindications : hypersensitivity to clindamycin or lincomycin
Special Precautions : Pseudomembranous colitis presented as diarrhea; perform
liver and kidney fxn test for prolonged therapy
Fatal gasping syndrome in
premature infants for IV formula due to benzyl alcohol content; pregnancy and
lactation
Drug Interactions: Antoganism w/ erythromycin; synergistic with neuromuscular
blockers
Adverse Drug Reactios : maculopapular rash, leucopenia, eosinophilia,
agranulocystosis, thrombocytopenia. N & v , GI upset
ORAL : esophagitis & ulcer
IM : irritation: pain abscess IV:
thrombophlebitis
Storage : HCL - <30C ; Palmitate HCL 15 30C ; Phosphate : <25C , do not
refrigerate or freeze
16.Depo Medrol
(by zuellig; methylprednisone acetate; corticosteroid;rx only; cat c)
Indication and Dosage: endo & hema d/o; rheumatic d/o; collagen d/o; etc
Contraindications: hypersensitivity; intrathecal; epidural & IV admin; fungal
infections: live vaccines; lactation
Special Precautions: Inj Sites changes; water retention; latent TB; hyperthyroididm;
ocular herpes;ulcerative colitis; diverticulitis; peptic ulcer; HTN; MG; cushings
dse;exophthalmos; GI ulcer with NSAIDs; inc risk to infection
Adverse Drug Reactions: infection; hypersensitivity; hypopituatarism, psych d/o, F &
E disturbance, HTN, inc IOP & ICP, menstrual irregularities; hypo/hyperpigmantation
Drug Interactions: INH, rifampin; oral anticoagulants; carbamazepine, phenobarb,
phenytoin,zoles, eryhthromycin, NSAIDs, K depleting agents; grapefruit juice
Storage: <25C ; protect from freezing
17.Depo Provera
( by zuellig; medroxyprogesterone acetate; Depot contraceptives; CAT X; rx only)
Indication and Dosage : Contraception :150mg ddeep IM 3 monthhly;
Endometriosis: 50mg wkly / 100mg IM 2 wkly
for atleast 6 mths
Menopausal Vasomotor Symp:
150mg IM 3 monthly
Endometrial/Renal
Carcinoma:400 1000mg IM wkly then maint @ 400mg/mth
Hormone Depndnt BreastCA: 500mg/day IM for 28 days maint @
500mg2xwkly
Contraindications: undx vag bleeding; malignancy of breast; thromboembloic d/o or
CVD, liver impairment pregnancy
Special Precautions: epilepsy, migraine, asthma, cardiac or renal dysfunction; hx of
depression; diabetes

Adverse Drug Reactions: Menstrual irregularities; wt changes; h/a; nervousness,

abdnl pain; dizziness; asthenia; vaginitis, decreased libido
Drug Interactions: aminoglutethimide -> depress serum concentration of depo
provera
Storage: <25C; protect from freezing

18.Diflucan
(by zuellig; fluconazole; antifungal;rx only cat c in indication: cat D if not candidiasis)
Indication and Dosage: candidemia, candida infections
Administration: w/ or w/o food
Contraindication : hypersensivity; co admin w/ terfenadine, cisapride, astemizole,
pimozide, quinidine, erythromycin
Special Precautions: monitor liver fxn; d/c tx if clinical s & sy consistent w/ devt of
liver dse; pregnancy
Adverse Drug Reaction : n & v; abdl pain; dizziness; seizures; taste perversion, QT
prolongation; leucopenia; thrombocytopenia; angioedema; face edema;
hypertriglyceridemia and hypoK
Drug Interactions : warfarin, oral sulfonylureas, phenytoin, rifampicin, cyclosporine,
theophylline, terfenadine, zidovudine, OC, losartan, benzodiazepines, cisapride,
eryhthromycin; voriconazole
Storage : <30C
19.Dilantin
(by zuellig; phenytoin;anticonvulsant; rx only ; cat D)
Indication and Dosage : cap/susp control of grand mal & complex partial seizure,
tx of seizure after neuro surgery; migraine, trigeminal neuralgia; psychoses; cardiac
arrhythmias; digitalis intoxication, post event tx of MI
inj status
epilepticus of grand mal type; prevention & tx of seizures during post
neurosurgery/severe head injury
Administration : with food; when on NGT/parenteral feeding do not administer
feeds 2hr before or after a dose; be consistent @ feed times; swallow whole; do not
switch forms/brands
Contraindications : hx of hypersensitivity to phenytoin & hydantoins. Sinus
bradycardia, SA block , 2nd or 3rd degree AV block. Pts with adams stokes syndrome,
lactation
Special Preacautions : MI, hepatic impairment; porphyria; avoid abrupt withdrawal;
INJ hypotension; do not administer rapidly; monitor for suicidal ideation &
behavior; monitor ECG & BP; resp depression, hepatic impairment; purple glove
syndrome, impaired ability to drive
Adverse Drug Reactions : anaphylaxis; ataxia; slurred speech. Diplopia, nystagmus,
h/a, gingival hyperplasia, hirsutism, hypertrichosis,
Drug Interactions : antibitotics & other anticonvulsants; alcohol, antifungals,
benzodiazepines, ca channel blockers; disulfiram, inh, ssris, phenylbutazone,
tolbutamide, chronic alcohol intake, digitoxin, quinidine, corticosteroids, coumarin,
antidepressants, folic acid, fluorouracil
Storag: <30C protect from light and moisture; freezing and light; light
20.Dilzem
(by zuellig; diltiazem HCL; Calcium antagonists; cat c; )
Indication and Dosage : angina pectoris inc prinzmetals angina; mild to moderate
HTN
Administration: taken on an empty stomach; preferably before meals, SA & SR tab;
swallow whole

Contraindication : hypersensitivity , sick sinus syndrome; 2 nd or 3rd degree AV block:

hypotension, acute MI; pulmonary congestion
Special Precautions : impaired renal or hepatic fxn; heart failure; pregnancy
Adverse Drug Reactions : dizziness, h/a, edema, skin rash, bradycardia, asthenia,
flushing, 1st degree AV block, nausea
Drug Interactions : combination w/ B blockers or digitalis may enhance myocardial
depression, may increase plasma digoxin & cyclosporine level. Competitive
inhibition of metabolism w/ drugs biotransformed by CYP450. H2 antagonists,
anesth, warfarin, eryhthromycin, lithium, rifampin
Storage : <30C or <25C

21.Dynastat
(by zuellig; Parecoxib Na; NSAIDs; rx only; )
Indication and Dosage : short term tx of acute & post op pain, pre op to prevent
post op pain; can reduce opioid reqt when use concomitantly
Contraindications : hypersensitivity; post op pain ff CABG sx, hx of CVA, MI, CHF,
HTN, ischemic heart dse, CVD, pregnancy 3rd time
Special Precautions : CV & thrombotic events, hx of GI dse, aspirin and
anticoagulant therapy, hypotension, volume depletion
Drug Interactions : CYP3a4 inhibitors, ACE, thiazides & furosemides, NSAIDs, lithium
and warfarin, COX2
Storage: <30C, do not refrigerate or freeze reconstituted dynastat
22.Eliquis
(by zuellig; apixaban;anticoagulant; antiplatelet;fibrinolytics;direct factor Xa inhibitor;rx
only; cat b)
Indication and Dosage : prevention of venous thromboembolic (VTE) in adult pts
who have undergone elective hip/knee replacement sx; stroke & systemic
embolism; nonvalvular atrial fibrillation(NVAF)
Administration: w/ or w/o food
Contraindication : hypersensitivity; active bleeding
Special Precautions: risk of hemorrhage in pts w/ congenital or acquired bleeding
d/o; bacterial endocarditis; uncontrolled HTN; recent spinal or opthalmological sx;
d/c if pts w/ CrCL <15ml/min & those undergoing dialysis;spinal anesth, children
<18yr
Adverse Drug Reactions: confusion; anemia, hemorrhage; nausea; gingival bleeding;
epistaxis; hematuria
Drug Interactions: inc bleeding with NSAIDs; inc plasma conc w CYP3A4 inhibitors
Storage : <25c
23.Enbrel
( by Pfizer ; etanercept; disease modifying rheumatic drug(DMARDs) , used as
immunosuppressant ; rx only; cat B, )
Indication and Dosage : Disease modification of early RA, psoriasis, ankylosing
spondylitis, psoriatic arthritis ; juvenile RA & pediatric pts w/ plaque psoriasis

Contraindications: hypersensitivity. Risk of sepsis; serious active infections;

concurrent use with live vaccines
Special Precautions : Sepsi, tb & fungal infection may occur; monitor patients;
wgeners granulomatosis; hepatitis; hypersensitivity to latex; perform skin exam for
all pts who are risk for non melanoma skin cancer; hx of blood dyscrasias; multiple
sclerosis; autoimmune antibodies; pre existing CNS demyelinating dse, CHF;
diabetes ; children <2 yrs old

 Drug Interactions : anakinra, abatecept, sulfalazine, live vaccines

Adverse Drug Rxns : Allergic Rxns, infections
Storage : 2 8C in a refrigerator; do not freeze, protect from light
24.Eraxis
(by zuellig;anidulafungin;candida infections; antifungal; rx only; inj for solution)
25.Feldene Gel
(by zuellig; piroxicam; pain & inflammation for OA, musculoskeletal pain; NSAIDs; rx only)
26.Gelfoam
(by zuellig; absorbable gelatin sponge; aids in hemostatis in sx; hemostatic; non Rx)
27.Incremin
(by metrodrug; Vit b1 b6 b12 lysine Fe, prevention of Vit B & Fe defieciency anemia; non
rx)
28.Iselpin
(by Pfizer ; Sucralfate ; antacid, antireflux & antiulcerant; rx only; cat B)
Indication and Dosage : tx of duodenal ulcer, gastric ulcer & chronic gastritis ; 1g
qid
Administration : taken on an empty stomach; take 1 hr antecebum & at bedtime
Contraindication : hypersensitivity; pts undergoing dialysis
Special Precaution : chronic renal impairment
Adverse Drug Rcns : constipation; dry mouth; nausea
Drug Interactions : Fluoroquinolones, digoxin, ketoconazole, sulpiride, levothyroxine,
phenytoin, warfarin, theophylline SR, citrate prep
Storage : <25C
29.Isordil
(by Pfizer ; isosorbide dinitrate ;anti angina drug; nitrate vasodilator; tx of cardiac dse; rx
only; cat c
Indication and Dosage : Angina Pectoris : ORAL : 5 -30mg QID (SL tab 5 10mg 23hrly )
Acute CHF: ORAL 10 40mg qid ( SL tab 5
-10mg hrly)
Chronic CHF : initial 5 100mg
2 hrly SL (mainte 20 40mg qid oral)
Administration: taken on an empty stomach; hour before meals
Contraindication : hypersensitivity
Special Precaution : paradoxical side effects; hemodynamic monitoring & frequent
assessment w/ use of organic nitrates in early infarction; hypotensive response;
paradoxical braydcardia; nitrate induced hypotension; Blood Volume Depletion :
<90mmHg monitor capillary refill not to fall below 15mmHg; may aggravate angina
caused by hypertrophic cardiomyopathy; avoid abrupt withdrawal
Adverse Drug Reactions : Cutaneous vasodialtion w/ flushing; dizziness; weakness;
cerebral ischemia asstd w/ postural htn, n & v, pallor, exfoliative dermatitis
Storage : <25C ; protect from light
30.Kitnos Forte
(by zuellig; etofamide; acute & chronic intestinal amebiasis; antiamoebics; rx only)
31.Lincocin
(by zuellig ; Lincomycin HCl monohydrate; infection caused by step pneumococci &
staph;rx only)
32.Lipitor
(by zuellig; atorvastatin Ca; anti HPN; CAT X; dyslipidaemic agent; rx only)
33.Lopid/ Lopid OD
(by zuellig; gemfibrozil; mixed dyslipidemia; dyslipidaemic; cat c; rx only)
34.Loviscol
(metrodrug; carbocisteine; URTI & LRTI; cough and cold prep; non rx)
35.Lyrica
(by zuellig; pregabalin; tx of neuropathic pain & fibromyalgia, seizures,
GAD;anticonvulsant; cat c; rx only)

36.Macugen
(by zuellig; pegatanib Na; tx of neovascular macular degen; eye prep;
antineovasculatisation; rx only; cat B )
37.Medrol
(by zuellig; methylprednisolone; endocrine & hema d/o; corticosteroid; cat c; rx only)
38.Minidiab/Minidiab OD
(by zuellig; glipizide; adjunctive therapy diet & exercise to improve glycemic control in
type 2 DM; cat c; antidiabetic; belongs to the class of sulfonamides & urea derivatives)
39.Minocin
(by Pfizer; Minocycline HCL; tetracyclines; rx only; cat D)
Indication and Dosage: Adult initial 200mg followed by 100mg 12hrly max
400mg/day
Acne 100mg bid
Uncomplicated Gonococcal MEN other then
urethritis anorectal infection initial 200mg followed by 100mg 12hrly for at least 4
days
Un complicated
Gonococcal urethritis MEN 100mg 12hrly for 5 days
Syphilis 200mg for 10 15 days
Meningococcal carrier state 100mg 12 hrly for 5 days
Mycobacterium marinum infctions : 100mg
12hrly for 6 8 wks
Urethal, endocervical,
rectal infctn caused by Chlamydia trachomatis or ureaplasma urealyticum ADULT
100mg 12 hrly for 7 days CHILDRN >8yr initial 4mg/kg followed by 2mg/kg 12hrly
Patients w/ renal impairment : MAX DOSE 200mg/day
Administration : may be taken with / without food, with food to reduce GI upset with
a full glass of watr
Contraindication: hypersensivity to tetracyclines
Special Precautions : may cause permanent discoloration of teeth during tooth devt;
enamel hypoplasia
pseudotumor cerebri(benign intracranial HTN; bulging
fontanels in infants; avoid direct sunlight; monitor labs. False elevations of urinary
catecholamine: may impair ability to drive
Adverse Drug Rxns : Dizziness lightheadedness
Drug Interactions : antacids containing Al, Ca, and Mg; Fe containing prep; food milk
and dairy products; anticoagulants; penicillin, OCs , isotrtinoin or other systemic
retinoids , retinol, ergot alkaloids
Storage: <30c; protect from light, moisture and excessive heat
40.Myrin / Myrin Forte(ref to MIMS)
(by Pfizer; rifampicin 150mg, ethambutol hcl 300mg, inh 75mg;anti TB agents; rx only;)
Indication and Dosage : initial & continuation phase of pulmonary & extrapulmonary
TB
1tab/15hg body wt/day ALTERNATIVE >50kg 4tab/day, 40
19kg 3 tab/day
Administration : taken on empty stomach; 1 hr before or 2 hr after meals; maybe
taken with food and antacid( except Al containing )
Contraindication : alcoholism, optic neuritis, hepatic fxn, renal insufficiency, gouty
arthritis; REPORT visual side effects; mental illness
Special Precaution : Perfrom full opthal exam before and after tx; red orange
discoloration of secretions: contact lenses may be stained, assess organ fxns;
monitor pyridoxine def. ; patients w/ epilepsy, Dm, psychtic states; risk for
peripheral neuropathy; false + copper sulfate urine glucose test; children <13yrs
old; impaired driving
Adverse Drug Rxns : refer to MIMS
Drug Interactions :Neurotoxics; Al containing drugs, phyllines, antidiabetic drugs,
phencols cheese, tuna or sardines
Storage : <30C ; forte <25C, protect from light, heat and moisture, pink tab
41.Neurontin

(by zuellig; gabapentin; tx of neuropathic pain; anticonvulsant & antineuropathic pain;

antiepileptics; cat c)
42.Nordette
(by Pfizer; oral contraceptive; levonorgestrel 150mcg ethinylestradiol 30mcg; cat x; rx
only)
Indication and Dosage : OC ; 1 tab daily for 21 consecutive days starting on day 1 of
the menstrual cycle followed by either 7 days inactive(placebo tab) or 7 tab free
days
Administration : may be taken with or without food
Contraindication: current or hx of DVT & thromboembolism; CV or CAD; thrombo
diseases;; h/a w/ focal nuerological symptoms; aura; diabetes w/ vascular
involvement; HTN or hepatic adenomas; breast carcinoma; pregnancy; vaginal
bleeding
Special Precaution : inc risk of thromboemblic events; obesity; surgery or trauma,
recent delivery, age, hyperlipidemia: DISCONTINUE if visual problems occur; close
monitoring BP: DM:
Adverse Drug Rxns : Vaginal candidiasis, depression, changes in libido, h/a,
migrains, weight changes, breast changes
Drug Interactions : rifampicin, barbis etc . refer to MIMS
Storage : tab 21s
43.Normetec
(by zuellig; amlodipine, olmesartan; angiotensin II antagonists, anti angina, CA
antagonists; cat d; rx only
44.Norvasc
(byzuellig; amlodipine besilate; anti HTN,MI, CHD; rx only; cat c)
45.Norvasc Protect
(by zuellig; amlodipine & atorvastatin; cat X; same as norvasc)
46.Olmetec zuellig olmesartan medoxomil- angiotensin II antagonist; anti HTN
47.Olmetec Plus zuellig diuretic + thiazide + angio antagonist; anti HTN
48.Pharmorubicin RD
(by zuellig; epirubicin HCL; anti CA drug; cytotoxic; cat D;rx only)
49.Ponstan / Ponstan SF
(by zuellig; mefenamic acid; NSAIDs; 250mg non rx; 500mg rx only)
50.Premarin
(by Pfizer,conjugated estrogens; progesterones & rltd synthetic drugs, rx only; )
Indication and Dosage : Vasomotor Sy, Atrophic Vaginisits, uretrhitis assctd w/
estrogen defieciency
- 0.3 1.25mg daily
Osteoporosis 625mcg
daily
Female
hypoestrogenism 0.3 1.25mg daily
Administration: may be w/ or w/o food; swallow whole
Contraindications : hypersensivity; hx of breast CA; or estrogen rltd neoplasia;
uterine bleeding; hx of thrombo dse; liver dysfunction; pregnancy
Special Precautions : inc risk of MI, pulmo emboli, hypothyroidos, not a
contraceptibve refer to MIMS
Adverse Drug Rxns : abnormal uterine bleeding; breast pain, leucorrhea; athralgias;
leg cramps; alopecia; wt changes; inc triglycerides
Drug Interactions : CYP3A4 inducers, phenobarb, phenytoin, mycins, zoles,
grapefruit juice, thyroid replacement therapy
Storage : <30C; 300mcg green 625 mg maroon
51.Prevanar
(by Pfizer ; pneumococcal 13 valent vaccine; rx only; cat C;)

Indication and Dosage : active immunization of invasive dse; PNEUMONIA and otitis
media caused by streptococcus pneumonia in infant & children 6wk 5yr or adults
>50yr
Administration : IM
Contraindications : hypersensitivity
Special Precautions :Delay vaccination in febrile illness; do not IV w/ children w/
thrombocytopenia or any coagulation d/o
Adverse Drug Rxn : Dec. appetite, pyrexia. Erythema, sweeling pain, poor sleep
quality
Drug Interactions : Diff vaccination sites
Storage : 2 8C, do not freeze, discard if frozen
52.Pristiq SR
(by Pfizer; desvenlafaxine succinate; antidepressant; rx only; cat C)
Indication and Dosage: tx of major depressive d/o & vasomotor symptoms assct
with menopause
Contraindications : Hypersensitivity to desvenlafaxine succinate; concominant use
w/ MAOI or w/in atleast 14 days of discontinuing MAOI
Administration : may be taken with/w/p food; take at the same time each day;
swallow whole
Special Precautions : monitor for clinical worsening and suicide; hx of mania;
seizures; increase IOP; metabolism d/o ; coagulation d/o; concominant use w/
antipsychotics; may impair ability to drive
Adverse Drug Reactions : Palpitations , tinnitus, mydriasis, n & v;, fatigue, irritability,
wt changes, inc BP, decrease appetite,, dec libido, erectile dysfunction, yawning etc
Drug Interactions : MAOIs,seretonergic agents
Storage : <30C
53.Provera
(by zuellig; medroxypregesterone acetate; oestrogen, progesterone synthetic drug; cat x;
rx only)
54.Rapamune
(by Pfizer, sirolimus; immunosuppressants; cat c; rx only )
Indication and Dosage : acute cyclosporine & corticosteroid for prophylaxis of organ
rejection in renal transplant inc. pts w/ high immunologic risk
Administration : w/ or w/o food, take consistently with or always w/o food; avoid
grapejuice
Contraindications : hypersensitivity
Special Precautions : susceptibility to infection and devt of lymphoma; monitor
WBC; whole blood w/ pts w/ hepatic impairment; <13yrold
Adverse Drug Reactions : lymphocele, edema, fever, h/a, HTN, GI upset, increase
cholesterol, epistaxis, pneumonia, acne, UTI
Drug Interaction: strong CYP3A4 inhibitors ( ketoconazoles etc), rhabdomyolysis;
grapejuice reduces CYP3a4 metabolism
Storage : <30C; sugar coated
55.Robikids
(by zuellig; carbocisteine; reduction of sputum viscosity; mucolytic; non rx)
56.Robitussin Expectorant
(metrodrug; guaifenesin; expectorant; non rx for wet cough)
57.Robitussin DM
(metro drug; dextromethorphan hbr & guafenesin; cough suppressant + expectorant)
58.Serenace
(zuellig; haloperidol; schizophrenia and other psychotic d/o; antipsychotics; cat c)

59.Solu cortef
(zuellig; hydrocortisone Na succinate; corticosteroid; cat c then cat d @ 3 rd trimester)
60.Solu medrol
(zuellig; methylprednisolone Na succinate; corticosteroid; for CA; cat c, rx only)
61.Stresstabs
(metrodrug; folic acid, nicotinamide, pantothenic acid, b complex and e; multivitamins)
62.Sulperazone
(zuellig; cefoperazone & sulbactam; cephalosporins; antibiotic; rx only)
63.Sutent
(zuellig; sunitinib malate; targeted cancer therapy; rx only; cat d; anti CA)
64.Tazocin
( by Pfizer ; Piperacillin Na Tazobactam Na ; Penicillins ; cat b; rx only)
Indication and Dosage : bacterial septicemia, UTI, LRTI, intraabdominal, skin,
polymicrobic, bone & joint, gyne, neutropenice infections
Contraindications : hypersensitivity to penicillin or cephalosporins
Special Precautions : pseudomembranous colitis; conduct periodic electrolyte
determination & assessment of organ system functions including renal, hepatic &
hematopoietic during prolonged therapy, d/c if bleeding; possibility of super
infection; steven johnsons syndrome, toxic epidermal necrosis
Adverse Drug Reactons: GI upset, rash
Drug Interactions : probenecid, vecuronium, aminoglycosides, heparin,
anticoagulants
Storage: <25C, INJ
65.Terramycin Eye
(zuellig; oxytetracycline polymyxin; prophylaxis and tx of ocular infection; rx only; eye
antiseptic)
66.Terramycin Plus
(zuellig; polymicin B, bacitracin Zn, neomycin; 1 st aid of prevention of pimples & pustules,
minor, cuts, scrapes & burns)
67.Torisel
(by Pfizer; temsirolimus; protein kinase inhibitor; CA drug; targeted cancer therapy; cat d)
Indication and Dosage : tx of advanced(metastatic) or locally advanced renal cell
carcinoma(RCC) & mantle cell lymphoma (MCL)
PREMED: Diphenhydramine 25-50mg 30 min
before infusion
Contraindication : patients w/ bilirubin >1.5 x upper limit of normal
Special Precaution : hypersensitivity to sirolimus & antihistamines; hyperglycemia;
infections; lung dse; peri op; CNS Tumors; receiving anticoagulants; use of ACE
inhibitors; avoid use of live vaccines; pregnancy; children and elderly
Adverse Drug Reactions : refer to MIMS
Drug Interaction : CYP3A4 inducers & inhibitors, P-gp substrate eg digoxin
Storage : inj 2 8 C , avoid light , stable for 24 mts
68.Toviaz
(by Pfizer ; fesoterodine fumarate; drug for bladder and prostate d/o; urinary
antispasmodic; cat C; )
Indication and Dosage : tx of overactive bladder; adult & elderly ; initial 4mg once
daile, may be increased to 8 mg once daily
Administration: may be taken w/ or w/o food, swallow whole.
Contraindication: Urinary retention & uncontrolled narrow angle glaucoma
Special Precaution: risk of urinary retention & dec. GI motility; glaucoma; MG; renal
and hepatic impairment ,use of CYP3a4 inhibitors like ketoconazole; angioedema;
impaired ability to drive
Adverse Drug Reaction: Dry eyes; mouth & throat, constipation, dyspepsia, dysuria,
urticarioa, pruritus, palpitations, blurred vision

 Drug Interactions : CYP3a4 inhibitos ( ketoconazole, miconazole, clarithromycin)

Storage :<25C , protect from moisture
69.TriHEMIC
70.Tygacil
(by Pfizer ; tigecycline; tetracyclines; rx only ; cat d )
Indication and Dosage: skin infection inc those w/ mrsa ; intraabdominal infections;
CAPneumonia
Contraindications : hypersensivity
Special Precautions : hypersensitivity to tetracycline class; anyphylactoid reactions;
permanent tooth discoloration; pseudomembranous colitis; monotherapy in
abdominal infections; Children <18yr
Adverse Drug Reactions : prolonged aPTT & PT, bilirubinemia, hypoproteinmia;
hypoglycemia; inc. BUN, dizziness, n & v, diarrhea, elevated serum amylase; ast &
alt, rash, h/a, abnormal healing
Drug Interactions : decreased clearance & increased AUC of warfarin; reduced
effectiveness of OCs
Storage : 20 -25C; once reconstituted maybe at room temp
71.Unasyn IM/IV
(zuellig; sultamiccin, sulbactam & ampicillin; penicillins; cat B)
72.Unasyn Oral
(zuellig; sultamiccin tosylate; same as above)
73.VFEND
(zuellig; voriconazole; antifungal; tx of mycotic infection; cat d; rx only)
74.Viagra
(zuellig; sildenafil citrate; for erectile dysfunction; cat b; rx only)
75.Vibramycin
(Zuellig; doxycycline HCl; tetracyclines; cat D; antiinfective)
76.Xalacom
(zuellig; latanoprost, timolol; reduction of IOP in ocular HTN and for glaucoma;
antiglaucoma prep; rx only)
77.Xalatan
(zuellig; latanoprost; same as above; cat c)
78.Xanor
(zuellig; alprazolam; anti anxiety, depression,panic; anxiolytic; cat d; rx only)
79.Xanor XR
(same as above but EDD)
80.Zavedos
(zuellig; idarubin HCL; acute non lymphocytic anemia ANLL or ALL; cat d; cytotoxic; rx
only)
81.Zithromax
(zuellig; azithromycin dehydrate; macrolides; rx only; cat b)
82.Zmax One Dose
(zuellig; azithromycine dehydrate; macrolides; cat b, rx only)
83.Zoloft
(zuellig; sertraline HCl; antidepressant; cat c then cat D @ 3 rd trim, rx only)
84.Zyvox
(zuellig; linezoid; antibiotic; for vancomycin resistant; ; cat c; rx only)