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Abstract
The central paradox of schizophrenia is that the condition, apparently genetic in origin, persists in spite of a substantial fecundity
disadvantage. The hypothesis is proposed that the predisposition to schizophrenia is a component of Homo sapiens-specific variation
associated with the capacity for language. A genetic change the speciation event, predicted to be related to the Xq21.3 to Yp
chromosomal transposition that separates Homo sapiens from the great apes. allowed the hemispheres to develop with a cerebral torque,
reflected particularly in association cortex, from right frontal to left occipital. Variations in the dimension of lateralization are associated
with differences in the rate at which verbal and non-verbal ability develops. The nuclear symptoms of schizophrenia can be understood as
a failure to establish dominance for a key component the phonological sequence of language in one hemisphere, with consequent
disruption of the mechanism of indexicality that allows the speaker to distinguish his thoughts from the speech output that he generates
and the speech input that he receives and decodes from others. q 2000 Elsevier Science B.V. All rights reserved.
Keywords: Language; Schizophrenia; Evolution; Homo sapiens; XY homology; Speciation
Contents
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1.
2.
Universality of schizophrenia
3.
4.
5.
6.
7.
8.
9.
)
1
120
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10. Conclusions
References
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0165-0173r00r$ - see front matter q 2000 Elsevier Science B.V. All rights reserved.
PII: S 0 1 6 5 - 0 1 7 3 9 9 . 0 0 0 2 9 - 6
2. Universality of schizophrenia
This issue should be considered in relation to what is
known of the epidemiology of psychosis. Kraepelin travelled to Java and considered that the form of psychotic
illness he saw there was the same as he had described in
his patient populations in Germany. From investigations
amongst the Yoruba of Nigeria and the Eskimo Inuit,
Murphy w94x concluded that the phenomena of psychosis
were essentially independent of the social structure of the
population. Features typical of schizophrenia e.g., the
nuclear symptoms. are well documented in the Australian
aboriginal population w92x and the African Bantu w105x,
119
120
tions a mechanism of universal grammar has been postulated as a unique feature of the human brain w15,16x. But
what is striking in the evolutionary record is the recency of
the evidence for symbolic representation that might parallel the acquisition of the capacity for language. Such
evidence, as instanced by rock art, goes back perhaps
50 000 years but not more w8,96x. But by the same argument deployed above in relation to the incidence of
schizophrenia, if this capacity is now present in each of the
populations that make up humanity either it, or a change
that made its development inevitable, must have been
present at the time of the species transition. A parsimonious conclusion is that the function that characterises the
species language was introduced by the genetic change
the speciation event that initiated the transition.
But what could this change conceivably have been?
What could account for the de novo ability to generate
sentences of indeterminate length, that nevertheless can be
understood because they have a reference and a grammatical structure that can be decoded by a competent hearer?
As demonstrated by sign language these syntactic-semantic
capacities are independent of the phonological and acoustic modalities w5,54,59x. They must relate to the brain as a
whole.
It is necessary to postulate some radical change in brain
function. MaynardSmith and Szathmary w86x characterised the origin of language in Homo sapiens as the
seventh of the major transitions in evolution. The facts
challenge the gradualist concept of speciation, the notion
that species originate by a process of multiple and cumulative genetic change in populations that are geographically
separated, over long periods of time. This notion the
biological or isolation concept. has been opposed by
the theory of punctuated equilibria e.g., Eldredge and
Gould, w48x; Eldredge w47x. although a genetic mechanism
for the latter is lacking. The case of Homo sapiens is
relevant. What is required is a change that is simple, that
could be accounted for by a modification in a single gene,
and that enabled a relatively rapid transformation.
ing that "the regions of the brain which are latest evolved
and which are located on the left side of the brain might
suffer first in insanity". Eberstaller w46x and Cunningham
w42x described anatomical asymmetries the length of the
Sylvian fissure was longer on the left in most individuals
the speciation event had left an imprint on the surface of
the brain. These anatomical asymmetries were almost forgotten until those of the planum temporale were re-discovered by Geschwind and Levitsky w53x in 1964.
That there are asymmetries of brain function has long
been apparent from the phenomena of handedness w22x and
the notion that these could be accounted for in terms of a
genetic influence that is specific to Homo sapiens has been
developed by Annett w2x and Corballis w19x. This case is
strengthened by the observations of Marchant and McGrew w84x that at least in the wild directional handedness
on a population basis is absent in chimpanzees, and of
Buxhoeveden and Casanova w14x that asymmetries of the
columnar structure of the planum temporale are present in
man but absent in the chimpanzee.
121
Fig. 1. Verbal ability in approximately 12 000 11 yr old children subdivided by sex and writing hand in relation to relative hand skill. The test
of verbal ability required the child to fill in the fourth in a logical,
semantic or phonological sequence of four words when presented with
the first three together with a template sequence of four words to be
matched. Relative hand skill was calculated from the function RyLrRq
LU 100 from the number of squares checked in one minute with the left
and right hands in an array of squares on a printed sheet. The curves are
iteratively smoothed w39x.
The concept of serious mental illness as a Homo sapiens specific condition was entertained by CrichtonBrowne
w21x, Southard w117x, Miskolczy w91x and Parfitt w99x. The
prediction is that such anatomical deviations as are present
will be seen in relation to those regions of the cerebral
cortex that have evolved most recently. The best established changes are a degree of ventricular enlargement
w66,124x and a modest reduction in cortical w126x and brain
w12x mass. The changes are compatible with a failure of
development but are non-specific. More informative is a
loss of asymmetry. In a post-mortem study Luys w81x
reported a reduction in mass on the left side but this was
122
Gur w57x first reported that individuals with schizophrenia are less strongly right-handed than the population as a
whole. This is consistent with the concept that it is degree
rather than direction of handedness that is anomalous w56x
and the finding that the incidence of ambiguous or inconsistent handedness is increased. In the National Child
Development cohort pre-schizophrenic children were more
likely to be reported as ambidextrous for writing hand at
the age of 7 years p - 0.005. Table 1., and were less
strongly lateralised on the index of relative hand skill
p - 0.01. at age 11 years w41x Table 2.. Each of these
findings is consistent with the concept that on the contin-
Table 1
Hand preference: age 7 assessments by mother each patient group
compared with normal controls.
RH
LH
Ambidextrous
%.
x2
df
p
Pearson.
Schizophrenia
narrow.
20
8 25.8.
16.09
0.0003
Schizophrenia
broad.
34
11 22.4.
16.58
0.00025
Affective
psychosis
21
5 17.9.
4.9
0.08
Neurosis
57
4 6.1.
0.36
0.8
Controls
1241
140
103 6.9.
123
Table 2
Relative hand skill age 11 years: mean number of squares marked in 1 min
n
Schizophrenia
narrow.
Schizophrenia
broad.
Affective
psychosis
Neurosis
Controls
RH
LH
Relhand
low
high
22
79.9
72.7
4.2
y4.2
12.6
0.008
36
81.9
71.3
6.1
0.4
11.8
0.01
25
89.9
67.6
13.9
8.8
18.6
NS
60
1302
88.3
89.0
67.7
69.2
13.7
12.9
11.2
12.1
16.2
13.7
NS
124
125
126
10. Conclusions
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I. Zur Verebung und Neuentstehung der Dementia
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