Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
on Adolescent
Compliance
in Use of Oral Contraceptives
M. Susan Jay, MD, Robert H. DuRant, MA, Tamsen Shoffitt, RN,
Charles
W. Linder,
ABSTRACT.
Poor compliance
with
School,
MD,
of Pediatrics,
Stanford,
contraceptive
regi-
Noncompliance
with oral contraceptive
regimens
has been shown
to be an important
antecedent
of
adolescent
pregnancy.
Compliance
has been de-
for publication
June 21, 1982; accepted
April 22, 1983.
in part, at the American
Pediatric
Society
Meeting,
Washington,
DC, May 14, 1982.
Reprint
requests
to (R.H.D.)
Department
of Pediatrics,
Children
and Youth
Clinic,
Medical
College
of Georgia,
Augusta,
GA
30912.
PEDIATRICS
(ISSN
0031 4005).
Copyright
1984 by the
American
Academy
of Pediatrics.
126
Iris F. Liii,
Medical
MD
College of Georgia,
Augusta;
and Stanford
California
mens
has been
shown
to be an important
antecedent
of
adolescent
pregnancy.
The purpose
of this study
was to
test prospectively
the effect
of a peer
v nurse
counseling
program
on adolescent
compliance
with
the use of oral
contraceptives.
Fifty-seven
females
aged
14 to 19 years
from
a lower
socioeconomic
background
were
randomly
assigned
to a peer
(n = 26) or nurse
(n = 31) group.
At
the initial visit and at 1-, 2-, and 4-month
follow-up
visits,
subjects
received
Ortho-Novum
1/35
combined
with
a tablet
marker
and were
counseled
by a nurse
or
peer. Noncompliance
was
measured
using
a Guttman
scale
consisting
of: (1) avoidance
of pregnancy,
(2) appointment
adherence,
(3) pill count,
and
(4) urinary
fluorescence
for riboflavin.
At the first and second followups, the adolescents
counseled
by a peer
had a significantly
(P
.038) lower noncompliance
level than the
nurse-counseled
group.
Adolescents
with
more
frequent
sexual activity
(P
.027),
with one sexual
partner
(P <
.04), and who worried
that
they
might
become
pregnant
(P
.01) had significantly
lower
levels
of noncompliance
when
counseled
by a peer than
by a nurse.
At the fourth
month
follow-up,
adolescents
who expressed
feelings
of
hopelessness
about
the future
had significantly
(P
.036)
higher
levels of noncompliance
when
counseled
by a nurse
than
when
counseled
by a peer.
These
results
suggest
that
incorporating
a peer counselor
into the health
care
team
may be an effective
method
of increasing
adolescent
compliance.
Pediatrics
1984;73:126-131;
peer counselors,
compliance,
oral contraceptives.
Received
Presented,
and
in
order
to
investigate
the
impact
of
peer counseling
program
on adolescents
compliance with the use of oral contraceptives.
Peers are an important
source of sexual education
for adolescents,
and as adolescence
progresses,
peer
influence
tends
to become
increasingly
important.9t#{176}Several
schools
and health
centers
have
successfully
established
peer counseling
sessions
in
which young people
are trained
to help peers seeking advice
on dealing
with personal
problems.5
The training
is generally
carried
out in small groups
and covers
a wide range of topics
such as listening
and communication
skills,
family
problems,
academic
motivation,
sexuality,
and
relationships.
Those in training
benefit
by receiving
help in working through
personal
problems
and gaining
experience in helping
others.
Several
peer
counseling
efforts
have
emphasized
health-related
issues
such
as venereal
disease
(VD)16 and smoking,17
but involvement
of adolescent
peer counselors
in sex education
and contraceptive
distribution
has not been
critically
evaluated.
Inasmuch
as the quality
of
interaction
between
a patient
and provider
may
influence
her compliance
with her medical
regimen,
and because
teenagers
can be a powerful
influence
on one another,
their
involvement
in certain
aspects of health
education
may be a positive
factor
in enhancing
adolescent
compliance.
Accordingly,
the present
study
was undertaken
to test prospectively
the effect
of a peer v nurse
counseling
program
on adolescent
compliance
with
oral contraceptives.
PEDIATRICS
Vol. 73 No. 2 February 1984
Downloaded from pediatrics.aappublications.org at Indonesia:AAP Sponsored on March 28, 2015
METHODS
Subjects
The first 60 adolescent
females
who came to the
adolescent
gynecology
clinic of the Title V Children
and Youth
(C&Y) Project
for the State of Georgia8
were asked
to participate
in the research
project.
Fifty-seven
(95%) of the adolescents
agreed
to participate.
The volunteer
subjects
were compared
with all
adolescent
females
registered
in the C&Y Project
and were found
to be highly
representative
with
regard
to age, race, previous
contraceptive
use, and
previous
pregnancies
and abortions.
In order to be
eligible
for clinic services,
the subjects
had to reside
in one of five federally
funded
housing
projects
in
the city of Augusta.
The 57 subjects
(55 black and
two white)
ranged
in age from 14 to 19 years with
a mean age of 16.6 years.
Peer
Counselors
Five adolescent
females
were selected
from the
C&Y Project
area to serve as peer counselors
based
on their verbal
interaction
skills,
leadership
abilities, and social and sexual maturity.
The peer counsebors were between
17 and 18 years
of age. Peer
counselors
were given organized
training
sessions
in (1) conversational
and interaction
skills, (2) observational
skills,
(3) decision-making,
(4) formal
counseling,
(5) confidentiality,
(6) problem
solving,
and (7) birth control.
The training
included
participation
in role playing
in order to refine counseling
skills prior to participating
in the peer counseling
program.
possible
correlates
with either
contraceptive
noncompliance
or adolescent
pregnancy.
Subjects
were
then
randomly
assigned
to either
peer or nurse
counseling
groups
utilizing
a computer-generated
random
numbers
table.
Thirty-one
(54%) subjects
were assigned
to the nurse counselor
group,
and 26
(46%)
were assigned
to the peer counselor
group.
We would expect
50% (28 or 29) of the subjects
to
be assigned
to each group.
A sampling
error of this
degree was not significant
with a sample
size of 57.
At the initial
visit,
subjects
assigned
to each
group were given one cycle of oral contraceptives
and were instructed
on their proper
use by either
a
peer or nurse
counselor,
according
to the group
to
which they had been assigned.
The oral contraceptives
utilized
were Ortho
Novum
1/35 combined
with 28 mg of riboflavin
as a urinary
marker23
in
00 hard
gelatin
capsules
and packaged
in numbered pill dispensers
(Control
Cube 30, Columbus,
OH). All subjects
were followed
up at 1, 2, and 4
months.
At each
follow-up
appointment
a urine
sample
was obtained,
compliance
was measured,
and the subject
was counseled
and received
oral
TABLE
1.
ental
Nurse-Counseled
Group
(N
Peer-Counseled
Group
(N = 26)
31)
Groups*
16.61.2
16.71.3
9.72.7
10.21.9
12.71.1
3.91.5
12.91.2
3.81.6
14.51.1
14.61.5
partners
0.90.5
0.90.6
of sexual
partners
in last 6 mo
1.10.6
1.10.7
Age (yr)
Parents
education
(grades)
Age at menarche
(yr)
Postmenarchal
age
(yr)
of sexual
in last 3 mo
Nurse
Counselors
The three
female
nurses
working
in the C&Y
Project
served
as the nurse counselors.
The nurses
ranged
in age from 26 to 29 years and were experienced in caring
for adolescents.
The nurses
participated
in the same training
program
as the peers.
Experimental
No.
Values
tests,
cally
are means
values
for
significant
these
(P
>
on analysis
variables
.05) from
of variance
were
not
Indicators
for
Nurse-Counseled
Coddington
events
self-conlife
62.1
8.3
62.2
7.5
crisis
320.3
172.4
294.9
208.5
life
change
367.5
236.1
385.2
228.3
1.4
1.4
events scale
Autonomy
scale
Dissatisfaction
Group
scale
Yeaworths
2.0
with
previous medical
care scale
Values are means
tests,
Experi-
Peer-Counseled
Group
Piers-Harris
cept scale
statisti-
one another.
TABLE 2. Social-Psychological
mental Groups*
Design
Each
subject
was administered
a pretest
questionnaire
which
measured
various
demographic
variables,
medical
history,
sexual
activity
and devebopment,
and sociopsychological
variables
(Tables 1 and 2). Included
in the questionnaire
were
Millers
motivation
for seeking
birth control
scale,
factors
for predicting
compliance
as described
by
Litt et al,
an autonomy
scale,9 the Piers-Harris20
self-concept
scale,
the
Coddington2
life crisis
events
scale, and the adolescent
life change
scale of
Yeaworth
et al.22 These
instruments
were chosen
because
they
had previously
been
implicated
as
SD. Based
pretest
values
cally significant
for
these
(P
2.6
1.6 1.7
SD. Based
pretest
>
1.5 1.1
on analysis
variables
were
of variance
not
satisti-
ARTICLES
127
contraceptives
from either
a nurse
or peer counselor. The subjects
did not necessarily
see the same
nurse
or peer counselor
at every
follow-up
visit.
However,
continuity
of counselors
was similar
in
both experimental
groups.
Urine
samples
were tested
for the presence
of
riboflavin
by placing
them
in front
of a 375M
ultraviolet
light
source
(Gelman
Instrument
Co,
model 51438).23
The adolescents
urine plus that of
positive
and negative
control
subjects
were evaluated for fluorescence
in a double-blind
fashion
by a
panel of three independent
observers.
Noncompliance
Scale
Noncompliance
was measured
with a four-factor
Guttman
scale that consisted
of the following:
(1)
whether
the subject
became
pregnant
during
the
previous
month,
(2) whether
she missed
her appointment,
(3) whether
she missed
taking
three or
more oral contraceptives
during
the month,
and (4)
absence
of urinary
fluorescence
at the time of follow-up.
Based
on a Guttman
scale analysis,
these
four items
had a coefficient
of reproducibility
of
0.96 and a coefficient
of scalability
of 0.84.24
The
coefficient
of reproducibility
is a measure
of the
extent
to which
a respondents
scale
score
is a
predictor
of ones
response
pattern.
A score
of
greater
than
0.90 is considered
a valid scale. The
coefficient
of scalability
measures
the degree
that
the scale is unidimensional
and cumulative.
This
score should
be well above 0.60.25
Of the 57 subjects
in the study,
26 who were
randomly
chosen
at random
follow-up
periods
had
serum
samples
tested
for the presence
of norethindrone
levels.
Serum
norethindrone
was measured
using a radioimmunoassay
method
by the Endocrinology
Laboratory
at the Medical
College
of Georgia.2m
The 26 subjects
had a mean norethindrone
level of 694.75 46.6; SEM was 23.3 and coefficient
of variation
was 6.7%. The serum
norethindrone
test was used to ensure
that the urinary
fluorescence test was an accurate
measure
of compliance
with
an oral contraceptive
regimen.
Based
on a
Fishers
exact test, a high degree
of association
(P
: .02) was found
between
the serum
norethindrone
test and urinary
fluorescence.3#{176}
Statistical
Analysis
128
PEER
COUNSELORS
AND
after
all
other
been
adjusted.
main
and
interaction
effects
have
RESULTS
There
were no significant
(P > .05) differences
between
the nurse-counseled
and peer-counseled
groups
in any of the pretest
measurements
(Tables
1 and 2). This
suggests
that the subjects
in both
groups
were similar
with regard
to these
variables
prior to the institution
of the treatment
effect (peer
V nurse
counseling).
At the first month
follow-up,
the subjects
in the
peer-counseled
group
had significantly
(P
.038)
lower
noncompliance
than
the
nurse-counselor
group
(Table
3). When
additional
pretest
factors
were entered
into the analysis
of variance
model to
determine
whether
they influenced
the response
to
nurse
v peer counselors,
worrying
about
becoming
pregnant
significantly
(P
.01) interacted
with the
treatment
effect.
Adolescents
in the nurse-counseled group who stated
that they worried
that they
might
become
pregnant
had significantly
higher
levels
of noncompliance.
In the peer
group,
the
difference
between
worriers
and nonworriers
was
not significant.
These
findings
suggest
that peer
counselors
may have a positive
influence
on this
subgroup
of adolescents.
Frequency
of sexual activity
also significantly
(P
.027) interacted
with the treatment
groups
at the
first month
follow-up.
Adolescents
in the nursecounseled
group who had sexual
intercourse
once a
week
or less had slightly
higher
noncompliance
than those adolescents
in the peer-counseled
group
with the same frequency
of sexual
activity.
However, adolescents
who had sexual
intercourse
two
or more times a week and were counseled
by a nurse
had significantly
higher
levels
of noncompliance
than any of the other adolescents.
At the second
month
follow-up,
the nurse-counseled group continued
to have higher
levels of noncompliance
than
the peer-counseled
group.
This
difference
was statistically
significant
when
controlling
for the effects
of number
of sexual partners
(P
.006) and frequency
of sexual
activity
(P
.044).
Similar
to the findings
at the first month
follow-up,
there was little difference
in noncompliance between
nurse-counseled
and peer-counseled
adolescents
having
sex once a week or less. However, among
adolescents
having
sexual
intercourse
two or more times
a week,
those
counseled
by a
nurse
had significantly
(P
.044) higher
levels of
noncompliance
than
those
counseled
by a peer at
the second
month
follow-up.
The number
of sexual
partners
also significantly
(P
.03) interacted
with
the treatment
groups.
Adolescents
with one sexual
partner
had the same level of noncompliance,
re-
CONTRACEPTIVES
TABLE
3.
Noncompliance
Levels
for ExperimentaiGroups
at Each
1.68t
1.18
(N
(N
1.06 1.11 (N
Total attrition
rate
Values are means
of
P
.001.
4.331,
gardless
which
4.531;
P
8.888;
P
.044 when
counseling
1.22
1.10
with
no
sexual
.038.
.006 when
controlling
group
partners
controlling
for sexual
they
were
not
statistically
in the
preceding
significant
(Table
3).
(P
of the
indicators
of sexual
behavior
interacted
to being
were
assigned
pretested
to treatment
on
(N
0.78 (N
0.98
(N
26)
22)
20)
23%
a variety
groups,
of
the
measures.
The purpose
of this was to ensure
that other factors
previously
implicated
as possible
correlates
with
noncompliance
or adolescent
pregnancy
did not
differ
between
the groups.68922
The subjects
in
of sexual
the
partners;
F ratio
and
peer-counseled
were
physical
the nurse-counseled
group
had signifi.001) higher attrition
(42% v 23%) from
the study
than
the peer-counseled
group
by the
fourth
month
follow-up.
Attrition
was
defined
as
failing
to keep the second
rescheduled
broken
appointment
or discontinuing
the oral contraceptive
regimen.
Unlike
the first and second
month
follow-ups,
none
groups
However,
cantly
1.16
0.95
0.85
both
in.
appeared
to respond
better
to nurse counseling than peer counseling.
The adolescents
in the
nurse-counseled
group
with
two or more
sexual
partners
had the highest
level of noncompliance
at
the second
month
follow-up.
At the fourth
month
follow-up,
the nurse-coiinseled group still had higher
levels of noncompliance
than the peer-counseled
group,
although
the differwere
1.OOt
22)
18)
for number
frequency.
months
ences
31)
SD.
The adolescents
in the peer-counseled
group
with
no sexual partners
in the last 3 months
had significantly
higher
noncompliance
levels than
the adolescents
with
two or more
partners.
In contrast,
the
subjects
=
=
42%
tFratio
:1:F ratio
Peer-Counseled
_____Group
Group
1st mo follow-up
2nd mo follow-up
4th mo follow-up
Period*
__________
Nurse-Counseled
Follow-up
found
and
nurse-counseled
similar
in sexual
be
to
development,
sexual
history,
and
self-concept,
autonomy,
life crisis events,
and satisfaction
with
previous
medical
care.
At the first month
follow-up,
our peer-counseled
group had significantly
lower levels of noncompliance than
our nurse-counseled
group.
Two additional
factors
were found to influence
the effect of
the type of counselor
on noncompliance.
Adolescents
who
stated
that they worried
about becoming
pregnant
had higher
levels of noncompliance
when
counseled
by a nurse
than by a peer. Those
adolescents
who
expressed
pregnant
previous
knew
worry
may represent
sexual
and
that
they
might
oral
that
they
might
girls who,
contraceptive
have
to take
their
higher
risk of becoming
difficulty
contraceptives
become
due to their
experiences,
remembering
and,
in turn,
pregnant.
be at
However,
the
findings
also suggest
that being counseled
by a peer
may
have had a positive
impact
on this subgroup
of adolescents.
In addition,
adolescents
who reported
having
sex two or more
times
a week were
at higher
risk of noncompliance
when counseled
by
a nurse,
but not when counseled
by a peer.
At the second
month
follow-up,
when the effect
of previous
sexual
activity
was
statistically
controlled,
the peer-counseled
group continued
to have
significantly
lower
dition,
two
selors
effect
on
during
the
first
sexual
intercourse
nificantly
levels
factors
of
noncompliance.
interacted
with
compliance.
subjects
than
weekly
levels
of
once
noncompliance
a week
were counseled
by a nurse. However,
difference
between
the groups
that
olescents
having
by
We
a peer.
partners
months
that
month
also
found
her
Adolescents
having
period,
that
only
had
with
one
sexual
the
same
were
the
number
had
in the
response
to
more
having
had
sig-
than
ad-
counseled
of sexual
previous
a peer
stable
partner
level
findings
or less if they
there was little
once
an adolescent
influenced
counselor.
ships,
sex
ad-
of coun-
to the
follow-up,
more
higher
type
Similar
month
In
the
or
relationover
of
ARTIClES
nurse
a
3-
compliance
129
regardless
of
whether
counseled
by
nurse
or
with
more
sexual
and
contraceptive
ex-
perience,
the introduction
of a peer counselor
appeared
to enhance
compliance.
This finding
may be
explained
by the fact that adolescents
with greater
sexual experience
may be more receptive
to positive
role models
such as a peer provider.
At the fourth
month
follow-up,
the nurse-counseled group continued
to have higher
levels of noncompliance
than
the
peer-counseled
group,
although
the differences
were not statistically
significant.
However,
by 4 months
a significantly
higher
proportion
of the adolescents
in the nursecounseled
group than
in the peer-counseled
group
discontinued
taking
oral contraceptives.
During
the
first 2 months
of follow-up,
previous
sexual activity
had the greatest
influence
on how the adolescents
responded
to nurse v peer counseling.
By the fourth
month
a social-psychological
indicator
had an impact on compliance.
We found that among
adolescents
who felt hopeless
or apathetic3
about
their
future,
those counseled
by a peer had significantly
lower levels of noncompliance
than those
who received nurse counseling.
Ryan and Sweeney32
point
out that among
adolescents
who have no hope for
the future,
pregnancy
does not appear
to be a threat
to their
future
life-style
and thus may be an acceptable
alternative.
They
argue
that
until
this
subgroup
of adolescents
are able to have their hopes
for the future
realistically
threatened
by pregnancy,
they
will continue
to seek
personal
fulfillment
through
childbearing.
The findings
from our study
suggest
that
the use of peer
counselors
may be
beneficial
in helping
these
high-risk
adolescents
deal with their hopelessness
by providing
them with
positive
role models.
This,
in turn,
may increase
their compliance
with contraceptive
regimens.
In confirmation
of previous
reports,6
the findings
from our study suggest
that the nature
of the interaction
between
the health
care provider
and the
patient,
combined
with the adolescents
sexual
behavior
and social-psychological
status,
may influence how compliant
she will be with her oral con-
130
PEER
COUNSELORS
AND
traceptive
from
regimen.
our
study
More
that
peer
specifically,
it appears
counselors
can
work
as
adjuncts
to the health
care team in providing
information,
education,
and counseling
in the use of oral
contraceptives.
These
findings
also suggest
that the
impact
of peer counselors
on adolescent
compliance
may
be greatest
during
the first
2 months
after
initiation
of oral contraceptives.
This is significant
as most
of the adolescents
who
do become
noncompliant do so during
the first few months
after taking
oral contraceptives.67
Of three adolescents
who became
pregnant
during
our study,
one pregnancy
occurred
in each group during
the first month
follow-up,
and one additional
pregnancy
occurred
in
the
nurse-counseled
group
during
the
second
month.
We are now aware
that knowledge
of contraceptive
availability
is not enough
to prevent
adolescent
pregnancy,
and other
modalities
must
be used to reach
our adolescent
population.
As
adolescents
seek contraception,
structure
and guidance are needed
and peer counselors
can frequently
fulfill these needs in a nonthreatening
way.
It would have been desirable
to have studied
this
problem
with a larger
sample
size over a longer
follow-up
period.
However,
this prospective
study
was conducted
with greater
experimental
control
and for longer
follow-up
periods
than previous
reports.
In
addition,
inasmuch
as
this
sample
was
drawn
from a lower socioeconomic
population
considered
to be at high risk of adolescent
pregnancy,
it would be beneficial
to test prospectively
the influence
of peer counselors
on compliance
with oral
contraceptive
use in other groups
of adolescents.
ACKNOWLEDGMENTS
This
work
was
funded,
in part,
by
a grant
from
the
Georgia Department
of Human
Resources.
We would like to thank Dr V. B. Mahesh
and J. 0.
Ellegood
for completing
the serum norethindrone
tests
and Kathy Pilcher for assistance
with the manuscript.
REFERENCES
1. McAnarney
ER:
Am J Dis Child
2.
Kantner
women
3. Chilman
Society,
Health,
4. Cvetkovich
formation.
5.
Population
Human
Fustenberg
sequence
6.
JF,
Adolescent
pregnancy:
A national
priority.
1978;132:125
Zelnick
M:
Sexual
experience
of
unmarried
in the United
States.
Fam
CE: Adolescent
Sexuality
Plann Perspect
1972;4:9
in a Changing
American
DHEW Publication
No. (NIA) 79, Department
of
Education,
and Welfare,
1979, chap 7
G,
Grote
Presented
B: Antecedents
at
responsible
a Conference
Division,
Development
FF Jr:
for
family
sponsored
by the
of Child Health
and
National
Institute
(NICHHD),
Bethesda,
MD,
1976
Unplanned
Parenthood:
The Social
Conof Teenage
Childbearing.
New
York,
Free
Press,
1976
Litt IF, Cuskey
for non-compliance
1980;86:742
7. Litt
IF, Cuskey
WR,
Rudd
with
WR:
S: Identifying
contraceptive
Compliance
with
adolescents
at risk
therapy.
J Pediatr
medical
CONTRACEPTIVES
regimens
during
8.
9.
J Adoles
and
Utech
Simon
in Fink
Dysfunction.
DA,
influences
Davis
PJ,
Hoving
on
Soc Psychol
11.
Pediatr
Clin North
Am 1980;27:3
Jay
MS,
Linder
CW,
et al: The
influence
factors
on adolescent
compliance
with
contraceptives.
Gagnon
JH,
ment,
10.
adolescence.
DuRant
RH,
psycho-social
AK,
the
Health
W:
Sex
Care,
Hammett
Philadelphia,
KL:
in press
education
and
of
oral
1984
22.
human
develop-
Patients
decisions
and
peers
of children
as
23.
competing
of different
JM,
Shute
RE:
Positive
peer
ages.
influence
and
use.
13.
Hamburg
BA,
Varenhorst
ondary
schools:
J Orthopsychiatry
14.
Vriend
T: High
BB:
A community
1972;42:566
performing
Peer
counseling
health
project
inner
city
in the
sec-
for youth.
Am
assist
low
adolescents
performing
peers in counseling
groups.
Personnel
Guidance
J 1969;48:897
15. Baldwin
BA: Moving
from drugs to sex: New directions
for
youth-oriented
peer counseling.
J Am Coil Health
Assoc
16.
1978;27:75
Aiwine
G:
need
love,
come
to
us:
An
overview
of a
life
RM,
preg-
change
event
scale.
Adolescence
S: A method
to evaluate
whether
Clin Pediatr
1966;5:239
24. Doby JT: An Introduction
to Social
Research,
ed 2. New
York, Appleton-Century-Crofts,
1967, chap 8
25. Nie NH, Hull CH, Jenkins
JG, et al: Statistical
Package
For
the Social Sciences,
ed 2. New York, McGraw-Hill,
1975, pp
348-430,
532-537
26. Mills TM, Lin TJ, Hernandez-Ayup
5, et al: The metabolic
clearance
rate and urinary
excretion
of oral contraceptive
drugs
1-norethindrone.
Am J Obstet Gynecol
1974;120:764
27.
Parker
CR, Ellegood
JO, Mahesh
VB: Methods
for multiple
steroid
radioimmunoassay.
J Steroid Biochem
1975;6:1
28. Mills
TM,
Lin TJ, Braselton
WE,
et al: Metabolism
of oral
contraceptive
drugs: The formulation
and disappearance
of
take
metabolites
nous
Blackman
prescribed
medication.
of norethindrone
and
oral
administration.
and
mestranol
Am
after
Obstet
intrave-
Gynecol
1976;126:987
Mahesh
VB, Mills TM, Lin TJ, et al: Metabolism,
metabolic
clearance
rate, blood
metabolites,
and blood
half-life
of
norethindrone
and mestranol,
in Garratini
5, Berendes
HW
(eds): Pharmacology
of Steroid
Contraceptive
Drugs.
New
York, Raven Press, 1977, p 117
30. Jay 5, DuRant
RH, Linder CW et al: Reliability
of riboflavin
as an indicator
of compliance
with oral contraceptives.
J
Adoles
31. Smith
1979;68:811
Piers
Silberstein
York J, Hussey
1964;55:91
with adolescent
29.
If you
peer-counseling
program
in a senior
high school.
J Sch
Health
1974;44:463
17. McAlister
AL, Penny
C, Macoby
N: Adolescent
smoking:
Onset
and prevention.
Pediatrics
1979;63:650
18. McNamara
V, King LA, Green MF: Adolescent
perspectives
on sexuality,
contraception,
and pregnancy.
J Med Assoc Ga
20.
Yeaworth
RC,
of an
adolescent
1980;57:92
patients
1969;78:267
Weener
concept
in children.
J Educ Psychol
21. Coddington
RD: Life events associated
nancies.
J Clin Psychiatry
1979;40:180
Harris
DB:
Age
and
other
correlates
of
self-
Care
1982;13:140
32.
Health
DL, DuRant
and
anomia.
R, Carter
Criminology
ARTICLES
131
Citations
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PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly publication, it
has been published continuously since 1948. PEDIATRICS is owned, published, and trademarked by the
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Copyright 1984 by the American Academy of Pediatrics. All rights reserved. Print ISSN: 0031-4005.
Online ISSN: 1098-4275.
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PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly publication,
it has been published continuously since 1948. PEDIATRICS is owned, published, and trademarked
by the American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village,
Illinois, 60007. Copyright 1984 by the American Academy of Pediatrics. All rights reserved. Print
ISSN: 0031-4005. Online ISSN: 1098-4275.