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CHAPTER I
INTRODUCTION
1.1 Back ground and Motivation
Advances in micromachining technologies and in low power electronics create
ever-increasing opportunities in personal healthcare devices. These opportunities include
new wearable and implantable medical systems for continuous and non-invasive
monitoring of physiological parameters of the human body (diagnostic devices) as well as
controlling and minimally-invasive treatment of its various diseases (therapeutic devices).
The application areas of diagnostic devices range from common measurements such
as ECG (electrocardiogram), blood pressure, sugar level, temperature, respiratory rate, and
oxygen saturation to others like gastrointestinal endoscopy, monitoring physical activity
and strain in orthopaedic devices, personal tracking, and fall detection. Unlike these,
therapeutic devices are designed to interfere with the human body by supporting or
restoring the functionality of diseased parts and organs (e.g. pacemakers, cardiac
defibrillators, drug and insulin pumps, neuro stimulators etc.) or replacing them (e.g.
cochlear and retinal implants, artificial hearts and joints, vascular grafts etc.).[2]
Generally, the in-vivo devices need the internal battery. The time that the internal
battery can operate is limited, the replacement of the battery is necessary. To replace the
battery, the surgical operation is demanded to the patient. It attends with the risk and the
physical pain of the patient. For overcoming of this problem, the wireless power
transmission technology is studied. In this study, the electric power is supplied to the invivo device from outside of the human body by electromagnetic wave. However, the
human body is made of around 60% of water so, electromagnetic wave greatly attenuates in
the human body. And the influence of electromagnetic wave on the human body is feared.
Therefore, the wireless power transmission technology by ultrasonic is studied.
Ultrasonic is used in the observation of the baby in the womb; it is good at medical
viewpoint. And there is no influence of the electromagnetic radiation on biological
systems.[1]
Depending on the application, the requirements for implantable medical devices
vary in terms of the size, mode of operation (continuous or intermittent), lifetime, and, in
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particular, energy supply. The latter is a key factor for most implantable systems. Table 1.1
illustrates some of the existing and emerging implantable medical devices along with their
power requirements.
Table 1.1: Power requirements for existing and emerging implantable medical devices
New implantable medical devices are used for monitoring biological parameters of
the human body, as well as devices aimed at improving human body treatment, reducing
discomfort and promoting better health and wellbeing. Biomedical implants have been
powered mainly by batteries so far. However, batteries frequently dominate the size and the
cost of the device and have to be replaced or recharged occasionally. As the devices get
smaller these facts make them less attractive as the primary power source. Therefore
alternative techniques of energizing implantable microdevices are needed. Energy
harvesting is an attractive alternative to batteries in low-power biomedical implants and has
received increasing research interest in recent years. Ambient motion is one of the main
sources of energy for harvesting, and a wide range of motion powered energy harvesters
have been proposed or demonstrated, particularly at the microscale.
Another alternative to batteries is wireless power delivery, where a receiver, instead
of harvesting ambient energy, is energized wirelessly by sending a signal of a particular
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frequency. One of the most widespread and well established methods of wireless power
delivery is via inductively coupled coils. However this tends to have low efficiency at
larger distances, and as the size of the receiving device decreases this becomes an ever
greater problem. For inductive powering the coil size to separation ratio is the key issue. Its
efficiency can be improved up to a point by increasing the operating frequency, but this is
limited by higher cost, higher tissue attenuation and increased radiation for a given coil
size.
To date power delivery by ultrasound has been used mainly in the fields of nondestructive testing and remote sensing. Several groups reported systems for delivering
power through a steel wall. Acoustic waves, due to their lower speed, have much smaller
wavelengths than radio waves for a given frequency, which means that more directional
transmitters and receivers can be achieved at reasonable frequencies. For powering
embedded sensors, in the body or in structures, acceptable attenuation levels can also be
reached.[3]
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Suzuki et al. reported a combined system for delivering power and data to an
implantable medical device [6]. The optimal operating frequency of 1 MHz was found for
piezo oscillators of 30 mm diameter, giving a maximum efficiency of 20%. During the
experiment the distance between source and receiver varied in the range 7100 mm. Philips
et al.designed a peripheral nerve stimulator powered by externally applied ultrasound [7].
The piezoceramic test chips of 3.5 mm diameter were implanted inside a living tissue (near
sciatic trunk of large American Bullfrogs) and excited externally by a 6 mm transducer at a
frequency of 2.25 MHz. With the output power of up to 1.5 mW/cm2 the ultrasonic system
was capable of providing enough energy to the peripheral nerve micro stimulator.
Shih et al. presented a subcutaneously implantable device which receives energy
though externally applied ultrasound [8]. It has a bulk piezoelectric resonator packaged by
biocompatible cohesive gel (in cubic, spherical and irregular shapes) and incorporating an
acoustic antenna which can receive refracted waves propagating inside the package.
During the experiment the spherical package of 7.8 mm radius implanted inside the soft
tissue (streaky pork) at 0.58 cm separations was excited externally by an ultrasonic
transducer at frequencies in the range of 5100 kHz. The maximum power transmission
efficiency of -40 dB (0.01%) was obtained at a frequency of 75 kHz and 2.5 cm separation.
Arra et al. built and tested an ultrasonic powering system with the potential to be used in
implantable applications [9]. Their acoustic link operates in degassed water at a frequency
of 840 kHz and the transducer diameters are about 25 30 mm, giving efficiencies of 2135
% at transmitter receiver distances between 5 mm and 105 mm.
Recently Ozeri et al. investigated an ultrasonic transcutaneous energy transfer for
wireless power delivery to implanted micro devices [10]. The authors proposed a system
consisting of two piezoelectric transducers of 15 mm diameter and 3 mm thickness with a
1.3 mm thick acoustic matching layer (made of graphite). Experimental measurements were
carried out for soft tissues (slices of pork of 535 mm thickness) immersed in a test water
tank. Operating at a frequency of 673 kHz the system demonstrated the overall power
transmission efficiency of 27% (at 5 mm separation). The authors analysed in detail such
important design considerations for maximum power transfer as selection of operating
frequency, acoustic impedance matching, circuit design for excitation of transducers, and
output power conditioning. They also built a finite element model in order to study the
pressure intensity profile generated by a transducer and define the preferred receiver
location in its different zones (near/far field and the focus).
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In the past reports, the transducer is designed for the acoustic matching with water.
But it is not designed to have electrical matching with input source, amplifier circuit and
rectification circuit etc. and it causes the large loss. In our study, we propose the efficient
ultrasonic wireless power transmission system. For realizing the efficient system, first, the
impedance matching between the input source, amplifier circuit, and transducer is
considered. And, the optimum position of two transducers necessary for obtaining a high
transmission efficiency in water is searched. Moreover, to achieve the high DC output
voltage, the voltage booster circuit is designed.
In the transmission experiment of ultrasonic by proposed system, the availability of
our system is confirmed, and the high DC output voltage for the operation of the in-vivo
devices is obtained.
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CHAPTER II
POWER SOURCES FOR IMPLANTABLE ELECTRONIC
DEVICES
2.1 Batteries
Nowadays, electrochemical batteries are the dominant source of energy for
implantable medical devices. They are commonly categorized as primary (single-use) and
secondary (rechargeable). Various battery technologies exist and more are emerging, but
the most commonly used are lithium-based. Primary lithium batteries are used in lowpower or intermittent applications. Due to their high energy density (up to 1.25 Wh/cm3),
safety and reliability these can power such implantable medical devices as cardiac
pacemakers for 10 years or more. In addition, they can also be used in drug delivery [9] and
bio-monitoring systems [2].
Secondary lithium batteries (e.g. Li-ion) have lower energy densities (up to 0.57
Wh/cm3) but are smaller and can be recharged. This makes them usable in high-power
medical devices with strict size limitations such as LVAD (left ventricular assist device),
TAH (total artificial heart) or hearing aids. In order to recharge the battery, these devices
have to employ additional mechanisms of on-board energy generation such as energy
harvesting or wireless power delivery that will be discussed in the next sections.
Despite significant progress in battery technologies in the last 40 years, their
miniaturization capabilities still lag behind those of current microelectronic and MEMS
devices. This means that the size and the cost of the implantable medical devices will likely
be dominated by batteries. However, one promising technology was developed
commercially as early as 1999, which is rechargeable thin lithium-ion battery cell with
hybrid polymer electrolyte, also called plastic Li-ion. Since then, several similar concepts
have emerged offering lightweight design, flexibility, and the footprint of less than 1 mm2.
In addition, these cells have low self-discharge and very long lifetime (>90000
charge/discharge cycles vs. 1000 in traditional Li-ion cells). However, their energy density
is still limited (>800W.h/cm2 for a total thickness of 35-60m) and has to be improved to
satisfy energy needs of therapeutic medical devices. Micro scale 3D battery structures have
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great potential to accomplish this in the near future. As for now, depending on the
application, batteries still have to be replaced or recharged occasionally. This inevitably
reduces patient comfort and brings additional financial and clinical burdens. To overcome
these limitations, alternative technologies are being investigated such as energy harvesting
and wireless power delivery. These provide the opportunity of having battery-less operation
and essentially perpetual power.
As for now, depending on the application, batteries still have to be replaced or
recharged occasionally. This inevitably reduces patient comfort and brings additional
financial and clinical burdens. To overcome these limitations, alternative technologies are
being investigated such as energy harvesting and wireless power delivery. These provide
the opportunity of having battery-less operation and essentially perpetual power.
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higher energy densities than in traditional battery materials , these cells cannot be used
inside the human body as they are not biocompatible. Instead, glucose based solutions are
promising in medical applications.
2.2.5 RF radiation
RF radiation is another abundant source of energy nowadays, and its harnessing
inside the human body would suffer less from the above mentioned problems. However, as
the microwave energy has adverse effects on biological organisms, its maximum levels are
legally regulated and limited. This brings power generation capabilities in a typical urban
environment (not in the vicinity of cellular base stations) to <1 W/cm2.This results in a
very limited applicability of the RF radiation energy harvesting for driving implantable
medical devices, even with low-power biosensing functions.
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Figure 2.1:Inductively coupled energy transfer system for a ventricular assist device (a)
primary coil (90 mm in diameter); (b) secondary coil (70 mm in diameter)
Analysing the performance of this system, it becomes clear that with reducing size
of the receiving coil the level of delivered power drops significantly. This gets worse as the
distance between coils increases. Therefore, for inductively coupled system, the ratio of
coil size to source-receiver separation is the key issue. The efficiency can be improved up
to a point by increasing the operating frequency, but this is limited by tissue attenuation.
This limits its applicability in miniature medical devices (10 mm or less) deeply implanted
into the human body (25 mm or more).
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receiving transducer (similar PZT disk). The latter performs inverse conversion: it
generates electrical energy from mechanical vibrations induced by incoming acoustic
waves. The receiver side contains all the electronic modules (e.g. AC/DC voltage
conversion) that are required to drive a load.
Fig. 2.2: Basic principle of an ultrasonic energy transfer system (T: transmitter, R: receiver)
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CHAPTER III
ULTRASONIC WIRELESS POWER TRANSMISSION
SYSTEM
3.1 SYSTEM OVERVIEW
Figure 3 shows the ultrasonic wireless power transmission system. The input signal
is generated at the input source (signal generator), and the input signal is amplified by the
amplifier circuit. The amplified signal is inputted to the transmitting transducer. At the
transmitting transducer, the electric energy is converted to the vibrational energy, and it
transmits in water. The received power by the receiving transducer is converted the
vibrational energy into the electric energy, and it is rectified and boosted by the CockcroftWalton circuit. Finally, the output DC power is obtained at the load resistance.
Table I shows the specifications of two transducers used in the system. In this case,
the transmitting transducer has the focus point, and the receiving transducer is flattransducer, it has no focus point. The resonance frequencies are 3.15MHz and 4.20MHz,
respectively. The transmitted ultrasonic frequency is 4.20MHz according to the
transmitting transducer.
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Figure 2 shows the return loss of the transmitting transducer, and fig.3 shows the
input impedance corresponding to the frequency. By the matching circuit, the input
impedance of the transmitting transducer is matched to the output impedance of the
amplifier circuit, and it is confirmed that there is no reflection between the amplifier circuit
and the transmitting transducer.
Figure 4 shows the output voltage waveform of the receiving transducer. In this
result, the output terminal of the receiving transducer is open-ended terminal. From fig.4,
the voltage amplitude of the matched transducer is 2 times of no-matched transducer, and it
is confirmed the availability of the matching between the transmitting transducer and the
amplifier circuit.
3.2.2 Matching of distance between two transducers
In the past report, it is known that the ultrasonic transmission efficiency is strongly
dependent on the distance between two transducers. From this report, the characteristic of
the output AC voltage corresponding to the distance between two transducers should be
measured.
Figure 5 shows the measurement result of the output AC voltage at close-range, and
fig.6 shows the measurement result at long-range. In fig.5, the output voltage amplitude is
vibrated, and the vibration interval is 0.18mm. This interval is the same to the halfwavelength at 4.2MHz. The standingwaves generated between two transducers is the cause
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of this vibration. In fig.6, the output AC amplitude changes according to the distance
between two transducers, and the distance that output voltage is maximum is about 70mm.
70mm is equal to the distance that the beam diameter of transmitting transducer agrees with
the beam diameter of receiving transducer. At over 70mm, the ultrasonic beam diffuses,
and the received power by the receiving transducer decreases. Therefore, the output voltage
amplitude also decreases.
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Fig. 3.9. Output DC voltage vs. load resistance at 229mW input power
Figure 8 shows the measurement result of output DC voltage with the designed
Cockcroft-Walton circuit. In fig.8, dotted line shows the input AC voltage waveform at the
Cockcroft-Walton circuit (Vin), and solid line shows the output DC voltage. The obtained
output DC voltage is 9.1V, and 9.1V output DC voltage is enough to drive the cardiac
pacemaker. For investigation of the power transmission efficiency, the output DC power is
measured with the Cockcroft-Walton circuit and the load resistance. Figure 9 shows the
output DC power corresponding to the load resistance. (In this case, input AC power is
229mW.) From this result, it is confirmed that the power transmission efficiency is low.
This cause is that the conversion efficiency of the electric energy to the vibrational energy
is low. And, the input impedance of the Cockcroft-Walton circuit is very high, so, it is
impossible to match the output impedance of the receiving transducer to the input
impedance of the Cockcroft-Walton circuit. The mismatch raises the reflection of the
received power by receiving transducer.
However, the obtained output DC voltage is enough high, and the output power or
the output voltage satisfy the parameters for driving a cardiac pacemaker.
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CHAPTER IV
ADVANTAGES AND LIMITATIONS
4.1 Advantages
1. Ultrasonic is good at medical viewpoint. And there is no influence of the
radio waves for a given frequency, which means that more directional transmitters
and receivers can be achieved at reasonable frequencies.
3. Direct wire connection significantly increases the risk of having infections that can
result in serious disabilities or even worse. A burden associated with the need of
penetrating the skin causes the patient discomfort. In addition, providing wired
energy to the sites deeply inside the human body and near vital organs (e.g. heart)
can affect the reliability of the implanted device and raise the safety issues. But here
we use wireless power transmission.
4. Improved energy density is obtained.
5. Ultrasonic wireless power delivery can be a convenient and safe way of replacing
(or supplementing) batteries, in particular for deeply implanted medical devices.
4.2 Limitations
1. Power transmission efficiency is low because here the transducers used are those of
imaging technologies.
2. Input impedance of the Cockcroft-Walton circuit is high- impossible to match the
output impedance of the receiving transducer to the input impedance of the
Cockcroft-Walton circuit. This mismatch raises the reflection of the received power
by receiving transducer.
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CHAPTER V
CONCLUSION AND FUTURE SCOPE
Most suitable method for providing energy supply for medical electronic devices is
wireless energy transfer due to its benefits. The efficient method is considered to be
ultrasonic energy transfer.
In this work an efficient ultrasonic wireless power transmission system is proposed.
To realize the efficient system the impedance matching between the input source, amplifier
circuit, and transducer is considered. And, the optimum position of two transducers
necessary for obtaining high transmission efficiency is searched. Moreover, to achieve a
high DC output voltage, the voltage booster circuit is designed. In the transmission
experiment of ultrasonic by proposed system, the high DC output voltage necessary for the
operation of the in-vivo devices is obtained, and it is confirmed the availability of proposed
system.
However, the transducers used in the experiment are designed for the ultrasonic
imaging applications, and the high transmission efficiency of the electric power is not
achieved.
In the future works, we search the optimum transducer and the ultrasonic frequency
for wireless power transmission and we realize the more efficient ultrasonic wireless power
transmission system.
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References:
[1] Yusuke SHIGETA #1, Tsunayuki YAMAMOTO #, Kazuhiro FUJIMORI #, Minoru
SANAGI #, Shigeji NOGI #, Takuya TSUKAGOSHI ##, Development of Ultrasonic
Wireless Power Transmission System for Implantable Electronic Devices 6th International
Conference 2010, 18-20 December 2010
[2] Alexey Denisov and Eric Yeatman, Ultrasonic vs. Inductive Power Delivery for
Miniature Biomedical Implants 2010 International Conference on Body Sensor Networks
[3]Stepper microactuators driven by ultrasonic power transfer Ph.D work by Alexey
Denisov in July 2013.
[4] G. V. B. Cochran, M. W. Johnson, M. P. Kadaba, F. Vosburgh, M. W.Ferguson-Pell and
V. R. Palmieri, "Piezoelectric Internal Fixation Devices - A New Approach to Electrical
Augmentation of Osteogenesis," Journal of Orthopaedic Research, vol. 3, pp. 508-513,1985.
[6] S. Suzuki, S. Kimura, T. Katane, H. Saotome, O. Saito and K. Kobayashi, "Power and
Interactive Information Transmission to Implanted Medical Device Using Ultrasonic,"
Japanese Journal of Applied Physics, vol. 41, pp. 3600-3603, 2002.
[8] P. Shih, W. Weng, W. Shih, Y. Tsai and P. Chang, "Acoustic polarization for optimized
implantable power transimittion," in Micro Electro Mechanical Systems, 2007. MEMS. IEEE
20th International Conference on, 2007, pp. 879-882.
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[9] S. Arra, J. Leskinen, J. Heikkila and J. Vanhala, "Ultrasonic Power and Data Link for
Wireless Implantable Applications," Wireless Pervasive Computing, 2007. ISWPC '07. 2nd
International Symposium on, 2007.
[10] S. Ozeri and D. Shmilovitz, "Ultrasonic transcutaneous energy transfer for powering
implanted devices," Ultrasonics, In Press, Corrected Proof, doi:10.1016/j.ultras.2009.11.004.
[11] P. Sprawls, The Physical Principles of Medical Imaging, 2nd ed.Madison, Wis: Medical
Physics Publishing, 1995.
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