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1. Biocompatibility and Permeability of Dialyzer Membranes Do Not Affect Anemia,
Erythropoietin Dosage or Mortality in Japanese Patients on Chronic Non-Reuse Hemodialysis:
A Prospective Cohort Study from
the J-DOPPS II
Study...................................................................................................................................... 1

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Biocompatibility and Permeability of Dialyzer Membranes Do Not Affect Anemia,

Erythropoietin
Dosage or Mortality in Japanese Patients on Chronic Non-Reuse Hemodialysis: A
Prospective Cohort
Study from the J-DOPPS II Study
Author: Yokoyama, Hitoshi; Kawaguchi, Takehiko; Wada, Takashi; Takahashi, Yoshinori; Higashi,
Takahiro; Yamazaki, Shin; Fukuhara, Shunichi; Akiba, Takashi; Akizawa, Tadao; Asano, Yasushi;
Kurokawa, Kiyoshi; Saito, Akira
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Abstract: Background: Considerable controversy existsover the impact of the biocompatibility
and flux characteristics ofdialyzer membranes on anemia in chronic hemodialysis patients.
Methods: A subset of 1,207 subjects from the Japanese arm of DOPPS phase II was analyzed.
Results: Patient characteristics included mean age 59 years, male sex 60%, BMI 20.6, time on
dialysis therapy 7.8 years, and diabetes rate 27%.
Dialysis parameters were Kt/V 1.33, and normalized protein catabolic rate 1.05 g/kg/day. Initial
hemoglobin level was 10.1 g/dl. 79% were treated by intravenous erythropoietin with mean
weekly doses of 4,500 IU.
Hemoglobin levels and erythropoietin doses during 2-year study period were not affected by
dialysis membrane biocompatibility (unmodified cellulose or biocompatible) or flux (standard or
high performance). The 2-year survival rate was 90.9% and was influenced by older age,
presence of cardiovascular diseases and
amyloidosis, lower levels of BMI and serum albumin, but not by other variables, including dialysis
membranes. Use of biocompatible membranes was associated with a lower all-cause mortality
(8.3 vs. 13.0% for bioincompatible, p = 0.037), but this difference was not significant in
multivariate analyses (hazard ratio 0.70, p
= 0.17 by Cox multivariate analysis). Conclusion: The biocompatibility and permeability of dialyzer
membranes had no effect on anemia, erythropoietin dosage or all-cause mortality in Japanese
chronic hemodialysis patients treated by non-reuse dialysis.
Copyright 2008 S. Karger AG, Basel [PUBLICATION ABSTRACT]
Publication title: Nephron
Volume: 109
Issue: 2
Pages: c100-c108
Number of pages: 9
Publication year: 2008
Publication date: Jul 2008
Year: 2008
Publisher: S. Karger AG
Place of publication:
Basel
Country of publication:
Switzerland Publication subject:
Medical Sciences ISSN: 00282766
CODEN: NPRNAY

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Source type: Scholarly Journals

Language of publication:
English Document type:
PERIODICAL ProQuest
document ID: 274386880
Document URL: http://search.proquest.com/docview/274386880?accountid=17242
Copyright: Copyright (c) 2008 S. Karger AG, Basel
Last updated: 2014-05-24
Database: ProQuest Health & Medical Complete

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