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Felipe De Gante
Becerra
14346
2
14437
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Laboratorio Sensores
Moleculares
22 de Septiembre
del 2014
PRCTICA NO. 4:
SNTESIS DE CALIX[4]PIRROL Y EVALUACIN DE SUS PROPIEDADES DE RECONOCIMIENTO
MOLECULAR DE ANIONES
Objetivos:
Abstract:
In 1886 the German magazine, Ber. Dtsch. Chem. Ges, published in its 19 th volume two
different methods for the synthesis of octamethylcalix[4]pyrroles. The first of this was described
by M. Dennstedt and J. Zimmerman, the second one by Baeyer. Both of this synthesis are now
considered as pioneers in the study of macrocycles. The second synthesis was based in the
condensation of pyrrole with acetone using hydrochloric acid as a catalyst, in which, as the first
synthesis, a white crystal product was obtained and reported to have a melting point of 296C
which corresponds to octamethylcalix[4]pyrrole. During this laboratory session a method likely to
the one developed by Baeyer was used with the objective of preparing a host-guest system. One
of the emerging fields of organic chemistry is the study of synthetic macrocycles capable of
interacting with small anionic species, octamethylcalix[4]pyrrole is one of this macrocycles group,
as well as other calixpyrroles. The structure of octamethylcalix[4]pyrrole has pyrrole in an
independent position which allows each of this to donate one hydrogen bond, these observations
had led to the development of these systems as anion binding agents used to target a great
number of useful functions. In this practice not only synthesis was accomplished, but also the
purification of the product and the proof of its sensor properties was reached. The
octamethylcalix[4]pyrrole was mixed with previously prepared solutions of NFTBA and HFTBA for
chloride and fluoride ions. All the results, preparation, specification and analysis of this method
are included in the following report.
14346
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14437
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Laboratorio Sensores
Moleculares
22 de Septiembre
del 2014
Cuestionario:
C 6 H 5 N O3 +
1mol
1
=0.1 M
|139.11
g || 0.1 L|
Concentracin de la solucin:1.39 g
En el laboratorio se prepar la solucin 3.6 x10 -5 M de 4-NFTBA a partir de una solucin 0.5 M
del mismo compuesto.
Clculo de rendimientos
5 mmol pirrol+5 mmol acetona 1 mol calx [ 4 ] pirrol
g
g
+ ( 5 103 mol ) 58.00
=0.625 g
mol
mol
Rendimiento en bruto:
0.461 g
100=73.76
0.625 g
0.284 g
100=45.44
0.625 g
14346
2
14437
2
Laboratorio Sensores
Moleculares
22 de Septiembre
del 2014
0.284 g
100=61.61
0.461 g
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14437
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Laboratorio Sensores
Moleculares
22 de Septiembre
del 2014
ser muy similares, causando probablemente interferencias en las mediciones. Por otro
lado, iones que no cumplen las caractersticas de complementariedad con el calix[4]pirrol
(como el caso del ion bromuro estudiado en el laboratorio) no generarn un cambio en
las propiedades pticas iniciales de la solucin.
Conclusiones:
Durante el experimento se comprob la afinidad del calix[4]pirrol por iones como el 4nitrofenolato y fluoruro. Tambin se observ que el ion fluoruro es ms compatible con la cavidad del
anfitrin con respecto al ion 4-nitrofenolato. Finalmente se concluy que el ion bromuro no es
reconocido por parte del macrociclo. Con estos resultados fuimos capaces de apreciar las
capacidades de reconocimiento molecular del calix[4]pirrol, as como su potencial para ser utilizado
en sensores qumicos.
Referencias
[1] Anzenbacher, Pavel, et. al. N-confused calix[4]pyrroles. Center for Photochemical Sciences.
Bowling Green State University. (2006). Web. 2 Sep. 2014. Available at www.sciencedirect.com
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del 2014
[2] A.Moyer, Bruce and P.Singh, Raj. Fundamentals and Applications of Anion Separations. (2004).
[3] Shriver, James A., and Scott G. Westphal. "Calix[4]Pyrrole: Synthesis And Anion-Binding
Properties." Journal Of Chemical Education 83.9 (2006): 1330-1332. Academic Search Complete.
Web. 2 Oct. 2014.