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Abstract
The crude herbal formulation, Gamgungtang (GGT), has been shown to protect animals
against a wide range of spontaneously developing or induced autoimmune diseases. We
have previously reported that GGT shows marked down-regulation of several
experimental autoimmune diseases. Although very effective at preventing thyroid
infiltrates in mice immunized with mouse deglycosylated thyroglobulin and complete
Freund's adjuvant and in spontaneous models of thyroiditis, it completely failed to
modify experimental autoimmune thyroiditis (EAT) induced in mice immunized with
mouse thyroglobulin and lipopolysaccharide. In this study, in an effort to elucidate the
mechanisms by which GGT suppresses EAT, and autoimmunity in general, we
investigated the in vivo effects of this drug on the Th1/Th2 lymphocyte balance, which is
important for the induction or inhibition of autoreactivity. Naive SJL/J mice were treated
orally for 5 days with GGT (80 mg/(kg day)). Spleen cells were obtained at various time
points during the treatment period and were stimulated in vitro with concanavalin A.
Interleukins IL-4, IL-10 and IL-12, transforming growth factor- (TGF-) and interferon (IFN-) cytokine production was evaluated at the protein levels of the cytokines in the
medium and mRNA expressions. A significant upregulation of IL-4, IL-10 and TGF-
was observed following treatment with GGT, which peaked at day 5 (IL-10) or day 10
(IL-4). On the other hand, IL-12 and IFN- production were either unchanged or
decreased. It seems therefore that GGT induces in vivo a shift towards Th2 lymphocytes
which may be one of the mechanisms of down-regulation of the autoimmune reactivity in
EAT. Our observations indicate that down-regulation of TH1 cytokines (especially IL-12)
and enhancement of Th2 cytokine production may play an important role in the control of
T-cell-mediated autoimmunity. These data may contribute to the design of new
immunomodulating treatments for a group of autoimmune diseases.
..
Abstract:
Herbal medicines are widely used as immunomodulators. The number
of reported clinical complications from incidental use is on the
increase. Similarly, there are increasing reports for specific drug
interactions with many common herbal medicines. As the frequency of
herbal medicine use increases, physicians must be constantly aware of
potential interactions and interference caused by these natural
compounds. This report focuses on a panel of immunomodulatory
herbal medicines that exhibit drug-herb interactions and potential
interference with standard pharmaceuticals. We also address potential
interference of the herbal medicines with therapeutic drug monitoring.
Awareness of these interactions will allow physicians to make informed
decisions when treating patients using alternative therapeutics.
Overview
Summary
References
Summary:
There is a great need to explore alternative treatments for ADHD. As the use of
Ritalin and amphetamine in children have increased to alarming proportions,
parents and professionals alike are searching for effective alternatives to
stimulant drugs. Herbal medicines may offer a safe alternative, especially in
combination with complementary therapies.
Although more research is necessary to confirm the implied benefits of
commercially available herbal formulas, there are at least a few clinical trials of
herbs and herbal extracts, notably Chinese herbal formulas, that have shown
promising results in this arena.
http://www.healing-arts.org/children/ADHD/herbal.htm#Summary
..
ome Health Autoimmune Disease Autoimmune Disease (general)
Articles Anti-inflammatory Herbs
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This article describes the use of plant chemicals with anti-inflammatory properties
as complementary therapies for patients with autoimmune disease.
Inflammation is a key feature in autoimmune disease. In some conditions, such
as Hashimoto's thyroiditis, inflammation contributes to the disease process. In
other conditions, such as Crohn's disease, inflammation may occur as a result of
the disease. Inflammation occurs as the immune system reacts to injury,
infection, environmental agents, malignancy, and cellular changes. In skin,
inflammation is most visible because it causes noticeable swelling, redness,
discomfort and pain. The process leading to inflammation, which is known as the
inflammatory response, also induces changes that aren't seen but influence the
effects of inflammation and their severity.
The inflammatory response is a complex cascade of steps that include an
activation of white blood cells, the release of immune system chemicals such as
complement and cytokines, and the production and release of inflammatory
mediators and prostaglandins. Inflammation may be acute or chronic or
relapsing-remitting depending on the disease course. Most conventional
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Medical Treatments
Drug
Function
Uses
Evidence
Based
Medicine
Zemaphyte
(Chinese Herbal
Therapy)6,10-14
Evening Primrose
Oil (EPO)
(Efamol)4,6,8
Anti-inflammatory
Acne, atopic
Yes
dermatitis,
psoriasis
Borage Oil15
Anti-pruritic, antiinflammatory
Atopic Dermatitis No
Aloe Vera4,6,8,9,16
Anti-inflammatory,
Abrasions, acne,
Yes
antimicrobial,
vulnerary
(promotes wound
healing)
aphthous ulcers,
AD, bites, burns,
dermabrasions,
frostbite, leg
ulcers, poison
ivy, psoriasis,
sunburn
Calendula
(Calendula
officionalis)4,8,9,16
Anti-inflammatory,
anti-septic,
vulnerary
Boils, burns,
Yes
eczema, herpes
(re:wound
simplex or zoster, healing)
mouth irritations,
ulcers, wounds
Capsaicin
(Zostrix)8,9,16
Deplete neuronal
stores of substance
P
Pityriasis Rubra
Yes (re:
Pilaris, post
PHN,
herpetic
Psoriasis)
neuralgia (PHN),
prurigo nodularis,
pruritus
associated with
psoriasis (Ps) and
PUVA
Goldenseal
(Hydratis
canadensi)4
Anti-inflammatory,
antimicrobial,
antiseptic,
astringent,
vulnerary
Boils,
hemorrhoids,
tinea
Licorice
(Glycyrrhiza
glabralensis or
ura)4,6,8,16
Anti-inflammatory, Eczema,
antiviral, demulcent melasma, "sore
(mucous membrane mouth"
soother)
No
Anti-inflammatory,
antimicrobial,
antiseptic,
immunomodulator
external-Boils,
burns, herpes
simplex, ulcers
internalPrevention of
yeast infections
No
Antiviral,
external-
No
No
(Ulmas fulva)
demulcent,
emollient
Abscesses, boils,
herpes simplex,
skin irritations,
ulcers
Anti-inflammatory,
astringent,
antimicrobial,
immunomodulator
external- Burns, No
neuralgia,wounds
Thyme (Thymus
vulgaris)4
Antimicrobial,
astringent,
antiseptic
Combined with
herbs for
alopecia,
halitosis,
stomatitis
No
Ginkgo (Ginkgo
biloba)
Garlic, Ginger,
Ginseng (Panax
ginseng)4,8,17
Various
Various
No
Antimicrobial,
antiseptic
Acne, impetigo,
mouth ulcers,
psoriasis, tinea
infections
Yes
BromelainPineapple (Ananas
comosus)16
Anti-inflammatory
Wound healing,
postsurgical pain
No
Yarrow (Achillea
millefolium)16
Anti-inflammatory
Compress for
weeping lesions,
pruritus
No
Compress for
weeping lesions
No
Fenugreek
Anti-inflammatory
(Trigonella foenumgraecum)16
Chamomile
(Matricaria recuita
L)4,6,9,16,18
Yes
Arnica (A
Montana)8,9
Anti-inflammatory
Acne, boils,
bruises,
gingivitis,
hemorrhoids,
insect bites
No
Horse Chestnut
seed extract
(Aesculus
hippocastanum)6,8
Anti-inflammatory
Chronic venous
insufficiency
(swelling,
pruritus,
tenderness)
Yes
Drug
Side-Effects
Drug Interactions
Zemaphyte (Chinese
Herbal Therapy)6,10-14
GI upset, headaches
phenothiazines,
seizure threshold of
phenobarbital,
phenytoin
Borage Oil15
Potential for
hepatotoxicity orally, no
toxicity data for topical
use
Aloe Vera4,6,8,9,16
Contact dermatitis
corticosteroids,
Potassium
NK
Capsaicin
(Zostrix)8,9,16
Severe burning,
intolerability, allergy:
can cross react with
latex, bananas, kiwi,
chestnut, avocado
NK
Goldenseal (Hydratis
canadensi)4
Allergic Contact
Dermatitis
NK
Licorice (Glycyrrhiza
glabralensis or
ura)4,6,8,16
Contraindicated in
hypertension, diabetes
mellitus, hypokalemia,
liver/kidney disorders
Cyclosporin A (CyA) ,
digoxin, prednisone,
thiazides
Recurrent erythema
nodosum
CAUTION!: in HIV, CTD,
TB, MS, ragweed,
sunflower allergies
Immunomodulators
and CyA,
Methotrexate,
coticosteroids
Dermatitis
CAUTION! Oral form
induces miscarriage
NK
amitriptyline CyA ,
digoxin, paroxetine,
HIV protease
inhibitors, oral
contraceptives,
retrovirals
Thyme (Thymus
vulgaris)4
NK
Ginkgo (Ginkgo
biloba)
Garlic, Ginger,
Ginseng (Panax
ginseng)4,8,17
NK
Bromelain-Pineapple
(Ananas comosus)16
Ethyl acrylate
Yarrow (Achillea
millefolium)16
ACD
NK
Fenugreek
(Trigonella foenumgraecum)16
Hypoglycemics
Chamomile
(Matricaria recuita
L)4,6,9,16,18
ACD, anaphylaxis
NK
NK
ext-ACD int-Dizziness,
drug induced lupus, GI
upset, headache,
pruritus
1. Cutaneous Cleansers
2. Adverse Reactions to Herbal Therapy in Dermatology
3. Important Safety Information About DIANE-35 and the Risk of
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Echinacea spp.
David L. Hoffmann B.Sc. (Hons), M.N.I.M.H.
Echinacea spp.
Compositeae
Names: Purple Coneflower
activated destroys the integrity of the ground substance. This causes the barrier
to become leaky, allowing pathogens to invade, attach themselves to exposed
cells, penetrate the membrane and kill the cell. The result as an inflammatory
infection. Echinacea inhibits the action of hyaluronidase by bonding with it in
some way, resulting in a temporary increase in the integrity of the barrier. Fewer
pathogens are able to stimulate the destruction of the ground substance. A range
of constituents mediate this process, especially a complex polysaccharide called
echinacin B. This anti-hyaluronidase action is involved in regeneration of
connective tissue destroyed during infection and in the elimination of pathogenic
organisms creating the infection. Purified polysaccharides prepared from
Echinacea possess a strong activating force on the body's macrophagemediated defense system. These macrophages initiate the destruction of
pathogens and cancer cells. Echinacea activates macrophages by itself,
independent of any effect with T-cells. A tumor-inhibiting principle has been
found, a oncolytic lipid-soluble hydrocarbon from the essential oil. The
echinacosides glycosides appear to be the primary `antibiotics', but there are
many other active substances present which probably function synergistically.
The polysaccharides possess the best immune stimulating properties and are
also antiviral. Other constituents have been shown to possess good anti-tumor,
bacteriostatic, and anesthetic activity.
This all points to the conclusion that its actions relate to immune system
functioning on some level, helping deal with infections and stimulating the
immune response. It activates the macrophages that destroy both cancerous
cells and pathogens, increases the level of phagocytosis by raising levels of
white blood cells such as the neutrophils, monocytes, eosinophils, and B
lymphocytes. It also has an effect on properidin levels, indication an activation of
the complement system.
Preparations & Dosage: Decoction: put 1-2 teaspoonfuls of the root in one cup
of water and bring it slowly to boil. Let it simmer for 10-15 minutes. This should
be drunk three times a day. Tincture: take 1-4 ml of the tincture three times a
day. Echinacea is often, inappropriately, used as a daily `immune support'
(whatever that is!). A quote from Dr. Daniel Mowrey's excellent review of
Echinacea in Next Generation Herbal Medicine is pertinent here:
"Daily intake should be restricted to what is deemed necessary. During cold and
flu season, two to four capsules per day is sufficient. In the presence of acute
infection, that dosage may be increased, without danger, to more than 8
capsules. In the presence of chronic infections, such as chronic hepatitis,
echinacea may be used continuously for several months. However, for the
maintenance of a healthy immune system, echinacea is most wisely used
periodically--a few weeks on, and a few weeks off, throughout the year.
Echinacea is not a tonic in all aspects; granted that it has been observed to
stabilize the production of neutrophils, such tonic action has not been observed
on other immune factors, such as properdin production. In the absence of
conclusive experimental findings, it is both safe and wise to assume that the
constant, unremitting use of echinacea could be stressful on certain aspects of
the immune system. During breaks, the immune system will adapt and increase
in natural strength."
http://www.healthy.net/scr/mmedica.asp?MTId=1&Id=200
.
Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators.: Altern Med Rev.
2006 Jun; 11(2): 128-50 Spellman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M
Modulation of cytokine secretion may offer novel approaches in the treatment of a variety of diseases. One strategy in
the modulation of cytokine expression may be through the use of herbal medicines. A class of herbal medicines, known
as immunomodulators, alters the activity of immune function through the dynamic regulation of informational
molecules such as cytokines. This may offer an explanation of the effects of herbs on the immune system and other
tissues. For this informal review, the authors surveyed the primary literature on medicinal plants and their effects on
cytokine expression, taking special care to analyze research that utilized the multi-component extracts equivalent to or
similar to what are used in traditional medicine, clinical phytotherapy, or in the marketplace. METHODOLOGY:
MEDLINE, EBSCO, and BIOSIS were used to identify research on botanical medicines, in whole or standardized
form, that act on cytokine activity through different models, i.e., in vivo (human and animal), ex vivo, or in vitro.
RESULTS: Many medicinal plant extracts had effects on at least one cytokine. The most frequently studied cytokines
were IL-1, IL-6, TNF, and IFN. Acalypha wilkesiana, Acanthopanax gracilistylus, Allium sativum, Ananus comosus,
Cissampelos sympodialis, Coriolus versicolor, Curcuma longa, Echinacea purpurea, Grifola frondosa, Harpagophytum
procumbens, Panax ginseng, Polygala tenuifolia, Poria cocos, Silybum marianum, Smilax glabra, Tinospora cordifolia,
Uncaria tomentosa, and Withania somnifera demonstrate modulation of multiple cytokines. CONCLUSION: The in
vitro and in vivo research demonstrates that the reviewed botanical medicines modulate the secretion of multiple
cytokines. The reported therapeutic success of these plants by traditional cultures and modern clinicians may be
partially due to their effects on cytokines. Phytotherapy offers a potential therapeutic modality for the treatment of
many differing conditions involving cytokines. Given the activity demonstrated by many of the reviewed herbal
medicines and the increasing awareness of the broad-spectrum effects of cytokines on autoimmune conditions and
chronic degenerative processes, further study of phytotherapy for cytokine-related diseases and syndromes is
warranted.
herbal | immunity | review | traditional
http://herbalscienceresearch.com/node/436
from herbs used in traditional Chinese medicine (TCM) have been shown to have
immunomodulating activity.
More than 70 compounds have been isolated from the poisonous liana Tripterygium
wilfordii Hook.f., Celastraceae, largely alkaloids and terpenoids. Many have been
shown to be immunosuppressors in vitro and in vivo. T. wilfordii has been used in TCM
to treat fever, chills, edema, and inflammation, and extracts of the plant's xylem have
been used for rheumatoid arthritis, chronic nephritis, skin diseases, and immunological
disorders.
Artemisinin, known as qing haosu in TCM, a sesquiterpene lactone isolated from
Artemisia annua (Sweet Annie, Artemisia annua "Qing-Hao" L., Asteraceae), is an
antimalarial drug. Recent clinical studies have found it to be an immunomodulator, and
that it can be effective in the treatment of systemic lupus erythematosis, psoriasis, and
other autoimmune-related disorders. Arteether, a semisynthetic analogue of
dihydroartemisinin (an artemisinin derivative), is being developed by the World Health
Organization to treat malaria. Another compound, artemether (a homologue of
arteether), is proving to have more potent antimalarial activity than artemisinin.
The fruits of Sophora alopecuoides (Fabaceae) and the roots of S. flavescens are used in
TCM for their antipyretic (fever reducing) effects. Alkaloids isolated from these plants
have been shown both to be immunosuppressors (at high doses) and immunostimulators
(at low doses). Diterpenoid alkaloids isolated from the axial roots of Aconitum species
used in TCM have shown anti-inflammatory, analgesic, antipyretic and
immunomodulatory activity. The sinomenine alkaloids, derived from Sinomenium
acutum Diels. (Menispermaceae), have been shown to be clinically effective in arthritis
and rheumatoid arthritis.
In addition to these compounds, several polysaccharides, such as those from the fruiting
bodies of Ganoderma lucidum (Reishi mushroom), ling chih (Leyss. ex Fr., P. Karst.,
Ganodermataceae), the fruits of Lycium barbarum L. Solanaceae, the whole plants of
Epimedium koreanum Berberidaceae nec pubescens, the roots of Panax ginseng C. A.
Mey., Araliaceae, Acanthopanax obovatus nec senticosus, and Achyranthes bidentata L.,