Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
http://www.clevelandclinicmeded.com/medicalpubs/pharmacy/marchapril2005/overactive.htm[21-01-2014 00:13:02]
and blurred vision. While the most commonly reported adverse events from use of darifenacin are dry
mouth, constipation, and urinary tract infection. Dry mouth was the most frequent reason for
discontinuation of therapy reported for both solifenacin and darifenacin. 6,7 Higher doses of each are
associated with an increased risk of developing anticholinergic side effects compared to the starting
doses. However, patients on initial doses of solifenacin and darifenacin reported lower incidences of
dry mouth compared to oxybutynin XL, tolterodine LA, and trospium (See Table 1). 6-10
Both solifenacin and darifenacin are contraindicated in patients with urinary or gastric retention,
uncontrolled narrow-angle glaucoma, or a known hypersensitivity to either drug compound. These
medications should be used with caution in patients at risk for bladder outflow obstruction, decreased
gastric motility, and controlled narrow-angle glaucoma.6,7 Solifenacin and darifenacin are rated as a
pregnancy-risk category C, indicating that studies in animals have revealed adverse effects on the
fetus and there are no controlled studies in women, or that studies in women and animals are not
available. These drugs should only be administered during pregnancy if the potential benefit justifies
the potential risk to the fetus.11
Solifenacin is primarily metabolized hepatically through the cytochrome P450 (CYP) 3A4 enzyme,
while darifenacin is metabolized through both the CYP 3A4 and 2D6 pathways. Potential drug
interactions exist between solifenacin, darifenacin, and medications metabolized via the CYP 3A4
enzyme. Known CYP 3A4 enzyme inducers, including carbamazepine (Tegretol), phenytoin
(Dilantin), and phenobarbital as well as CYP 3A4 enzyme inhibitors such as azole antifungals
(ketoconazole [Nizoral]), clarithromycin (Biaxin), and verapamil (Calan), may alter the
pharmacokinetic profiles of solifenacin and darifenacin. In addition, darifenacin should be used with
caution in patients concomitantly on medications metabolized through the CYP 2D6 pathway with
narrow therapeutic indexes such as flecainide (Tambocor) and tricyclic antidepressants (e.g.,
imipramine [Tofranil] and amitriptyline [Elavil]).6,7
Both medications are oral tablets that should be swallowed whole, are dosed once daily, and can be
taken with or without food. Solifenacin dosing should be initiated at 5 mg once daily and may be
increased to 10 mg (no time frame specified) if the desired effect is not achieved and the patient has
tolerated therapy. The recommended starting dose of darifenacin is 7.5 mg once daily which may be
increased to 15 mg once daily 2 weeks after initial therapy has begun if the desired effect is not
achieved.6,7 For both solifenacin and darifenacin, dosage adjustments are not necessary for patients
with mild hepatic impairment. However, patients with moderate hepatic impairment should not receive
greater than 5 mg of solifenacin daily or 7.5 mg of darifenacin daily. In addition, neither solifenacin nor
darifenacin are recommended for use in patients with severe hepatic impairment. Patients with
impaired renal function (CrCl < 30 mL/min) should not receive doses of solifenacin exceeding 5 mg
daily. In contrast, dose adjustments are not necessary with darifenacin in patients with renal
dysfunction. 4
The average wholesale price for a 30-day supply of both the solifenacin 5 mg tablets and 10 mg
tablets is $101.16. While the average wholesale price for a 30-day supply of darifenacin 7.5- and 15mg extended-release tablets is $95.76 (See Table 2). 12,13
Solifenacin and darifenacin represent a new class of selective M3 receptor anticholinergics that may
help patients with OAB gain control over the symptoms of urgency, urge incontinence, and frequency.
Solifenacin 5 mg is associated with the lowest incidence of anticholinergic side effects including dry
http://www.clevelandclinicmeded.com/medicalpubs/pharmacy/marchapril2005/overactive.htm[21-01-2014 00:13:02]
mouth and constipation in comparison to darifenacin and the non-selective muscarinic anticholinergics
used to treat OAB. All of the currently available anticholinergics used for OAB, including solifenacin
and darifenacin, require dose adjustment for varying degrees of hepatic impairment. Solifenacin
requires dose adjustment in patients with renal insufficiency, while darifenacin does not. The new
treatments for OAB offer comparable efficacy, lower incidence of select anticholinergic side effects at
lower doses, and competitive pricing compared to branded long-acting, non-selective muscarinic
anticholinergics for OAB. Solifenacin and darifenacin have not been requested for formulary review
(i.e., both medications are currently non-formulary).
At the time of writing, Abigail was a student in the Drug Information Center. She is currently a Clinical
Pharmacist working for the Indian Health Service at the Tsaile Health Center in Tsaile, Arizona.
References
1. Rovner R, Wyman J, Lackner T, Guay D. Urinary incontinence. In: Dipiro J, Talbert R, Yee G,
Matzke Wells B, Posey L, editors. Pharmacotherapy: a pathophysiologic approach. 5th ed. New
York: McGraw-Hill Medical Publishing Division; 2002. p. 1543-56.
2. Wood AJ. Management of overactive bladder. N Engl J Med 2004;350:786-96.
3. Hashim H, Abrams P. Drug treatment of overactive bladder: efficacy, cost and quality-of-life
considerations. Drugs 2004;64:1643-56.
4. Lexi-Comp Online. www.crlonline.com. Accessed 3/14/05.
5. Chapple C, Yamanishi T, Chess-Williams R. Muscarinic receptor subtypes and management of
the overactive bladder. Urology 2002;60 (Suppl 5A):82-9.
6. Vesicare Package Insert: Research Triangle Park, NC: GlaxoSmithKline; 2004 Nov.
7. Enablex Package Insert: East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2004 Dec.
8. Detrol LA Package Insert: Kalamazoo, MI: Pharmacia & Upjohn; 2004 April.
9. Ditropan XL Package Insert: Palo Alto, CA: ALZA Corporation; 1998 Dec.
10. Sanctura Package Insert: East Hanover, NJ: Odyssey Pharmaceuticals; 2004 July.
11. Briggs GG, Freeman RK, Gaffe SJ. Drugs in pregnancy and lactation. 6th ed. Philadelphia:
Lippincott Williams & Wilkins; 2002.
12. Redbook Update: Thomson 2005 March; 24. p. 37, 73.
13. Redbook: Thomson 2004; 23. p. 303, 321, 486-7.
http://www.clevelandclinicmeded.com/medicalpubs/pharmacy/marchapril2005/overactive.htm[21-01-2014 00:13:02]