Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
I. INTRODUCTION
Multiple biomedical imaging forms an essential part
of cancer clinical protocols and is able to furnish
morphological, structural, metabolic and functional
information. Early detection of cancer through screening
based on imaging is probably the major contributor to a
reduction in mortality for certain cancers. [1] Diagnosis
usually requires the histological examination of biopsy
samples; a pathologist typically assesses the deviation in the
cell structures and/or the change in the distribution of the
cells. [2] Integration with diagnostic tools assists in clinical
decision-making. For such applications it is desired to have
intelligent systems, which can handle temporal data by doing
dynamic adjustment in the learnt pattern using underlying
criticalities. Evolutionary Artificial Neural Networks (EANN)
has ability to be able to adapt to the situation, where evolution
is another fundamental form of adaptation in addition to
learning [3].
The paper is organized as, section II presents brief review
of work in cancer detection and diagnosis.Section III
This Project is partially funded by University of Pune, Under Grant No.
BCUD/183 Year 2009-2011
PROPOSED METHODOLOGY
Tf f 0
t xt xt
Estimation Error
C Known a priori
1,t State parameter uncertainties
2,t Measurement disturbances
Vector responsible for matching f 0 (, ) & f (, )
Evolutionary dynamic update strategy for network learning is
given by
xt f ( xt , ut ) 1,t
yt C xt 2,t
1
1
f f 0
A0 x w10 w20 1
1 ( x)u
2
2
1 x 2 x l1 x x
( x) ( x)u (t ) l2 x x
( ij , kl ) ij kl i, j , k , l Z
h0 ( z )
i
ij
ij
ij
( x)
ij
h0 ( x, )
( x)dx
N2
i j i j ( x)
Where
i M1 j N1
( M 1 , M 2 , N1 , N 2 ) h0 ( x, )
T T
Wi ,t K i ,t ( P1 PW
2 1,t i ,t f 2 xt ) i
21 K 1 K W
f0 f1 x t
f0 f1 1f
( f2 2f f1 1f
d
xt Axt w1,t ( x ) w2,t 2 ( x ) ut
dx
y cxt
k1[ yt cxt ] k2 t
yt cxt
M2
ut
h ( x)
2
1f
f 2 x t
i ,t
2
1f
i ,t
i ,t
1
(max i )C T et etT c
t
(min 2i 1) i Ti
i ,t :
x t
2
2
f0 f t f 2 x t
f0 , f1 R f0 , f1
1
: lim g.
t
t
s 0
xs xs Q0 ds
Training of Network
d
t Yt X tT t t t X t X tT t
dt
( f * g )( x)
f ( y ) g ( x y )dy
f ( x y ) g ( y ) dy
R
R
Use un-sharpening
filter for sharpening
and contrast
enhancement.
Training Quality
T
T
w (0)
1
}T dt
tr { t t1[t1 ]T
t
T t 0
1
c
V1 : tr {w1,Tt w1,t } [ K1,t K1, min ]2
2
4
T
1
1
V1 : t r {w 1,t ( K1,t 1 (t , x ) 2 K i ,t K 1,t w 1,t )}
1
2 K1,t (
1
k1,t
IV. EXPERIMENTATION
IV A. Data collection and Domain Expert support:
Huge volume of data is required.. Data collected from
Histopathology Dept, Cancer Research Centre, Ruby Hall
Clinic, Pune, in the form of glass slides. Images are processed
using microscope-CCD setup. Manual annotation plays a key
role in establishing a ground truth. Validate the results against
the state-of-the-art, which may lead to give best predicted
pathological solutions by avoiding the subjectivity in
processing and underlying algorithms. Due to evolutionary
nature of algorithm, manual annotation is required for training
and validation for every new class of pattern.
f ( x; , 2 )
2
2
1
e ( x ) /(2 )
2
CONCLUSION
[8]
REFERENCES
[9]
[1]
[2]
[3]
[4]
[7]