Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Genome
Factors
Causing
Project
Dandruff
Free
PT
Skin
irritation
Malassezia
Fungal Cell
Extra
Zn
ZPT
Free
Zn
Malassezia fungus
Scalp oil
The Work
100
90
percentage of subjects
80
70
1.5
60
50
40
30
0.5
20
10
0
malassezia malassezia malassezia malassezia
furfur
slooffiae sympodialis
obtusa
malassezia malassezia
restricta
globosa
Lipids
Skin surface
Corneocyte
Hydrolysis of
Triglycerides
Barrier Breach
Proliferation
Consumption
of Lipids
Penetration of fatty
acids diglycerides
The Results
Malassezia globosa is the first Malessezia species
to be sequenced:
4285 Protein coding genes
Amongst the smallest genomes of free-living
eukaryotic cells
300x smaller than the human genome
Malassezias adaptation to the skin environment
and pathogenicity are due to unique metabolic
limitations and capabilities discovered by this study
The closest relative of Malassezia globosa is
Ustilago maydis a common crop pathogen
(corn smut).
Presence of mating type genes - likely capable of
having sexual interactions (further evidence for
highly efficient adaptation)
Comparative
Genomics and
Proteomics
Malassezia globosa genome encodes for 14
lipases, 9 phospholipases,
Most lipases expressed on scalp, not in medium
8 lipases expressed, 3 phospholipases expressed
Conclusion: secreted enzymes enable
lipid-depended lifestyle on scalp
Future targets for AD treatment