Ganoderma long term prevention

disease
Model, duration

effect

paper

Location, year

Cancer

Mice, 9 weeks

Inhibition of lung Taik-Koo Yun

Korea, 2003
tumour
Experimental and
epidemiological
evidence on nonorgan specific
cancer preventive
effect of Korean
ginseng and
identification of
active compounds

Cancer

N/a review
abstract

Boost immune
function: T
lymphocyte,
macrophages, and
natural killer cells

Yihuai Gao,
Singapore, 2003
Cancer Prevention
and Treatment by
Ganoderma, a
Mushroom with
Medicinal
Properties

N/a in vitro

In vitro

Immune
modulation:
promote APC
function,
mononuclear
phagocyte,
humoral and
cellular immunity

Zhi-Bin Lin
Cellular and
Molecular
Mechanisms of
Immunomodulation
by Ganoderma
lucidum

Diabetes

N/a review
abstract

Restore pancreatic
beta cell function,
enhance
microcirculation,
increase insulin
production,
improve insulin
dependent process

Wei jia,
China, 2003
Antidiabetic
herbal drugs
ofcially
approved in China

Colon cancer

Mice, 10 weeks

Reduce size of
tumour cf control

H. Lu,
Japan, 2002
Prevention of
development of
N,N'dimethylhydrazine
-induced colon
tumors by a watersoluble extract
from cultured
medium of
Ganoderma
lucidum (Rei-shi)
mycelia in male
ICR mice

China, 2000

Colon cancer

Mice, 5 weeks

Reduce number
and size of colon
tumours

H. Lu,
Japan, 2001
Prevention of the
development of
preneoplastic
lesions, aberrant
crypt foci, by a
water-soluble
extract from
cultured medium
of Ganoderma
lucidum (Rei-shi)
mycelia in male
F344 rats

Auto-immune
disease, lupus

Mice, start from 2 Improve survival

months of age
rate, decrease
proteinuria,
decrease serum
anti-dsDNA
autoantibody,
decrease
mononuclear cell
infiltration in vital
organ

N-S Lai,
China, 2001
Prevention of
autoantibody
formation and
prolonged survival
in New Zealand
Black/New
Zealand White F1
mice with an
ancient Chinese
herb, Ganoderma
tsugae

Protection of
normal cell in
cancer
radiotherapy

In vitro

Reduced DNA
strand-break,
microsomal
membrane
damage induced
by gamma
radiation

Thulasi G. Pillai India, 2006

Prevention of
radiation-induced
damages by
aqueous extract of
Ganoderma
lucidum occurring
in
southern parts of
India

Mammary
adenocarcinoma
and skin tumour

Mice, n/a

Reduce tumour
induction, latency
period and
proliferation

Lakshmi B
India, 2009
Prevention of
mammary
adenocarcinoma
and skin tumour
by Ganoderma
lucidum, a
medicinal
mushroom
occurring in South
India.

Breast cancer

Human, 36

Improve social

Ping-Ping Bao

China, 2012

months

wellbeing, reduce Ginseng and

physical wellbeing Ganoderma
lucidum Use after
Breast
Cancer Diagnosis
and Quality of
Life: A Report
from the
Shanghai Breast
Cancer Survival
Study

Colon cancer

Human, 10 years

Reduced risk of
death

Michael
USA, china, 2011
McCulloch
Colon Cancer
Survival With
Herbal Medicine
and Vitamins
Combined With
Standard Therapy
in a

Lung cancer

Human, 10 years

Reduce risk of
death

Michael
McCulloch
Lung Cancer
Survival With
Herbal Medicine
and Vitamins in a
Whole-Systems
Approach : TenYear

Reduce urea,
creatinine, ALP
level, and
maintain renal
superoxide
dismutase,
catalase, and
glutathione
peroxidase level

Thulasi G. Pillai India, 2009

Prevention of
cisplatin induced
nephrotoxicity by
terpenes isolated
from Ganoderma
lucidum occurring
in Southern Parts
of India

Terpene
Protection from
Mice, n/a
nephrotoxicity by
cisplatin in
chemotherapy

Oral mucosa
cancer

Mice, n/a

USA, china, 2011

Reduce cancer
CAI Yan
China, 2010
cell, decrease bcl- Prevention of
2in and survivin? Triterpenoids
Isolated from
Ganoderma
Lucidum on
Cancerization of
the Oral Mucosa
and its Mechanism

Polysaccharides
Chemoprevention Mice, n/a review

Immunostimulatio
n of NK cell and
cytotoxic T cell
immunosurveillan
ce by ganoderma
polysaccharide

HSV

Antiviral activity Young-So Kim

South korea, 2000
with no cytotoxic Antiherpetic
effect on vero cell activities of acidic
protein bound
polysacchride
isolated from
Ganoderma
lucidum alone and
in combinations
with interferons

In vitro

Raymond Y.
USA, 1996
Chang
Potential
application of
Ganoderma
polysaccharides in
the immune
surveillance and
chemoprevention
of cancer