11/10/2014

USP Monographs: Zinc Chloride

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Zinc Chloride
ZnCl2
136.30
Zinc chloride.
Zinc chloride

[7646-85-7].

Zinc Chloride contains not less than 97.0 percent and not more than 100.5 percent of ZnCl2.
Packaging and storage Preserve in tight containers.
Identification A solution of it responds to the tests for Zinc

191

and for Chloride

191 .

Limit of oxychloride Dissolve 1.0 g in 20 mL of water, add 20 mL of alcohol, and mix. To 10 mL of the mixture add 0.30
mL of 1.0 N hydrochloric acid: the solution becomes perfectly clear.
Sulfate 221 Dissolve 1.0 g in 30 mL of water: 20 mL of this solution shows no more sulfate than corresponds to 0.20
mL of 0.020 N sulfuric acid (0.03%).
Limit of ammonium salts To 5 mL of a solution (1 in 10) add 1 N sodium hydroxide until the precipitate first formed is
redissolved, and then warm the solution: no odor of ammonia is perceptible.
Lead 251 Dissolve 0.50 g in 5 mL of water, and transfer the solution to a color-comparison tube (A). Add 15 mL of
Potassium Cyanide Solution (1 in 10), mix, and allow the mixture to become clear. In a similar, matched color-comparison
tube (B) place 5 mL of water, and add 2.50 mL of Standard Lead Solution (see Heavy Metals 231 ) and 15 mL of
Potassium Cyanide Solution (1 in 10). Add to the solution in each tube 0.1 mL of sodium sulfide TS. Mix the contents of
each tube, and allow to stand for 5 minutes: viewed downward over a white surface, the solution in tube A is not darker than
that in tube B (indicating not more than 0.005% of lead).
Alkalies and alkaline earths Dissolve 2.0 g in about 150 mL of water contained in a 200-mL volumetric flask. Add
sufficient ammonium sulfide TS to precipitate the zinc completely, dilute with water to volume, and mix. Filter through a dry
filter, and reject the first portion of the filtrate. To 100 mL of the subsequent filtrate add 5 drops of sulfuric acid, evaporate to
dryness, and ignite: the weight of the residue does not exceed 10 mg (1.0%).
Organic volatile impurities, Method I

467 : meets the requirements.

Residual solvents 467 : meets the requirements.

(Official January 1, 2007)
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USP Monographs: Zinc Chloride

Assay Dissolve about 12 g of Zinc Chloride, accurately weighed, in about 500 mL of water in a 1 L volumetric flask, add
12 g of ammonium chloride, dilute with water to volume, and mix. Pipet 25 mL of the solution into a 400-mL beaker, add 100
mL of water, 10 mL of ammoniaammonium chloride buffer TS, and 1 mL of eriochrome black T solution (1 in 2000), and
titrate with 0.05 M edetate disodium VS to a deep blue endpoint. Each mL of 0.05 M edetate disodium is equivalent to
6.815 mg of ZnCl2.
Auxiliary Information Staff Liaison : Feiwen Mao, M.S., Senior Scientific Associate
Expert Committee : (MDOOD05) Monograph Development-Ophthalmics Oncologics and Dermatologicals
USP29NF24 Page 2287
Phone Number : 1-301-816-8320

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