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Histamine antagonists
adrenaline
antihistamines
corticosteroids
Chlorpheniramine
Chlorphenoxamin
e
Pheniramine(avil)R
Cyproheptadine
Diphenhydramine
promethazine
Chlorphenoxamine(allergex)R
Desloratadine (desa)R
Cetirizine
Levocetirizine
terfenadine
acrivastine(semprex)R
pharmacokinetics
.the onset of action occurs within 1 to 3 hours-1
The duration of action for many oral H1 antihistamines is at least 24 hours,facilitating once-daily -2
dosing. They are most effective when used prophylactically before allergen exposure rather than as
.needed
. Tolerance to the action of H1 antihistamines has not been observed-3
Therapeutic uses
Allergic and inflammatory-1
conditions (allergic rhinitis and
urticaria)
cholinergic
-adrenergic
dry mouth
urinary retention
sinus tachycardia
hypotension
dizziness
reflex tachycardia
serotonin
appetite
Histamine H1
allergic inflammation,
itching,rhionrrhea
neurotransmission in
the CNS
sedation
Sedating antihistamines should be avoided in severe liver disease as they increase risk of coma
Most manufactures of antihistamines advise avoiding use during pregnancy however, there is no
evidence of teratogenicity except for hydroxyzine and loratadine