Cold Water Extraction of Opioids

Cold Water Extraction of Opioids - Drugs Forum
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Cold Water Extraction of Opioids

The purpose of this wiki article is to provide easy-to-follow procedures on Cold Water Extraction of Opioids
Drugs-Forum users; ones that you can do at home in order to minimize the risks of using OTC and prescription
painkillers. All steps and methods are explained both in detail and summarized throughout. Many people who
inquire and perform CWEs usually have the same questions to ask. This Wiki/FAQ will attempt to address all of
these, and more.
Contents
1 Introduction
1.1 How Extraction Works
2 Extraction Manuals
2.1 Crushing Tablets and Pills
2.2 Quick Step-by-Step CWE-Technique (5 Minutes)
2.3 Quick Step-by-Step CWE Manual (With Pictures)
2.4 Detailed CWE Manual
2.5 Another Detailed CWE Manual
2.5.1 Do's & Don'ts by Darkglobe
2.5.2 The Results/Final Product
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Contents
2.6 Quick-Links & Further Information
3 Pharmacology and Drug Interactions of Codeine
3.1 Codeine: First Use & Dosage (Beginning and Medicinal)
3.2 Codeine: Administration & Effects on the Body and Mind
3.3 Your Product
4 Chemical Properties of the Ingredients
4.1 Melting Point
4.2 Opioids
4.2.1 Codeine
4.2.2 Hydrocodone
4.2.3 Oxycodone
4.2.4 (Dextro)propoxyphene
4.2.5 Heroin / Diacetylmorphine
4.2.6 Morphine
4.3 NSAIDS: Non-steroidal Anti-inflammatory Drugs & PCM/APAP
4.3.1 Paracetamol / Acetominaphen
4.3.2 Aspirin (Acetylsalicylic acid)
4.3.3 Ibuprofen
4.4 Other Ingredients Possibly Present
4.4.1 Caffeine
4.4.1.1 Removing Caffeine
4.4.2 Chlorpheniramine maleate
4.4.3 Doxylamine succinate
4.4.3.1 Removing both Chlorpheniramine Maleate and/or Doxylamine Succinate
4.4.4 Promethazine Hydrochloride
4.4.5 Gluthethimide
4.4.6 Sodium Bicarbonate - NaHCO3 (Baking Soda)
4.4.7 Pseudoephedrine
4.4.8 Salicylic acid
4.4.9 Acetic acid (Vinegar)
5 Methods of Treating Ingredient Poisoning, Overdosing, and Liver Damage; How to Minimize
Side-Effects
5.1 PCM (APAP) Poisoning: Benefits of Acetylcysteine
5.2 Aspirin Poisoning (Salicylate Poisoning)
5.3 Ibuprofen Poisoning
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Introduction
Performing Cold Water Extractions is not a hard process. However, since we are dealing with potentially harmful
ingredients, all possible precautions should be taken. For the best and safest results, each and every CWE metho
should be read fully and carefully. That means all of them.
(I have recently done an entire overhaul on this Wiki to make it flow better and easier to read. Please take the
time to do so for yours and others healths sake. -Joben)
Participating in and taking drugs is a lifestyle choice, and should be taken very seriously. One can never gain too
much knowledge.
PPoosstt C
Coon
nssu
um
mp
pttiioon
n : If you feel sick- extremely sick- immediately contact professional help and call the
ambulance! Do not induce vomiting nor try to solve the problem by consuming other drugs! Also very importantdo not, under any circumstances, attempt to seek help by posting to Drugs-Forum! Medical help cannot be
administered over the internet. Response time will never be fast enough and proper knowledge of the situation
can never be conveyed. All DF users will tell you the same thing: get off the forum and call the ambulance.
H o w E x t ra c t i o n Wo r k s
Extraction works because APAP (Acetaminophen ), ibuprofen, and aspirin are hardly soluble in water, especially
when cold. Opiates, however, are very soluble in water. (This only partly applies to Ibuprofen.)
Solubility information on APAP:
According to the Merck Chemical Index, APAP is: "Soluble in methanol, ethanol, dimethyl-formamide, ethylene
dichloride, acetone, ethyl acetate; slightly soluble in ether; very slightly soluble in cold water, considerably more
soluble in hot water; insoluble in petroleum ether, pentane, benzene."
Solubility information on ibuprofen:
According to the Merck Chemical Index, ibuprofen is: "Relatively insoluble in water; very soluble in alcohol
most organic solvents." The colder the water, the less aspirin dissolves.
Due to the difficulty in obtaining Rx drugs containing enough codeine to be used recreationally, I have included a
procedure that allows one to extract the codeine from OTC products to obtain enough of the drug to use
recreationally.
This extraction can oon
nllyy be used on OTC products containing either acetaminophen or aspirin (ibuprofen
possible to extract) in addition to the codeine. There is one exception to this rule. Products containing
be used with the knowledge that the most of the caffeine contained in the OTC product, w
wiillll be found in the
finished product. This should not matter to most people, but to those with problems in taking caffeine
b
beeeen
nw
waarrn
need
d!! (See: caffeine removal section)
(I have found that it is better to use products containing aspirin, as opposed to Tylenol, because the filtering
process goes more smoothly. And, if one is not allergic to salicilates, aspirin is safer [easier on the liver, etc.].
Given its solubility, you will also end up with far less aspirin than acetaminophen per volume of the product.)
The idea behind the following extraction is that acetaminophen and aspirin are very insoluble in cold water.
Codeine phosphate (the most common form of codeine) is very soluble in water; cold water will yield the best
results. The following table explains:
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Type
Solubility (31C water) Solubility (21C water)
Aspirin
1g / 100 ml
1g / 300ml
Acetaminophen (Paracetamol) 1g / 70 ml
1g / 150 ml
Codeine
1g / 0.7 ml
1g / 2.3 ml
So as you can see, both APAP and aspirin aren't very soluble in 21C water, so if you cool the water to around 10C
the solubility will drop even further. That way you can dissolve 20 tablets in 50ml of warm (not hot) water, cool th
water down to 10C, filter the solution and end up with the same amount of codeine as the tablets contained but
only a fraction of the original amount of APAP and aspirin . Opiates are very soluble in water. Extraction works
because the cold water dissolves opiates but not the APAP, aspirin , or ibuprofen. Also, if cold, the aspirin will
change its status and become crystals, which are caught in the filter.
It should be noted that because most of the caffeine (or other ingredients; look at your product and the list of
chemicals on this site) will remain in the finished product, using large amounts of tablets in the following
procedure will result in large amount of caffeine, etc., in the finished product. For example, the use of 20 tablets
with 15mg Caffeine may result in about 300mg of caffeine in the finished product. (15mg/tablets * 20 tablets)
There are strong side effects with all of the other ingredients and one has to be aware of these.
One can use less opioids and get same effects by potentiating the effects, see the link list.
E x t ra c t i o n M a n u a l s
Here are a few manuals- some better, some faster, some more careful, some more detailed- but they all work.
They are all very similar, but each different in its own particular, special way. The author recommends that if one
wants to be on the absolute safe side and also have a "near perfect" result, he/she should read the entire thread
or at least a few manuals and the rest of the thread. The other chemicals and dosages are also very important
to study.
Listed below are many Cold Water Extraction manuals. They are all very similar, but each different in its own
particular way. To gain the most knowledge on the subject, one should not only read the two short CWE
techniques, but also the detailed ones. It is recommended they also view the do's and donts list.
C r u s h i n g Ta b l e t s a n d P i l l s
For the sake of Cold Water Extractions, one should prefer capsules, as they contain less fillers and don't have to b
crushed. They are also much easier to dissolve. However, if one has only access to tablets, he/she has a multitud
of options on how to crush them.
Listed below are a few methods on how to crush pills while minimizing powder loss. One should always be carefu
though, as some tablet pieces tend to fly-away when initially crushed. It is recommended that prior to smashing
break apart tablets with hands into the smallest possible segments.
Place the tablets in an envelope, fold it shut, and then using a large rolling pin to smash them. This makes it
near impossible to lose powder.
Place two pills in a spoon and then use another spoon over top and apply pressure.
A simple mortar and pestle can do the trick.
If one has the resources, use a ball mill with steel crushing media.
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A coffee grinder used for only five to six seconds will sufficiently blend up to 72 tablets into fine talc, making
them easily dissolvable.
Personally, my best results came using a large knife sharpening stone to pummel the tablets. After the main
crushing is performed, use a thick, round mug to roll on the pills turning the tiny segments into a fine powder.
A thread that may provide further information can be found here: How to Crush Pills (Codeine)
Q u i c k S t e p - b y-S t e p C W E -Te c h n i q u e ( 5 M i n u t e s )
The following technique is proof of a perfect working method that can also be done in a relatively short period of
time. Apart from cooling the water (which takes around 20-30 minutes), this process will take aab
boou
utt ffiivvee m
miin
nu
uttee
m
maaxx..
This is a quick and easy way to do the CWE. Lots of other guides take the long way around and make it seem a b
harder than it actually is. This is intended to be a brief explanation, as it will not go into very detailed chemistry.
S
Siim
mp
plliiffiieed
dO
Ovveerrvviieew
wG
GO
OA
ALL:: To remove acetaminophen (APAP), ibuprofen, aspirin, etc., from tablets containing opiates, like codeine
H
HO
OW
W:: Crush tablets; dissolve powder in water; strain through a filter
S
Stteep
pO
On
nee-- C
Crru
ussh
hT
Taab
blleettss iin
nttoo aa FFiin
nee PPoow
wd
deerr w
wh
hiillee M
Miin
niim
miizziin
ng
g PPoow
wd
deerr LLoossss
Put tablets into a thick Ziploc bag. (You can choose to put this inside another Ziploc bag for extra leakage
protection.) Use an object to crush the tablets to a fine powder without puncturing the Ziploc bags. These can
include but are not limited to: a sharpening stone (for knives), a brick, a round glass cup, or a hammer.
S
Stteep
pT
Tw
woo-- D
Diissssoollvvee tth
hee C
Crru
ussh
heed
d PPoow
wd
deerr iin
nttoo W
Waarrm
m//H
Hoott W
Waatteerr
Get hot water from the tap- but not too hot! In between warm and hot is perfect. Don't use boiling water unless
you want to destroy the codeine.
Put it in a container or bowl with a wide surface area (cools faster) and add the powder you crushed. (If youre
using a Ziploc, some powder may stick to the plastic, but I think it's negligible.)
The amount of water used should usually be 3/4 of a cup. Start with that and experiment. It's better to add too
much water than too little, or it won't filter properly later.
S
Stteep
pT
Th
hrreeee-- LLeett M
Miixxttu
urree S
Siitt aan
nd
dC
Cooooll ttoo R
Roooom
mT
Teem
mp
peerraattu
urree ((1
10
0--2
20
0m
miin
nu
utteess))
Be careful about cooling the mixture too quickly, as it may destroy some codeine within. Leave it sit on the
counter for a period of time, until it is at or near room temperature. (It doesnt have to be perfect.)
S
Stteep
p FFoou
urr-- M
Moovvee tth
hee C
Coon
nttaaiin
neerr iin
nttoo tth
hee FFrreeeezzeerr u
un
nttiill C
CO
OLLD
D
This is where the magic happens. Leave the mixture sit in the freezer (without a lid) until it is extremely cold to
the touch. Be very careful! The key is to get the solution as cold as possible yet ccrru
ucciiaall to keep it from freezing o
icing up. Pay close attention!
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19/11/2014 14:48
S
Stteep
p FFiivvee-- FFiilltteerriin
ng
g ((A
Allm
moosstt tth
heerree!!))
First, place a pre-wet coffee filter over the top of a Solo cup and secure it with a rubber band or something simila
(One glass and filter will normally do the job, however, if you wish to do this as quickly as possible and yield the
best results, you may choose to use two to three cups equipped with a filter. Thats filtering at three times the
speed!)
Slowly pour the solution from the freezer into the cup(s) and wait!
S
Stteep
pS
Siixx -- T
Th
hee FFiin
naall PPrrood
du
ucctt
When it looks like the filters arent dripping anymore, and there is nothing left to filter through, you will be left
with a dense, marshmallow-like substance.
Some people choose to squeeze the contents of the old filters through a new filter to save any remaining
moisture. Be careful not to spill any residue into the liquid solution, though.
At this point some people add a little water to the leftover mush and re-filter it, but I dont think its necessary or
worth the time. Were now ready to consume.
S
Stteep
pS
Seevveen
n -- D
Drriin
nkk iitt!!
The final product should be very clear (like water), or just slightly cloudy. Most (if not all) of the APAP, ibuprofen,
and/or aspirin have been successfully removed.
The remaining water is eexxttrreem
meellyy bbiitttteerr.. Personally, I suffer through it and drink it straight, just to get it over
with. Most people drink it with something sweet very sweet. Mixing Kool-Aid packages will cover some of the
bitter taste. Bottoms up!
For added effects, see: Opioid Potentiators
Q u i c k S t e p - b y- S t e p C W E M a n u a l ( W i t h P i c t u r e s )
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Step One The product that I will be using for this manual is shown above. Its a generic painkiller/cough relief/overall
well-being product, available (in different brands of course) OTC in most countries. Capsules work great because
the codeine is easy to extract. If you begin with tablets, crush them to a ffiin
nee powder.
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Step Two-
You can see this product contains paracetamol (acetaminophen), aspirin, and Klorfeniramin, which is an
antihistamine. These should NOT be in your final product. For best results, the less of these ingredients already in
the product (pre-extraction), the better. Obviously, the less material needing filtered will make the process go by
quicker and lower the chances of any remaining in the final solution. (I will refer to the paracetamol, aspirin, and
Klorfeniramin blend as PPA
AK
K in future references [for this manual exclusively].)
Side note: Klorfeniramin in low doses doesnt pose too much of a problem, but never think about consuming this
before getting proper information on it! That goes for any drug for that matter! (Lots of information available on
Drugs Forum)
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Step Three -
The following procedure will work best by using coffee filters. If they are unavailable or unobtainable, (as in some
Middle-Eastern countries), do n
noott use a t-shirt. The spaces between the threads are too wide and will allow
dangerous ingredients to flow through. Use good judgment. For this example, we will be using coffee filters.
Fill a cup with warm ((n

noott h
hoott!!)) water, and dump the crushed tablets from Step One in. Stir until completely
dissolved. You may have some residue rise to the top, even though youve stirred vigorously. Thats okay; it will b
filtered out later. At this point, the water should look snowy. To what degree will depend on the amount of tablet
you use.
For this example, we are using 30 capsules containing 10mg codeine and 300mg PAK.
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Step Four -
Once youve stirred the mixture very well, place the cup in the freezer. Wait 20-25 minutes (will differ by freezers
and settings) until water is cold. Very cold. Be very careful! The key is to get the solution as cold as possible yet
ccrru
ucciiaall to keep it from freezing or icing up. Pay close attention!
At these temperatures, the PAK becomes thick and sinks to the bottom of the cup, thus becoming easier to filter.
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Step Five Filter the solution.
It is recommended you slightly wet the filter before using it. (Not doing it can cause this stage to go even slower
and heighten the risk for filter tearing!) You can either secure the filter to a separate cup using a rubber band, or
like the diagram shows above, hang the filter above a wide bowl. Now thats ingenuity!
Now, pour the mixture into the filter. Do this slowly! Filter paper isnt exactly the sturdiest material made, and th
risk of tearing is always prevalent. If a tear does occur, re-filter the solution! Dont take any chances.
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(This photo was taken after the first filtration of the mixture. For this manual, there will be multiple filtering
[personal choice] and as you can see, there is already a significant amount of material left behind.)
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------Its finally done! Wasnt that fast? The final product should look like the image above.
Great job!
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Once completed, the solution should look similar to the liquid shown in the photo above. The codeine will
sometimes make the mixture cloudy, not to mention any PAK or colorants that may have made their way through
the filter. If you are unsure about this, you can always repeat the filtration. (For some, a tiny bit of PAK-snow on
the bottom of the glass is nothing to worry about.)
If you are paranoid about the PAK, but dont want to repeat the filter stage, place the glass in the fridge so the
rest of the PAK will sink. When you finally drink it, stop before sipping the contents of the very bottom.
Enjoy!
Detailed CWE Manual

A
A.. M
Meetth
hood
dss ooff FFiillttrraattiioon
n
-Your chosen method of filtration will greatly affect how much PCM/APAP , ibuprofen, aspirin, (or any
other ingredient) is present in your end product. The best working methods are shown below:
1
1.. LLaab
bG
Grraad
dee FFiilltteerrss
a. These may not be readily available to most, but can be obtained from someone you
may know at a local school or university.
b. Aside from those places, there are plenty of companies who will sell these products to
individuals. Check your yellow pages or search the internet for distributors.
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2
2.. C
Cooffffeeee FFiilltteerrss
a. These will work almost as well as the lab grade variety, and will filter considerably
faster. The only downside is accuracy.
b. Some people recommend filtering numerous times (two to three), but it isnt always
necessary. Use your own personal judgment.
B
B.. T
Th
hee T
Teecch
hn
niiccaall S
Sttu
uffff
- How you perform the CWE in conjunction with your level of caution and cleanliness will affect how
clean your final product will be. Below are some tips on the general method and uses of equipment.
1
1.. C
Crru
ussh
hiin
ng
gY
Yoou
urr PPiillllss
a. For best results, use a pill crusher.
b. If one is not available, use something enclosed/sealed.
i. Keep from getting white powder all over your hand and work area.
ii. Keep everything clean!
c. Crush to a fine powder. The finer, the better it will dissolve.
d. (There is a section earlier in the Wiki with various ideas on how to accomplish this.)
2
2.. D
Diissssoollvviin
ng
gY
Yoou
urr C
Crru
ussh
heed
d PPiillllss
o This is where many opinions will differ. Unless youre looking for the highest possible yield from
your pills, follow these steps:
a. Fill a glass or solo cup about half full with warm (not hot) water. Keep the
temperature around 30 degrees Centigrade. (86 degrees Fahrenheit)
i. If a great amount of pills are being used, use more water. Use your best
judgment. Dont be afraid to use too much. This is much safer. You can
always change it up next time you perform a CWE.
b. Carefully pour the crushed pills into the cup of water.
c. Stir vigorously until completely dissolved.
i. Some material may rise to the surface no matter how much you stir. Not
much you can do about it. It wont cause any harm.
d. Place mixture into freezer until it is extremely cold.
i. DO NOT let the mixture freeze. Get it as cold as possible.
3
3.. FFiilltteerriin
ng
g ((FFiin
naallllyy!!))
o There are many methods of filtering. For this procedure, we will be using a funnel draining directly
into a cup. However, there are many ways possible. Use your imagination, but always keep it safe
and proper!
a. Fold your chosen filter into the correct shape.
b. Make sure your filter fits like a glove into the funnel.
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c. Pour your mixture in slowly, ensuring none escapes the filter.

i. Pour all material in, including what has already clumped together. It will
take longer, but ensure more codeine content.
1. If very paranoid, ignore the above instruction.
d. Once complete, remove the filter carefully, paying close attention that no unfiltered
content makes its way into the codeine water.
e. If you wish to, repeat filtration.
f. Throw away all sour material.
4
4.. D
Drriin
nkk!!
Another Detailed CWE Manual
1. Obtain a quantity of tablets containing codeine. Check to see if they contain anything other than codeine,
caffeine, acetaminophen, or aspirin. If they do, and you arent sure about whether it will be a problem or not, yo
best bet is not to use them. If you still wish to, use the list of ingredients in the latter section of this wiki or searc
the forums of DF to be sure they are filterable.
Measure out your desired amount of codeine. For example:
64 mg = 8 tablets @ 8 mg per tablet
You may want to add two extra tablets as it is likely you will lose some codeine in the process. As you become
more experienced with this procedure, you will be able to obtain approximately 95% of the codeine attempted to
be extracted.
Crush the tablets into a fine powder while minimizing powder loss.
2. Now we need water in which to dissolve the crushed tablets. Choose how much water you use according to ho
many tablets are being dissolved. Approximately 40ml will work for 20 tablets. I would suggest you dont go over
50ml for the same amount.
Make sure you are using warm/hot water for dissolving. Boiling water will destroy codeine. Pour crushed powder
into the cup of water and stir until the vast majority of it is dissolved.
Not all of the powder will dissolve. Some fillers are water-insoluble and not all of the PCM/APAP, aspirin, and/or
ibuprofen will dissolve either, (which is exactly what we want!).
3. Place the cup containing the solution in a cold bath. I use some ice cubes and water in a large bowl. Stir the
mixture occasionally until the temperature drops to about 15 degrees Celsius (59 degrees Fahrenheit) or lower.
You wont need a thermometer to measure the temperature, just make sure its cold. Very cold.
If you wish you speed this up, you can use less water to dissolve the crushed tablets, and add ice chips to cool th
mixture. (Dont add so much ice you drastically increase the volume of the mixture.)
Instead of a cooling in a bath, you may also choose to cool the solution in the freezer. Pay close attention to mak
sure the mixture does not begin to freeze. This will ruin the final product.
4. Filter the solution by whatever means you wish. Coffee filters work well, but lab filters will work the best. Make
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sure you dont end up with obvious solids in the filtered solution. This process will take about one hour. (With
aspirin, this will only take about 20-30 minutes.)
You may also want to rinse the solids left over in the filter with some ice-water to extract any remaining codeine.
5. Drink and enjoy! The solution will be very bitter, so I mix a little Kool-Aid powder into it. The taste isnt horribl
it is similar to sucking on a lemon.
6. Sit back, wait, and enjoy! Because the codeine is already dissolved in the water, it only needs to be absorbed.
Whereas normally, in tablet form, the codeine must take time to dissolve to later be absorbed.
Because of this, effects should be noticeable within 15 minutes.
N
Noottee:: There are some who wish to evaporate the mixture to obtain pure codeine in powder form. I dont suggest
you do this unless you are willing to wait a while. The Merck index warns that codeine is sensitive to heat and
light. For that reason, if you wish to evaporate the mixture, do it without heat, and shield the solution form all
forms of UV light.
Do's & Don'ts by Darkglobe

D
Dooss
- Make sure youre meticulous with hygiene. Many chemical processes go tits up due to carelessness.
- Use a sensible amount of water
o Too little, and it will taste even more unpleasant and you may have too little water for the codeine
to properly dissolve.
o Too much, and you may end up with PCM/APAP finding its way into the codeine solution.
- Use a suitable filter, and use it properly!
o Improper filtration = to put it bluntly, imminent death. Or at least imminent pain. Probably both.
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- Guess. Dont even guesstimate. Do not, under any circumstances do this for any measurement or quantity. I
cannot stress how important a bit of caution can be for your health and well-being.
- Get impatient. My friend was guilty of this one. He couldnt wait for the solution to cool in order for the
PCM/APAP to precipitate out of the solution. It ended up in him having his stomach pumped. I was there in the
hospital with him, and I can safely say it did not look pleasant.
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Be careful, be methodical, and be happy. Let SWIM enjoy his/her drug use as safely as possible. Think about it- i
the substances have risks, you dont want to add more.
Paracetamol and Acetaminophen are not friendly substances!
T h e Re s u l t s / F i n a l P r o d u c t
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Above is an example of how the final product should appear. Sometimes slightly cloudy, but very similar to water.
As mentioned before, if the liquid is too cloudy, (or you feel it isnt filtered enough), you may need to perform
another filtration. Some cloudiness may be present from ingredients other than medicines. These may be fillers,
dyes, or possibly residue on the glass preceding the CWE.
One must know that the majority of times your final product will still contain trace amounts of paracetamol
(acetaminophen), aspirin, ibuprofen, etc. In most cases, the amount is miniscule and poses no harm to the user.
1. There are two choices as far as how you can exploit the codeine in the final product. The easiest
and most exercised method is simply drinking the elixir. It will taste extremely bitter when drunk
alone. Experiment with ways to improve the taste (then share the ideas!) or muster up the courage
to down it with a few great, big gulps.
2. One may also choose to evaporate the water to reap only the codeine powder. This works best
when poured into a wide and shallow dish. Large glass cookware would be the nominal choice.
Your goal is to evaporate the water out of the mixture, allowing the codeine to dry and adhere to the
glass. This codeine can then be scraped from the sides and compiled into mass amount. Some people
will use a small flame or heat source to speed up the evaporation process. Be very careful! Great
amounts of heat can cause the break-down of opioids; this will occur at about 150 degrees Celsius
and higher. Any type of UV exposure will also break down codeine, so be weary of evaporating it in
open light.
Q u i c k- L i n k s & F u r t h e r I n f o r m a t i o n
Dosage List of Opioids (starting dosage in this post in the chemicals list)
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A Big CWE Thread

Extracting Caffeine from CWE/Codeine combination
How to Crush Pills (Codeine)
Codeine-Basics Thread
Saving Money by Potentiating the Effects of Opioids Careful! If taken with APAP this will also be potentiated and
thus harder on the liver. See: APAP Poisoning section.
Extracting DXM from Syrup
Injecting Basics and Dangers of IVing Pills
P h a r m a c o l o g y a n d D r u g I n t e ra c t i o n s o f C o d e i n e
In order to take full advantage of codeine, it is helpful to be familiar with some relevant pharmacology:
The body converts codeine into morphine (~10%) by using the P450 cytochrome pathway. The most utilized of
these is cytochrome 2d6 (cyp2d6). Unfortunately, cyp2d6 is missing in about 7% of the white population, and its
manifestation is quite variable in the rest. Individuals who inherited a cyp2d6 deficiency will get many of the
adverse effects associated with codeine but little euphoria. If codeine doesn't seem to work for you, this may be
why.
Some drugs also interfere with cyp2d6. Prime among these are the SSRIs, with the exception of Zoloft
potent inhibitor is paroxetine (Paxil), followed by fluoxetine (Prozac). If you are taking an SSRI, you will probably
experience a markedly decreased euphoria when using codeine. (Paxil has a half life of only 24 hours, so not
taking it for a few days will do miracles; the half life of Prozac is seven days.)
Finally, codeine itself is a cyp2d6 inhibitor. This means that taking the whole dose at the exact same time will
probably give you the biggest sense of euphoria. It is a waste of codeine to re-dose every 20 to 30 minutes. You
will not experience a greater high by doing so.
Codeine: First Use & Dosage (Beginning and Medicinal)

One should also check the codeine thread and dosage thread; this being just a basic introduction.
Codeine is an excellent opiate to start experimenting with. A proper dose at which to begin using is in the 30 to 6
mg range. This dosage will produce quite pleasurable feelings of euphoria, while low enough to keep the adverse
effects at a minimum. Some individuals may be allergic to codeine. If you have never used it before, do not
surpass the previously stated dosage. Wait and see how it affects you; it is dangerous to begin consuming high
doses.
For best results, take the drug on an empty stomach. If nausea or stomach aching is experienced, or if you
become hungry, eat something small. On an empty stomach the effects will become noticeable within 15 minutes
(yet depends on the dose). It also must be noted that like most other drugs, some experience is required before
the full effects can be noticed and enjoyed.
The effects will usually begin with a slight sedation, and a feeling of warmth coming over your body. Muscular
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relaxation is also quite noticeable. The subjective effects are quite hard to describe beyond the word euphoria. Th
sedation associated with codeine is quite a lot less than that experienced with morphine or other stronger opiates
A strong feeling of contentment is usually also experienced. Most people enter a phase where you become quite
content and tend to lose interest in their surroundings. A heavy feeling in the limbs also becomes quite noticeabl
This will peak at about one hour with the strongest effects slowly tapering off after two hours.
Codeine is mainly used as a pain reliever, but is also used for the relief of a non-productive cough, and as an
anti-diarrheal agent. 120mg of codeine administered subcutaneously (injected under the skin) provides pain relie
equal to 10mg of morphine administered by the same route. Doses used to relieve cough or diarrhea range from
5mg to 30mg.
C o d e i n e : A d m i n i s t ra t i o n & E f f e c t s o n t h e B o d y a n d M i n d
One should also check the codeine thread and dosage thread; this being just a basic introduction
Codeine is absorbed quickly from the GI tract and its first pass through the liver results in very little loss of the
drug. This contrasts with morphine in which over 90% of the drug is metabolized in the first pass through the live
resulting in a considerable loss of potency when administered orally. This is why codeine is a common opiate in th
relief of pain; the ease of oral administration.
Codeine can be administered by many routes, this includes, SC, IM (intramuscularly), as an enema, and orally.
Note: codeine can't be administered safely by IV (intravenously) injection as it can result in pulmonary edema
(fluid in lungs), facial swelling and other life threatening complications.
Codeine is converted to morphine in the brain. This of course will result in a positive result in a drug test for the
opiates. It is not known whether or not the drugs heroin, morphine or codeine can be separately determined on a
drug test. In other words, it isn't likely that the drug tester can determine which of the three above drugs you
have taken; he just knows you've taken one or more of them.
Some common side effects from codeine include drowsiness, light-headedness, dry mouth, urinary retention
(difficulty in urination), constipation and of course, euphoria. Adverse effects can include itchiness (common),
confusion, nausea and vomiting. The nausea experienced with codeine is less common and less intense than that
experienced with the stronger opiates such as morphine. A tip to all those using opiates, lying down does wonder
to the nausea. If you ever experience nausea on opiates it is different than the commonly experienced nausea as
it is more of a light-headed feeling. Lying down will almost always relieve the nausea in a couple minutes, which
after you can attempt to stand up again.
Note: Addiction to codeine is possible. Tolerance is also seen with chronic use. Although the withdrawal
with codeine, it is not a fun time. Please be cautious in your use of the drug.
The LD50 (lethal dose for %50) is 800mg in the average person. Death from codeine, unlike most opiates,
includes restlessness, seizures, and eventually death from respiratory arrest. [Some sources indicate that the
lower-end LD50 may be around 500mg, so doses above 450mg are in the red zone.]
Yo u r P r o d u c t
If one has a product containing Opioids (i.e. Codeine ) plus PCM/APAP/Ibuprofen/Aspirin, he/she should always
overview exactly what and how much is present in the medication. The best choice is an opioid in conjunction wit
PCM/APAP or aspirin, as these are the quickest and easiest to filter. Also present are colorants, which do no harm
as well as fillers (for tablets) and other things; one should check on all.
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In general, capsules will yield the best results being that they contain less filler and only contain the wanted
chemicals and the filterable chemicals. (See: Chemicals list)
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Sodium Bicarbonate
Pseudoephedrine
Salicylic acid
Acetic Acid
Promethazine Hydrochloride
Doxylamine (extraction )
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Colorants
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See also: Chemicals List
Chemical Properties of the Ingredients

Although some of the chemicals can be taken safely up to a certain amount one should almost always perform a
Cold Water Extraction. Since one doesnt know their individual limits and other factors involved, filtering
everything out nearly removes all risks involved and promotes good health! These chemicals also interact with
each other, yet the results of this cannot always be foretold.
Dosages-
The listed dosages for opioids are starting points for therapeutic usage. One should consider his/her tolerance an
generally start as low as possible and work their way up.
The listed dosages for the other ingredients are maximum one-time amounts. Do not take that amount on a
regular basis; even one-time dosages can be considered high-risk.
M e l t i n g Po i n t
The melting point of a crystalline solid is defined as the temperature range at which it changes state from solid to
liquid; or the other way around. Although the phrase would suggest a specific temperature and is commonly and
incorrectly used as such in most textbooks and literature, most crystalline compounds actually melt over a range
of a few degrees or less. At the precise melting point the solid and liquid phases exist in equilibrium.
Opioids
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Codeine
Melting Point : 154-156 C (309-312 F)
Boiling Point: 250 C (482 F)
Soluble in : Water - (1g/ 2.3mL at 31C) and (1g/ 150mL at 21C)
Insoluble in:
Therapeutic dosage: Starts at: 0.5 - 2mg per kg of bodyweight
- Because codeine needs to be metabolized to an active form, there is a ceiling effect around
400-450 mg per intake. This low ceiling further contributes to codeine being less addictive than other
opiates. Roughly 5-10% of codeine will be converted to morphine, with the remainder either free,
conjugated to form codeine-6-glucuronide (~70%), or converted to norcodeine (~10%) and
hydromorphone (~1%)
Cold Water Extraction -Codeine will remain in the water after filtration if performed correctly.
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Codeine monohydrate
o One gram dissolves in the following: 120mL water at room temperature, 60mL water
at 80; 2mL alcohol, 1.2mL hot alcohol; 13mL benzene; 18 ml ether; and 0.5 ml
chloroform.
o Freely soluble in: amyl alcohol, methanol, and diluted acids.
o Almost insoluble in: petroleum ether or in solutions of alkali hydroxides.
Codeine Hydrochloride dehydrate

o One gram dissolves in the following: 20mL water, 1mL boiling water, and 180mL
alcohol.
Codeine Sulfate trihydrate

o One gram dissolves in the following: 30ml water, 6.5mL water at 80, 1300mL
alcohol.
o Insoluble in: chloroform and ether.
Codeine phosphate
o One gram dissolves in 4mL of water at 20C.
Codeine-Basics
Hydrocodone
Melting Point : 198 C (388 F)
Boiling Point :
Soluble in : Water, alcohol
Insoluble in :
Therapeutic dosage : Starts at 0.1 mg per kg bodyweight.
Cold Water Extraction: Hydrocodone remain in the water after filtration if performed correctly
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Hydrocodone Bitartrate hemipentahydrate

o One gram dissolves in: 16mL water, 150g 95% ethanol.
o Almost insoluble in: ether and chloroform.
Hydrocodone Basics & Experiences
O x yc o d o n e
Melting Point : 270-272 C (518-522 F)
Boiling Point :
Soluble in : Water
Slightly soluble in : alcohol
Insoluble in :
Therapeutic dosage : Starts at 0.075-0.1 mg per kg bodyweight
Cold Water Extraction : Oxycodone will remain in the water after filtration if performed correctly
Oxycodone Hydrochloride
- One gram dissolves in 10ml water.
Oxycodone Basics & Experiences
( D e x t r o ) p r o p ox y p h e n e
Melting Point :
Boiling Point :
Soluble in : Water, alcohol, chloroform, acetone.
Insoluble in : benzene, ether.
Therapeutic dosage :
Cold Water Extraction:
- Dextropropoxyphene hydrochloride will remain in the water after filtration if performed correctly
- Propoxyphene napsylate is n
noott water soluble and will not pass through the filter
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Propoxyphene napsylate
o Some believe it is soluble in water, while others believe it is not
o 100mg propoxyphene napsylate is equivalent to 65mg propoxyphene hydrochloride.
(Dextro)propoxyphene Basics & Experiences
Heroin / Diacetylmorphine
Melting Point :
Boiling Point :
Soluble in : water, chloroform, alcohol, ether, and alkalies
Insoluble in : ether
Cold Water Extraction : Heroin will remain in the water after filtration if performed correctly
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Diacethylmorphine Base
o One gram dissolves in: 1.5mL chloroform, 31mL alcohol, 100mL ether, 1700mL water.
o Slightly soluble in: ammonia or sodium carbonate solution.
o Soluble in alkalies.
o Decomposes by boiling with water.
Diacethylmorphine Hydrochloride monohydrate

o One gram dissolves in: 2mL water, 11mL alcohol.
o Insoluble in: ether.
Heroin Basics
Morphine
Melting Point :
Boiling Point :
Soluble in : water, alcohol, benzene, ether, chloroform, amyl alcohol, methanol, and dilute acids
Insoluble in :
Cold Water Extraction : Morphine will remain in the water after filtration if performed correctly
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Morphine monohydrate o One gram dissolves in: 120mL water, 60mL water at 80, 2mL alcohol, 1.2mL hot
alcohol, 13mL benzene, 18mL ether, 0.5mL chloroform
o Freely soluble in: amyl alcohol, methanol, and dilute acids.
o Almost insoluble in: petroleum ether or in solutions of alkali hydroxides.
Morphine Hydrochloride dehydrate

o One gram dissolves in: 20mL water, 1mL boiling water, 180mL alcohol.
Morphine Sulphate trihydrate

o One gram dissolves in: 30mL water, 6.5mL water at 80, 1300mL alcohol.
o Insoluble in: chloroform or ether.
Morphine Basics
N S A I D S : N o n - s t e r o i d a l A n t i - i n f l a m m a t o r y D r u g s & P C M / A PA P
(The "Other" Painkillers in Many OTC Products)
Pa r a c e t a m o l / A c e t o m i n a p h e n
Melting Point : 169 C (336 F)
Boiling point: Not applicable; PCM/APAP will decompose
Soluble in: water (0.1-0.5 g/100mL at 22C mg/mL [20 C]), methanol, ethylene dichloride, acetone, ethyl
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acetate
Slightly insoluble in : ether
Insoluble in : petroleum ether, pentane, and benzene
Therapeutic Dosage: The highest level that a person can take at once will differ with each individual; this being
true with every drug. If one does decide to use products containing these ingredients, they are advised to do so
with caution. It is recommended they begin with a low dose, perhaps around 500mg to 750mg. Once accustomed
to taking it, try not to exceed 1000mg to 1500mg per dosage, and never 4000mg within a 24 hour period.
Cold Water Extraction : Filtration is possible by the method of extraction using cold water. When properly filtered,
the PCM/APAP will be separated from the codeine; considerably more in warm water than cold when initially
mixed.
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- Side-effects : Paracetamol (Acetaminophen) taken in high doses can be potentially lethal. Due to
the wide availability of it, there is a large potential for toxicity and overdose. Without timely
treatment, overdose can lead to liver failure and death within a matter of days. It is a slow,
extremely painful death.
- Paracetamol toxicity is, by far, the most common cause of acute liver failure in both the United
States and United Kingdom. It is sometimes used in suicide attempts by those unaware of the
prolonged time course and high morbidity (likelihood of significant illness) associated with
paracetamol-induced toxicity in survivors.
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- White Grapefruit Juice is an inhibitor of CYP3A4, which is a minor metabolizer of hydrocodone
major metabolizer of acetaminophen. This means that the degree to which plasma concentrations of
acetaminophen increase would be much greater than the degree to which plasma levels of
hydrocodone would increase; thus the risk of liver toxicity is made higher.
Aspirin (Acetylsalicylic acid)

Melting point : 138-140 C (280-284 F)
Boiling point: 140 C (284 F)
Soluble in: Water 10 mg/mL
Insoluble in: ?
Therapeutic Dosage :
Cold Water Extraction: Filtration is possible by the method of extraction using cold water. When properly filtered,
the Aspirin will be separated from the codeine; considerably more in warm water than cold when initially mixed.
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- One gram dissolves in: 300mL water at 25, in 100mL water at 37, in 5mL alcohol, 17mL
chloroform, and 10-15mL ether.
- Less soluble in: anhydrous ether.
- Decomposes by: boiling it in water or when dissolved in solutions of alkali hydroxides and
carbonates.
(Inorganic salts of acetylsalicylic acid are soluble in water (especially the Ca salt, q.v.), but are
decomposed quickly.)
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- High Dosage : The toxic dose of aspirin is generally considered greater than 150mg per kg of body
mass. Moderate toxicity occurs at doses up to 300mg/kg, severe toxicity occurs between 300 to
500mg/kg, and a potentially lethal dose is greater than 500mg/kg. This is the equivalent of many
dozens of the common 325mg tablets, depending on body weight. However, children cannot tolerate
as much aspirin per unit body weight as adults can.
- Side-effects : Aspirin overdose has potentially serious consequences, sometimes leading to
significant morbidity and mortality. Patients with mild intoxication frequently have nausea and
vomiting, abdominal pain, lethargy, tinnitus, and dizziness. More significant symptoms occur in more
severe poisonings and include hyperthermia, tachypnea, respiratory alkalosis, metabolic acidosis,
hyperkalemia, hypoglycemia, hallucinations, confusion, seizure, cerebral edema, and coma. The most
common cause of death following an aspirin overdose is cardiopulmonary arrest usually due to
pulmonary edema.
For more info, see: poisoning section
Ibuprofen
Melting Point : 76C (169 F)

Boiling Point:
Soluble in : organic solvents
Insoluble in : water
Therapeutic Dosage : 1200mg of ibuprofen is the maximum standard dose for a day. In medical practice, doses o
3200mg can be used reportedly.
Cold Water Extraction: Possible to filter out, but not as easy & efficient as Paracetamol (Acetaminophen) & Aspirin
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- High Dosage : High doses involve a whole plethora of nasty side effects ranging from
gastrointestinal ulceration to diarrhea.
- Side-effects: Human response in cases of overdose ranges from absence of symptoms to fatal
outcome in spite of intensive care treatment. Most symptoms are an excess of the pharmacological
action of ibuprofen and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache,
tinnitus, and nystagmus. Rarely more severe symptoms such as gastrointestinal bleeding, seizures,
metabolic acidosis, hyperkalaemia, hypotension, bradycardia, tachycardia, atrial fibrillation, coma,
hepatic dysfunction, acute renal failure, cyanosis, respiratory depression, and cardiac arrest have
been reported.
For more info, see: poisoning section
O t h e r I n g r e d i e n t s Po s s i b l y P r e s e n t
If using the CWE method with tablets/capsules containing the following ingredients, one should be aware that
these may alter the effects of opioids. Because of this, severe side effects are perfectly possible; in worst case
scenarios, an OD can occur.
Caffeine
Melting point : 237 C (Non-equilibrium, Superheated; Caffeine 'sublimes'- goes from solid to gas, no liquid
phase)
Boiling point: 178 C
Soluble in: Water (22 mg/ 1mL [25 C]), (180 mg/ 1mL [80 C]), (670 mg/ 1mL [100 C])
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- Solubility in water is increased by alkali benzoates, cinnamates, citrates or salicylates.
Insoluble in : ?
Therapeutic Dosage :
Cold Water Extraction: When using this method to remove caffeine, one must be prepared to wait a good amoun
of time and do not rush the process. Studying the chemicals and subject beforehand is recommended. Take an
ample amount of time and be careful.
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- One gram dissolves in: 46mL water, 5.5mL water at 80, 1.5 L boiling water, 66mL alcohol, 22mL
alcohol at 60, 50mL acetone, 5.5mL chloroform, 530mL ether, 100mL benzene, and 22mL boiling
benzene.
- Freely soluble in: pyrrole, in tetrahydrofuran containing about 4% water, and ethyl acetate.
- Slightly soluble: in petr ether.
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- High Dosage : Though achieving the lethal dose with caffeine would be exceptionally difficult with
regular coffee, there have been reported deaths from overdosing on caffeine pills; with serious
symptoms of overdose requiring hospitalization occurring from as little as 2 grams of caffeine. One
should judge for him/herself whether or not they have a tolerance to caffeine. In theory everything
above 300mg constitutes an OD, but can be higher in reality. One should not go a lot further! To
check tolerance levels, one can look up caffeine contents in the following database:
http://www.energyfiend.com/the-caffeine-database/
- Side effects : Altered effects of other drugs consumed (i.e. opioids), nervousness, irritability,
anxiety, tremulousness, muscle twitching (hyperreflexia), insomnia, headaches, respiratory alkalosis,
and heart palpitations.
o An acute overdose of caffeine, usually in excess of 250 milligrams, can result in an
over stimulation of the central nervous system called caffeine intoxication. It may
include restlessness, nervousness, excitement, insomnia, flushing of the face, increased
urination, gastrointestinal disturbance, muscle twitching, a rambling flow of thought and
speech, irritability, irregular or rapid heartbeat, and psychomotor agitation.
o In cases of much larger overdoses, mania, depression, lapses in judgment,
disorientation, loss of social inhibition, delusions, hallucinations, psychosis,
rhabdomyolysis, and death may occur.
o In cases of extreme overdose, death can result.
The Combined Snorting Caffeine Thread On the subject of insufflation, but also includes other useful informatio
about the effects of caffeine.
Re m o v i n g C a f f e i n e
Upon searching, there seems to be several methods. Each should be performed with the utmost patience and
attention. One should still be careful though, especially if using any solvents such as acetone. For more
information, a thread is available: https://www.drugs-forum.com/forum/showthread.php?t=44769
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hood
dss ffoorr tth
hee R
Reem
moovvaall ooff C
Caaffffeeiin
nee::
Activated Carbon Method:
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Prior to this step, a Cold Water Extraction should have already been performed. Following this, simply filter the
solution through Activated Carbon. This should be available at any local pet shop for a low price. Be sure to rinse
the carbon prior to filtering as to avoid turning the water black! One may use a permanent coffee filter, yet any
small screen strainer will work. Dump the solution cup to cup, (or however you so choose), for several minutes
making multiple passes through the carbon. By doing so, you will succeed in creating a caffeine-free solution!
Not only will the carbon filter out caffeine, but can remove any remaining traces of APAP that might be present. I
is recommended that the AC filtering only be performed when caffeine is present, and not as a way to help remov
APAP/PCM.
Filtering Using Solvents:
Your product may have different amounts of the following substances, but it shouldnt be of great importance.
Stay on the safe side and calculate it up or follow the manual below. For the examples shown, the product used
will be AC&C.
8mg codeine phosphate (1.6g codeine phosphate / 200ct)

15mg caffeine (3g caffeine / 200ct)
325mg aspirin (75g aspirin / 200ct)
127mg junk (25.4g / 200ct)
Read carefully.
- 200ct uncrushed AC&C added to 600ml beaker (net 95g). Hot water was added to 550ml mark.
Stirred every 30 minutes (3). Cooled in fridge for 4h.
o 360ml decanted to 2nd beaker.
- 190ml left in sludge layer. (65% of 1.6g codeine extracted.)
- 200ml hot water added to 600ml beaker. Stirred 5min. Cooled in fridge for 4h.
o Decanted 200ml to 2nd beaker. (18% of 1.6g codeine extracted.)
- 190ml hot water added to 600ml beaker. Stirred 5min. Cooled in fridge for 4h.
o Decanted 190ml to 2nd beaker. (9% of 1.6g codeine extracted.)
This means that 92% of the total codeine/caffeine was extracted into a net volume of 750ml. (1.47g codeine
2.74g caffeine.) What remains in the beaker is mostly junk & aspirin.
- Reduced volume in 2nd beaker to 150mL by boiling.
The room will fill with the mild smell of vinegar as some of the aspirin decomposes. The solution is cooled in the
fridge and then filtered (1). The volume is again reduced to 50mL. The solution is cooled in the fridge and then
filtered (2). After this treatment, less than 15% of the original amount of caffeine will remain in the solution.
What remains is a solution of codeine without a discernable amount of caffeine. The solution can be boiled down
a powder that looks something like brown sugar and is intensely bitter. (This step is not normally recommended a
high temperatures cause the break-down of codeine.) This is a relatively concentrated form of codeine phosphate
Enjoy responsibly.
1. Some amount of caffeine is filtered off at this step. Remember to wash your filter paper with a
bit of ice-cold water to reduce the losses. What you're doing is actually re-crystallizing the
caffeine, and for people who haven't seen it before, it almost looks like cotton candy.
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2. More caffeine is filtered off at this step.

3. If you don't have automated stirring, just stir occasionally over a half-hour period of time.
Note how this technique refrains from using acids, bases, or organic solvents to accomplish the removal of caffein
from the caffeine/codeine; thus I feel it is a significant breakthrough.
Chromic would like to thank a name-withheld codeine fanatic who he worked alongside with via PM to discover
this technique.
C h l o r p h e n i ra m i n e m a l e a t e
Melting Point :
Boiling Point :
Soluble in : water (0.55g/ 100mL, liquid mg/mL [20 C])
Insoluble in :
Therapeutic dosage : A maximum of 24-30 mg/day. An antihistamine, Chlorpheniramine relieves red, itchy, wate
eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. It may also relieve the
itching of insect bites, bee stings, poison ivy, and poison oak.
Cold Water Extraction : Chlorpheniramine is nearly impossible to extract using a CWE. See extraction for a
working, non CWE, method for filtering.
- Soluble in mg/mL at 25: ethanol 330 mg, chloroform 240mg, water 160 mg, methanol 130 mg.
- Slightly soluble in: benzene, ether.
((T
Th
hee iin
nffoorrm
maattiioon
nb
beelloow
w iiss vveerryy iim
mp
poorrttaan
ntt!!))
- Side-Effects: Symptoms of a Chlorpheniramine overdose include extreme fatigue, confusion,
weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking,
insomnia, hallucinations, and possibly raising the risk of seizures.
- Potentiating Effects: It has analgesic-sparing (potentiating) effects on opioid analgesics, commonly
reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 per cent.
Chlorpheniramine maleate thread
D ox y l a m i n e s u c c i n a t e
Melting Point :
Boiling Point :
Soluble in : water, alcohol, chloroform.
Insoluble in :
Therapeutic dosage : Doxylamine is an anti-histamine in the same class as chlorpheniramine and
diphenhydramine. Large quantities could prove fatal. Even smaller doses can lead to an awful experience.
Cold Water Extraction : Doxylamine is nearly impossible to extract using a CWE. See extraction for a working, no
CWE, method of filtering.
- One gram soluble in: 1mL water, 2mL alcohol, 2mL chloroform.
- Slightly soluble in: benzene, ether.
((T
Th
hee iin
nffoorrm
maattiioon
nb
beelloow
w iiss vveerryy iim
mp
poorrttaan
ntt!!))
- Side-Effects: May include- dysphoria, vision problems, difficulty urinating, muscle weakness,
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excitement, and hallucinations. Given the danger of antihistamines, these sound like some of the
more benign side effects (See: chlorpheniramine side effects; they are very similar!) More times than
not, achieving an opiate high with these chemicals present is not worth the risk.
- Potentiating Effects: Doxylamine has analgesic-sparing (potentiating) effects on opioid analgesics,
commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 per cent.
Questions about Doxylamine Succinate
Re m o v i n g b o t h C h l o r p h e n i r a m i n e M a l e a t e a n d / o r D o x y l a m i n e S u c c i n a t e
1. Crush the tablets into powder as fine as possible.
2. Wash them sseevveerraall times using anhydrous ethanol that has been dried with calcium oxide.
3. Normally, two to three washes of 10mL dried ethanol is sufficient for several boxes of codeine with
Chlorpheniramine maleate and/or Doxylamine succinate present.
Hardly any codeine is dissolved while using this method!
Promethazine Hydrochloride
Melting Point :
Boiling Point :
Soluble in : water, alcohol, chloroform.
Insoluble in : acetone, ether, ethyl acetate.
Cold Water Extraction : Not known to be possible to filter using a CWE.
Promethazine Recreational Potential?
Gluthethimide
- A combination of codeine and gluthethimide (a sleeping agent) has been used in some places as a
heroin substitute.
- Gluthethimide is an enzyme-inducer, allowing the body to convert more than 10% of codeine
consumed into morphine.
-N
Noottee:: T
Th
hiiss ccoom
mb
biin
naattiioon
n iin
nccrreeaasseess tth
hee aad
dd
diiccttiioon
np
pootteen
nttiiaall ooff ccood
deeiin
nee..
Further information is needed on the subject and is currently being worked on. Be safe; do not try without gettin
additional information!
Sodium Bicarbonate - NaHCO3 (Baking Soda)

-- N
Noott ttoo b
bee ccoon
nffu
usseed
dw
wiitth
hS
Sood
diiu
um
mC
Ch
hlloorriid
dee
N
NaaC
Cll ((S
Saalltt))!!
Melting Point :
Boiling Point :
Soluble in :
Insoluble in :
Therapeutic dosage : The maximum daily dosage of sodium bicarbonate is 200mEq (16.6 grams of N
NaaH
HC
CO
O3
3
patients younger than 60 years of age and 100mEq (8.3 grams of N
NaaH
HC
CO
O3
3) in patients 60 years of age or older.
Generally not dangerous, high doses should be avoided due to risk of harming organs. Drinking lots of fluids is
advised.
31 of 36
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Cold Water Extraction : It is not possible to filter out NaHCO3 using a CWE.
E
Effffeeccttss::
- As an Alkalizer (systemic): Increases the plasma bicarbonate, buffers excess hydrogen ion
concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis.
- As an Alkalizer (urinary): Increases the excretion of free bicarbonate ions in the urine, thus
effectively raising the urinary pH. By maintaining alkaline urine, the actual dissolution of uric acid
stones may be accomplished.
- As an Antacid: Reacts chemically to neutralize or buffer existing quantities of stomach acid but has
no direct effect on its output. This action results in increased pH value of stomach contents, thus
providing relief of hyperacidity symptoms.
For more information, see: https://www.drugs.com/mmx/sodium-bicarbonate.html
Pseudoephedrine
Pseudoephedrine alters the effects of opioids. If overdosed on, serious side-effects experienced will be similar to
those of caffeine but much stronger. Melting Point :
Boiling Point :
Soluble in : water (slightly)
Insoluble in :
Cold Water Extraction : It is practically impossible to filter out pseudoephedrine using a CWE.
O
Otth
heerr E
Exxttrraaccttiioon
nM
Meetth
hood
dss ((ffoorr D
Diiffffeerreen
ntt FFoorrm
mss aan
nd
dC
Ch
heem
miiccaallss))::
Pseudoephedrine Base:
o Freely Soluble in: alcohol, ether.
o Slightly soluble in: water.
Pseudoephedrine Hydrochloride:
o Solubility at 25 C (g/ml): water (2.0g), chloroform (0.011g), ethanol (0.278g).
For further information, see:
https://www.drugs.com/pseudoephedrine.html
Pseudoephedrine filtration with Active Carbone?
Salicylic acid
Melting Point : 159 C
Boiling Point : 211 C
Soluble in :
Insoluble in :
Cold Water Extraction :
((T
Th
hee iin
nffoorrm
maattiioon
nb
beelloow
w iiss vveerryy iim
mp
poorrttaan
ntt!!))
- Safety : Salicylic acid has an ototoxic effect, and can induce transient hearing loss in zinc-deficient
individuals.
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19/11/2014 14:48
o This finding is based on clinical studies with rats. An injection of salicylic acid induced
hearing loss in zinc-deficient rats, while a simultaneous injection of zinc reversed the
hearing loss. An injection of magnesium in the zinc-deficient rats did not reverse the
salicylic acid-induced hearing loss.
- Salicylic acid is toxic in large amounts.
For further information, see: http://en.wikipedia.org/wiki/Salicylic_acid
Acetic acid (Vinegar)

Melting Point : 16.5 C
Boiling Point : 118.1 C
Soluble in : Miscible with water.
Insoluble in :
Cold Water Extraction :
((T
Th
hee iin
nffoorrm
maattiioon
nb
beelloow
w iiss vveerryy iim
mp
poorrttaan
ntt!!))
- Safety: Concentrated acetic acid is corrosive and must therefore be handled with appropriate care,
since it can cause skin burns, permanent eye damage, and irritation to the mucous membranes.
These burns or blisters may not appear until hours after exposure. Latex gloves offer no protection,
so special resistant gloves, such as those made of nitrile rubber, should be worn when handling the
compound.
- Concentrated acetic acid can be ignited with difficulty in the laboratory. It becomes a flammable risk
if the ambient temperature exceeds 39 C (102 F), and can form explosive mixtures with air above
this temperature (explosive limits: 5.4%16%).
For further information, see: http://en.wikipedia.org/wiki/Acetic_acid
M e t h o d s o f Tr e a t i n g I n g r e d i e n t Po i s o n i n g , O ve r d o s i n g , a n d
L i ve r D a m a g e ; H o w t o M i n i m i ze S i d e - E f f e c t s
A
Ass ssttaatteed
d eexxaaccttllyy iin
n tth
hee iin
nttrrood
du
uccttiioon
n:: IIff yyoou
u ffeeeell ssiicckk-- eexxttrreem
meellyy ssiicckk-- iim
mm
meeddiiaatteellyy ccoon
nttaacctt pprrooffeessssiioon
naall
h
heellpp aan
ndd ccaallll tth
hee aam
mbbu
ullaan
nccee!! D
Doo n
noott iin
nddu
uccee vvoom
miittiin
ngg n
noorr ttrryy ttoo ssoollvvee tth
hee pprroobblleem
m bbyy ccoon
nssu
um
miin
ngg ootth
heerr
ddrru
uggss!!
The steps listed are best used for preventative measures rather than treatment. Aside from the following, it is be
to uphold a healthy nutrition and to take breaks between uses. Drinking plenty of water is also advised.
P C M ( A PA P ) Po i s o n i n g : B e n e f i t s o f A c e t y l c y s t e i n e
PCM (APAP) Poisoning Experiences, Infos & Discussion Thread
Using Acetylcysteine as antidote: Overdosed toxic itself; drinking lots of water is always recommended due to
possible harm to kidneys.
Administration of activated charcoal should be considered if paracetamol in excess of 150mg/kg or 12g (whicheve
is smaller) is thought to have been ingested within the previous hour.
Acetylcysteine protects the liver if infused within 24 hours of ingesting paracetamol. It is most effective if given
within 8 hours of ingestion, after which effectiveness declines sharply. If more than 24 hours has elapsed then
33 of 36
19/11/2014 14:48
advice should be sought from a Poisons Information Center or from a liver unit on the management of serious liv
damage. In remote areas, methionine (2.5g) by mouth is an alternative if acetylcysteine cannot be given
promptly. Once the patient reaches hospital the need to continue treatment with the antidote will be assessed
from the plasma-paracetamol concentration.
Patients at risk of liver damage and therefore requiring treatment can be identified from a single measurement o
the plasma-paracetamol concentration, related to the time from ingestion, provided this time interval is not less
than 4 hours; earlier samples may be misleading. The concentration is plotted on a paracetamol treatment graph
of a reference line (normal treatment line') joining plots of 200mg/L (1.32mmol/L) at 4 hours and 6.25mg/L
(0.04mmol/L) at 24 hours. Those whose plasma-paracetamol concentration is above the normal treatment line a
treated with acetylcysteine by intravenous infusion. If acetylcysteine is not available, the patient will be treated
with methionine by mouth, provided the overdose occurred within 1012 hours and the patient is not vomiting.
Patients on enzyme-inducing drugs (e.g. carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, alcoho
and St Johns Wort) or who are malnourished (e.g. in anorexia, in alcoholism, or those who are HIV-positive) may
develop toxicity at lower plasma-paracetamol concentration and should be treated if the concentration is above
the high-risk treatment line (which joins plots that are at 50% of the plasma-paracetamol concentrations of the
normal treatment line.)
The prognostic accuracy of a plasma-paracetamol concentration measurement taken after 15 hours is uncertain
but a concentration above the relevant treatment line should still be regarded as carrying a serious risk of liver
damage.
Plasma-paracetamol concentration may be difficult to interpret when paracetamol has been ingested over several
hours. If there is doubt about timing or the need for treatment then the patient should be treated with an antidot
in any case. -Thanks to Jatelka.
A s p i r i n Po i s o n i n g ( S a l i c y l a t e Po i s o n i n g )
Aspirin Poisoning: Infos, Basics & Discussion Thread
There is no antidote to salicylate poisoning (the active ingredient in aspirin). Frequent blood work is performed to
check metabolic, salicylate, and blood sugar levels while arterial blood gas assessments are performed to test for
respiratory alkalosis and metabolic acidosis. Patients are monitored and often treated according to their individua
symptoms.
Patients may be given intravenous potassium chloride to counteract hypokalemia, glucose to restore blood sugar
levels, benzodiazepines for any seizure activity, fluids for dehydration, and most importantly sodium bicarbonate
to restore the blood's sensitive pH balance. Sodium bicarbonate also has the effect of increasing the pH of urine,
which in turn increases the elimination of salicylate.
Additionally, hemodialysis can be implemented to enhance the removal of salicylate from the blood. Hemodialysis
is usually used in severely poisoned patients; for example, patients with significantly high salicylate blood levels,
significant neurotoxicity (agitation, coma, and convulsions), renal failure, pulmonary edema, or cardiovascular
instability. Hemodialysis also has the advantage of restoring electrolyte and acid-base abnormalities, and often
plays life-saving roles in severely ill patients.
All overdose patients should be conveyed to a hospital for assessment immediately. Initial treatment of an acute
overdose includes gastric decontamination. This is achieved by administering activated charcoal which adsorbs th
aspirin in the gastrointestinal tract. Repeated doses of charcoal have been proposed to be beneficial in
overdose. A study performed found that repeating doses of charcoal might not be of significant value. However,
most toxicologists will administer additional charcoal if serum salicylate levels are increasing.
34 of 36
19/11/2014 14:48
Stomach pumps are no longer routinely used in the treatment of poisonings but are sometimes considered if the
patient has ingested a potentially lethal amount within one hour beforehand.
I b u p r o f e n Po i s o n i n g
Basics, Infos & Experiences on Ibuprofen Poisoning Thread
Therapy is largely symptomatic. In cases presenting early, gastric decontamination is recommended. This is
achieved using activated charcoal to absorb the drug before it can enter the systemic circulation. Gastric lavage i
now rarely used, but can be considered if the amount ingested is potentially life threatening and it can be
performed within 60 minutes of ingestion.
Emesis is not recommended. The majority of ibuprofen ingestions produce only mild effects and the managemen
of overdose is straightforward. Standard measures to maintain normal urine output should be instituted and rena
function monitored. Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresi
is theoretically beneficial. However, due to the fact ibuprofen is highly protein-bound in the blood, there is minim
renal excretion of unchanged drug. Forced alkaline diuresis is therefore of limited benefit.
Symptomatic therapy for hypotension, GI bleeding, acidosis, and renal toxicity may be indicated. Occasionally,
close monitoring in an intensive care unit for several days is necessary. If a patient survives the acute intoxicatio
he/she will usually experience no late sequelae.
A
An
nyy ffeeeeddbbaacckk oon
n aan
nyytth
hiin
ngg ppoosstteedd aabboovvee,, oorr iin
nffoorrm
maattiioon
n,, cch
haan
nggeess,, lliin
nkkss,, m
maan
nu
uaallss,, aan
ndd ccrriittiicciissm
mss w
woou
ulldd bbee
aapppprreecciiaatteedd.. FFeeeell ffrreeee ttoo ppoosstt iin
n tth
hee ccoom
mm
meen
nttss sseeccttiioon
n.. II h
hooppee yyoou
u ((tth
hee rreeaaddeerr)) ffoou
un
ndd tth
hiiss W
Wiikkii aarrttiiccllee
u
usseeffu
ull aan
ndd tth
hee iin
nffoorrm
maattiioon
n llaaiidd oou
utt iin
n aa cclleeaarr aan
ndd ccoon
ncciissee m
maan
nn
neerr..
W
Wh
heen
n ppeerrffoorrm
miin
ngg C
Coolldd W
Waatteerr E
Exxttrraaccttiioon
nss,, pplleeaassee bbee ccaarreeffu
ull!! B
Beesstt ooff llu
ucckk ttoo yyoou
u aallll!!
Contributors: Joben, A
Allffaa, salviablue
, csharpprogrammer, 0utrider
Created by A
Allffaa, 27-04-2008 at 11:
Last edited by salviablue
, 21-02-2012 at 00:
Last comment by Unas on 26-07-2012 at 01:
13 Comments
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codeine cold water extraction, codeine extraction, cold water extraction, cwe, cwe faq improvement, cwe procedure
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